A hyaluronic acid granular hydrogel nerve guidance conduit promotes regeneration and functional recovery of injured sciatic nerves in rats
A hyaluronic acid granular hydrogel can promote neuronal and astrocyte colony formation and axonal extension in vitro, suggesting that the hydrogel can simulate an extracellular matrix structure to promote neural regeneration. However, in vivo experiments have not been conducted. In this study, we t...
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| Abstract | A hyaluronic acid granular hydrogel can promote neuronal and astrocyte colony formation and axonal extension in vitro, suggesting that the hydrogel can simulate an extracellular matrix structure to promote neural regeneration. However, in vivo experiments have not been conducted. In this study, we transplanted a hyaluronic acid granular hydrogel nerve guidance conduit to repair a 10-mm long sciatic nerve gap. The Basso, Beattie, and Bresnahan locomotor rating scale, sciatic nerve compound muscle action potential recording, Fluoro-Gold retrograde tracing, growth related protein 43/S100 immunofluorescence staining, transmission electron microscopy, gastrocnemius muscle dry/wet weight ratio, and Masson's trichrome staining results showed that the nerve guidance conduit exhibited similar regeneration of sciatic nerve axons and myelin sheath, and recovery of the electrophysiological function and motor function as autologous nerve transplantation. The conduit results were superior to those of a bulk hydrogel or silicone tube transplant. These findings suggest that tissue-engineered nerve conduits containing hyaluronic acid granular hydrogels effectively promote the morphological and functional recovery of the injured sciatic nerve. The nerve conduits have the potential as a material for repairing peripheral nerve defects. |
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| AbstractList | A hyaluronic acid granular hydrogel can promote neuronal and astrocyte colony formation and axonal extension in vitro, suggesting that the hydrogel can simulate an extracellular matrix structure to promote neural regeneration. However, in vivo experiments have not been conducted. In this study, we transplanted a hyaluronic acid granular hydrogel nerve guidance conduit to repair a 10-mm long sciatic nerve gap. The Basso, Beattie, and Bresnahan locomotor rating scale, sciatic nerve compound muscle action potential recording, Fluoro-Gold retrograde tracing, growth related protein 43/S100 immunofluorescence staining, transmission electron microscopy, gastrocnemius muscle dry/wet weight ratio, and Masson's trichrome staining results showed that the nerve guidance conduit exhibited similar regeneration of sciatic nerve axons and myelin sheath, and recovery of the electrophysiological function and motor function as autologous nerve transplantation. The conduit results were superior to those of a bulk hydrogel or silicone tube transplant. These findings suggest that tissue-engineered nerve conduits containing hyaluronic acid granular hydrogels effectively promote the morphological and functional recovery of the injured sciatic nerve. The nerve conduits have the potential as a material for repairing peripheral nerve defects. A hyaluronic acid granular hydrogel can promote neuronal and astrocyte colony formation and axonal extension in vitro, suggesting that the hydrogel can simulate an extracellular matrix structure to promote neural regeneration. However, in vivo experiments have not been conducted. In this study, we transplanted a hyaluronic acid granular hydrogel nerve guidance conduit to repair a 10-mm long sciatic nerve gap. The Basso, Beattie, and Bresnahan locomotor rating scale, sciatic nerve compound muscle action potential recording, Fluoro-Gold retrograde tracing, growth related protein 43/S100 immunofluorescence staining, transmission electron microscopy, gastrocnemius muscle dry/wet weight ratio, and Masson's trichrome staining results showed that the nerve guidance conduit exhibited similar regeneration of sciatic nerve axons and myelin sheath, and recovery of the electrophysiological function and motor function as autologous nerve transplantation. The conduit results were superior to those of a bulk hydrogel or silicone tube transplant. These findings suggest that tissue-engineered nerve conduits containing hyaluronic acid granular hydrogels effectively promote the morphological and functional recovery of the injured sciatic nerve. The nerve conduits have the potential as a material for repairing peripheral nerve defects.A hyaluronic acid granular hydrogel can promote neuronal and astrocyte colony formation and axonal extension in vitro, suggesting that the hydrogel can simulate an extracellular matrix structure to promote neural regeneration. However, in vivo experiments have not been conducted. In this study, we transplanted a hyaluronic acid granular hydrogel nerve guidance conduit to repair a 10-mm long sciatic nerve gap. The Basso, Beattie, and Bresnahan locomotor rating scale, sciatic nerve compound muscle action potential recording, Fluoro-Gold retrograde tracing, growth related protein 43/S100 immunofluorescence staining, transmission electron microscopy, gastrocnemius muscle dry/wet weight ratio, and Masson's trichrome staining results showed that the nerve guidance conduit exhibited similar regeneration of sciatic nerve axons and myelin sheath, and recovery of the electrophysiological function and motor function as autologous nerve transplantation. The conduit results were superior to those of a bulk hydrogel or silicone tube transplant. These findings suggest that tissue-engineered nerve conduits containing hyaluronic acid granular hydrogels effectively promote the morphological and functional recovery of the injured sciatic nerve. The nerve conduits have the potential as a material for repairing peripheral nerve defects. |
| Author | Yang, Jie Li, Yun-Qing Hsu, Chia-Chen Ye, Hua Cao, Ting-Ting Chen, Jing |
| AuthorAffiliation | Institute of Medical Research,Northwestern Polytechnical University,Xi'an,Shaanxi Province,China%Institute of Biomedical Engineering,Department of Engineering Science,University of Oxford,Oxford,UK%Institute of Biomedical Engineering,Department of Engineering Science,University of Oxford,Oxford,UK;The Oxford Suzhou Centre for Advanced Research(OSCAR),Suzhou,Jiangsu Province,China%Department of Anatomy,Histology and Embryology&K.K.Leung Brain Research Centre,The Fourth Military Medical University,Xi'an,Shaanxi Province,China%Institute of Medical Research,Northwestern Polytechnical University,Xi'an,Shaanxi Province,China;Department of Anatomy,Histology and Embryology&K.K.Leung Brain Research Centre,The Fourth Military Medical University,Xi'an,Shaanxi Province,China;Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province,Hainan Medical University,Haikou,Hainan Province,China;Department of Anatomy,College of Basic Medical Sciences,Dali Univers |
| AuthorAffiliation_xml | – name: Institute of Medical Research,Northwestern Polytechnical University,Xi'an,Shaanxi Province,China%Institute of Biomedical Engineering,Department of Engineering Science,University of Oxford,Oxford,UK%Institute of Biomedical Engineering,Department of Engineering Science,University of Oxford,Oxford,UK;The Oxford Suzhou Centre for Advanced Research(OSCAR),Suzhou,Jiangsu Province,China%Department of Anatomy,Histology and Embryology&K.K.Leung Brain Research Centre,The Fourth Military Medical University,Xi'an,Shaanxi Province,China%Institute of Medical Research,Northwestern Polytechnical University,Xi'an,Shaanxi Province,China;Department of Anatomy,Histology and Embryology&K.K.Leung Brain Research Centre,The Fourth Military Medical University,Xi'an,Shaanxi Province,China;Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province,Hainan Medical University,Haikou,Hainan Province,China;Department of Anatomy,College of Basic Medical Sciences,Dali University,Dali,Yunnan Province,China – name: 1 Institute of Medical Research, Northwestern Polytechnical University, Xi’an, Shaanxi Province, China – name: 2 Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK – name: 3 The Oxford Suzhou Centre for Advanced Research (OSCAR), Suzhou, Jiangsu Province, China – name: 4 Department of Anatomy, Histology and Embryology & K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, Shaanxi Province, China – name: 5 Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, Hainan Province, China – name: 6 Department of Anatomy, College of Basic Medical Sciences, Dali University, Dali, Yunnan Province, China |
| Author_xml | – sequence: 1 givenname: Jie surname: Yang fullname: Yang, Jie organization: Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi Province – sequence: 2 givenname: Chia-Chen surname: Hsu fullname: Hsu, Chia-Chen organization: Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford – sequence: 3 givenname: Ting-Ting surname: Cao fullname: Cao, Ting-Ting organization: Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi Province – sequence: 4 givenname: Hua surname: Ye fullname: Ye, Hua organization: Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK; The Oxford Suzhou Centre for Advanced Research (OSCAR), Suzhou, Jiangsu Province, China – sequence: 5 givenname: Jing surname: Chen fullname: Chen, Jing organization: Department of Anatomy, Histology and Embryology & K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, Shaanxi Province – sequence: 6 givenname: Yun-Qing surname: Li fullname: Li, Yun-Qing organization: Institute of Medical Research, Northwestern Polytechnical University; Department of Anatomy, Histology and Embryology & K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, Shaanxi Province; Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, Hainan Province; Department of Anatomy, College of Basic Medical Sciences, Dali University, Dali, Yunnan Province |
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| Keywords | nerve conduit tissue engineering sciatic nerve injury granular hydrogel transection injury myelin sheath nerve regeneration peripheral nerve regeneration functional recovery hyaluronic acid |
| Language | English |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Author contributions: Study conception and design: YQL, JC, HY; experiment implementation and data analysis: JY, TTC; granular hydrogel preparation: CCH; manuscript draft: JY; manuscript revision: YQL, JC, HY, CCH. All authors read and approved the final version of this manuscript. Both authors contribute equally to this work. |
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| PublicationTitle | Neural regeneration research |
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| Publisher | Wolters Kluwer India Pvt. Ltd Medknow Publications & Media Pvt. Ltd Department of Anatomy,College of Basic Medical Sciences,Dali University,Dali,Yunnan Province,China The Oxford Suzhou Centre for Advanced Research(OSCAR),Suzhou,Jiangsu Province,China%Department of Anatomy,Histology and Embryology&K.K.Leung Brain Research Centre,The Fourth Military Medical University,Xi'an,Shaanxi Province,China%Institute of Medical Research,Northwestern Polytechnical University,Xi'an,Shaanxi Province,China Institute of Medical Research,Northwestern Polytechnical University,Xi'an,Shaanxi Province,China%Institute of Biomedical Engineering,Department of Engineering Science,University of Oxford,Oxford,UK%Institute of Biomedical Engineering,Department of Engineering Science,University of Oxford,Oxford,UK Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province,Hainan Medical University,Haikou,Hainan Province,China Department of Anatomy,Histology and Embryology&K.K.Leung Brain Research Centre,The Fourth Military Medical University,Xi'an,Shaanxi Province,China Wolters Kluwer - Medknow Wolters Kluwer Medknow Publications |
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| Title | A hyaluronic acid granular hydrogel nerve guidance conduit promotes regeneration and functional recovery of injured sciatic nerves in rats |
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