Rare variants in IFFO1, DTNB, NLRC3 and SLC22A10 associate with Alzheimer's disease CSF profile of neuronal injury and inflammation

Alzheimer's disease (AD) biomarkers represent several neurodegenerative processes, such as synaptic dysfunction, neuronal inflammation and injury, as well as amyloid pathology. We performed an exome-wide rare variant analysis of six AD biomarkers (β-amyloid, total/phosphorylated tau, NfL, YKL-4...

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Bibliographic Details
Published in:	Molecular psychiatry Vol. 27; no. 4; pp. 1990 - 1999
Main Authors:	Neumann, Alexander, Küçükali, Fahri, Bos, Isabelle, Vos, Stephanie J B, Engelborghs, Sebastiaan, De Pooter, Tim, Joris, Geert, De Rijk, Peter, De Roeck, Ellen, Tsolaki, Magda, Verhey, Frans, Martinez-Lage, Pablo, Tainta, Mikel, Frisoni, Giovanni, Blin, Oliver, Richardson, Jill, Bordet, Régis, Scheltens, Philip, Popp, Julius, Peyratout, Gwendoline, Johannsen, Peter, Frölich, Lutz, Vandenberghe, Rik, Freund-Levi, Yvonne, Streffer, Johannes, Lovestone, Simon, Legido-Quigley, Cristina, Ten Kate, Mara, Barkhof, Frederik, Strazisar, Mojca, Zetterberg, Henrik, Bertram, Lars, Visser, Pieter Jelle, van Broeckhoven, Christine, Sleegers, Kristel
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.04.2022
Subjects:	Alzheimer Disease - diagnosis Alzheimer's disease Amyloid beta-Peptides - genetics Biomarkers Cerebrospinal fluid Chitinase-3-Like Protein 1 - genetics Cytoskeleton Dementia Dementia disorders Dithionitrobenzoic Acid DNA-Binding Proteins Humans Inflammation Inflammation - genetics Intercellular Signaling Peptides and Proteins Neural coding Neurodegenerative diseases Neurogranin Neurogranin - genetics Tau protein tau Proteins Transcription Factors β-Amyloid
ISSN:	1359-4184, 1476-5578, 1476-5578
Online Access:	Get full text
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