Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes

Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust replication in large-scale genome-wide association studies. To understand the role of DNA methylation, it is important to have the prevailing genomic view to distinguish key sequence elements that influence gene...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 133; no. 4; pp. 1 - 18
Main Authors:	Khurana, Ishant, Kaipananickal, Harikrishnan, Maxwell, Scott, Birkelund, Sørine, Syreeni, Anna, Forsblom, Carol, Okabe, Jun, Ziemann, Mark, Kaspi, Antony, Rafehi, Haloom, Jørgensen, Anne, Al-Hasani, Keith, Thomas, Merlin C., Jiang, Guozhi, Luk, Andrea O.Y., Lee, Heung Man, Huang, Yu, Thewjitcharoen, Yotsapon, Nakasatien, Soontaree, Himathongkam, Thep, Fogarty, Christopher, Njeim, Rachel, Eid, Assaad, Hansen, Tine Willum, Tofte, Nete, Ottesen, Evy C., Ma, Ronald C.W., Chan, Juliana C.N., Cooper, Mark E., Rossing, Peter, Groop, Per-Henrik, El-Osta, Assam
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 15.02.2023
Subjects:	Binding sites Biomedical research Complications and side effects Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - genetics Diabetic nephropathies Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic nephropathy DNA Methylation Endothelial cells Endothelial Cells - metabolism Epigenetics Fibrosis Gene expression Genetic aspects Genome-Wide Association Study Genomes Humans Insulin Insulin - metabolism Kidney diseases Leukocytes Lipid metabolism Macrophages Metabolism Methylation Nephrology Nephropathy Phosphoproteins Risk factors Statistics Type 1 diabetes Thailand Finland Hong Kong, China Epigenetics Nephrology Diabetes Metabolism
ISSN:	1558-8238, 0021-9738, 1558-8238
Online Access:	Get full text
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