A decade of transcription factor-mediated reprogramming to pluripotency

This year marks the tenth anniversary of the generation of induced pluripotent stem cells (iPSCs) by transcription factor-mediated somatic cell reprogramming. Takahashi and Yamanaka portray the path towards this ground-breaking discovery and discuss how, since then, research has focused on understan...

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Veröffentlicht in:	Nature reviews. Molecular cell biology Jg. 17; H. 3; S. 183 - 193
Hauptverfasser:	Takahashi, Kazutoshi, Yamanaka, Shinya
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.03.2016 Nature Publishing Group
Schlagworte:	631/136/2444 631/136/532/2435 631/532/2064/2158 Animals Biochemistry Cancer Research Cell Biology Cellular control mechanisms Cellular Reprogramming Cellular Reprogramming Techniques - history Cellular Reprogramming Techniques - methods Developmental Biology Genetic aspects Genetic research Genetic transcription History, 21st Century Humans Innovations Life Sciences Properties Regenerative medicine Stem Cells timeline Transcription factors Transcription Factors - biosynthesis Transcription Factors - genetics
ISSN:	1471-0072, 1471-0080, 1471-0080
Online-Zugang:	Volltext
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Abstract	This year marks the tenth anniversary of the generation of induced pluripotent stem cells (iPSCs) by transcription factor-mediated somatic cell reprogramming. Takahashi and Yamanaka portray the path towards this ground-breaking discovery and discuss how, since then, research has focused on understanding the mechanisms underlying iPSC generation and on translating such advances to the clinic. The past 10 years have seen great advances in our ability to manipulate cell fate, including the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This process proved to be remarkably simple from a technical perspective, only needing the host cell and a defined cocktail of transcription factors, with four factors — octamer-binding protein 3/4 (OCT3/4), SOX2, Krüppel-like factor 4 (KLF4) and MYC (collectively referred to as OSKM) — initially used. The mechanisms underlying transcription factor-mediated reprogramming are still poorly understood; however, several mechanistic insights have recently been obtained. Recent years have also brought significant progress in increasing the efficiency of this technique, making it more amenable to applications in the fields of regenerative medicine, disease modelling and drug discovery.
AbstractList	The past 10 years have seen great advances in our ability to manipulate cell fate, including the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This process proved to be remarkably simple from a technical perspective, only needing the host cell and a defined cocktail of transcription factors, with four factors - octamer-binding protein 3/4 (OCT3/4), SOX2, Krüppel-like factor 4 (KLF4) and MYC (collectively referred to as OSKM) - initially used. The mechanisms underlying transcription factor-mediated reprogramming are still poorly understood; however, several mechanistic insights have recently been obtained. Recent years have also brought significant progress in increasing the efficiency of this technique, making it more amenable to applications in the fields of regenerative medicine, disease modelling and drug discovery. This year marks the tenth anniversary of the generation of induced pluripotent stem cells (iPSCs) by transcription factor-mediated somatic cell reprogramming. Takahashi and Yamanaka portray the path towards this ground-breaking discovery and discuss how, since then, research has focused on understanding the mechanisms underlying iPSC generation and on translating such advances to the clinic. The past 10 years have seen great advances in our ability to manipulate cell fate, including the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This process proved to be remarkably simple from a technical perspective, only needing the host cell and a defined cocktail of transcription factors, with four factors — octamer-binding protein 3/4 (OCT3/4), SOX2, Krüppel-like factor 4 (KLF4) and MYC (collectively referred to as OSKM) — initially used. The mechanisms underlying transcription factor-mediated reprogramming are still poorly understood; however, several mechanistic insights have recently been obtained. Recent years have also brought significant progress in increasing the efficiency of this technique, making it more amenable to applications in the fields of regenerative medicine, disease modelling and drug discovery. The past 10 years have seen great advances in our ability to manipulate cell fate, including the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This process proved to be remarkably simple from a technical perspective, only needing the host cell and a defined cocktail of transcription factors, with four factors - octamer-binding protein 3/4 (OCT3/4), SOX2, Krüppel-like factor 4 (KLF4) and MYC (collectively referred to as OSKM) - initially used. The mechanisms underlying transcription factor-mediated reprogramming are still poorly understood; however, several mechanistic insights have recently been obtained. Recent years have also brought significant progress in increasing the efficiency of this technique, making it more amenable to applications in the fields of regenerative medicine, disease modelling and drug discovery.The past 10 years have seen great advances in our ability to manipulate cell fate, including the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This process proved to be remarkably simple from a technical perspective, only needing the host cell and a defined cocktail of transcription factors, with four factors - octamer-binding protein 3/4 (OCT3/4), SOX2, Krüppel-like factor 4 (KLF4) and MYC (collectively referred to as OSKM) - initially used. The mechanisms underlying transcription factor-mediated reprogramming are still poorly understood; however, several mechanistic insights have recently been obtained. Recent years have also brought significant progress in increasing the efficiency of this technique, making it more amenable to applications in the fields of regenerative medicine, disease modelling and drug discovery. The past 10 years have seen great advances in our ability to manipulate cell fate, including the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This process proved to be remarkably simple from a technical perspective, only needing the host cell and a defined cocktail of transcription factors, with four factors--octamer-binding protein 3/4 (OCT3/4), SOX2, Kruppel-like factor 4 (KLF4) and MYC (collectively referred to as OSKM) --initially used. The mechanisms underlying transcription factor-mediated reprogramming are still poorly understood; however, several mechanistic insights have recently been obtained. Recent years have also brought significant progress in increasing the efficiency of this technique, making it more amenable to applications in the fields of regenerative medicine, disease modelling and drug discovery.
Audience	Academic
Author	Yamanaka, Shinya Takahashi, Kazutoshi
Author_xml	– sequence: 1 givenname: Kazutoshi surname: Takahashi fullname: Takahashi, Kazutoshi email: takahash@cira.kyoto-u.ac.jp organization: Kazutoshi Takahashi and Shinya Yamanaka are at the Center for iPS Cell Research and Application, Kyoto University, Kyoto, 606–8507, Japan, and the Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA – sequence: 2 givenname: Shinya surname: Yamanaka fullname: Yamanaka, Shinya email: yamanaka@cira.kyoto-u.ac.jp organization: Kazutoshi Takahashi and Shinya Yamanaka are at the Center for iPS Cell Research and Application, Kyoto University, Kyoto, 606–8507, Japan, and the Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26883003$$D View this record in MEDLINE/PubMed
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Snippet	This year marks the tenth anniversary of the generation of induced pluripotent stem cells (iPSCs) by transcription factor-mediated somatic cell reprogramming.... The past 10 years have seen great advances in our ability to manipulate cell fate, including the induction of pluripotency in vitro to generate induced...
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SubjectTerms	631/136/2444 631/136/532/2435 631/532/2064/2158 Animals Biochemistry Cancer Research Cell Biology Cellular control mechanisms Cellular Reprogramming Cellular Reprogramming Techniques - history Cellular Reprogramming Techniques - methods Developmental Biology Genetic aspects Genetic research Genetic transcription History, 21st Century Humans Innovations Life Sciences Properties Regenerative medicine Stem Cells timeline Transcription factors Transcription Factors - biosynthesis Transcription Factors - genetics
Title	A decade of transcription factor-mediated reprogramming to pluripotency
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