Priors and decision thresholds in phase 2 and phase 3 randomized controlled trials evaluating drug efficacy using Bayesian methods: a systematic review

To describe the priors and decision thresholds in phase 2 and 3 randomized controlled trials (RCTs) evaluating drug efficacy using Bayesian methods. A systematic review of phase 2 and 3 RCTs evaluating drug efficacy through Bayesian inference was conducted across the MEDLINE, EMBASE, and Cochrane da...

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Veröffentlicht in:	Journal of clinical epidemiology Jg. 179; S. 111651
Hauptverfasser:	Barret, Lorraine, Liaigre, Léa, Hlavaty, Alex, Giai, Joris, Laporte, Silvy, Ollier, Edouard, Meyer, Nicolas, Khouri, Charles, Cucherat, Michel, Roustit, Matthieu
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.03.2025 Elsevier Limited Elsevier
Schlagworte:	Applications Bayes Theorem Bayesian analysis Bayesian methods Clinical decision making Clinical trials Clinical Trials, Phase II as Topic - statistics & numerical data Clinical Trials, Phase III as Topic - statistics & numerical data Conditional probability COVID-19 Decision thresholds Drug development Drug dosages Drug efficacy Effectiveness Guidelines Heterogeneity Humans Hypotheses Internal Medicine Methodology Parameter sensitivity Priors Randomized controlled trials Randomized Controlled Trials as Topic - methods Randomized Controlled Trials as Topic - statistics & numerical data Regulatory agencies Reporting standards Sensitivity analysis Statistical analysis Statistical inference Statistics Systematic review Thresholds Drug efficacy Priors Bayesian methods Reporting standards Randomized controlled trials Decision thresholds
ISSN:	0895-4356, 1878-5921, 1878-5921
Online-Zugang:	Volltext
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