Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1–2 trial

Tisotumab vedotin is a first-in-human antibody–drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisot...

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Veröffentlicht in:	The lancet oncology Jg. 20; H. 3; S. 383 - 393
Hauptverfasser:	de Bono, Johann S, Concin, Nicole, Hong, David S, Thistlethwaite, Fiona C, Machiels, Jean-Pascal, Arkenau, Hendrik-Tobias, Plummer, Ruth, Jones, Robert Hugh, Nielsen, Dorte, Windfeld, Kristian, Ghatta, Srinivas, Slomovitz, Brian M, Spicer, James F, Yachnin, Jeffrey, Ang, Joo Ern, Mau-Sørensen, Paul Morten, Forster, Martin David, Collins, Dearbhaile, Dean, Emma, Rangwala, Reshma A, Lassen, Ulrik
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.03.2019 Elsevier Limited
Schlagworte:	Alopecia Angiogenesis Appetite loss Biology Bladder cancer Cell cycle Cervical cancer Conjunctivitis Constipation Cytotoxicity Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diarrhea Drug dosages Endometrial cancer Endometrium Esophagus Fatigue Fever Head & neck cancer Hematology, Oncology, and Palliative Medicine Hypoxia Infections Inflammatory bowel disease Lung cancer Medical prognosis Metastases Metastasis Monoclonal antibodies Mucositis Nausea Neutropenia Oncology Ovarian cancer Pain Patients Peripheral neuropathy Prostate Prostate cancer Sepsis Solid tumors Squamous cell carcinoma Studies Targeted cancer therapy Tumors Vomiting
ISSN:	1470-2045, 1474-5488, 1474-5488
Online-Zugang:	Volltext
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