Xpert MTB/RIF versus sputum microscopy as the initial diagnostic test for tuberculosis: a cluster-randomised trial embedded in South African roll-out of Xpert MTB/RIF

In South Africa, sputum smear microscopy has been replaced with Xpert MTB/RIF as the initial diagnostic test for tuberculosis. In a pragmatic parallel cluster-randomised trial, we evaluated the effect on patient and programme outcomes. We randomly allocated 20 laboratories (clusters) in medium-burde...

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Bibliographic Details
Published in:	The Lancet global health Vol. 3; no. 8; pp. e450 - e457
Main Authors:	Churchyard, Gavin J, Stevens, Wendy S, Mametja, Lerole D, McCarthy, Kerrigan M, Chihota, Violet, Nicol, Mark P, Erasmus, Linda K, Ndjeka, Norbert O, Mvusi, Lindiwe, Vassall, Anna, Sinanovic, Edina, Cox, Helen S, Dye, Christopher, Grant, Alison D, Fielding, Katherine L
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.08.2015 Elsevier
Subjects:	Adult Analysis of Variance Antitubercular Agents - therapeutic use Comorbidity Drug Resistance, Bacterial - drug effects Drug Resistance, Bacterial - genetics Endpoint Determination Female HIV Infections - diagnosis HIV Infections - epidemiology Humans Internal Medicine Male Middle Aged Molecular Diagnostic Techniques - methods Mortality - trends Outcome and Process Assessment, Health Care - methods Outcome and Process Assessment, Health Care - statistics & numerical data Rifampin - therapeutic use South Africa Sputum - microbiology Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - mortality Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - mortality South Africa
ISSN:	2214-109X, 2214-109X
Online Access:	Get full text
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