Increased frequency of CD4⁺ CD25⁺ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients
Naturally occurring CD4⁺ CD25⁺ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS), where T cells play a key role in orchestrating tissue d...
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| Vydané v: | Clinical and experimental immunology Ročník 147; číslo 3; s. 412 - 418 |
|---|---|
| Hlavní autori: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Oxford, UK
Oxford, UK : Blackwell Publishing Ltd
01.03.2007
Blackwell Publishing Ltd Blackwell Blackwell Science Inc |
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| ISSN: | 0009-9104, 1365-2249 |
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| Abstract | Naturally occurring CD4⁺ CD25⁺ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS), where T cells play a key role in orchestrating tissue damage. While CD4⁺ CD25⁺ nTreg have been investigated in peripheral blood from MS patients, little is known about their presence and possible function within the target organ, the CNS. In order to study whether these cells are present in the cerebrospinal fluid (CSF) under pathological conditions, we have analysed the frequency of CD4⁺ CD25⁺ nTreg in peripheral blood and CSF from MS patients (n = 14), patients with other neurological disorders (OND; n = 9) and compared peripheral levels with healthy controls (n = 40). We found that the frequency of CD4⁺ CD25⁺ forkhead transcription factor 3 (FOXP3)⁺ nTreg was significantly elevated in the CSF from MS patients (mean CSF = 4·05 ± 1·54% versus mean peripheral blood = 2·93 ± 0·94%) but not from patients with other neurological disorders (mean CSF = 3·78 ± 1·26% versus mean peripheral blood = 3·74 ± 1·4%). The frequency of nTreg in the periphery did not differ between MS patients and healthy donors; however, nTreg from MS patients showed reduced suppressive capacity. |
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| AbstractList | Naturally occurring CD4+ CD25+ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS), where T cells play a key role in orchestrating tissue damage. While CD4+ CD25+ nTreg have been investigated in peripheral blood from MS patients, little is known about their presence and possible function within the target organ, the CNS. In order to study whether these cells are present in the cerebrospinal fluid (CSF) under pathological conditions, we have analysed the frequency of CD4+ CD25+ nTreg in peripheral blood and CSF from MS patients (n=14), patients with other neurological disorders (OND; n=9) and compared peripheral levels with healthy controls (n=40). We found that the frequency of CD4+ CD25+ forkhead transcription factor 3 (FOXP3)+ nTreg was significantly elevated in the CSF from MS patients (mean CSF=4 x 05 +/- 1.54% versus mean peripheral blood = 2 x 93 +/- 0 x 94%) but not from patients with other neurological disorders (mean CSF = 3 x 78 +/- 1 x 26% versus mean peripheral blood = 3 x 74 +/- 1 x 4%). The frequency of nTreg in the periphery did not differ between MS patients and healthy donors; however, nTreg from MS patients showed reduced suppressive capacity. Naturally occurring CD4⁺ CD25⁺ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS), where T cells play a key role in orchestrating tissue damage. While CD4⁺ CD25⁺ nTreg have been investigated in peripheral blood from MS patients, little is known about their presence and possible function within the target organ, the CNS. In order to study whether these cells are present in the cerebrospinal fluid (CSF) under pathological conditions, we have analysed the frequency of CD4⁺ CD25⁺ nTreg in peripheral blood and CSF from MS patients (n = 14), patients with other neurological disorders (OND; n = 9) and compared peripheral levels with healthy controls (n = 40). We found that the frequency of CD4⁺ CD25⁺ forkhead transcription factor 3 (FOXP3)⁺ nTreg was significantly elevated in the CSF from MS patients (mean CSF = 4·05 ± 1·54% versus mean peripheral blood = 2·93 ± 0·94%) but not from patients with other neurological disorders (mean CSF = 3·78 ± 1·26% versus mean peripheral blood = 3·74 ± 1·4%). The frequency of nTreg in the periphery did not differ between MS patients and healthy donors; however, nTreg from MS patients showed reduced suppressive capacity. Summary Naturally occurring CD4+ CD25+ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self‐reactive T cells. Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS), where T cells play a key role in orchestrating tissue damage. While CD4+ CD25+ nTreg have been investigated in peripheral blood from MS patients, little is known about their presence and possible function within the target organ, the CNS. In order to study whether these cells are present in the cerebrospinal fluid (CSF) under pathological conditions, we have analysed the frequency of CD4+ CD25+ nTreg in peripheral blood and CSF from MS patients (n = 14), patients with other neurological disorders (OND; n = 9) and compared peripheral levels with healthy controls (n = 40). We found that the frequency of CD4+ CD25+ forkhead transcription factor 3 (FOXP3)+ nTreg was significantly elevated in the CSF from MS patients (mean CSF = 4·05 ± 1·54% versus mean peripheral blood = 2·93 ± 0·94%) but not from patients with other neurological disorders (mean CSF = 3·78 ± 1·26% versus mean peripheral blood = 3·74 ± 1·4%). The frequency of nTreg in the periphery did not differ between MS patients and healthy donors; however, nTreg from MS patients showed reduced suppressive capacity. SummaryNaturally occurring CD4+CD25+ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS), where T cells play a key role in orchestrating tissue damage. While CD4+CD25+ nTreg have been investigated in peripheral blood from MS patients, little is known about their presence and possible function within the target organ, the CNS. In order to study whether these cells are present in the cerebrospinal fluid (CSF) under pathological conditions, we have analysed the frequency of CD4+CD25+ nTreg in peripheral blood and CSF from MS patients (n=14), patients with other neurological disorders (OND; n=9) and compared peripheral levels with healthy controls (n=40). We found that the frequency of CD4+CD25+ forkhead transcription factor 3 (FOXP3)+ nTreg was significantly elevated in the CSF from MS patients (mean CSF=4.05 plus or minus 1.54% versus mean peripheral blood=2.93 plus or minus 0.94%) but not from patients with other neurological disorders (mean CSF=3.78 plus or minus 1.26% versus mean peripheral blood=3.74 plus or minus 1.4%). The frequency of nTreg in the periphery did not differ between MS patients and healthy donors; however, nTreg from MS patients showed reduced suppressive capacity. Naturally occurring CD4+ CD25+ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS), where T cells play a key role in orchestrating tissue damage. While CD4+ CD25+ nTreg have been investigated in peripheral blood from MS patients, little is known about their presence and possible function within the target organ, the CNS. In order to study whether these cells are present in the cerebrospinal fluid (CSF) under pathological conditions, we have analysed the frequency of CD4+ CD25+ nTreg in peripheral blood and CSF from MS patients (n = 14), patients with other neurological disorders (OND; n = 9) and compared peripheral levels with healthy controls (n = 40). We found that the frequency of CD4+ CD25+ forkhead transcription factor 3 (FOXP3)+ nTreg was significantly elevated in the CSF from MS patients (mean CSF = 4·05 ± 1·54% versus mean peripheral blood = 2·93 ± 0·94%) but not from patients with other neurological disorders (mean CSF = 3·78 ± 1·26% versus mean peripheral blood = 3·74 ± 1·4%). The frequency of nTreg in the periphery did not differ between MS patients and healthy donors; however, nTreg from MS patients showed reduced suppressive capacity. Naturally occurring CD4+ CD25+ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS), where T cells play a key role in orchestrating tissue damage. While CD4+ CD25+ nTreg have been investigated in peripheral blood from MS patients, little is known about their presence and possible function within the target organ, the CNS. In order to study whether these cells are present in the cerebrospinal fluid (CSF) under pathological conditions, we have analysed the frequency of CD4+ CD25+ nTreg in peripheral blood and CSF from MS patients (n=14), patients with other neurological disorders (OND; n=9) and compared peripheral levels with healthy controls (n=40). We found that the frequency of CD4+ CD25+ forkhead transcription factor 3 (FOXP3)+ nTreg was significantly elevated in the CSF from MS patients (mean CSF=4 x 05 +/- 1.54% versus mean peripheral blood = 2 x 93 +/- 0 x 94%) but not from patients with other neurological disorders (mean CSF = 3 x 78 +/- 1 x 26% versus mean peripheral blood = 3 x 74 +/- 1 x 4%). The frequency of nTreg in the periphery did not differ between MS patients and healthy donors; however, nTreg from MS patients showed reduced suppressive capacity.Naturally occurring CD4+ CD25+ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS), where T cells play a key role in orchestrating tissue damage. While CD4+ CD25+ nTreg have been investigated in peripheral blood from MS patients, little is known about their presence and possible function within the target organ, the CNS. In order to study whether these cells are present in the cerebrospinal fluid (CSF) under pathological conditions, we have analysed the frequency of CD4+ CD25+ nTreg in peripheral blood and CSF from MS patients (n=14), patients with other neurological disorders (OND; n=9) and compared peripheral levels with healthy controls (n=40). We found that the frequency of CD4+ CD25+ forkhead transcription factor 3 (FOXP3)+ nTreg was significantly elevated in the CSF from MS patients (mean CSF=4 x 05 +/- 1.54% versus mean peripheral blood = 2 x 93 +/- 0 x 94%) but not from patients with other neurological disorders (mean CSF = 3 x 78 +/- 1 x 26% versus mean peripheral blood = 3 x 74 +/- 1 x 4%). The frequency of nTreg in the periphery did not differ between MS patients and healthy donors; however, nTreg from MS patients showed reduced suppressive capacity. |
| Author | Feger, U Melms, A Wiendl, H Luther, C Tolosa, E Poeschel, S |
| Author_xml | – sequence: 1 fullname: Feger, U – sequence: 2 fullname: Luther, C – sequence: 3 fullname: Poeschel, S – sequence: 4 fullname: Melms, A – sequence: 5 fullname: Tolosa, E – sequence: 6 fullname: Wiendl, H |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18518277$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/17302889$$D View this record in MEDLINE/PubMed |
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| Keywords | Human Immunopathology Nervous system diseases Multiple sclerosis Helper cell Cerebrospinal fluid Blood Inflammatory disease regulatory T cells Immunology Central nervous system disease T-Lymphocyte CSF Frequency Regulatory cell |
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| Snippet | Naturally occurring CD4⁺ CD25⁺ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple... Summary Naturally occurring CD4+ CD25+ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self‐reactive T cells. Multiple... Naturally occurring CD4+ CD25+ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple... Naturally occurring CD4+ CD25+ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple... SummaryNaturally occurring CD4+CD25+ regulatory T cells (nTreg) play a major role in controlling autoimmunity by suppressing self-reactive T cells. Multiple... |
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| SubjectTerms | Adult Aged Aged, 80 and over Autoimmune Diseases - immunology Biological and medical sciences Cells, Cultured Clinical Studies CSF Female Forkhead Transcription Factors - cerebrospinal fluid Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immune Tolerance Immunopathology Interleukin-2 Receptor alpha Subunit - analysis Interleukin-2 Receptor alpha Subunit - blood Male Medical sciences Middle Aged multiple sclerosis Multiple Sclerosis - immunology Nervous System Diseases - immunology regulatory T cells T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - immunology |
| Title | Increased frequency of CD4⁺ CD25⁺ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients |
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