Alcohol consumption and risk of recurrent cardiovascular events and mortality in patients with clinically manifest vascular disease and diabetes mellitus: The Second Manifestations of ARTerial (SMART) disease study

This study investigated the relation between alcohol consumption and specific vascular events and mortality in a high risk population of patients with clinical manifestations of vascular disease and diabetes. Patients with clinically manifest vascular disease or diabetes (n=5447) from the SMART stud...

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Vydáno v:Atherosclerosis Ročník 212; číslo 1; s. 281 - 286
Hlavní autoři: Beulens, J.W.J., Algra, A., Soedamah-Muthu, S.S., Visseren, F.L.J., Grobbee, D.E., van der Graaf, Y.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Amsterdam Elsevier Ireland Ltd 01.09.2010
Elsevier
Témata:
acute myocardial-infarction
adults
Aged
Alcohol consumption
Alcohol Drinking - epidemiology
Amputation - statistics & numerical data
Associated diseases and complications
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiovascular
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - mortality
Cardiovascular events
cholesterol
Coronary Disease - epidemiology
Coronary Disease - mortality
coronary-heart-disease
density-lipoprotein
Diabetes Mellitus - epidemiology
Diabetes Mellitus - mortality
Diabetes. Impaired glucose tolerance
drinking
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
health
High risk patients
Humans
Linear Models
Male
Medical sciences
men
Middle Aged
Mortality
Netherlands - epidemiology
Proportional Hazards Models
Prospective Studies
Recurrence
Risk Assessment
Risk Factors
Stroke - epidemiology
Stroke - mortality
Surveys and Questionnaires
Time Factors
Vascular Diseases - epidemiology
Vascular Diseases - mortality
Wine
women
Netherlands
Alcohol consumption
Cardiovascular events
High risk patients
Mortality
Endocrinopathy
Human
Diabetes mellitus
Alcohol
Cardiovascular disease
Arterial disease
Vascular disease
Arteriopathy
Atherosclerosis
Risk factor
ISSN:0021-9150, 1879-1484, 1879-1484
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Shrnutí:This study investigated the relation between alcohol consumption and specific vascular events and mortality in a high risk population of patients with clinical manifestations of vascular disease and diabetes. Patients with clinically manifest vascular disease or diabetes (n=5447) from the SMART study were followed for cardiovascular events and mortality. Alcohol consumption was assessed with a baseline questionnaire and analysed in relation with coronary heart disease (CHD), amputations, stroke, and all-cause and vascular death. After a follow up of 4.7 years, we documented 363 cases of CHD, 187 cases of stroke, 79 amputations and 641 cases of all-cause death, of which 382 were vascular. In multivariate-adjusted models, alcohol consumption was inversely associated with CHD (plinear trend=0.007) and stroke (plinear trend=0.051) with respective hazard ratios of 0.39 (95%CI: 0.20–0.76) and 0.67 (0.31–1.46) for consuming 10–20 drinks/week compared with abstainers. We observed significant U-shaped associations between alcohol consumption and amputations (pquadratic trend=0.001), all-cause death (pquadratic trend=0.001) and vascular death (pquadratic trend=0.013). Hazard ratios for consuming 10–20 drinks/week were 0.29 (0.07–1.30) for amputations, 0.40 (0.24–0.69) for all-cause death and 0.34 (0.16–0.71) for vascular death compared with abstainers. Similar associations were observed for red wine consumption only. Moderate alcohol consumption (1–2 drinks/day) is not only associated with a reduced risk of vascular and all-cause death in a high risk patients with clinical manifestations of vascular disease, but also with reduced risks of non-fatal events like CHD, stroke and possibly amputations.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-9150
1879-1484
1879-1484
DOI:10.1016/j.atherosclerosis.2010.04.034