Xpert MTB/RIF versus sputum microscopy as the initial diagnostic test for tuberculosis: a cluster-randomised trial embedded in South African roll-out of Xpert MTB/RIF

In South Africa, sputum smear microscopy has been replaced with Xpert MTB/RIF as the initial diagnostic test for tuberculosis. In a pragmatic parallel cluster-randomised trial, we evaluated the effect on patient and programme outcomes. We randomly allocated 20 laboratories (clusters) in medium-burde...

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Veröffentlicht in:	The Lancet global health Jg. 3; H. 8; S. e450 - e457
Hauptverfasser:	Churchyard, Gavin J, Stevens, Wendy S, Mametja, Lerole D, McCarthy, Kerrigan M, Chihota, Violet, Nicol, Mark P, Erasmus, Linda K, Ndjeka, Norbert O, Mvusi, Lindiwe, Vassall, Anna, Sinanovic, Edina, Cox, Helen S, Dye, Christopher, Grant, Alison D, Fielding, Katherine L
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.08.2015 Elsevier
Schlagworte:	Adult Analysis of Variance Antitubercular Agents - therapeutic use Comorbidity Drug Resistance, Bacterial - drug effects Drug Resistance, Bacterial - genetics Endpoint Determination Female HIV Infections - diagnosis HIV Infections - epidemiology Humans Internal Medicine Male Middle Aged Molecular Diagnostic Techniques - methods Mortality - trends Outcome and Process Assessment, Health Care - methods Outcome and Process Assessment, Health Care - statistics & numerical data Rifampin - therapeutic use South Africa Sputum - microbiology Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - mortality Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - mortality South Africa
ISSN:	2214-109X, 2214-109X
Online-Zugang:	Volltext
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