Effect of atrial fibrillation on atrial thrombogenesis in humans: impact of rate and rhythm
We sought to assess the effect of atrial fibrillation (AF) on atrial thrombogenesis in humans by determining the impact of rate and rhythm. Although AF is known to increase the risk of thromboembolic stroke from the left atrium (LA), the exact mechanisms remain poorly understood. We studied 55 patie...
Uloženo v:
| Vydáno v: | Journal of the American College of Cardiology Ročník 61; číslo 8; s. 852 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
26.02.2013
|
| Témata: | |
| ISSN: | 1558-3597, 1558-3597 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | We sought to assess the effect of atrial fibrillation (AF) on atrial thrombogenesis in humans by determining the impact of rate and rhythm.
Although AF is known to increase the risk of thromboembolic stroke from the left atrium (LA), the exact mechanisms remain poorly understood.
We studied 55 patients with AF who underwent catheter ablation while in sinus rhythm; 20 patients were induced into AF, 20 patients were atrial paced at 150 beats/min, and 15 were control patients. Blood samples were taken from the LA, right atrium, and femoral vein at baseline and at 15 min in all 3 groups. Platelet activation (P-selectin) was measured by flow cytometry. Thrombin generation (thrombin-antithrombin [TAT] complex), endothelial dysfunction (asymmetric dimethylarginine [ADMA]), and platelet-derived inflammation (soluble CD40 ligand [sCD40L]) were measured using enzyme-linked immunosorbent assay.
Platelet activation increased significantly in both the AF (p < 0.001) and pacing (p < 0.05) groups, but decreased in control patients (p < 0.001). Thrombin generation increased specifically in the LA compared with the periphery in both the AF (p < 0.01) and pacing (p < 0.01) groups, but decreased in control patients (p < 0.001). With AF, ADMA (p < 0.01) and sCD40L (p < 0.001) levels increased significantly at all sites, but were unchanged with pacing (ADMA, p = 0.5; sCD40L, p = 0.8) or in control patients (ADMA, p = 0.6; sCD40L, p = 0.9).
Rapid atrial rates and AF in humans both result in increased platelet activation and thrombin generation. Prothrombotic activation occurs to a greater extent in the human LA compared with systemic circulation. AF additionally induces endothelial dysfunction and inflammation. These findings suggest that although rapid atrial rates increase the thrombogenic risk, AF may further potentiate this risk. |
|---|---|
| AbstractList | We sought to assess the effect of atrial fibrillation (AF) on atrial thrombogenesis in humans by determining the impact of rate and rhythm.OBJECTIVESWe sought to assess the effect of atrial fibrillation (AF) on atrial thrombogenesis in humans by determining the impact of rate and rhythm.Although AF is known to increase the risk of thromboembolic stroke from the left atrium (LA), the exact mechanisms remain poorly understood.BACKGROUNDAlthough AF is known to increase the risk of thromboembolic stroke from the left atrium (LA), the exact mechanisms remain poorly understood.We studied 55 patients with AF who underwent catheter ablation while in sinus rhythm; 20 patients were induced into AF, 20 patients were atrial paced at 150 beats/min, and 15 were control patients. Blood samples were taken from the LA, right atrium, and femoral vein at baseline and at 15 min in all 3 groups. Platelet activation (P-selectin) was measured by flow cytometry. Thrombin generation (thrombin-antithrombin [TAT] complex), endothelial dysfunction (asymmetric dimethylarginine [ADMA]), and platelet-derived inflammation (soluble CD40 ligand [sCD40L]) were measured using enzyme-linked immunosorbent assay.METHODSWe studied 55 patients with AF who underwent catheter ablation while in sinus rhythm; 20 patients were induced into AF, 20 patients were atrial paced at 150 beats/min, and 15 were control patients. Blood samples were taken from the LA, right atrium, and femoral vein at baseline and at 15 min in all 3 groups. Platelet activation (P-selectin) was measured by flow cytometry. Thrombin generation (thrombin-antithrombin [TAT] complex), endothelial dysfunction (asymmetric dimethylarginine [ADMA]), and platelet-derived inflammation (soluble CD40 ligand [sCD40L]) were measured using enzyme-linked immunosorbent assay.Platelet activation increased significantly in both the AF (p < 0.001) and pacing (p < 0.05) groups, but decreased in control patients (p < 0.001). Thrombin generation increased specifically in the LA compared with the periphery in both the AF (p < 0.01) and pacing (p < 0.01) groups, but decreased in control patients (p < 0.001). With AF, ADMA (p < 0.01) and sCD40L (p < 0.001) levels increased significantly at all sites, but were unchanged with pacing (ADMA, p = 0.5; sCD40L, p = 0.8) or in control patients (ADMA, p = 0.6; sCD40L, p = 0.9).RESULTSPlatelet activation increased significantly in both the AF (p < 0.001) and pacing (p < 0.05) groups, but decreased in control patients (p < 0.001). Thrombin generation increased specifically in the LA compared with the periphery in both the AF (p < 0.01) and pacing (p < 0.01) groups, but decreased in control patients (p < 0.001). With AF, ADMA (p < 0.01) and sCD40L (p < 0.001) levels increased significantly at all sites, but were unchanged with pacing (ADMA, p = 0.5; sCD40L, p = 0.8) or in control patients (ADMA, p = 0.6; sCD40L, p = 0.9).Rapid atrial rates and AF in humans both result in increased platelet activation and thrombin generation. Prothrombotic activation occurs to a greater extent in the human LA compared with systemic circulation. AF additionally induces endothelial dysfunction and inflammation. These findings suggest that although rapid atrial rates increase the thrombogenic risk, AF may further potentiate this risk.CONCLUSIONSRapid atrial rates and AF in humans both result in increased platelet activation and thrombin generation. Prothrombotic activation occurs to a greater extent in the human LA compared with systemic circulation. AF additionally induces endothelial dysfunction and inflammation. These findings suggest that although rapid atrial rates increase the thrombogenic risk, AF may further potentiate this risk. We sought to assess the effect of atrial fibrillation (AF) on atrial thrombogenesis in humans by determining the impact of rate and rhythm. Although AF is known to increase the risk of thromboembolic stroke from the left atrium (LA), the exact mechanisms remain poorly understood. We studied 55 patients with AF who underwent catheter ablation while in sinus rhythm; 20 patients were induced into AF, 20 patients were atrial paced at 150 beats/min, and 15 were control patients. Blood samples were taken from the LA, right atrium, and femoral vein at baseline and at 15 min in all 3 groups. Platelet activation (P-selectin) was measured by flow cytometry. Thrombin generation (thrombin-antithrombin [TAT] complex), endothelial dysfunction (asymmetric dimethylarginine [ADMA]), and platelet-derived inflammation (soluble CD40 ligand [sCD40L]) were measured using enzyme-linked immunosorbent assay. Platelet activation increased significantly in both the AF (p < 0.001) and pacing (p < 0.05) groups, but decreased in control patients (p < 0.001). Thrombin generation increased specifically in the LA compared with the periphery in both the AF (p < 0.01) and pacing (p < 0.01) groups, but decreased in control patients (p < 0.001). With AF, ADMA (p < 0.01) and sCD40L (p < 0.001) levels increased significantly at all sites, but were unchanged with pacing (ADMA, p = 0.5; sCD40L, p = 0.8) or in control patients (ADMA, p = 0.6; sCD40L, p = 0.9). Rapid atrial rates and AF in humans both result in increased platelet activation and thrombin generation. Prothrombotic activation occurs to a greater extent in the human LA compared with systemic circulation. AF additionally induces endothelial dysfunction and inflammation. These findings suggest that although rapid atrial rates increase the thrombogenic risk, AF may further potentiate this risk. |
| Author | Brooks, Anthony G Lau, Dennis H Young, Glenn D Kistler, Peter M Willoughby, Scott R Leong, Darryl P Schultz, Carlee Sanders, Prashanthan Gan, Cheryl Lim, Han S Alasady, Muayad Worthley, Matthew I Kalman, Jonathan M |
| Author_xml | – sequence: 1 givenname: Han S surname: Lim fullname: Lim, Han S organization: Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia – sequence: 2 givenname: Scott R surname: Willoughby fullname: Willoughby, Scott R – sequence: 3 givenname: Carlee surname: Schultz fullname: Schultz, Carlee – sequence: 4 givenname: Cheryl surname: Gan fullname: Gan, Cheryl – sequence: 5 givenname: Muayad surname: Alasady fullname: Alasady, Muayad – sequence: 6 givenname: Dennis H surname: Lau fullname: Lau, Dennis H – sequence: 7 givenname: Darryl P surname: Leong fullname: Leong, Darryl P – sequence: 8 givenname: Anthony G surname: Brooks fullname: Brooks, Anthony G – sequence: 9 givenname: Glenn D surname: Young fullname: Young, Glenn D – sequence: 10 givenname: Peter M surname: Kistler fullname: Kistler, Peter M – sequence: 11 givenname: Jonathan M surname: Kalman fullname: Kalman, Jonathan M – sequence: 12 givenname: Matthew I surname: Worthley fullname: Worthley, Matthew I – sequence: 13 givenname: Prashanthan surname: Sanders fullname: Sanders, Prashanthan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23333141$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkE1LxDAQhoOsuB_6BzxIjl5aM2mTtt5kWT9gwYuePJQ0ndosbbom6WH_vYWt4PDCDMPDyzuzJgs7WCTkFlgMDOTDIT4orWPOgMcAMUvlBVmBEHmUiCJb_JuXZO39gTEmcyiuyJInU0EKK_K1axrUgQ4NVcEZ1dHGVM50nQpmsHTSvA6tG_pq-EaL3nhqLG3HXln_SE1_VGcHpwJSZWvq2lNo-2ty2ajO483cN-TzefexfY327y9v26d9pEUuQ4Rp2mAtNDS5ZjyrIBUqKYROhayLQuY5r5XMpsgCoNYVJgmTwAGzrFJpnSDfkPuz79ENPyP6UPbGa5xusDiMvoRkwjMpBJ_Quxkdqx7r8uhMr9yp_HsI_wWO1WUi |
| CitedBy_id | crossref_primary_10_2147_RMHP_S435582 crossref_primary_10_1016_j_hrthm_2014_07_030 crossref_primary_10_18087_cardio_2020_1_n828 crossref_primary_10_1093_eurheartj_ehw210 crossref_primary_10_1111_jce_15277 crossref_primary_10_1016_j_ipej_2017_08_002 crossref_primary_10_1097_MAT_0000000000000576 crossref_primary_10_1093_ejcts_ezw313 crossref_primary_10_1007_s10840_022_01305_x crossref_primary_10_1016_j_athoracsur_2016_04_025 crossref_primary_10_1016_j_jacep_2019_12_013 crossref_primary_10_1093_eurheartj_ehv115 crossref_primary_10_1136_heartjnl_2018_314492 crossref_primary_10_1007_s13577_024_01145_z crossref_primary_10_1016_j_mayocp_2023_01_011 crossref_primary_10_1161_CIRCULATIONAHA_114_014145 crossref_primary_10_1093_eurheartj_suaa176 crossref_primary_10_1016_j_cjca_2016_05_002 crossref_primary_10_1016_j_hrthm_2014_07_039 crossref_primary_10_1016_j_atherosclerosis_2016_09_011 crossref_primary_10_1016_j_hrthm_2014_01_001 crossref_primary_10_3810_pgm_2013_09_2701 crossref_primary_10_1016_j_hrthm_2015_03_016 crossref_primary_10_1161_CIRCEP_113_000876 crossref_primary_10_1111_pace_12275 crossref_primary_10_1136_heartjnl_2015_309066 crossref_primary_10_1371_journal_pone_0111760 crossref_primary_10_1373_clinchem_2016_255182 crossref_primary_10_1016_j_ijcard_2015_03_092 crossref_primary_10_1016_j_jscai_2022_100405 crossref_primary_10_1111_jce_12312 crossref_primary_10_3389_fcvm_2021_684920 crossref_primary_10_1007_s10554_023_02841_x crossref_primary_10_1016_j_ijcard_2016_11_257 crossref_primary_10_1016_j_thromres_2015_10_021 crossref_primary_10_1016_j_jacep_2024_10_024 crossref_primary_10_1080_14779072_2020_1736563 crossref_primary_10_1016_j_jacc_2018_04_091 crossref_primary_10_1016_j_rccar_2019_10_002 crossref_primary_10_1016_j_athoracsur_2013_07_004 crossref_primary_10_1016_j_jacc_2013_02_084 crossref_primary_10_1134_S2079057020010166 crossref_primary_10_1016_j_ijcard_2018_11_096 crossref_primary_10_1016_j_jacc_2018_05_048 crossref_primary_10_1016_j_jacep_2023_08_037 crossref_primary_10_1177_2047487316679265 crossref_primary_10_1161_CIRCULATIONAHA_118_034187 crossref_primary_10_1161_CIRCULATIONAHA_115_016795 crossref_primary_10_1016_j_ccep_2017_11_007 crossref_primary_10_1016_j_ijcard_2017_03_068 crossref_primary_10_1038_nrcardio_2017_107 crossref_primary_10_1159_000536024 crossref_primary_10_1016_j_mayocp_2015_09_013 crossref_primary_10_1007_s00392_023_02349_3 crossref_primary_10_1016_j_jacc_2013_03_046 crossref_primary_10_1016_j_crvasa_2017_06_005 crossref_primary_10_1016_j_jtcvs_2013_07_011 crossref_primary_10_1002_clc_23699 crossref_primary_10_1111_pace_13495 crossref_primary_10_1136_openhrt_2022_002012 crossref_primary_10_1016_j_cjca_2013_07_679 crossref_primary_10_1007_s11239_013_1034_5 crossref_primary_10_1016_j_jacep_2016_03_006 crossref_primary_10_1160_TH15_06_0477 crossref_primary_10_1089_ars_2013_5542 crossref_primary_10_1093_cvr_cvv001 crossref_primary_10_1016_j_tvjl_2020_105548 crossref_primary_10_1016_j_ijcard_2017_09_154 crossref_primary_10_1111_jce_12978 crossref_primary_10_1080_09537104_2017_1293805 crossref_primary_10_1002_j_2040_4603_2017_tb00771_x crossref_primary_10_1136_heartjnl_2018_313351 crossref_primary_10_1016_j_jacc_2014_01_002 crossref_primary_10_1186_s12889_024_20703_6 crossref_primary_10_1007_s00246_016_1441_4 crossref_primary_10_1007_s00392_015_0922_4 crossref_primary_10_1007_s11239_013_1023_8 crossref_primary_10_1016_j_ajem_2016_05_012 crossref_primary_10_2217_fca_14_63 crossref_primary_10_1016_j_ihj_2015_07_047 crossref_primary_10_1159_000526088 crossref_primary_10_1093_ehjqcco_qcy003 crossref_primary_10_1111_eci_13477 crossref_primary_10_1016_j_jacep_2015_03_011 crossref_primary_10_1080_14779072_2019_1550718 crossref_primary_10_1177_1747493016641965 crossref_primary_10_1161_JAHA_124_037552 crossref_primary_10_1016_j_cjca_2019_06_006 crossref_primary_10_3389_fphys_2022_862164 crossref_primary_10_1080_07853890_2018_1523552 crossref_primary_10_1016_j_arr_2021_101363 crossref_primary_10_2337_dc22_0717 crossref_primary_10_1016_j_hlc_2014_01_005 crossref_primary_10_1016_j_jacc_2014_12_026 crossref_primary_10_1111_pace_14640 crossref_primary_10_1016_j_jacep_2016_05_011 crossref_primary_10_1016_j_jtcvs_2019_03_103 crossref_primary_10_3390_ijms25074109 crossref_primary_10_1016_j_ahj_2016_03_007 crossref_primary_10_1007_s12265_017_9754_0 crossref_primary_10_1186_s12872_025_04680_1 crossref_primary_10_1097_MAT_0000000000000762 crossref_primary_10_1016_S1634_7072_20_44011_5 crossref_primary_10_1111_1440_1681_12256 crossref_primary_10_1093_ejcts_ezx340 crossref_primary_10_1038_srep23207 crossref_primary_10_1016_j_thromres_2017_12_015 crossref_primary_10_1111_iju_13725 crossref_primary_10_1016_j_thromres_2021_02_019 crossref_primary_10_1016_j_biomaterials_2021_121208 crossref_primary_10_1002_clc_22813 crossref_primary_10_1136_heartjnl_2014_306008 crossref_primary_10_1016_j_ccep_2019_11_003 crossref_primary_10_1038_s41598_023_27622_3 crossref_primary_10_1016_j_jacep_2015_05_003 crossref_primary_10_1016_j_ccep_2015_05_010 crossref_primary_10_1016_j_jacc_2012_11_047 crossref_primary_10_1016_j_ijcard_2018_05_033 crossref_primary_10_1016_j_jacc_2013_06_025 crossref_primary_10_1016_j_yjmcc_2014_03_004 crossref_primary_10_1016_j_mayocp_2020_11_005 crossref_primary_10_1093_europace_euv235 crossref_primary_10_1016_j_ijcard_2015_05_102 crossref_primary_10_1016_j_ahj_2014_12_020 crossref_primary_10_1016_j_rpth_2023_100127 crossref_primary_10_1007_s11739_019_02151_y crossref_primary_10_2217_fca_15_65 crossref_primary_10_1080_14656566_2016_1267140 crossref_primary_10_1016_j_ijcard_2019_10_026 crossref_primary_10_1016_j_ijcard_2017_04_074 crossref_primary_10_1007_s00380_018_1257_7 crossref_primary_10_1097_HCO_0000000000000121 crossref_primary_10_1093_europace_euw295 crossref_primary_10_1007_s10840_016_0192_8 crossref_primary_10_3390_nu13020651 crossref_primary_10_1007_s12170_017_0554_5 crossref_primary_10_1002_vms3_1210 crossref_primary_10_1002_joa3_12714 crossref_primary_10_1093_cvr_cvw007 crossref_primary_10_1007_s11897_016_0308_6 crossref_primary_10_1177_0003319714546183 crossref_primary_10_1586_14779072_2013_811980 crossref_primary_10_3390_cells11192963 |
| ContentType | Journal Article |
| Copyright | Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.jacc.2012.11.046 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1558-3597 |
| ExternalDocumentID | 23333141 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .1- .FO .~1 0R~ 18M 1B1 1P~ 1~. 1~5 2WC 4.4 457 4G. 53G 5GY 5RE 5VS 6PF 7-5 71M 8P~ AABNK AABVL AAEDT AAEDW AAIKJ AAKUH AALRI AAOAW AAQFI AAXUO ABBQC ABFNM ABFRF ABLJU ABMAC ABMZM ABOCM ABWVN ABXDB ACGFO ACGFS ACIUM ACJTP ACPRK ACVFH ADBBV ADCNI ADEZE ADVLN AEFWE AEKER AENEX AEUPX AEVXI AEXQZ AFCTW AFETI AFPUW AFRAH AFRHN AFTJW AGCQF AGHFR AGYEJ AHMBA AIGII AITUG AJRQY AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ BAWUL BLXMC CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EFKBS EIF EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FNPLU G-Q GBLVA GX1 H13 HVGLF IHE IXB J1W K-O KQ8 L7B MO0 N9A NPM O-L O9- OA. OAUVE OK1 OL~ OZT P-8 P-9 P2P PC. PQQKQ PROAC Q38 RIG ROL RPZ SCC SDF SDG SDP SES SSZ TR2 UNMZH UV1 W8F WH7 WOQ WOW YYM YZZ Z5R 7X8 EFLBG ~HD |
| ID | FETCH-LOGICAL-c586t-e44fed5c1f8c027b145a395c456d996882da67233511dcbe3306121e77ba4d3e2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 163 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000315199400009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1558-3597 |
| IngestDate | Thu Oct 02 06:35:20 EDT 2025 Mon Jul 21 05:52:27 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| License | Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c586t-e44fed5c1f8c027b145a395c456d996882da67233511dcbe3306121e77ba4d3e2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://dx.doi.org/10.1016/j.jacc.2012.11.046 |
| PMID | 23333141 |
| PQID | 1312176552 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1312176552 pubmed_primary_23333141 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-02-26 |
| PublicationDateYYYYMMDD | 2013-02-26 |
| PublicationDate_xml | – month: 02 year: 2013 text: 2013-02-26 day: 26 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of the American College of Cardiology |
| PublicationTitleAlternate | J Am Coll Cardiol |
| PublicationYear | 2013 |
| References | 23603696 - J Am Coll Cardiol. 2013 Jul 9;62(2):167-8 23603704 - J Am Coll Cardiol. 2013 Jul 9;62(2):167 23333144 - J Am Coll Cardiol. 2013 Feb 26;61(8):861-2 |
| References_xml | – reference: 23603704 - J Am Coll Cardiol. 2013 Jul 9;62(2):167 – reference: 23333144 - J Am Coll Cardiol. 2013 Feb 26;61(8):861-2 – reference: 23603696 - J Am Coll Cardiol. 2013 Jul 9;62(2):167-8 |
| SSID | ssj0006819 |
| Score | 2.5020258 |
| Snippet | We sought to assess the effect of atrial fibrillation (AF) on atrial thrombogenesis in humans by determining the impact of rate and rhythm.
Although AF is... We sought to assess the effect of atrial fibrillation (AF) on atrial thrombogenesis in humans by determining the impact of rate and rhythm.OBJECTIVESWe sought... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 852 |
| SubjectTerms | Aged Antithrombin III - metabolism Arginine - analogs & derivatives Arginine - metabolism Atrial Fibrillation - blood Atrial Fibrillation - complications Atrial Fibrillation - diagnosis Atrial Fibrillation - physiopathology Atrial Fibrillation - therapy Catheter Ablation - methods CD40 Ligand - metabolism Enzyme Inhibitors - metabolism Enzyme-Linked Immunosorbent Assay - methods Female Heart Atria - metabolism Heart Atria - physiopathology Heart Rate Humans Male Middle Aged P-Selectin - metabolism Peptide Hydrolases - metabolism Platelet Activation Risk Assessment Risk Factors Statistics as Topic Stroke - etiology Stroke - prevention & control Thrombosis - blood Thrombosis - etiology Thrombosis - physiopathology Thrombosis - prevention & control |
| Title | Effect of atrial fibrillation on atrial thrombogenesis in humans: impact of rate and rhythm |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/23333141 https://www.proquest.com/docview/1312176552 |
| Volume | 61 |
| WOSCitedRecordID | wos000315199400009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEF7Uinjx_agvVvC6avaV1IuIWLy09KBQ8FA2uxNbsUltquC_d3aT0pMgCCGHQB5MZme_2Zn9PkIuEqeElCCYdkIxyQGHlEoMk4lNjTQGNKRBbCLudpN-v9WrF9zKuq1yHhNDoHaF9WvkV5GIED1rpfjt5IN51ShfXa0lNJZJQyCU8S1dcX_BFq6TIOyBU2bCBCLnetNM1d_1ZqynMIz4pWfxlPp3iBmmmvbmfz9yi2zUIJPeVV6xTZYg3yFrnbqMvkteKs5iWmTUBNkOmvnO__eqL47iUV_2IgrjtHj1AXFU0lFOg6ZfeUOr3ZX-CZ5rgprc0enwezYc75Hn9sPT_SOrVRaYVYmeMZAyA6dslCUWc9Q0ksqIlrKIrBwmQ4jAndExF77i6GwKQnhUFEEc4890Avg-WcmLHA4JBQwXYH22HV9LE4sU4RWIzHHprHJx1iTnc7MN0It9acLkUHyWg4XhmuSgsv1gUtFtDPDVQkQyOvrD3cdknQe9Cs64PiGNDMcwnJJV-zUbldOz4B547vY6P17CxFc |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+atrial+fibrillation+on+atrial+thrombogenesis+in+humans%3A+impact+of+rate+and+rhythm&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.au=Lim%2C+Han+S&rft.au=Willoughby%2C+Scott+R&rft.au=Schultz%2C+Carlee&rft.au=Gan%2C+Cheryl&rft.date=2013-02-26&rft.eissn=1558-3597&rft.volume=61&rft.issue=8&rft.spage=852&rft_id=info:doi/10.1016%2Fj.jacc.2012.11.046&rft_id=info%3Apmid%2F23333141&rft_id=info%3Apmid%2F23333141&rft.externalDocID=23333141 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1558-3597&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1558-3597&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1558-3597&client=summon |