Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells

Viruses causing chronic infection artfully manipulate infected cells to enable viral persistence in vivo under the pressure of immunity. Human T-cell leukemia virus type 1 (HTLV-1) establishes persistent infection mainly in CD4+ T cells in vivo and induces leukemia in this subset. HTLV-1-encoded Tax...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 115; H. 6; S. E1269
Hauptverfasser:	Mahgoub, Mohamed, Yasunaga, Jun-Ichirou, Iwami, Shingo, Nakaoka, Shinji, Koizumi, Yoshiki, Shimura, Kazuya, Matsuoka, Masao
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 06.02.2018
Schlagworte:	Gene Expression Regulation, Viral Gene Products, tax - genetics Gene Products, tax - metabolism HTLV-I Infections - genetics HTLV-I Infections - metabolism HTLV-I Infections - virology Human T-lymphotropic virus 1 - pathogenicity Humans Leukemia-Lymphoma, Adult T-Cell - genetics Leukemia-Lymphoma, Adult T-Cell - metabolism Leukemia-Lymphoma, Adult T-Cell - virology Single-Cell Analysis T-Lymphocytes - virology Virus Activation Virus Replication HBZ computational simulation HTLV-1 Tax adult T-cell leukemia–lymphoma
ISSN:	1091-6490, 1091-6490
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