Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a

Normal neurodevelopment requires precise expression of the key ubiquitin ligase gene Ube3a . Comparing newly generated mouse models for Ube3a downregulation (models of Angelman syndrome) vs. Ube3a upregulation (models for autism), we find reciprocal effects of Ube3a gene dosage on phenotypes associa...

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Bibliographic Details
Published in:	Frontiers in Behavioral Neuroscience Vol. 16; p. 837523
Main Authors:	Shi, Shu-qun, Mahoney, Carrie E., Houdek, Pavel, Zhao, Wenling, Anderson, Matthew P., Zhuo, Xinming, Beaudet, Arthur, Sumova, Alena, Scammell, Thomas E., Johnson, Carl Hirschie
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media SA 23.03.2022 Frontiers Research Foundation Frontiers Media S.A
Subjects:	Angelman syndrome Angelman's syndrome Animal models Autism Brain research circadian Circadian rhythm Circadian rhythms Dosage Gene dosage Gene expression Genotype & phenotype Imprinting Locomotor activity Neurodevelopment neurodevelopmental disorders Neurons Neuroscience Neurosciences. Biological psychiatry. Neuropsychiatry Phenotypes Physical activity Proteins RC321-571 sleep Sleep deprivation Sleep disorders UBE3A (E6AP) Ubiquitin ubiquitin ligase Ubiquitin-protein ligase UBE3A (E6AP) sleep ubiquitin ligase Angelman syndrome circadian imprinting neurodevelopmental disorders autism
ISSN:	1662-5153, 1662-5153
Online Access:	Get full text
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