PRC1 coordinates timing of sexual differentiation of female primordial germ cells

The Polycomb repressive complex 1 (PRC1) is found to have important gene-dosage-dependent and sex-specific roles in primordial germ cell (PGC) development, including the maintenance of high levels of Oct4 and Nanog and ensuring the proper timing of meiosis through the suppression of retinoic acid si...

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Bibliographic Details
Published in:	Nature (London) Vol. 495; no. 7440; pp. 236 - 240
Main Authors:	Yokobayashi, Shihori, Liang, Ching-Yeu, Kohler, Hubertus, Nestorov, Peter, Liu, Zichuan, Vidal, Miguel, van Lohuizen, Maarten, Roloff, Tim C., Peters, Antoine H. F. M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.03.2013 Nature Publishing Group
Subjects:	631/136/2434 631/208/176/2016 Adaptor Proteins, Signal Transducing Animals Biological control systems Chemical properties Chromatin - genetics Chromatin - metabolism Down-Regulation Embryos Female Gene expression Gene Expression Regulation, Developmental Germ cells Homeodomain Proteins - metabolism Humanities and Social Sciences letter Male Meiosis Mice multidisciplinary Nanog Homeobox Protein Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Ontology Ovum - cytology Ovum - metabolism Physiological aspects Polycomb Repressive Complex 1 - deficiency Polycomb Repressive Complex 1 - metabolism Polycomb Repressive Complex 2 - metabolism Proteins Proteins - genetics Science Sex Characteristics Sex differentiation Sex Differentiation - physiology Signal Transduction Time Factors Transcription, Genetic Tretinoin Tretinoin - metabolism Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - metabolism Switzerland Japan
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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