Network Inference Algorithms Elucidate Nrf2 Regulation of Mouse Lung Oxidative Stress

A variety of cardiovascular, neurological, and neoplastic conditions have been associated with oxidative stress, i.e., conditions under which levels of reactive oxygen species (ROS) are elevated over significant periods. Nuclear factor erythroid 2-related factor (Nrf2) regulates the transcription of...

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Bibliographic Details
Published in:	PLoS computational biology Vol. 4; no. 8; p. e1000166
Main Authors:	Taylor, Ronald C., Acquaah-Mensah, George, Singhal, Mudita, Malhotra, Deepti, Biswal, Shyam
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 29.08.2008 Public Library of Science (PLoS)
Subjects:	Algorithms Amyotrophic lateral sclerosis Animals Artificial Intelligence Computational Biology Computational Biology/Signaling Networks Computational Biology/Systems Biology Computational Biology/Transcriptional Regulation Diabetes Disease Experiments Gene expression Gene Expression Profiling - methods Gene Regulatory Networks - drug effects Gene Regulatory Networks - genetics Guanine Nucleotide Exchange Factors - drug effects Guanine Nucleotide Exchange Factors - genetics Health sciences Lung - metabolism Mice Mice, Knockout NF-E2-Related Factor 2 - drug effects NF-E2-Related Factor 2 - metabolism Oligonucleotide Array Sequence Analysis - methods Oxidative stress Oxidative Stress - drug effects Oxidative Stress - genetics Oxidoreductases Acting on Sulfur Group Donors - drug effects Oxidoreductases Acting on Sulfur Group Donors - genetics Promoter Regions, Genetic Proteins Rheumatoid arthritis Signal Transduction - genetics Smoking - adverse effects Smoking - genetics Software Transcription, Genetic - drug effects Transcription, Genetic - genetics Promoter Regions, Genetic Oligonucleotide Array Sequence Analysis Oxidative Stress Signal Transduction Artificial Intelligence Lung Gene Expression Profiling Gene Regulatory Networks Guanine Nucleotide Exchange Factors Mice, Knockout Algorithms Animals Oxidoreductases Acting on Sulfur Group Donors NF-E2-Related Factor 2 Transcription, Genetic Mice Software Smoking
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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