Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community
Whereas regular exercise is associated with lower risk of cardiovascular disease and mortality, mechanisms of exercise-mediated health benefits remain less clear. We used metabolite profiling before and after acute exercise to delineate the metabolic architecture of exercise response patterns in hum...
Gespeichert in:
| Veröffentlicht in: | Circulation (New York, N.Y.) Jg. 142; H. 20; S. 1905 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
17.11.2020
|
| Schlagworte: | |
| ISSN: | 1524-4539, 1524-4539 |
| Online-Zugang: | Weitere Angaben |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Whereas regular exercise is associated with lower risk of cardiovascular disease and mortality, mechanisms of exercise-mediated health benefits remain less clear. We used metabolite profiling before and after acute exercise to delineate the metabolic architecture of exercise response patterns in humans.
Cardiopulmonary exercise testing and metabolite profiling was performed on Framingham Heart Study participants (age 53±8 years, 63% women) with blood drawn at rest (n=471) and at peak exercise (n=411).
We observed changes in circulating levels for 502 of 588 measured metabolites from rest to peak exercise (exercise duration 11.9±2.1 minutes) at a 5% false discovery rate. Changes included reductions in metabolites implicated in insulin resistance (glutamate, -29%;
=1.5×10
; dimethylguanidino valeric acid [DMGV], -18%;
=5.8×10
) and increases in metabolites associated with lipolysis (1-methylnicotinamide, +33%;
=6.1×10
), nitric oxide bioavailability (arginine/ornithine + citrulline, +29%;
=2.8×10
), and adipose browning (12,13-dihydroxy-9Z-octadecenoic acid +26%;
=7.4×10
), among other pathways relevant to cardiometabolic risk. We assayed 177 metabolites in a separate Framingham Heart Study replication sample (n=783, age 54±8 years, 51% women) and observed concordant changes in 164 metabolites (92.6%) at 5% false discovery rate. Exercise-induced metabolite changes were variably related to the amount of exercise performed (peak workload), sex, and body mass index. There was attenuation of favorable excursions in some metabolites in individuals with higher body mass index and greater excursions in select cardioprotective metabolites in women despite less exercise performed. Distinct preexercise metabolite levels were associated with different physiologic dimensions of fitness (eg, ventilatory efficiency, exercise blood pressure, peak Vo
). We identified 4 metabolite signatures of exercise response patterns that were then analyzed in a separate cohort (Framingham Offspring Study; n=2045, age 55±10 years, 51% women), 2 of which were associated with overall mortality over median follow-up of 23.1 years (
≤0.003 for both).
In a large sample of community-dwelling individuals, acute exercise elicits widespread changes in the circulating metabolome. Metabolic changes identify pathways central to cardiometabolic health, cardiovascular disease, and long-term outcome. These findings provide a detailed map of the metabolic response to acute exercise in humans and identify potential mechanisms responsible for the beneficial cardiometabolic effects of exercise for future study. |
|---|---|
| AbstractList | Whereas regular exercise is associated with lower risk of cardiovascular disease and mortality, mechanisms of exercise-mediated health benefits remain less clear. We used metabolite profiling before and after acute exercise to delineate the metabolic architecture of exercise response patterns in humans.
Cardiopulmonary exercise testing and metabolite profiling was performed on Framingham Heart Study participants (age 53±8 years, 63% women) with blood drawn at rest (n=471) and at peak exercise (n=411).
We observed changes in circulating levels for 502 of 588 measured metabolites from rest to peak exercise (exercise duration 11.9±2.1 minutes) at a 5% false discovery rate. Changes included reductions in metabolites implicated in insulin resistance (glutamate, -29%;
=1.5×10
; dimethylguanidino valeric acid [DMGV], -18%;
=5.8×10
) and increases in metabolites associated with lipolysis (1-methylnicotinamide, +33%;
=6.1×10
), nitric oxide bioavailability (arginine/ornithine + citrulline, +29%;
=2.8×10
), and adipose browning (12,13-dihydroxy-9Z-octadecenoic acid +26%;
=7.4×10
), among other pathways relevant to cardiometabolic risk. We assayed 177 metabolites in a separate Framingham Heart Study replication sample (n=783, age 54±8 years, 51% women) and observed concordant changes in 164 metabolites (92.6%) at 5% false discovery rate. Exercise-induced metabolite changes were variably related to the amount of exercise performed (peak workload), sex, and body mass index. There was attenuation of favorable excursions in some metabolites in individuals with higher body mass index and greater excursions in select cardioprotective metabolites in women despite less exercise performed. Distinct preexercise metabolite levels were associated with different physiologic dimensions of fitness (eg, ventilatory efficiency, exercise blood pressure, peak Vo
). We identified 4 metabolite signatures of exercise response patterns that were then analyzed in a separate cohort (Framingham Offspring Study; n=2045, age 55±10 years, 51% women), 2 of which were associated with overall mortality over median follow-up of 23.1 years (
≤0.003 for both).
In a large sample of community-dwelling individuals, acute exercise elicits widespread changes in the circulating metabolome. Metabolic changes identify pathways central to cardiometabolic health, cardiovascular disease, and long-term outcome. These findings provide a detailed map of the metabolic response to acute exercise in humans and identify potential mechanisms responsible for the beneficial cardiometabolic effects of exercise for future study. Whereas regular exercise is associated with lower risk of cardiovascular disease and mortality, mechanisms of exercise-mediated health benefits remain less clear. We used metabolite profiling before and after acute exercise to delineate the metabolic architecture of exercise response patterns in humans.BACKGROUNDWhereas regular exercise is associated with lower risk of cardiovascular disease and mortality, mechanisms of exercise-mediated health benefits remain less clear. We used metabolite profiling before and after acute exercise to delineate the metabolic architecture of exercise response patterns in humans.Cardiopulmonary exercise testing and metabolite profiling was performed on Framingham Heart Study participants (age 53±8 years, 63% women) with blood drawn at rest (n=471) and at peak exercise (n=411).METHODSCardiopulmonary exercise testing and metabolite profiling was performed on Framingham Heart Study participants (age 53±8 years, 63% women) with blood drawn at rest (n=471) and at peak exercise (n=411).We observed changes in circulating levels for 502 of 588 measured metabolites from rest to peak exercise (exercise duration 11.9±2.1 minutes) at a 5% false discovery rate. Changes included reductions in metabolites implicated in insulin resistance (glutamate, -29%; P=1.5×10-55; dimethylguanidino valeric acid [DMGV], -18%; P=5.8×10-18) and increases in metabolites associated with lipolysis (1-methylnicotinamide, +33%; P=6.1×10-67), nitric oxide bioavailability (arginine/ornithine + citrulline, +29%; P=2.8×10-169), and adipose browning (12,13-dihydroxy-9Z-octadecenoic acid +26%; P=7.4×10-38), among other pathways relevant to cardiometabolic risk. We assayed 177 metabolites in a separate Framingham Heart Study replication sample (n=783, age 54±8 years, 51% women) and observed concordant changes in 164 metabolites (92.6%) at 5% false discovery rate. Exercise-induced metabolite changes were variably related to the amount of exercise performed (peak workload), sex, and body mass index. There was attenuation of favorable excursions in some metabolites in individuals with higher body mass index and greater excursions in select cardioprotective metabolites in women despite less exercise performed. Distinct preexercise metabolite levels were associated with different physiologic dimensions of fitness (eg, ventilatory efficiency, exercise blood pressure, peak Vo2). We identified 4 metabolite signatures of exercise response patterns that were then analyzed in a separate cohort (Framingham Offspring Study; n=2045, age 55±10 years, 51% women), 2 of which were associated with overall mortality over median follow-up of 23.1 years (P≤0.003 for both).RESULTSWe observed changes in circulating levels for 502 of 588 measured metabolites from rest to peak exercise (exercise duration 11.9±2.1 minutes) at a 5% false discovery rate. Changes included reductions in metabolites implicated in insulin resistance (glutamate, -29%; P=1.5×10-55; dimethylguanidino valeric acid [DMGV], -18%; P=5.8×10-18) and increases in metabolites associated with lipolysis (1-methylnicotinamide, +33%; P=6.1×10-67), nitric oxide bioavailability (arginine/ornithine + citrulline, +29%; P=2.8×10-169), and adipose browning (12,13-dihydroxy-9Z-octadecenoic acid +26%; P=7.4×10-38), among other pathways relevant to cardiometabolic risk. We assayed 177 metabolites in a separate Framingham Heart Study replication sample (n=783, age 54±8 years, 51% women) and observed concordant changes in 164 metabolites (92.6%) at 5% false discovery rate. Exercise-induced metabolite changes were variably related to the amount of exercise performed (peak workload), sex, and body mass index. There was attenuation of favorable excursions in some metabolites in individuals with higher body mass index and greater excursions in select cardioprotective metabolites in women despite less exercise performed. Distinct preexercise metabolite levels were associated with different physiologic dimensions of fitness (eg, ventilatory efficiency, exercise blood pressure, peak Vo2). We identified 4 metabolite signatures of exercise response patterns that were then analyzed in a separate cohort (Framingham Offspring Study; n=2045, age 55±10 years, 51% women), 2 of which were associated with overall mortality over median follow-up of 23.1 years (P≤0.003 for both).In a large sample of community-dwelling individuals, acute exercise elicits widespread changes in the circulating metabolome. Metabolic changes identify pathways central to cardiometabolic health, cardiovascular disease, and long-term outcome. These findings provide a detailed map of the metabolic response to acute exercise in humans and identify potential mechanisms responsible for the beneficial cardiometabolic effects of exercise for future study.CONCLUSIONSIn a large sample of community-dwelling individuals, acute exercise elicits widespread changes in the circulating metabolome. Metabolic changes identify pathways central to cardiometabolic health, cardiovascular disease, and long-term outcome. These findings provide a detailed map of the metabolic response to acute exercise in humans and identify potential mechanisms responsible for the beneficial cardiometabolic effects of exercise for future study. |
| Author | Miller, Patricia E Dailey, Lucas Vasan, Ramachandran S Moore, Stephanie A Tanguay, Melissa Houstis, Nicholas E Bullock, Kevin Shah, Ravi V Deik, Amy Baggish, Aaron L Pierce, Kerry A Larson, Martin G Ho, Jennifer E Murthy, Venkatesh L Malhotra, Rajeev Clish, Clary B Lewis, Gregory D Nayor, Matthew Pico, Alexander R Blodgett, Jasmine B Velagaleti, Raghava S |
| Author_xml | – sequence: 1 givenname: Matthew surname: Nayor fullname: Nayor, Matthew organization: Cardiology Division and the Simches Cardiovascular Research Center, Department of Medicine, Harvard Medical School (M.N., R.V.S., J.B.B., M.T., R.M., N.E.H., J.E.H., A.L.B., G.D.L.), Massachusetts General Hospital, Boston – sequence: 2 givenname: Ravi V surname: Shah fullname: Shah, Ravi V organization: Cardiology Division and the Simches Cardiovascular Research Center, Department of Medicine, Harvard Medical School (M.N., R.V.S., J.B.B., M.T., R.M., N.E.H., J.E.H., A.L.B., G.D.L.), Massachusetts General Hospital, Boston – sequence: 3 givenname: Patricia E surname: Miller fullname: Miller, Patricia E organization: Department of Biostatistics, Boston University School of Public Health, MA (P.E.M., M.G.L.) – sequence: 4 givenname: Jasmine B surname: Blodgett fullname: Blodgett, Jasmine B organization: Cardiology Division and the Simches Cardiovascular Research Center, Department of Medicine, Harvard Medical School (M.N., R.V.S., J.B.B., M.T., R.M., N.E.H., J.E.H., A.L.B., G.D.L.), Massachusetts General Hospital, Boston – sequence: 5 givenname: Melissa surname: Tanguay fullname: Tanguay, Melissa organization: Cardiology Division and the Simches Cardiovascular Research Center, Department of Medicine, Harvard Medical School (M.N., R.V.S., J.B.B., M.T., R.M., N.E.H., J.E.H., A.L.B., G.D.L.), Massachusetts General Hospital, Boston – sequence: 6 givenname: Alexander R surname: Pico fullname: Pico, Alexander R organization: Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA (A.R.P.) – sequence: 7 givenname: Venkatesh L surname: Murthy fullname: Murthy, Venkatesh L organization: Division of Cardiovascular Medicine, Department of Medicine, and Frankel Cardiovascular Center, University of Michigan, Ann Arbor (V.L.M.) – sequence: 8 givenname: Rajeev surname: Malhotra fullname: Malhotra, Rajeev organization: Cardiovascular Research Center (R.M., J.E.H., G.D.L.), Massachusetts General Hospital, Boston – sequence: 9 givenname: Nicholas E surname: Houstis fullname: Houstis, Nicholas E organization: Cardiology Division and the Simches Cardiovascular Research Center, Department of Medicine, Harvard Medical School (M.N., R.V.S., J.B.B., M.T., R.M., N.E.H., J.E.H., A.L.B., G.D.L.), Massachusetts General Hospital, Boston – sequence: 10 givenname: Amy surname: Deik fullname: Deik, Amy organization: Broad Institute of MIT and Harvard, Cambridge, MA (A.D., K.A.P., K.B., L.D., C.B.C.) – sequence: 11 givenname: Kerry A surname: Pierce fullname: Pierce, Kerry A organization: Broad Institute of MIT and Harvard, Cambridge, MA (A.D., K.A.P., K.B., L.D., C.B.C.) – sequence: 12 givenname: Kevin surname: Bullock fullname: Bullock, Kevin organization: Broad Institute of MIT and Harvard, Cambridge, MA (A.D., K.A.P., K.B., L.D., C.B.C.) – sequence: 13 givenname: Lucas surname: Dailey fullname: Dailey, Lucas organization: Broad Institute of MIT and Harvard, Cambridge, MA (A.D., K.A.P., K.B., L.D., C.B.C.) – sequence: 14 givenname: Raghava S surname: Velagaleti fullname: Velagaleti, Raghava S organization: Cardiology Section, Department of Medicine, Boston VA Healthcare System, West Roxbury, MA (R.S. Velagaleti, S.A.M.) – sequence: 15 givenname: Stephanie A surname: Moore fullname: Moore, Stephanie A organization: Cardiology Section, Department of Medicine, Boston VA Healthcare System, West Roxbury, MA (R.S. Velagaleti, S.A.M.) – sequence: 16 givenname: Jennifer E surname: Ho fullname: Ho, Jennifer E organization: Cardiovascular Research Center (R.M., J.E.H., G.D.L.), Massachusetts General Hospital, Boston – sequence: 17 givenname: Aaron L surname: Baggish fullname: Baggish, Aaron L organization: Cardiology Division and the Simches Cardiovascular Research Center, Department of Medicine, Harvard Medical School (M.N., R.V.S., J.B.B., M.T., R.M., N.E.H., J.E.H., A.L.B., G.D.L.), Massachusetts General Hospital, Boston – sequence: 18 givenname: Clary B surname: Clish fullname: Clish, Clary B organization: Broad Institute of MIT and Harvard, Cambridge, MA (A.D., K.A.P., K.B., L.D., C.B.C.) – sequence: 19 givenname: Martin G surname: Larson fullname: Larson, Martin G organization: Boston University and National Heart, Lung, and Blood Institute Framingham Heart Study, MA (M.G.L., R.S. Vasan) – sequence: 20 givenname: Ramachandran S surname: Vasan fullname: Vasan, Ramachandran S organization: Sections of Preventive Medicine and Epidemiology and Cardiology, Department of Medicine, Boston University School of Medicine, MA (R.S. Vasan) – sequence: 21 givenname: Gregory D surname: Lewis fullname: Lewis, Gregory D organization: Pulmonary Critical Care Unit (G.D.L.), Massachusetts General Hospital, Boston |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32927962$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkEtLw0AYRQep2If-BYk7N6nzyDyyHEK1hdZCacFdSWa-2JE8amYC9t9bsYKre7gc7uKO0aBpG0DogeApIYI8ZYtNtlvq7WL9qud6SiieYo6pIldoRDhN4oSzdPCPh2js_QfGWDDJb9CQ0ZTKVNAReltByIu2cibSnTm4ACb0HURtGWnTB4hmX9AZ5yHagD-2zRlcE62ctRXE-h1spG1fBf_ThgNEWVvXfePC6RZdl3nl4e6SE7R7nm2zebxcvywyvYwNV4rEwApJheFMEoO5LQgjKSMglS2Lc51SwLIQCidC5TI3hTKGJWUJaVHmVhhJJ-jxd_fYtZ89-LCvnTdQVXkDbe_3NEmoSjAX6Vm9v6h9UYPdHztX591p__cG_QYuF2Xy |
| CitedBy_id | crossref_primary_10_1007_s00125_021_05641_x crossref_primary_10_3390_metabo11010059 crossref_primary_10_1016_j_jtcme_2024_02_001 crossref_primary_10_1016_j_tem_2023_08_019 crossref_primary_10_1113_JP282000 crossref_primary_10_3389_fendo_2023_1265175 crossref_primary_10_1016_j_lfs_2021_120229 crossref_primary_10_1093_cvr_cvae199 crossref_primary_10_1111_acel_14090 crossref_primary_10_1161_JAHA_124_039457 crossref_primary_10_3389_fcvm_2022_1072191 crossref_primary_10_1093_eurjpc_zwad113 crossref_primary_10_1093_eurjpc_zwad157 crossref_primary_10_3389_fnut_2021_796360 crossref_primary_10_3390_metabo13060694 crossref_primary_10_1111_jch_14461 crossref_primary_10_2478_jtim_2022_0050 crossref_primary_10_1124_molpharm_121_000328 crossref_primary_10_1038_s41598_022_10976_5 crossref_primary_10_1038_s41591_024_03039_x crossref_primary_10_1016_j_exger_2021_111634 crossref_primary_10_1186_s12933_022_01647_w crossref_primary_10_1007_s11892_022_01449_0 crossref_primary_10_1161_CIRCGEN_121_003592 crossref_primary_10_1097_FJC_0000000000001254 crossref_primary_10_3390_jcdd10090400 crossref_primary_10_3390_ijms25094659 crossref_primary_10_1016_j_lfs_2023_121923 crossref_primary_10_1152_physiol_00024_2024 crossref_primary_10_1161_ATVBAHA_124_320737 crossref_primary_10_1136_bmjsem_2022_001474 crossref_primary_10_1016_j_archger_2025_105879 crossref_primary_10_1016_j_amjcard_2021_07_020 crossref_primary_10_1152_physiolgenomics_00008_2024 crossref_primary_10_1007_s10741_024_10439_1 crossref_primary_10_1093_eurheartj_ehac446 crossref_primary_10_1161_JAHA_122_026670 crossref_primary_10_12688_f1000research_128978_3 crossref_primary_10_1016_j_heliyon_2023_e19661 crossref_primary_10_12688_f1000research_128978_2 crossref_primary_10_1016_j_isci_2024_111366 crossref_primary_10_12688_f1000research_128978_1 crossref_primary_10_2196_56676 crossref_primary_10_1111_liv_16147 crossref_primary_10_1073_pnas_2107621118 crossref_primary_10_1249_MSS_0000000000002960 crossref_primary_10_3390_metabo11100675 crossref_primary_10_1016_j_jacc_2021_01_059 crossref_primary_10_1016_j_jacc_2021_02_070 crossref_primary_10_1016_j_lfs_2024_122471 crossref_primary_10_1097_CRD_0000000000000417 crossref_primary_10_1055_a_1925_7588 crossref_primary_10_1161_ATVBAHA_122_318512 crossref_primary_10_1016_j_jconrel_2024_07_010 crossref_primary_10_1016_j_jaccao_2024_04_006 crossref_primary_10_1016_j_lfs_2022_121284 crossref_primary_10_3390_metabo11120856 crossref_primary_10_3390_metabo11030151 crossref_primary_10_1093_eurheartj_ehab580 crossref_primary_10_1210_clinem_dgaa799 crossref_primary_10_64904_fpm25001 crossref_primary_10_3389_fspor_2025_1557887 crossref_primary_10_1038_s41598_025_94932_z crossref_primary_10_1515_teb_2024_2006 crossref_primary_10_1161_CIRCRESAHA_125_325526 crossref_primary_10_3390_ijms26125529 crossref_primary_10_3390_ijms26178697 crossref_primary_10_1002_adbi_202300633 crossref_primary_10_1016_j_cdtm_2021_06_002 crossref_primary_10_1186_s12889_024_19833_8 crossref_primary_10_3390_ijms24021659 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1161/CIRCULATIONAHA.120.050281 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1524-4539 |
| ExternalDocumentID | 32927962 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | Massachusetts |
| GeographicLocations_xml | – name: Massachusetts |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: K23 HL138260 – fundername: NHLBI NIH HHS grantid: R01 HL134893 – fundername: NHLBI NIH HHS grantid: 75N92019D00031 – fundername: NHLBI NIH HHS grantid: N01 HC025195 – fundername: NHLBI NIH HHS grantid: R01 HL131029 – fundername: NHLBI NIH HHS grantid: R01 HL142809 – fundername: NHLBI NIH HHS grantid: HHSN268201500001I – fundername: NIDDK NIH HHS grantid: P30 DK040561 – fundername: NHLBI NIH HHS grantid: K23 HL127099 – fundername: NHLBI NIH HHS grantid: R01 HL140224 |
| GroupedDBID | --- .-D .3C .XZ .Z2 01R 0R~ 0ZK 18M 1J1 29B 2FS 2WC 354 40H 4Q1 4Q2 4Q3 53G 5GY 5RE 5VS 6PF 71W 77Y 7O~ AAAAV AAAXR AAFWJ AAGIX AAHPQ AAIQE AAJCS AAMOA AAMTA AAQKA AARTV AASCR AASOK AASXQ AAUEB AAWTL AAXQO ABASU ABBUW ABDIG ABJNI ABOCM ABPMR ABPXF ABQRW ABVCZ ABXVJ ABXYN ABZAD ABZZY ACDDN ACDOF ACEWG ACGFO ACGFS ACILI ACLDA ACOAL ACRKK ACWDW ACWRI ACXJB ACXNZ ACZKN ADBBV ADCYY ADGGA ADHPY AE3 AE6 AEBDS AENEX AFBFQ AFCHL AFDTB AFEXH AFMBP AFNMH AFSOK AFUWQ AGINI AHMBA AHOMT AHQNM AHQVU AHRYX AHVBC AIJEX AINUH AJCLO AJIOK AJNWD AJZMW AKCTQ AKULP ALKUP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AOQMC ASPBG AVWKF AYCSE AZFZN BAWUL BOYCO BQLVK BYPQX C45 CGR CS3 CUY CVF DIK DIWNM DU5 E3Z EBS ECM EEVPB EIF ERAAH EX3 F2K F2L F2M F2N F5P FCALG GNXGY GQDEL GX1 H0~ HLJTE HZ~ IKREB IKYAY IN~ IPNFZ JF9 JG8 JK3 K-A K-F K8S KD2 KMI KQ8 L-C L7B N9A NPM N~7 N~B O9- OAG OAH OBH OCB ODMTH OGEVE OHH OHYEH OK1 OL1 OLB OLG OLH OLU OLV OLY OLZ OPUJH OVD OVDNE OVIDH OVLEI OVOZU OWBYB OWU OWV OWW OWX OWY OWZ OXXIT P2P PQQKQ RAH RIG RLZ S4R S4S T8P TEORI TR2 TSPGW UPT V2I VVN W2D W3M W8F WH7 WOQ WOW X3V X3W XXN XYM YFH YOC YSK YYM YZZ ZFV ZY1 ~H1 7X8 ADKSD ADSXY |
| ID | FETCH-LOGICAL-c5881-e3b726c5371c05db131931e78dfb6c592e07b680468a7acb8cc34ffe9bfad6c72 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 80 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=00003017-202011170-00005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1524-4539 |
| IngestDate | Sun Sep 28 15:19:21 EDT 2025 Mon Jul 21 06:04:55 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 20 |
| Keywords | metabolomics exercise prevention & control |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5881-e3b726c5371c05db131931e78dfb6c592e07b680468a7acb8cc34ffe9bfad6c72 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/8049528 |
| PMID | 32927962 |
| PQID | 2442840569 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2442840569 pubmed_primary_32927962 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-November-17 |
| PublicationDateYYYYMMDD | 2020-11-17 |
| PublicationDate_xml | – month: 11 year: 2020 text: 2020-November-17 day: 17 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Circulation (New York, N.Y.) |
| PublicationTitleAlternate | Circulation |
| PublicationYear | 2020 |
| SSID | ssj0006375 |
| Score | 2.5892038 |
| Snippet | Whereas regular exercise is associated with lower risk of cardiovascular disease and mortality, mechanisms of exercise-mediated health benefits remain less... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1905 |
| SubjectTerms | Adult Aged Body Mass Index Cardiovascular Diseases - blood Cardiovascular Diseases - physiopathology Cardiovascular Diseases - therapy Exercise Female Humans Male Massachusetts Metabolome Metabolomics Middle Aged Prospective Studies |
| Title | Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32927962 https://www.proquest.com/docview/2442840569 |
| Volume | 142 |
| WOSCitedRecordID | wos00003017-202011170-00005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bS-QwFD64q8i-rK7uxfVCBPEtTps0TfK0lEFRsMMwrDJvQ5qky8Buq8644L_fk7SD-yIIvvQhUCjpyfnO5ct3AE4cYmpmvaK1EY5mUkhqMO6gUhgtnXOsirfSbq_laKSmUz3uC26Lnla58onRUbvWhhr5AGEIPSnCtf5xd0_D1KjQXe1HaLyDdY6hTKB0yemzWnjOo9AuQlRGM8H1JhxHJ5Gng-HVZHhz3QnOXoaKYHKWCMTa9OVIMyLOxdZbv3UbPvaxJik64_gEa77Zgd2iwTz7zxM5JZH9GcvqO7BZ9k32XZiWfomm8XtuSfFfm4G0NSns49KT835ME5l0BFtP5g0pY6WDFr-8I0UQ9ViEVQwvSX8HZfn0GW4uzn8OL2k_gIFaoVRKPa8ky63gMrWJcFWK55WnXipXV7ismU9klStMsZWRxlbKWp7VtddVbVxuJfsC75u28d-ApMIYjkCYJ8pnRqIXSIULcnJGW2MZ24Pj1VbO0MBD18I0vn1czJ43cw--dv9jdtcpccw400zqnH1_xdv78IGFXDlQ-OQBrNd4vP0hbNi_y_ni4ShaDj5H4_Ifjh_MEw |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Metabolic+Architecture+of+Acute+Exercise+Response+in+Middle-Aged+Adults+in+the+Community&rft.jtitle=Circulation+%28New+York%2C+N.Y.%29&rft.au=Nayor%2C+Matthew&rft.au=Shah%2C+Ravi+V&rft.au=Miller%2C+Patricia+E&rft.au=Blodgett%2C+Jasmine+B&rft.date=2020-11-17&rft.issn=1524-4539&rft.eissn=1524-4539&rft.volume=142&rft.issue=20&rft.spage=1905&rft_id=info:doi/10.1161%2FCIRCULATIONAHA.120.050281&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1524-4539&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1524-4539&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1524-4539&client=summon |