MicroRNAs prevent the generation of autoreactive antibodies

MicroRNAs have been shown to be critical for a number of aspects of immune system regulation and function. Here, we have examined the role of microRNAs in terminal B cell differentiation by analyzing Cd19-Cre(ki/+) Dicer1(fl/fl) mice. We found that in the absence of Dicer, the transitional and margi...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 33; no. 5; p. 713
Main Authors:	Belver, Laura, de Yébenes, Virginia G, Ramiro, Almudena R
Format:	Journal Article
Language:	English
Published:	United States 24.11.2010
Subjects:	Agammaglobulinaemia Tyrosine Kinase Animals Antigens, CD19 - genetics Autoantibodies - biosynthesis B-Lymphocytes - immunology Cell Differentiation DEAD-box RNA Helicases - genetics Down-Regulation Endoribonucleases - genetics Female Immune Tolerance Lymphocyte Activation Mice Mice, Knockout MicroRNAs - metabolism Protein-Tyrosine Kinases - metabolism Receptors, Antigen, B-Cell - metabolism Ribonuclease III
ISSN:	1097-4180, 1097-4180
Online Access:	Get more information
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