Relationship between dementia and gut microbiome-associated metabolites: a cross-sectional study in Japan

Dysregulation of the gut microbiome is associated with dementia. However, the relationship between microbiome-associated metabolites and dementia has yet to be identified. Outpatients visiting a memory clinic in Japan enrolled in this cross-sectional study; 107 subjects were eligible for the study,...

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Bibliographic Details
Published in:Scientific reports Vol. 10; no. 1; p. 8088
Main Authors: Saji, Naoki, Murotani, Kenta, Hisada, Takayoshi, Kunihiro, Tadao, Tsuduki, Tsuyoshi, Sugimoto, Taiki, Kimura, Ai, Niida, Shumpei, Toba, Kenji, Sakurai, Takashi
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 18.05.2020
Nature Publishing Group
Subjects:
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Activities of daily living
Aged
Aged, 80 and over
Ammonia
Ammonia - analysis
Ammonia - metabolism
Bacteria - classification
Bacteria - genetics
Bacteria - isolation & purification
Bacteria - metabolism
Cognition
Cognitive ability
Cross-Sectional Studies
Dementia
Dementia - microbiology
Dementia - psychology
Dementia disorders
Demography
Digestive system
Feces - chemistry
Feces - microbiology
Female
Gastrointestinal Microbiome
Gut microbiota
Health risk assessment
Humanities and Social Sciences
Humans
Intestinal microflora
Japan
Lactic acid
Lactic Acid - analysis
Lactic Acid - metabolism
Male
Metabolites
Microbiomes
Microbiota
multidisciplinary
Neuroimaging
Restriction fragment length polymorphism
Risk factors
Science
Science (multidisciplinary)
Japan
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Dysregulation of the gut microbiome is associated with dementia. However, the relationship between microbiome-associated metabolites and dementia has yet to be identified. Outpatients visiting a memory clinic in Japan enrolled in this cross-sectional study; 107 subjects were eligible for the study, 25 of which had dementia. We collected demographics, activities of daily living, risk factors, cognitive function, and brain imaging data. The gut microbiome was assessed using terminal restriction fragment length polymorphism analysis. Concentrations of faecal metabolite were measured. We used multivariable logistic regression analyses to identify whether metabolites were independently related to dementia. The concentrations of metabolites were significantly different between subjects with and those without dementia. Every 1 standard deviation increment in faecal ammonia concentration was associated with around a 1.6-fold risk for the presence of dementia. A higher faecal lactic acid concentration was related to a lower risk of dementia, by around 60%. A combination of higher faecal ammonia and lactic acid concentrations was indicative of the presence of dementia, and had a similar predictive value as traditional biomarkers of dementia. Thus, faecal ammonia and lactic acid are related to dementia, independently of the other risk factors for dementia and dysregulation of the gut microbiome.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-65196-6