The Role of the Autonomic Nervous System in the Regulation of Aortic Stiffness
The autonomic nervous system is important in regulating blood pressure, but whether it regulates aortic stiffness is more contentious. We conducted 3 studies in young, healthy individuals to address this important question. Study 1 was a cross-sectional study of 347 subjects with detailed measuremen...
Gespeichert in:
| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Jg. 68; H. 5; S. 1290 - 1297 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
01.11.2016
|
| Schlagworte: | |
| ISSN: | 1524-4563 |
| Online-Zugang: | Weitere Angaben |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | The autonomic nervous system is important in regulating blood pressure, but whether it regulates aortic stiffness is more contentious. We conducted 3 studies in young, healthy individuals to address this important question. Study 1 was a cross-sectional study of 347 subjects with detailed measurements of hemodynamics and heart rate variability. In study 2, 9 subjects were given a bolus of intravenous nicotinic ganglion blocker, pentolinium, or saline in a random order and hemodynamics and heart rate variability were assessed before and after. In study 3, changes in hemodynamics and heart rate variability were assessed during stimulation of the sympathetic nervous system with the use of isometric handgrip exercise in 12 subjects. Study 1: aortic pulse wave velocity (P=0.003) was lowest in the subjects with the highest parasympathetic activity, but after adjusting for mean arterial pressure, the effect was abolished (P=0.3). Study 2: after pentolinium, sympathetic and parasympathetic activity fell (P=0.001 for both), mean arterial pressure, and heart rate increased (P=0.004 and P=0.04, respectively), but there was no change in pulse wave velocity in comparison to placebo (P=0.1). Study 3: during handgrip exercise, sympathetic activity (P=0.003), mean arterial pressure (P<0.0001), and aortic pulse wave velocity increased (P=0.013). However, pulse wave velocity adjusted for mean arterial pressure did not change (P=0.1). The main finding of these studies is that in young healthy subjects, the autonomic nervous system does not have a pressure-independent role in the regulation of aortic stiffness. However, these findings may not apply to patients with increased sympathetic tone or hypertension. |
|---|---|
| AbstractList | The autonomic nervous system is important in regulating blood pressure, but whether it regulates aortic stiffness is more contentious. We conducted 3 studies in young, healthy individuals to address this important question. Study 1 was a cross-sectional study of 347 subjects with detailed measurements of hemodynamics and heart rate variability. In study 2, 9 subjects were given a bolus of intravenous nicotinic ganglion blocker, pentolinium, or saline in a random order and hemodynamics and heart rate variability were assessed before and after. In study 3, changes in hemodynamics and heart rate variability were assessed during stimulation of the sympathetic nervous system with the use of isometric handgrip exercise in 12 subjects. Study 1: aortic pulse wave velocity (P=0.003) was lowest in the subjects with the highest parasympathetic activity, but after adjusting for mean arterial pressure, the effect was abolished (P=0.3). Study 2: after pentolinium, sympathetic and parasympathetic activity fell (P=0.001 for both), mean arterial pressure, and heart rate increased (P=0.004 and P=0.04, respectively), but there was no change in pulse wave velocity in comparison to placebo (P=0.1). Study 3: during handgrip exercise, sympathetic activity (P=0.003), mean arterial pressure (P<0.0001), and aortic pulse wave velocity increased (P=0.013). However, pulse wave velocity adjusted for mean arterial pressure did not change (P=0.1). The main finding of these studies is that in young healthy subjects, the autonomic nervous system does not have a pressure-independent role in the regulation of aortic stiffness. However, these findings may not apply to patients with increased sympathetic tone or hypertension. |
| Author | Barrett, Sharon M L Wilkinson, Ian B Mäki-Petäjä, Kaisa M McEniery, Carmel M Cheriyan, Joseph Evans, Sarah V |
| Author_xml | – sequence: 1 givenname: Kaisa M surname: Mäki-Petäjä fullname: Mäki-Petäjä, Kaisa M email: km391@medschl.cam.ac.uk organization: From the Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, United Kingdom. km391@medschl.cam.ac.uk – sequence: 2 givenname: Sharon M L surname: Barrett fullname: Barrett, Sharon M L organization: From the Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, United Kingdom – sequence: 3 givenname: Sarah V surname: Evans fullname: Evans, Sarah V organization: From the Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, United Kingdom – sequence: 4 givenname: Joseph surname: Cheriyan fullname: Cheriyan, Joseph organization: From the Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, United Kingdom – sequence: 5 givenname: Carmel M surname: McEniery fullname: McEniery, Carmel M organization: From the Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, United Kingdom – sequence: 6 givenname: Ian B surname: Wilkinson fullname: Wilkinson, Ian B organization: From the Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, United Kingdom |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27672029$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kMtOwzAQRS0Eog_4BRR2bFL8jO1lVVFAqorUlnXkJGMalNgldpD696RQVnM198xDd4IunXeA0D3BM0Iy8rg_HqCL4ELtndmbU3OGFWbiAo2JoDzlImMjNAnhE2PCOZfXaERlJimmeozWuz0kG99A4m0SBz3vo3e-rctkDd2370OyPYYIbVK7X38DH31j4nDtNDH3XRzQbaytdRDCDbqypglwe65T9L582i1e0tXb8-tivkpLoZRIS5YRqzUtqLaskAVRBSgsBSvKUlOWmUzRqtKWVoqXUhOREcaYpFxJUWGwdIoe_vYeOv_VQ4h5W4cSmsY4GH7OiWKCaamUGtC7M9oXLVT5oatb0x3z_wzoDyjAYVI |
| CitedBy_id | crossref_primary_10_1097_HJH_0000000000002452 crossref_primary_10_1161_HYPERTENSIONAHA_118_12462 crossref_primary_10_3389_fcvm_2021_716938 crossref_primary_10_3390_healthcare10102037 crossref_primary_10_1186_s10194_024_01726_1 crossref_primary_10_1016_j_ijpsycho_2020_06_015 crossref_primary_10_1016_j_exger_2020_110938 crossref_primary_10_3390_biomedicines10010056 crossref_primary_10_3390_biomedicines9081007 crossref_primary_10_1161_HYPERTENSIONAHA_117_08933 crossref_primary_10_3390_diagnostics10121104 crossref_primary_10_3390_ijerph192214697 crossref_primary_10_1161_JAHA_117_007971 crossref_primary_10_1152_japplphysiol_00701_2022 crossref_primary_10_1016_j_ancard_2017_04_007 crossref_primary_10_1016_j_hrtlng_2023_05_011 crossref_primary_10_1177_1358863X251333672 crossref_primary_10_1152_japplphysiol_00412_2024 crossref_primary_10_1093_ajh_hpaa127 crossref_primary_10_1016_j_cct_2022_107048 crossref_primary_10_1016_j_diabres_2023_110915 crossref_primary_10_1177_20543581231213798 crossref_primary_10_1055_a_2053_7613 crossref_primary_10_3389_fmed_2021_788243 crossref_primary_10_1161_HYPERTENSIONAHA_119_13299 crossref_primary_10_1007_s40471_021_00276_3 crossref_primary_10_1161_JAHA_119_012601 crossref_primary_10_3390_ijerph18073393 crossref_primary_10_14814_phy2_13357 crossref_primary_10_3389_fphys_2021_734038 crossref_primary_10_3390_jcm12216919 crossref_primary_10_1016_j_artres_2017_07_001 crossref_primary_10_1161_HYPERTENSIONAHA_119_13292 crossref_primary_10_3389_fphys_2021_758299 crossref_primary_10_1016_j_biopsycho_2023_108513 crossref_primary_10_1177_10711813251357929 crossref_primary_10_1007_s11332_022_00941_0 crossref_primary_10_1161_HYPERTENSIONAHA_117_10620 crossref_primary_10_3389_fcvm_2022_952621 |
| ContentType | Journal Article |
| Copyright | 2016 The Authors. |
| Copyright_xml | – notice: 2016 The Authors. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1161/hypertensionaha.116.08035 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1524-4563 |
| EndPage | 1297 |
| ExternalDocumentID | 27672029 |
| Genre | Comparative Study Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: British Heart Foundation grantid: FS/12/8/29377 |
| GroupedDBID | --- .-D .3C .55 .GJ .XZ .Z2 01R 0R~ 18M 1J1 2WC 3O- 40H 4Q1 4Q2 4Q3 53G 5GY 5RE 5VS 71W 77Y 7O~ AAAAV AAAXR AAFWJ AAGIX AAHPQ AAIQE AAJCS AAMOA AAMTA AAQKA AARTV AASCR AASOK AAXQO AAYEP ABASU ABBUW ABDIG ABJNI ABOCM ABPXF ABQRW ABVCZ ABXVJ ABXYN ABZAD ABZZY ACCJW ACDDN ACEWG ACGFO ACGFS ACILI ACLDA ACWDW ACWRI ACXJB ACXNZ ACZKN ADBBV ADFPA ADGGA ADGHP ADHPY ADKSD ADNKB ADSXY AE3 AE6 AEBDS AEETU AENEX AFBFQ AFDTB AFEXH AFFNX AFNMH AFUWQ AGINI AHMBA AHOMT AHQNM AHQVU AHRYX AHVBC AIJEX AINUH AJCLO AJIOK AJNWD AJNYG AJZMW AKCTQ AKULP ALKUP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AOQMC BAWUL BCGUY BOYCO BQLVK BS7 C1A C45 CGR CS3 CUY CVF DIK DIWNM DUNZO E.X E3Z EBS ECM EEVPB EIF EJD ERAAH EX3 F2K F2L F2M F2N F5P FCALG FL- FW0 GNXGY GQDEL GX1 H0~ H13 HLJTE HZ~ IKREB IKYAY IN~ IPNFZ JF9 JG8 JK3 JK8 K-A K-F K8S KD2 KMI KQ8 L-C L7B N4W N9A NPM N~7 N~B N~M O9- OAG OAH OB3 OCUKA ODA ODMTH OGROG OHYEH OK1 OL1 OLG OLH OLU OLV OLY OLZ OPUJH ORVUJ OUVQU OVD OVDNE OVIDH OVLEI OWBYB OWU OWV OWW OWX OWY OWZ OXXIT OZ- P-K P2P PQQKQ R58 RAH RIG RLZ S4R S4S T8P TEORI TR2 TSPGW V2I VVN W3M W8F WH7 WOQ WOW X3V X3W X7M XXN XYM YFH YHZ YOC YYM YYP ZFV ZGI ZZMQN 7X8 |
| ID | FETCH-LOGICAL-c5885-c361f992b29f3b7b18be80753bcc9236a682dd9f2d84c791561333724875d0ef2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 44 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=00004268-201611000-00032&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| IngestDate | Wed Oct 01 13:27:03 EDT 2025 Sat Sep 13 02:30:33 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | blood pressure heart rate aortic stiffness autonomic nervous system hemodynamics healthy volunteers |
| Language | English |
| License | 2016 The Authors. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5885-c361f992b29f3b7b18be80753bcc9236a682dd9f2d84c791561333724875d0ef2 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC5058641 |
| PMID | 27672029 |
| PQID | 1835397888 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1835397888 pubmed_primary_27672029 |
| PublicationCentury | 2000 |
| PublicationDate | 2016-November |
| PublicationDateYYYYMMDD | 2016-11-01 |
| PublicationDate_xml | – month: 11 year: 2016 text: 2016-November |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Hypertension (Dallas, Tex. 1979) |
| PublicationTitleAlternate | Hypertension |
| PublicationYear | 2016 |
| SSID | ssj0014447 |
| Score | 2.419685 |
| Snippet | The autonomic nervous system is important in regulating blood pressure, but whether it regulates aortic stiffness is more contentious. We conducted 3 studies... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1290 |
| SubjectTerms | Adult Arterial Pressure - physiology Autonomic Nervous System - physiopathology Cross-Over Studies Cross-Sectional Studies Double-Blind Method Female Hand Strength - physiology Healthy Volunteers Heart Rate - drug effects Heart Rate - physiology Hemodynamics - physiology Humans Hypertension - physiopathology Male Pentolinium Tartrate - administration & dosage Prognosis Pulse Wave Analysis Role Vascular Stiffness - drug effects Vascular Stiffness - physiology Young Adult |
| Title | The Role of the Autonomic Nervous System in the Regulation of Aortic Stiffness |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27672029 https://www.proquest.com/docview/1835397888 |
| Volume | 68 |
| WOSCitedRecordID | wos00004268-201611000-00032&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3JasMwEBVtU0Iv3Zd0Q4Fe3diSZUmnEkpDLzEhbSE3Y20kUOw0S7-_I9shlx4KvfhgI2MNzzNvNNI8hB4cJTnTXAWUOBrETrJAxFIEiSI6osxE3ISV2ARPUzGZyFGz4LZstlVufGLlqE2p_Rp5D6DHIHZCwvY0_wq8apSvrjYSGruoRYHKeFTzybaKEMcxb6Nu5RiSqDeFzG5R7QsHkjvN_c1HIEyN0tuv7LKKMoOj_37fMTps-CXu14A4QTu2OEXtYVNBP0Mp4AKPy0-LS4eB_OH-elUfTcYpuI1yvcR1E3M8K6rn41qsHibjR_RL_2L8tpo5553kOfoYvLw_vwaNpkKgmRAs0DSJnJREEemo4ioSyvp-xFRpDVwvyRNBjJGOGBFrLiOfX1DKic9rTGgduUB7RVnYK4S1piYWmjlCdJyQUFETaWktV45D1GMd1N1YKgPM-kJEXliYR7a1VQdd1ubO5nVzjYzwhJOQyOs_jL5BB8Bfkvpo4C1qOfhj7R3a19-r2XJxX4EBrulo-AMx3sBy |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Role+of+the+Autonomic+Nervous+System+in+the+Regulation+of+Aortic+Stiffness&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+1979%29&rft.au=M%C3%A4ki-Pet%C3%A4j%C3%A4%2C+Kaisa+M&rft.au=Barrett%2C+Sharon+M+L&rft.au=Evans%2C+Sarah+V&rft.au=Cheriyan%2C+Joseph&rft.date=2016-11-01&rft.eissn=1524-4563&rft.volume=68&rft.issue=5&rft.spage=1290&rft_id=info:doi/10.1161%2Fhypertensionaha.116.08035&rft_id=info%3Apmid%2F27672029&rft_id=info%3Apmid%2F27672029&rft.externalDocID=27672029 |