Asymmetric Hydrogenation of 3-Substituted Pyridinium Salts

The use of an equivalent amount of an organic base leads to high enantiomeric excess in the asymmetric hydrogenation of N‐benzylated 3‐substituted pyridinium salts into the corresponding piperidines. Indeed, in the presence of Et3N, a Rh‐JosiPhos catalyst reduced a range of pyridinium salts with ee...

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Bibliographic Details
Published in:	Chemistry : a European journal Vol. 22; no. 28; pp. 9528 - 9532
Main Authors:	Renom-Carrasco, Marc, Gajewski, Piotr, Pignataro, Luca, de Vries, Johannes G., Piarulli, Umberto, Gennari, Cesare, Lefort, Laurent
Format:	Journal Article
Language:	English
Published:	WEINHEIM Blackwell Publishing Ltd 04.07.2016 Wiley Wiley Subscription Services, Inc
Subjects:	asymmetric catalysis Asymmetry Chemistry Chemistry, Multidisciplinary Equivalence homogeneous catalysis Hydrogenation Isotopic labeling Labyrinth Pathways Physical Sciences Piperidine Pyridines reaction mechanisms Salts Science & Technology SCOPE MONODENTATE PHOSPHORAMIDITE LIGANDS reaction mechanisms QUINOLINES asymmetric catalysis DEHYDROAMINO ACID-DERIVATIVES hydrogenation MULTIPLE STEREOGENIC CENTERS IRIDIUM-CATALYZED HYDROGENATION HIGHLY ENANTIOSELECTIVE HYDROGENATION pyridines homogeneous catalysis REDUCTION PIPERIDINES ISOQUINOLINIUM SALTS
ISSN:	0947-6539, 1521-3765, 1521-3765
Online Access:	Get full text
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