Role of fibroblasts in nonfibrotic autoimmune skin diseases

Autoimmune diseases, a disease characterized by immune imbalance caused by the human immune system mistakenly attacking its own components, include vitiligo, psoriasis and atopic dermatitis (AD). Previous studies on autoimmune diseases have focused mainly on immune cells, keratinocytes and endotheli...

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Veröffentlicht in:Molecular medicine (Cambridge, Mass.) Jg. 30; H. 1; S. 178 - 6
Hauptverfasser: He, Yuexi, Han, Zhenxin, Zhang, Qiuli, Liu, Lin, Chang, Jianmin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 17.10.2024
Springer Nature B.V
BMC
Schlagworte:
Animals
Apoptosis
Atopic dermatitis
Autoimmune Diseases - immunology
Autoimmune Diseases - metabolism
Autoimmune Diseases - pathology
Autoimmune skin diseases
Autophagy
Biomedical and Life Sciences
Biomedicine
Cell cycle
Chemokines
Cyclin-dependent kinases
Cytokines
Extracellular Matrix - metabolism
Fatty acids
Fibroblasts
Fibroblasts - metabolism
Fibroblasts - pathology
Growth factors
Humans
Kinases
Ligands
Lymphocytes
Mini-Review
Molecular Medicine
Proteins
Psoriasis
Reactive oxygen species
Scleroderma
Senescence
Signal transduction
Skin diseases
Skin Diseases - immunology
Skin Diseases - pathology
Tumor necrosis factor-TNF
Vitiligo
Fibroblasts
Vitiligo
Psoriasis
Atopic dermatitis
Autoimmune skin diseases
ISSN:1528-3658, 1076-1551, 1528-3658
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Autoimmune diseases, a disease characterized by immune imbalance caused by the human immune system mistakenly attacking its own components, include vitiligo, psoriasis and atopic dermatitis (AD). Previous studies on autoimmune diseases have focused mainly on immune cells, keratinocytes and endothelial cells. Fibroblasts, the main cells that secrete the extracellular matrix (ECM) in the dermis, have been studied thoroughly in terms of fibrosis and wound healing. However, an increasing number of studies have shown that fibroblasts play an important role in nonfibrotic autoimmune skin diseases. In this article, the previously reported role of fibroblasts in nonfibrous autoimmune skin diseases such as psoriasis, vitiligo and AD is summarized to provide new ideas for the treatment of this disease.
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ISSN:1528-3658
1076-1551
1528-3658
DOI:10.1186/s10020-024-00949-x