Rare variants in IFFO1, DTNB, NLRC3 and SLC22A10 associate with Alzheimer's disease CSF profile of neuronal injury and inflammation

Alzheimer's disease (AD) biomarkers represent several neurodegenerative processes, such as synaptic dysfunction, neuronal inflammation and injury, as well as amyloid pathology. We performed an exome-wide rare variant analysis of six AD biomarkers (β-amyloid, total/phosphorylated tau, NfL, YKL-4...

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Vydáno v:	Molecular psychiatry Ročník 27; číslo 4; s. 1990 - 1999
Hlavní autoři:	Neumann, Alexander, Küçükali, Fahri, Bos, Isabelle, Vos, Stephanie J B, Engelborghs, Sebastiaan, De Pooter, Tim, Joris, Geert, De Rijk, Peter, De Roeck, Ellen, Tsolaki, Magda, Verhey, Frans, Martinez-Lage, Pablo, Tainta, Mikel, Frisoni, Giovanni, Blin, Oliver, Richardson, Jill, Bordet, Régis, Scheltens, Philip, Popp, Julius, Peyratout, Gwendoline, Johannsen, Peter, Frölich, Lutz, Vandenberghe, Rik, Freund-Levi, Yvonne, Streffer, Johannes, Lovestone, Simon, Legido-Quigley, Cristina, Ten Kate, Mara, Barkhof, Frederik, Strazisar, Mojca, Zetterberg, Henrik, Bertram, Lars, Visser, Pieter Jelle, van Broeckhoven, Christine, Sleegers, Kristel
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 01.04.2022
Témata:	Alzheimer Disease - diagnosis Alzheimer's disease Amyloid beta-Peptides - genetics Biomarkers Cerebrospinal fluid Chitinase-3-Like Protein 1 - genetics Cytoskeleton Dementia Dementia disorders Dithionitrobenzoic Acid DNA-Binding Proteins Humans Inflammation Inflammation - genetics Intercellular Signaling Peptides and Proteins Neural coding Neurodegenerative diseases Neurogranin Neurogranin - genetics Tau protein tau Proteins Transcription Factors β-Amyloid
ISSN:	1359-4184, 1476-5578, 1476-5578
On-line přístup:	Získat plný text
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