Maternal Vitamin D3 Supplementation during the Third Trimester of Pregnancy: Effects on Infant Growth in a Longitudinal Follow-Up Study in Bangladesh

To estimate the effects of prenatal vitamin D supplementation on infant growth in Dhaka, Bangladesh. Longitudinal follow-up of infants born at term or late preterm (≥34 weeks) to participants in a randomized double-blind trial of maternal third-trimester vitamin D3 (35 000 IU/wk; vitamin D ) vs plac...

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Bibliographic Details
Published in:The Journal of pediatrics Vol. 163; no. 6; pp. 1605 - 1611.e3
Main Authors: Roth, Daniel E., Perumal, Nandita, Al Mahmud, Abdullah, Baqui, Abdullah H.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.12.2013
Mosby, Inc
Subjects:
anthropometric measurements
Bangladesh
Child Development
cholecalciferol
Cholecalciferol - therapeutic use
Dietary Supplements
Double-Blind Method
drug therapy
Female
Follow-Up Studies
Growth
growth retardation
Humans
infancy
Infant
infant growth
Infant, Newborn
infants
Longitudinal Studies
Male
Pediatrics
Pregnancy
Pregnancy Complications
Pregnancy Complications - drug therapy
Pregnancy Trimester, Third
therapeutic use
Vitamin D Deficiency
Vitamin D Deficiency - drug therapy
Vitamins
Vitamins - therapeutic use
World Health Organization
Bangladesh
WAZ
LAZ
HCAZ
PTH
25(OH)D
AViDD
WFL
25-hydroxyvitamin D
Weight-for-age z-score
Antenatal vitamin D in Dhaka
Head circumference-for-age z-score
Parathyroid hormone
Weight-for-length z-score
Length-for-age z-score
ISSN:0022-3476, 1097-6833, 1097-6833
Online Access:Get full text
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Summary:To estimate the effects of prenatal vitamin D supplementation on infant growth in Dhaka, Bangladesh. Longitudinal follow-up of infants born at term or late preterm (≥34 weeks) to participants in a randomized double-blind trial of maternal third-trimester vitamin D3 (35 000 IU/wk; vitamin D ) vs placebo. Anthropometry was performed at birth, 1, 2, 4, 6, 9, and 12 months of age. The primary analysis (n = 145 overall; n = 134 at 1 year) was a comparison of mean length-for-age z-score (LAZ) based on World Health Organization standards. LAZ was similar between groups at birth, but 0.44 (95% CI, 0.06-0.82) higher in vitamin D vs placebo at 1 year, corresponding to a sex-adjusted increase of 1.1 cm (95% CI, 0.06-2.0). Mean change in LAZ from birth to 1 month was significantly greater in vitamin D (0.53 per month) vs placebo (0.19 per month; P = .004); but there was no significant divergence thereafter. In longitudinal (repeated-measures) analysis, average LAZ during infancy was 0.41 higher in vitamin D vs placebo (95% CI, 0.11-0.71, P = .01). Stunting was less common in vitamin D (17% of infants were ever stunted) vs placebo (31%; P = .049). Other anthropometric indices were similar between groups. Maternal vitamin D3 supplementation (35 000 IU/wk) during the third trimester of pregnancy enhanced early postnatal linear growth in a cohort of infants in Bangladesh.
Bibliography:http://dx.doi.org/10.1016/j.jpeds.2013.07.030
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ISSN:0022-3476
1097-6833
1097-6833
DOI:10.1016/j.jpeds.2013.07.030