Cross-sectional analysis of the Parkinson’s disease Non-motor International Longitudinal Study baseline non-motor characteristics, geographical distribution and impact on quality of life
Growing evidence suggests that non-motor symptoms (NMS) in Parkinson’s disease (PD) have differential progression patterns that have a different natural history from motor progression and may be geographically influenced. We conducted a cross-sectional analysis of 1607 PD patients of whom 1327 were...
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| Published in: | Scientific reports Vol. 11; no. 1; pp. 9611 - 11 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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05.05.2021
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| ISSN: | 2045-2322, 2045-2322 |
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| Abstract | Growing evidence suggests that non-motor symptoms (NMS) in Parkinson’s disease (PD) have differential progression patterns that have a different natural history from motor progression and may be geographically influenced. We conducted a cross-sectional analysis of 1607 PD patients of whom 1327 were from Europe, 208 from the Americas, and 72 from Asia. The primary objective was to assess baseline non-motor burden, defined by Non-Motor Symptoms Scale (NMSS) total scores. Other aims included identifying the factors predicting quality of life, differences in non-motor burden between drug-naïve and non-drug-naïve treated patients, and non-motor phenotypes across different geographical locations. Mean age was 65.9 ± 10.8 years, mean disease duration 6.3 ± 5.6 years, median Hoehn and Yahr stage was 2 (2–3), and 64.2% were male. In this cohort, mean NMSS scores were 46.7 ± 37.2. Differences in non-motor burden and patterns differed significantly between drug-naïve participants, those with a disease duration of less than five years, and those with a duration of five years or over (p ≤ 0.018). Significant differences were observed in geographical distribution (NMSS Europe: 46.4 ± 36.3; Americas: 55.3 ± 42.8; Asia: 26.6 ± 25.1; p < 0.001), with differences in sleep/fatigue, urinary, sexual, and miscellaneous domains (p ≤ 0.020). The best predictor of quality of life was the mood/apathy domain (β = 0.308, p < 0.001). This global study reveals that while non-motor symptoms are globally present with severe NMS burden impacting quality of life in PD, there appear to be differences depending on disease duration and geographical distribution. |
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| AbstractList | Growing evidence suggests that non-motor symptoms (NMS) in Parkinson’s disease (PD) have differential progression patterns that have a different natural history from motor progression and may be geographically influenced. We conducted a cross-sectional analysis of 1607 PD patients of whom 1327 were from Europe, 208 from the Americas, and 72 from Asia. The primary objective was to assess baseline non-motor burden, defined by Non-Motor Symptoms Scale (NMSS) total scores. Other aims included identifying the factors predicting quality of life, differences in non-motor burden between drug-naïve and non-drug-naïve treated patients, and non-motor phenotypes across different geographical locations. Mean age was 65.9 ± 10.8 years, mean disease duration 6.3 ± 5.6 years, median Hoehn and Yahr stage was 2 (2–3), and 64.2% were male. In this cohort, mean NMSS scores were 46.7 ± 37.2. Differences in non-motor burden and patterns differed significantly between drug-naïve participants, those with a disease duration of less than five years, and those with a duration of five years or over (p ≤ 0.018). Significant differences were observed in geographical distribution (NMSS Europe: 46.4 ± 36.3; Americas: 55.3 ± 42.8; Asia: 26.6 ± 25.1; p < 0.001), with differences in sleep/fatigue, urinary, sexual, and miscellaneous domains (p ≤ 0.020). The best predictor of quality of life was the mood/apathy domain (β = 0.308, p < 0.001). This global study reveals that while non-motor symptoms are globally present with severe NMS burden impacting quality of life in PD, there appear to be differences depending on disease duration and geographical distribution. Growing evidence suggests that non-motor symptoms (NMS) in Parkinson’s disease (PD) have differential progression patterns that have a different natural history from motor progression and may be geographically influenced. We conducted a cross-sectional analysis of 1607 PD patients of whom 1327 were from Europe, 208 from the Americas, and 72 from Asia. The primary objective was to assess baseline non-motor burden, defined by Non-Motor Symptoms Scale (NMSS) total scores. Other aims included identifying the factors predicting quality of life, differences in non-motor burden between drug-naïve and non-drug-naïve treated patients, and non-motor phenotypes across different geographical locations. Mean age was 65.9 ± 10.8 years, mean disease duration 6.3 ± 5.6 years, median Hoehn and Yahr stage was 2 (2–3), and 64.2% were male. In this cohort, mean NMSS scores were 46.7 ± 37.2. Differences in non-motor burden and patterns differed significantly between drug-naïve participants, those with a disease duration of less than five years, and those with a duration of five years or over (p ≤ 0.018). Significant differences were observed in geographical distribution (NMSS Europe: 46.4 ± 36.3; Americas: 55.3 ± 42.8; Asia: 26.6 ± 25.1; p < 0.001), with differences in sleep/fatigue, urinary, sexual, and miscellaneous domains (p ≤ 0.020). The best predictor of quality of life was the mood/apathy domain (β = 0.308, p < 0.001). This global study reveals that while non-motor symptoms are globally present with severe NMS burden impacting quality of life in PD, there appear to be differences depending on disease duration and geographical distribution. Growing evidence suggests that non-motor symptoms (NMS) in Parkinson's disease (PD) have differential progression patterns that have a different natural history from motor progression and may be geographically influenced. We conducted a cross-sectional analysis of 1607 PD patients of whom 1327 were from Europe, 208 from the Americas, and 72 from Asia. The primary objective was to assess baseline non-motor burden, defined by Non-Motor Symptoms Scale (NMSS) total scores. Other aims included identifying the factors predicting quality of life, differences in non-motor burden between drug-naïve and non-drug-naïve treated patients, and non-motor phenotypes across different geographical locations. Mean age was 65.9 ± 10.8 years, mean disease duration 6.3 ± 5.6 years, median Hoehn and Yahr stage was 2 (2-3), and 64.2% were male. In this cohort, mean NMSS scores were 46.7 ± 37.2. Differences in non-motor burden and patterns differed significantly between drug-naïve participants, those with a disease duration of less than five years, and those with a duration of five years or over (p ≤ 0.018). Significant differences were observed in geographical distribution (NMSS Europe: 46.4 ± 36.3; Americas: 55.3 ± 42.8; Asia: 26.6 ± 25.1; p < 0.001), with differences in sleep/fatigue, urinary, sexual, and miscellaneous domains (p ≤ 0.020). The best predictor of quality of life was the mood/apathy domain (β = 0.308, p < 0.001). This global study reveals that while non-motor symptoms are globally present with severe NMS burden impacting quality of life in PD, there appear to be differences depending on disease duration and geographical distribution.Growing evidence suggests that non-motor symptoms (NMS) in Parkinson's disease (PD) have differential progression patterns that have a different natural history from motor progression and may be geographically influenced. We conducted a cross-sectional analysis of 1607 PD patients of whom 1327 were from Europe, 208 from the Americas, and 72 from Asia. The primary objective was to assess baseline non-motor burden, defined by Non-Motor Symptoms Scale (NMSS) total scores. Other aims included identifying the factors predicting quality of life, differences in non-motor burden between drug-naïve and non-drug-naïve treated patients, and non-motor phenotypes across different geographical locations. Mean age was 65.9 ± 10.8 years, mean disease duration 6.3 ± 5.6 years, median Hoehn and Yahr stage was 2 (2-3), and 64.2% were male. In this cohort, mean NMSS scores were 46.7 ± 37.2. Differences in non-motor burden and patterns differed significantly between drug-naïve participants, those with a disease duration of less than five years, and those with a duration of five years or over (p ≤ 0.018). Significant differences were observed in geographical distribution (NMSS Europe: 46.4 ± 36.3; Americas: 55.3 ± 42.8; Asia: 26.6 ± 25.1; p < 0.001), with differences in sleep/fatigue, urinary, sexual, and miscellaneous domains (p ≤ 0.020). The best predictor of quality of life was the mood/apathy domain (β = 0.308, p < 0.001). This global study reveals that while non-motor symptoms are globally present with severe NMS burden impacting quality of life in PD, there appear to be differences depending on disease duration and geographical distribution. Abstract Growing evidence suggests that non-motor symptoms (NMS) in Parkinson’s disease (PD) have differential progression patterns that have a different natural history from motor progression and may be geographically influenced. We conducted a cross-sectional analysis of 1607 PD patients of whom 1327 were from Europe, 208 from the Americas, and 72 from Asia. The primary objective was to assess baseline non-motor burden, defined by Non-Motor Symptoms Scale (NMSS) total scores. Other aims included identifying the factors predicting quality of life, differences in non-motor burden between drug-naïve and non-drug-naïve treated patients, and non-motor phenotypes across different geographical locations. Mean age was 65.9 ± 10.8 years, mean disease duration 6.3 ± 5.6 years, median Hoehn and Yahr stage was 2 (2–3), and 64.2% were male. In this cohort, mean NMSS scores were 46.7 ± 37.2. Differences in non-motor burden and patterns differed significantly between drug-naïve participants, those with a disease duration of less than five years, and those with a duration of five years or over (p ≤ 0.018). Significant differences were observed in geographical distribution (NMSS Europe: 46.4 ± 36.3; Americas: 55.3 ± 42.8; Asia: 26.6 ± 25.1; p < 0.001), with differences in sleep/fatigue, urinary, sexual, and miscellaneous domains (p ≤ 0.020). The best predictor of quality of life was the mood/apathy domain (β = 0.308, p < 0.001). This global study reveals that while non-motor symptoms are globally present with severe NMS burden impacting quality of life in PD, there appear to be differences depending on disease duration and geographical distribution. |
| ArticleNumber | 9611 |
| Author | van Wamelen, Daniel J. Rodriguez-Blazquez, Carmen Fung, Victor Sauerbier, Anna Leta, Valentina Rizos, Alexandra Martinez-Martin, Pablo Tsuboi, Y. Falup-Pecurariu, Cristian Prashanth, L. K. Rosales, Raymond Metta, Vinod Borgohain, Rupam Goyal, Vinay Lloret, Santiago Perez Rodriguez‐Violante, Mayela Behari, Madhuri Bhidayasiri, Roongroj Chaudhuri, K. Ray Lewis, Simon Kishore, Asha Bhattacharya, Kalyan |
| Author_xml | – sequence: 1 givenname: Daniel J. surname: van Wamelen fullname: van Wamelen, Daniel J. email: Daniel.van_Wamelen@kcl.ac.uk organization: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, Parkinson’s Foundation Centre of Excellence, King’s College Hospital, Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience – sequence: 2 givenname: Anna surname: Sauerbier fullname: Sauerbier, Anna organization: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, Department of Neurology, Faculty of Medicine University Hospital Cologne, University of Cologne – sequence: 3 givenname: Valentina surname: Leta fullname: Leta, Valentina organization: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, Parkinson’s Foundation Centre of Excellence, King’s College Hospital – sequence: 4 givenname: Carmen surname: Rodriguez-Blazquez fullname: Rodriguez-Blazquez, Carmen organization: National Center of Epidemiology, Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Carlos III Institute of Health – sequence: 5 givenname: Cristian surname: Falup-Pecurariu fullname: Falup-Pecurariu, Cristian organization: Department of Neurology, Faculty of Medicine, County Emergency Clinic Hospital, Transilvania University – sequence: 6 givenname: Mayela surname: Rodriguez‐Violante fullname: Rodriguez‐Violante, Mayela organization: Movement Disorders Unit, Instituto Nacional de Neurologia y Neurocirugía – sequence: 7 givenname: Alexandra surname: Rizos fullname: Rizos, Alexandra organization: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, Parkinson’s Foundation Centre of Excellence, King’s College Hospital – sequence: 8 givenname: Y. surname: Tsuboi fullname: Tsuboi, Y. organization: Department of Neurology, Faculty of Medicine, Fukuoka University – sequence: 9 givenname: Vinod surname: Metta fullname: Metta, Vinod organization: Parkinson’s Foundation Centre of Excellence, King’s College Hospital – sequence: 10 givenname: Roongroj surname: Bhidayasiri fullname: Bhidayasiri, Roongroj organization: Chulalongkorn University Hospital – sequence: 11 givenname: Kalyan surname: Bhattacharya fullname: Bhattacharya, Kalyan organization: Formerly RG Kar Medical College and Institute of Neuroscience – sequence: 12 givenname: Rupam surname: Borgohain fullname: Borgohain, Rupam organization: Nizam’s Institute of Medical Sciences – sequence: 13 givenname: L. K. surname: Prashanth fullname: Prashanth, L. K. organization: Center for Parkinson’s Disease and Movement Disorders Clinic, Vikram Hospitals, Parkinson’s Disease and Movement Disorders Clinic – sequence: 14 givenname: Raymond surname: Rosales fullname: Rosales, Raymond organization: University of Santo Tomas Hospital – sequence: 15 givenname: Simon surname: Lewis fullname: Lewis, Simon organization: ForeFront Parkinson’s Disease Research Clinic, Brain and Mind Centre, University of Sydney – sequence: 16 givenname: Victor surname: Fung fullname: Fung, Victor organization: Movement Disorders Unit, Neurology Department, Westmead Hospital, Sydney Medical School, University of Sydney – sequence: 17 givenname: Madhuri surname: Behari fullname: Behari, Madhuri organization: Department of Neurology, Cardiothoracic and Neurosciences Centre, All India Institute of Medical Sciences – sequence: 18 givenname: Vinay surname: Goyal fullname: Goyal, Vinay organization: Department of Neurology, All India Institute of Medical Sciences – sequence: 19 givenname: Asha surname: Kishore fullname: Kishore, Asha organization: Sree Chitra Tirunal Institute for Medical Sciences and Technology – sequence: 20 givenname: Santiago Perez surname: Lloret fullname: Lloret, Santiago Perez organization: Biomedical Research Center, Interamerican Open University (CAECIHS-UAI), National Research Council (CONICET), Department of Physiology, School of Medicine, University of Buenos Aires – sequence: 21 givenname: Pablo surname: Martinez-Martin fullname: Martinez-Martin, Pablo organization: Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Carlos III Institute of Health – sequence: 22 givenname: K. Ray surname: Chaudhuri fullname: Chaudhuri, K. Ray organization: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, Parkinson’s Foundation Centre of Excellence, King’s College Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33953218$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.jns.2012.10.004 10.1001/archpsyc.1983.01790060110016 10.1016/j.jns.2015.11.047 10.1016/0304-3959(75)90075-5 10.1002/mds.23135 10.1371/journal.pone.0057221 10.1136/jnnp-2017-316213 10.1212/wnl.17.5.427 10.1007/s11910-005-0072-6 10.1186/s12883-016-0548-9 10.1159/000335701 10.1136/jnnp.2003.017509 10.3389/fneur.2018.00170 10.1111/j.1600-0447.1983.tb09716.x 10.1002/mds.21596 10.1002/mds.10656 10.1002/mds.23368 10.1016/j.clineuro.2012.07.032 10.1111/ene.12950 10.1002/mds.22643 10.1007/s00415-012-6557-8 10.1016/j.parkreldis.2007.09.002 10.1002/mdc3.12728 10.1111/ane.13336 10.1159/000478702 10.1136/jnnp.73.6.629 10.1179/1743132815y.0000000020 10.1002/mds.21837 10.1002/mds.23462 10.1002/mds.23826 10.1017/S0317167100012920 10.5694/mja17.01074 |
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| References | Chaudhuri (CR12) 2002; 73 Ohnhaus, Adler (CR13) 1975; 1 Khedr (CR24) 2015; 37 Martinez-Martin (CR11) 2004; 19 Simuni (CR7) 2018; 89 Cheon, Ha, Park, Kim (CR28) 2008; 14 Kim (CR30) 2013; 324 Li (CR17) 2010; 25 Antonini (CR22) 2012; 259 Martinez-Martin, Rodriguez-Blazquez, Kurtis, Chaudhuri (CR2) 2011; 26 Chaudhuri, Yates, Martinez-Martin (CR3) 2005; 5 Martinez-Martin (CR33) 2019; 6 Zigmond, Snaith (CR10) 1983; 67 CR31 Zadikoff (CR9) 2008; 23 Tibar (CR27) 2018; 9 Krishnan, Sarma, Sarma, Kishore (CR32) 2011; 26 Hoehn, Yahr (CR14) 1967; 17 Khedr (CR26) 2012; 38 Politis (CR1) 2010; 25 CR5 Marinus (CR15) 2004; 75 CR29 Chaudhuri (CR21) 2013; 8 Khedr, El Fetoh, Khalifa, Ahmed, El Beh (CR25) 2013; 115 Barone (CR19) 2009; 24 Sauerbier (CR23) 2017; 49 Santos-Garcia (CR6) 2016; 16 van Wamelen (CR8) 2020 Folstein, Robins, Helzer (CR16) 1983; 40 Chaudhuri (CR4) 2007; 22 Ou (CR20) 2016; 360 Prakash, Nadkarni, Lye, Yong, Tan (CR18) 2016; 23 P Martinez-Martin (88651_CR2) 2011; 26 D Santos-Garcia (88651_CR6) 2016; 16 P Martinez-Martin (88651_CR33) 2019; 6 T Simuni (88651_CR7) 2018; 89 MF Folstein (88651_CR16) 1983; 40 C Zadikoff (88651_CR9) 2008; 23 J Marinus (88651_CR15) 2004; 75 EM Khedr (88651_CR24) 2015; 37 P Martinez-Martin (88651_CR11) 2004; 19 KM Prakash (88651_CR18) 2016; 23 MM Hoehn (88651_CR14) 1967; 17 P Barone (88651_CR19) 2009; 24 EM Khedr (88651_CR25) 2013; 115 KR Chaudhuri (88651_CR3) 2005; 5 EE Ohnhaus (88651_CR13) 1975; 1 KR Chaudhuri (88651_CR4) 2007; 22 A Sauerbier (88651_CR23) 2017; 49 H Li (88651_CR17) 2010; 25 M Politis (88651_CR1) 2010; 25 88651_CR5 AS Zigmond (88651_CR10) 1983; 67 88651_CR29 KR Chaudhuri (88651_CR12) 2002; 73 KR Chaudhuri (88651_CR21) 2013; 8 88651_CR31 HS Kim (88651_CR30) 2013; 324 EM Khedr (88651_CR26) 2012; 38 S Krishnan (88651_CR32) 2011; 26 SM Cheon (88651_CR28) 2008; 14 H Tibar (88651_CR27) 2018; 9 R Ou (88651_CR20) 2016; 360 A Antonini (88651_CR22) 2012; 259 DJ van Wamelen (88651_CR8) 2020 |
| References_xml | – volume: 324 start-page: 70 year: 2013 end-page: 73 ident: CR30 article-title: Nonmotor symptoms more closely related to Parkinson's disease: comparison with normal elderly publication-title: J. Neurol. Sci. doi: 10.1016/j.jns.2012.10.004 – volume: 40 start-page: 812 year: 1983 ident: CR16 article-title: The mini-mental state examination publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.1983.01790060110016 – volume: 360 start-page: 72 year: 2016 end-page: 77 ident: CR20 article-title: Progression of non-motor symptoms in Parkinson's disease among different age populations: A two-year follow-up study publication-title: J. Neurol. Sci. doi: 10.1016/j.jns.2015.11.047 – volume: 1 start-page: 379 year: 1975 end-page: 384 ident: CR13 article-title: Methodological problems in the measurement of pain: A comparison between the verbal rating scale and the visual analogue scale publication-title: Pain doi: 10.1016/0304-3959(75)90075-5 – volume: 25 start-page: 1646 year: 2010 end-page: 1651 ident: CR1 article-title: Parkinson's disease symptoms: The patient's perspective publication-title: Mov. Dis. doi: 10.1002/mds.23135 – ident: CR29 – volume: 8 start-page: e57221 year: 2013 ident: CR21 article-title: A proposal for a comprehensive grading of Parkinson's disease severity combining motor and non-motor assessments: Meeting an unmet need publication-title: PLoS ONE doi: 10.1371/journal.pone.0057221 – volume: 89 start-page: 78 year: 2018 end-page: 88 ident: CR7 article-title: Baseline prevalence and longitudinal evolution of non-motor symptoms in early Parkinson's disease: The PPMI cohort publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp-2017-316213 – volume: 17 start-page: 427 year: 1967 end-page: 442 ident: CR14 article-title: Parkinsonism: Onset, progression and mortality publication-title: Neurology doi: 10.1212/wnl.17.5.427 – volume: 5 start-page: 275 year: 2005 end-page: 283 ident: CR3 article-title: The non-motor symptom complex of Parkinson's disease: A comprehensive assessment is essential publication-title: Curr. Neurol. Neurosci. Rep. doi: 10.1007/s11910-005-0072-6 – volume: 16 start-page: 26 year: 2016 ident: CR6 article-title: COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015), a global–clinical evaluations, serum biomarkers, genetic studies and neuroimaging–prospective, multicenter, non-interventional, long-term study on Parkinson's disease progression publication-title: BMC Neurol. doi: 10.1186/s12883-016-0548-9 – volume: 38 start-page: 154 year: 2012 end-page: 163 ident: CR26 article-title: Epidemiological study and clinical profile of Parkinson's disease in the Assiut Governorate, Egypt: A community-based study publication-title: Neuroepidemiology doi: 10.1159/000335701 – volume: 75 start-page: 388 year: 2004 end-page: 395 ident: CR15 article-title: A short scale for the assessment of motor impairments and disabilities in Parkinson's disease: The SPES/SCOPA publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp.2003.017509 – volume: 9 start-page: 170 year: 2018 ident: CR27 article-title: Non-motor symptoms of Parkinson's disease and their impact on quality of life in a cohort of Moroccan patients publication-title: Front. Neurol. doi: 10.3389/fneur.2018.00170 – volume: 67 start-page: 361 year: 1983 end-page: 370 ident: CR10 article-title: The hospital anxiety and depression scale publication-title: Acta Psychiatr. Scand. doi: 10.1111/j.1600-0447.1983.tb09716.x – volume: 22 start-page: 1901 year: 2007 end-page: 1911 ident: CR4 article-title: The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study publication-title: Mov. Disord. doi: 10.1002/mds.21596 – volume: 19 start-page: 312 year: 2004 end-page: 318 ident: CR11 article-title: Health-related quality of life evaluation by proxy in Parkinson's disease: Approach using PDQ-8 and EuroQoL-5D publication-title: Mov. Disord. doi: 10.1002/mds.10656 – volume: 25 start-page: 2740 year: 2010 end-page: 2746 ident: CR17 article-title: Nonmotor symptoms are independently associated with impaired health-related quality of life in Chinese patients with Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.23368 – volume: 115 start-page: 673 year: 2013 end-page: 677 ident: CR25 article-title: Prevalence of non motor features in a cohort of Parkinson's disease patients publication-title: Clin. Neurol. Neurosurg. doi: 10.1016/j.clineuro.2012.07.032 – volume: 23 start-page: 854 year: 2016 end-page: 860 ident: CR18 article-title: The impact of non-motor symptoms on the quality of life of Parkinson's disease patients: a longitudinal study publication-title: Eur. J. Neurol. doi: 10.1111/ene.12950 – volume: 24 start-page: 1641 year: 2009 end-page: 1649 ident: CR19 article-title: The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.22643 – volume: 259 start-page: 2621 year: 2012 end-page: 2631 ident: CR22 article-title: The progression of non-motor symptoms in Parkinson's disease and their contribution to motor disability and quality of life publication-title: J. Neurol. doi: 10.1007/s00415-012-6557-8 – volume: 14 start-page: 286 year: 2008 end-page: 290 ident: CR28 article-title: Nonmotor symptoms of Parkinson's disease: Prevalence and awareness of patients and families publication-title: Parkinsonism Relat. Disord. doi: 10.1016/j.parkreldis.2007.09.002 – ident: CR31 – volume: 6 start-page: 227 year: 2019 end-page: 234 ident: CR33 article-title: Pilot study of the International Parkinson and Movement Disorder Society-sponsored Non-motor Rating Scale (MDS-NMS) publication-title: Mov. Disord. Clin. Pract. doi: 10.1002/mdc3.12728 – year: 2020 ident: CR8 article-title: The Non-Motor Symptoms Scale in Parkinson's disease: Validation and use publication-title: Acta Neurol. Scand. doi: 10.1111/ane.13336 – volume: 49 start-page: 1 year: 2017 end-page: 17 ident: CR23 article-title: Non-motor symptoms assessed by non-motor symptoms questionnaire and non-motor symptoms scale in Parkinson's disease in selected Asian populations publication-title: Neuroepidemiology doi: 10.1159/000478702 – ident: CR5 – volume: 73 start-page: 629 year: 2002 end-page: 635 ident: CR12 article-title: The Parkinson's disease sleep scale: A new instrument for assessing sleep and nocturnal disability in Parkinson's disease publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp.73.6.629 – volume: 37 start-page: 607 year: 2015 end-page: 618 ident: CR24 article-title: Prevalence of Parkinsonism and Parkinson's disease in Qena governorate/Egypt: A cross-sectional community-based survey publication-title: Neurol. Res. doi: 10.1179/1743132815y.0000000020 – volume: 23 start-page: 297 year: 2008 end-page: 299 ident: CR9 article-title: A comparison of the mini mental state exam to the Montreal cognitive assessment in identifying cognitive deficits in Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.21837 – volume: 26 start-page: 399 year: 2011 end-page: 406 ident: CR2 article-title: The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.23462 – volume: 26 start-page: 2110 year: 2011 end-page: 2113 ident: CR32 article-title: Do nonmotor symptoms in Parkinson's disease differ from normal aging? publication-title: Mov. Disord. doi: 10.1002/mds.23826 – ident: 88651_CR31 – volume: 1 start-page: 379 year: 1975 ident: 88651_CR13 publication-title: Pain doi: 10.1016/0304-3959(75)90075-5 – volume: 5 start-page: 275 year: 2005 ident: 88651_CR3 publication-title: Curr. Neurol. Neurosci. 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Scand. doi: 10.1111/j.1600-0447.1983.tb09716.x – volume: 22 start-page: 1901 year: 2007 ident: 88651_CR4 publication-title: Mov. Disord. doi: 10.1002/mds.21596 – volume: 24 start-page: 1641 year: 2009 ident: 88651_CR19 publication-title: Mov. Disord. doi: 10.1002/mds.22643 – volume: 75 start-page: 388 year: 2004 ident: 88651_CR15 publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp.2003.017509 – volume: 73 start-page: 629 year: 2002 ident: 88651_CR12 publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp.73.6.629 – volume: 19 start-page: 312 year: 2004 ident: 88651_CR11 publication-title: Mov. Disord. doi: 10.1002/mds.10656 – volume: 17 start-page: 427 year: 1967 ident: 88651_CR14 publication-title: Neurology doi: 10.1212/wnl.17.5.427 – volume: 9 start-page: 170 year: 2018 ident: 88651_CR27 publication-title: Front. Neurol. doi: 10.3389/fneur.2018.00170 – volume: 8 start-page: e57221 year: 2013 ident: 88651_CR21 publication-title: PLoS ONE doi: 10.1371/journal.pone.0057221 – volume: 324 start-page: 70 year: 2013 ident: 88651_CR30 publication-title: J. Neurol. Sci. doi: 10.1016/j.jns.2012.10.004 – volume: 6 start-page: 227 year: 2019 ident: 88651_CR33 publication-title: Mov. Disord. Clin. Pract. doi: 10.1002/mdc3.12728 – volume: 14 start-page: 286 year: 2008 ident: 88651_CR28 publication-title: Parkinsonism Relat. Disord. doi: 10.1016/j.parkreldis.2007.09.002 – volume: 26 start-page: 2110 year: 2011 ident: 88651_CR32 publication-title: Mov. Disord. doi: 10.1002/mds.23826 – volume: 38 start-page: 154 year: 2012 ident: 88651_CR26 publication-title: Neuroepidemiology doi: 10.1159/000335701 – volume: 26 start-page: 399 year: 2011 ident: 88651_CR2 publication-title: Mov. Disord. doi: 10.1002/mds.23462 – year: 2020 ident: 88651_CR8 publication-title: Acta Neurol. Scand. doi: 10.1111/ane.13336 – volume: 89 start-page: 78 year: 2018 ident: 88651_CR7 publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp-2017-316213 – volume: 40 start-page: 812 year: 1983 ident: 88651_CR16 publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.1983.01790060110016 – volume: 37 start-page: 607 year: 2015 ident: 88651_CR24 publication-title: Neurol. Res. doi: 10.1179/1743132815y.0000000020 – volume: 16 start-page: 26 year: 2016 ident: 88651_CR6 publication-title: BMC Neurol. doi: 10.1186/s12883-016-0548-9 – volume: 259 start-page: 2621 year: 2012 ident: 88651_CR22 publication-title: J. Neurol. doi: 10.1007/s00415-012-6557-8 – volume: 49 start-page: 1 year: 2017 ident: 88651_CR23 publication-title: Neuroepidemiology doi: 10.1159/000478702 |
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| Snippet | Growing evidence suggests that non-motor symptoms (NMS) in Parkinson’s disease (PD) have differential progression patterns that have a different natural... Growing evidence suggests that non-motor symptoms (NMS) in Parkinson's disease (PD) have differential progression patterns that have a different natural... Abstract Growing evidence suggests that non-motor symptoms (NMS) in Parkinson’s disease (PD) have differential progression patterns that have a different... |
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| Title | Cross-sectional analysis of the Parkinson’s disease Non-motor International Longitudinal Study baseline non-motor characteristics, geographical distribution and impact on quality of life |
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