A phase II study of frontline paclitaxel/carboplatin/bevacizumab, paclitaxel/carboplatin/temsirolimus, or ixabepilone/carboplatin/bevacizumab in advanced/recurrent endometrial cancer

Paclitaxel and carboplatin (PC) is a standard initial therapy for advanced endometrial cancer. We evaluated the efficacy and tolerability of incorporating three novel agents into initial therapy. In this randomized phase II trial, patients with chemotherapy-naïve stage III/IVA (with measurable disea...

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Veröffentlicht in:	Gynecologic oncology Jg. 150; H. 2; S. 274 - 281
Hauptverfasser:	Aghajanian, Carol, Filiaci, Virginia, Dizon, Don S., Carlson, Jay W., Powell, Matthew A., Secord, Angeles Alvarez, Tewari, Krishnansu S., Bender, David P., O'Malley, David M., Stuckey, Ashley, Gao, JianJiong, Dao, Fanny, Soslow, Robert A., Lankes, Heather A., Moore, Kathleen, Levine, Douglas A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.08.2018
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab Bevacizumab - administration & dosage Carboplatin Carboplatin - administration & dosage Endometrial cancer Endometrial Neoplasms - drug therapy Epothilones - administration & dosage Female Hematology, Oncology, and Palliative Medicine Humans Ixabepilone Middle Aged Neoplasm Recurrence, Local - drug therapy Obstetrics and Gynecology Paclitaxel Paclitaxel - administration & dosage Sirolimus - administration & dosage Sirolimus - analogs & derivatives Temsirolimus Carboplatin Temsirolimus Ixabepilone Endometrial cancer Paclitaxel Bevacizumab
ISSN:	0090-8258, 1095-6859, 1095-6859
Online-Zugang:	Volltext
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