The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

Recent studies demonstrate that rapid antidepressant response to ketamine is mediated by activation of the mammalian target of rapamycin (mTOR) signaling pathway, leading to increased synaptic proteins in the prefrontal cortex (PFC) of rats. Our postmortem studies indicate robust deficits in promine...

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Vydané v:	Progress in neuro-psychopharmacology & biological psychiatry Ročník 35; číslo 7; s. 1774 - 1779
Hlavní autori:	Jernigan, Courtney S., Goswami, Dharmendra B., Austin, Mark C., Iyo, Abiye H., Chandran, Agata, Stockmeier, Craig A., Karolewicz, Beata
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Amsterdam Elsevier Inc 15.08.2011 Elsevier
Predmet:	Adult Adult and adolescent clinical studies Aged Aged, 80 and over Autopsy Biological and medical sciences Depression Depressive Disorder, Major - genetics Depressive Disorder, Major - immunology Depressive Disorder, Major - metabolism Eukaryotic Initiation Factors - analysis Eukaryotic Initiation Factors - biosynthesis Eukaryotic Initiation Factors - genetics Eukaryotic Initiation Factors - immunology Family Female Humans Major depressive disorder Male Medical sciences Middle Aged Mood disorders Neuropharmacology Pharmacology. Drug treatments Postmortem Prefrontal cortex Prefrontal Cortex - immunology Prefrontal Cortex - pathology Prefrontal Cortex - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Ribosomal Protein S6 Kinases - analysis Ribosomal Protein S6 Kinases - biosynthesis Ribosomal Protein S6 Kinases - genetics Ribosomal Protein S6 Kinases - immunology Ribosomal Protein S6 Kinases, 70-kDa - analysis Ribosomal Protein S6 Kinases, 70-kDa - biosynthesis Ribosomal Protein S6 Kinases, 70-kDa - genetics Ribosomal Protein S6 Kinases, 70-kDa - immunology Signal Transduction - genetics Signal Transduction - immunology TOR Serine-Threonine Kinases - analysis TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - immunology TOR Serine-Threonine Kinases - metabolism Translation initiation pathway eIF4B eIF4E p70S6K p-eIF4B (Ser504) Postmortem Prefrontal cortex MDD PFC Major depressive disorder NR2B NR2A NMDA mTOR Translation initiation pathway PSD-95 p-eIF4E (Ser209) mGluR5 Mood disorder Signal transduction Central nervous system Mammalian target of rapamycin Depression Genetic translation Encephalon
ISSN:	0278-5846, 1878-4216, 1878-4216
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