Extracellular matrix remodeling and transforming growth factor-β signaling abnormalities induced by lamin A/C variants that cause lipodystrophy

Mutations in the lamin A/C gene encoding nuclear lamins A and C (lamin A/C) cause familial partial lipodystrophy type 2 (FPLD2) and related lipodystrophy syndromes. These are mainly characterized by redistribution of adipose tissue associated with insulin resistance. Several reports suggest that alt...

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Vydané v:	Journal of lipid research Ročník 58; číslo 1; s. 151 - 163
Hlavní autori:	Le Dour, Caroline, Wu, Wei, Béréziat, Véronique, Capeau, Jacqueline, Vigouroux, Corinne, Worman, Howard J
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier 01.01.2017
Predmet:	adipocytes adipose tissue Adipose Tissue - metabolism Adipose Tissue - pathology Aged Aged, 80 and over Animals Cell Line Extracellular Matrix - genetics Extracellular Matrix - metabolism fibrosis Gene Expression Regulation Humans Lamin Type A - genetics Lipodystrophy, Familial Partial - genetics Lipodystrophy, Familial Partial - metabolism Lipodystrophy, Familial Partial - pathology Male Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics Mice Mice, Knockout Middle Aged Mutation nuclear envelope Transforming Growth Factor beta - biosynthesis Transforming Growth Factor beta - genetics adipose tissue nuclear envelope fibrosis adipocytes
ISSN:	1539-7262, 0022-2275, 1539-7262
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