The Effect of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibition on the Risk of Venous Thromboembolism

The relationship between cholesterol levels and risk of venous thromboembolism (VTE) is uncertain. We set out to determine the effect of PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibition on the risk of VTE, explore potential mechanisms, and examine the efficacy in subgroups with clini...

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Bibliographic Details
Published in:	Circulation (New York, N.Y.) Vol. 141; no. 20; p. 1600
Main Authors:	Marston, Nicholas A, Gurmu, Yared, Melloni, Giorgio E M, Bonaca, Marc, Gencer, Baris, Sever, Peter S, Pedersen, Terje R, Keech, Anthony C, Roselli, Carolina, Lubitz, Steven A, Ellinor, Patrick T, O'Donoghue, Michelle L, Giugliano, Robert P, Ruff, Christian T, Sabatine, Marc S
Format:	Journal Article
Language:	English
Published:	United States 19.05.2020
Subjects:	Aged Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - therapeutic use Anticholesteremic Agents - adverse effects Anticholesteremic Agents - therapeutic use Biomarkers - blood Cholesterol, LDL - blood Clinical Trials as Topic Dyslipidemias - blood Dyslipidemias - diagnosis Dyslipidemias - drug therapy Dyslipidemias - epidemiology Female Humans Incidence Lipoprotein(a) - blood Male Middle Aged PCSK9 Inhibitors Pulmonary Embolism - diagnosis Pulmonary Embolism - epidemiology Pulmonary Embolism - prevention & control Risk Assessment Risk Factors Serine Proteinase Inhibitors - adverse effects Serine Proteinase Inhibitors - therapeutic use Time Factors Treatment Outcome Venous Thromboembolism - diagnosis Venous Thromboembolism - epidemiology Venous Thromboembolism - prevention & control Venous Thrombosis - diagnosis Venous Thrombosis - epidemiology Venous Thrombosis - prevention & control numbers needed to treat cholesterol, LDL PCSK9 protein, human venous thromboembolism evolocumab
ISSN:	1524-4539, 1524-4539
Online Access:	Get more information
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