Construction of a prognostic prediction model for concurrent radiotherapy in cervical cancer using GEO and TCGA databases with preliminary validation analysis

Radiotherapy is a primary treatment for intermediate and advanced cervical cancer (CC). Resistance to radiotherapy is a principal reason for treatment failure in synchronous applications, yet the molecular mechanisms remain poorly understood. Identifying reliable prognostic markers to predict and ev...

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Bibliographic Details
Published in:	PloS one Vol. 20; no. 10; p. e0334281
Main Authors:	Yang, Siqi, Liu, Liting, Su, Qiuyue, Wang, Jianan, Xia, Jingqi, Zhao, Xinyao, Sun, Yajuan, Yang, Shanshan
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 31.10.2025 Public Library of Science (PLoS)
Subjects:	Anopheles B cells Biomarkers Biomarkers, Tumor - genetics Cancer Cancer therapies Care and treatment Cell cycle Cervical cancer Chemotherapy Correlation analysis Databases, Genetic Datasets Diagnosis Effectiveness Ethylenediaminetetraacetic acid Evaluation Female Gene expression Gene Expression Regulation, Neoplastic Gene sequencing Genes Genomics Health aspects Humans Immune checkpoint Immune system Immunohistochemistry Infiltration Kaplan-Meier Estimate Medical prognosis Medical research Medicine, Experimental Metastases Middle Aged Molecular modelling Patient outcomes Patients Prediction models Prognosis Radiation therapy Radiotherapy Regression analysis Remission (Medicine) Reproducibility Ribonucleic acid RNA RNA sequencing Sensitivity Therapeutic targets Tumors Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - mortality Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy Women China Taiwan
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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