Mifepristone (RU486) restores humoral and T cell‐mediated immune response in endotoxin immunosuppressed mice

Sepsis and septic shock can be caused by Gram‐positive and ‐negative bacteria and other microorganisms. In the case of Gram‐negative bacteria, endotoxin, a normal constituent of the bacterial wall, also known as lipopolysaccharide (LPS), has been considered as one of the principal agents causing the...

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Bibliographic Details
Published in:	Clinical and experimental immunology Vol. 162; no. 3; pp. 568 - 577
Main Authors:	Rearte, B, Maglioco, A, Balboa, L, Bruzzo, J, Landoni, V.I, Laborde, E.A, Chiarella, P, Ruggiero, R.A, Fernández, G.C, Isturiz, M.A
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.12.2010 Blackwell Oxford University Press Blackwell Science Inc
Subjects:	Analytical, structural and metabolic biochemistry Animal Models Animals Antigens, CD - biosynthesis Biological and medical sciences Cyclophosphamide - administration & dosage Cytokines Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives endotoxin tolerance Forkhead Transcription Factors - biosynthesis Fundamental and applied biological sciences. Psychology glucocorticoids Immune system Immunity, Cellular - drug effects Immunity, Humoral - drug effects Immunosuppression Immunosuppressive Agents - administration & dosage Lipopolysaccharides - administration & dosage Medical research Mice Mice, Inbred BALB C Mifepristone - administration & dosage Mifepristone - pharmacology Receptors, Glucocorticoid - antagonists & inhibitors Rodents RU486 T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology Antineoplastic agent Immune response RU486 Rodentia Tolerance Biochemistry Cellular immunity Antihormone Endotoxin Glucocorticoid Toxin Vertebrata Immunosuppression Mammalia Mouse Animal Antiprogesterone Mifepristone glucocorticoids endotoxin tolerance Humoral immunity
ISSN:	0009-9104, 1365-2249, 1365-2249
Online Access:	Get full text
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