Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials

Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden on individuals and society. The development of preventive and therapeutic strategies against sarcopenia is therefore perceived as an urgent need by health professionals and has instigated intensive research on th...

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Bibliographic Details
Published in:	The international journal of biochemistry & cell biology Vol. 45; no. 10; pp. 2288 - 2301
Main Authors:	Marzetti, Emanuele, Calvani, Riccardo, Cesari, Matteo, Buford, Thomas W., Lorenzi, Maria, Behnke, Bradley J., Leeuwenburgh, Christiaan
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.10.2013
Subjects:	Aged Aging - metabolism Aging - pathology Animals Apoptosis Apoptosis - physiology biochemistry Biomarkers clinical trials Fusion and fission health care workers Humans inflammation lifestyle Mitochondria - metabolism Mitochondria - pathology Mitophagy Mitophagy - physiology monitoring muscles myotubes oxidative stress Oxidative Stress - physiology pathogenesis pathophysiology Randomized Controlled Trials as Topic - methods sarcopenia Sarcopenia - metabolism Sarcopenia - pathology Sarcopenia - therapy Signal Transduction society Vascular dysfunction Bcl-2 Fusion and fission eNOS RCT mtDNA OXPHOS Vascular dysfunction Atg protein EndoG Mitophagy Drp1 CSA IFM NF-κB Mfn LAMP-2 SDH MFRTA iNOS UPS AngII LC3 AIF MQC 31P-NMR Fis1 GH VDR IGF-1 PGC-1α SSM COX TA OMM NOS TNF-α ETC VL nNOS ROS Biomarkers TFAM FoxO3 COPD Apoptosis nuclear factor κB outer mitochondrial membrane insulin-like growth factor-1 P-NMR Forkhead box O3 cytochrome c oxidase fission protein 1 mitochondrial quality control endothelial nitric oxide synthase vitamin D receptor nitric oxide synthase autophagy-related protein B-cell leukemia-2 vastus lateralis dynamin-related protein 1 ubiquitin–proteasome system oxidative phosphorylation endonuclease G angiotensin II subsarcolemmal mitochondria cross-sectional area P nuclear magnetic resonance tibialis anterior inducible nitric oxide synthase microtubule-associated protein 1 light chain 3 lysosomal-associated membrane protein 2 reactive oxygen species mitochondrial transcription factor A growth hormone electron transport chain mitochondrial free radical theory of aging mitochondrial DNA neuronal nitric oxide synthase peroxisome proliferator-activated receptor-γ coactivator-1α randomized controlled trial succinate dehydrogenase tumor-necrosis factor α apoptosis-inducing factor mitofusin chronic obstructive pulmonary disease interfibrillar mitochondria
ISSN:	1357-2725, 1878-5875, 1878-5875
Online Access:	Get full text
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