Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials
Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden on individuals and society. The development of preventive and therapeutic strategies against sarcopenia is therefore perceived as an urgent need by health professionals and has instigated intensive research on th...
Saved in:
| Published in: | The international journal of biochemistry & cell biology Vol. 45; no. 10; pp. 2288 - 2301 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Netherlands
Elsevier Ltd
01.10.2013
|
| Subjects: | |
| ISSN: | 1357-2725, 1878-5875, 1878-5875 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden on individuals and society. The development of preventive and therapeutic strategies against sarcopenia is therefore perceived as an urgent need by health professionals and has instigated intensive research on the pathophysiology of this syndrome. The pathogenesis of sarcopenia is multifaceted and encompasses lifestyle habits, systemic factors (e.g., chronic inflammation and hormonal alterations), local environment perturbations (e.g., vascular dysfunction), and intramuscular specific processes. In this scenario, derangements in skeletal myocyte mitochondrial function are recognized as major factors contributing to the age-dependent muscle degeneration. In this review, we summarize prominent findings and controversial issues on the contribution of specific mitochondrial processes – including oxidative stress, quality control mechanisms and apoptotic signaling – on the development of sarcopenia. Extramuscular alterations accompanying the aging process with a potential impact on myocyte mitochondrial function are also discussed. We conclude with presenting methodological and safety considerations for the design of clinical trials targeting mitochondrial dysfunction to treat sarcopenia. Special emphasis is placed on the importance of monitoring the effects of an intervention on muscle mitochondrial function and identifying the optimal target population for the trial.
This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. |
|---|---|
| AbstractList | Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden on individuals and society. The development of preventive and therapeutic strategies against sarcopenia is therefore perceived as an urgent need by health professionals and has instigated intensive research on the pathophysiology of this syndrome. The pathogenesis of sarcopenia is multifaceted and encompasses lifestyle habits, systemic factors (e.g., chronic inflammation and hormonal alterations), local environment perturbations (e.g., vascular dysfunction), and intramuscular specific processes. In this scenario, derangements in skeletal myocyte mitochondrial function are recognized as major factors contributing to the age-dependent muscle degeneration. In this review, we summarize prominent findings and controversial issues on the contribution of specific mitochondrial processes – including oxidative stress, quality control mechanisms and apoptotic signaling – on the development of sarcopenia. Extramuscular alterations accompanying the aging process with a potential impact on myocyte mitochondrial function are also discussed. We conclude with presenting methodological and safety considerations for the design of clinical trials targeting mitochondrial dysfunction to treat sarcopenia. Special emphasis is placed on the importance of monitoring the effects of an intervention on muscle mitochondrial function and identifying the optimal target population for the trial.
This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden on individuals and society. The development of preventive and therapeutic strategies against sarcopenia is therefore perceived as an urgent need by health professionals and has instigated intensive research on the pathophysiology of this syndrome. The pathogenesis of sarcopenia is multifaceted and encompasses lifestyle habits, systemic factors (e.g., chronic inflammation and hormonal alterations), local environment perturbations (e.g., vascular dysfunction), and intramuscular specific processes. In this scenario, derangements in skeletal myocyte mitochondrial function are recognized as major factors contributing to the age-dependent muscle degeneration. In this review, we summarize prominent findings and controversial issues on the contribution of specific mitochondrial processes – including oxidative stress, quality control mechanisms and apoptotic signaling – on the development of sarcopenia. Extramuscular alterations accompanying the aging process with a potential impact on myocyte mitochondrial function are also discussed. We conclude with presenting methodological and safety considerations for the design of clinical trials targeting mitochondrial dysfunction to treat sarcopenia. Special emphasis is placed on the importance of monitoring the effects of an intervention on muscle mitochondrial function and identifying the optimal target population for the trial. This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden on individuals and society. The development of preventive and therapeutic strategies against sarcopenia is therefore perceived as an urgent need by health professionals and has instigated intensive research on the pathophysiology of this syndrome. The pathogenesis of sarcopenia is multifaceted and encompasses lifestyle habits, systemic factors (e.g., chronic inflammation and hormonal alterations), local environment perturbations (e.g., vascular dysfunction), and intramuscular specific processes. In this scenario, derangements in skeletal myocyte mitochondrial function are recognized as major factors contributing to the age-dependent muscle degeneration. In this review, we summarize prominent findings and controversial issues on the contribution of specific mitochondrial processes - including oxidative stress, quality control mechanisms and apoptotic signaling - on the development of sarcopenia. Extramuscular alterations accompanying the aging process with a potential impact on myocyte mitochondrial function are also discussed. We conclude with presenting methodological and safety considerations for the design of clinical trials targeting mitochondrial dysfunction to treat sarcopenia. Special emphasis is placed on the importance of monitoring the effects of an intervention on muscle mitochondrial function and identifying the optimal target population for the trial. This article is part of a Directed Issue entitled: Molecular basis of muscle wasting.Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden on individuals and society. The development of preventive and therapeutic strategies against sarcopenia is therefore perceived as an urgent need by health professionals and has instigated intensive research on the pathophysiology of this syndrome. The pathogenesis of sarcopenia is multifaceted and encompasses lifestyle habits, systemic factors (e.g., chronic inflammation and hormonal alterations), local environment perturbations (e.g., vascular dysfunction), and intramuscular specific processes. In this scenario, derangements in skeletal myocyte mitochondrial function are recognized as major factors contributing to the age-dependent muscle degeneration. In this review, we summarize prominent findings and controversial issues on the contribution of specific mitochondrial processes - including oxidative stress, quality control mechanisms and apoptotic signaling - on the development of sarcopenia. Extramuscular alterations accompanying the aging process with a potential impact on myocyte mitochondrial function are also discussed. We conclude with presenting methodological and safety considerations for the design of clinical trials targeting mitochondrial dysfunction to treat sarcopenia. Special emphasis is placed on the importance of monitoring the effects of an intervention on muscle mitochondrial function and identifying the optimal target population for the trial. This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden on individuals and society. The development of preventive and therapeutic strategies against sarcopenia is therefore perceived as an urgent need by health professionals and has instigated intensive research on the pathophysiology of this syndrome. The pathogenesis of sarcopenia is multifaceted and encompasses lifestyle habits, systemic factors (e.g., chronic inflammation and hormonal alterations), local environment perturbations (e.g., vascular dysfunction), and intramuscular specific processes. In this scenario, derangements in skeletal myocyte mitochondrial function are recognized as major factors contributing to the age-dependent muscle degeneration. In this review, we summarize prominent findings and controversial issues on the contribution of specific mitochondrial processes – including oxidative stress, quality control mechanisms and apoptotic signaling – on the development of sarcopenia. Extramuscular alterations accompanying the aging process with a potential impact on myocyte mitochondrial function are also discussed. We conclude with presenting methodological and safety considerations for the design of clinical trials targeting mitochondrial dysfunction to treat sarcopenia. Special emphasis is placed on the importance of monitoring the effects of an intervention on muscle mitochondrial function and identifying the optimal target population for the trial. |
| Author | Calvani, Riccardo Leeuwenburgh, Christiaan Buford, Thomas W. Behnke, Bradley J. Lorenzi, Maria Cesari, Matteo Marzetti, Emanuele |
| AuthorAffiliation | d Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL 32610, USA e Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA b Institute of Crystallography, Italian National Research Council (CNR), Bari 70126, Italy c Institut du Vieillissement, Gérontopôle and INSERM Unit 1027, University of Toulouse, Toulouse 31000, France a Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Rome 00168, Italy |
| AuthorAffiliation_xml | – name: a Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Rome 00168, Italy – name: d Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL 32610, USA – name: e Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA – name: c Institut du Vieillissement, Gérontopôle and INSERM Unit 1027, University of Toulouse, Toulouse 31000, France – name: b Institute of Crystallography, Italian National Research Council (CNR), Bari 70126, Italy |
| Author_xml | – sequence: 1 givenname: Emanuele surname: Marzetti fullname: Marzetti, Emanuele email: emarzetti@live.com organization: Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Rome 00168, Italy – sequence: 2 givenname: Riccardo surname: Calvani fullname: Calvani, Riccardo organization: Institute of Crystallography, Italian National Research Council (CNR), Bari 70126, Italy – sequence: 3 givenname: Matteo surname: Cesari fullname: Cesari, Matteo organization: Institut du Vieillissement, Gérontopôle and INSERM Unit 1027, University of Toulouse, Toulouse 31000, France – sequence: 4 givenname: Thomas W. surname: Buford fullname: Buford, Thomas W. organization: Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL 32610, USA – sequence: 5 givenname: Maria surname: Lorenzi fullname: Lorenzi, Maria organization: Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Rome 00168, Italy – sequence: 6 givenname: Bradley J. surname: Behnke fullname: Behnke, Bradley J. organization: Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA – sequence: 7 givenname: Christiaan surname: Leeuwenburgh fullname: Leeuwenburgh, Christiaan organization: Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL 32610, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23845738$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUstuFDEQtFAQecAfIPCRywx-P3JAQhEhSEEcIEdkeT2eWa9m7cX2Bu3f49UmUeBATu1uV1W3u3wKjmKKHoDXGPUYYfF-1S9Ccn7uCcK0R6JHhD0DJ1hJ1XEl-VE7Uy47Igk_BqelrBBCmBP6AhwTqhiXVJ2An19DTW6Z4pCDneGwK-M2uhpShDYOsNjs0sbHYGEaoZ1CnM7hZU5rWMIU7dxyuLF1-dvuCqwJulYJrgnVvVx5CZ6PLfhXd_EM3Fx--nFx1V1_-_zl4uN157gStZOeOskJ4qNgjijGLNejFi33w6CwY3y0SiPOF4INXFCrW6lB-egWUiJOz8CHg-5mu1j7wflYs53NJoe1zTuTbDB_38SwNFO6NVRyLQhuAu_uBHL6tfWlmnUobbmzjT5ti8EKUaQpp-ppKCNaMCI1atA3j8d6mOd-_Q3ADgCXUynZjw8QjMzeZbMyB5fN3mWDhGkuN9r5PzQXqt2b1h4X5qfIbw_k0SZjpxyKufneAKJ9D4W1frRN3yy7DT6b4oKPzg8he1fNkML_W_wBbdLPfA |
| CitedBy_id | crossref_primary_10_1007_s13167_025_00420_9 crossref_primary_10_1007_s00424_020_02357_6 crossref_primary_10_1155_2017_7083049 crossref_primary_10_3390_ijms26146740 crossref_primary_10_15252_embj_201593084 crossref_primary_10_3390_nu9121303 crossref_primary_10_1007_s00018_020_03476_0 crossref_primary_10_3389_fphys_2023_1281715 crossref_primary_10_1111_cts_13441 crossref_primary_10_2147_IJGM_S301141 crossref_primary_10_3390_antiox9060498 crossref_primary_10_3390_jcm13154496 crossref_primary_10_1016_j_fbio_2021_101390 crossref_primary_10_1016_j_exger_2018_09_020 crossref_primary_10_3390_biom14101289 crossref_primary_10_1139_apnm_2024_0272 crossref_primary_10_3389_fphys_2022_782000 crossref_primary_10_1177_17085381211059383 crossref_primary_10_4163_jnh_2021_54_4_335 crossref_primary_10_1177_02692155211036956 crossref_primary_10_3390_ijms17101771 crossref_primary_10_1186_s12877_024_05179_8 crossref_primary_10_1177_0300985815625169 crossref_primary_10_3389_fmicb_2025_1559119 crossref_primary_10_3389_fphys_2021_727585 crossref_primary_10_3389_fnagi_2014_00233 crossref_primary_10_1152_japplphysiol_00090_2022 crossref_primary_10_1177_1559325820974543 crossref_primary_10_1007_s40279_024_02072_7 crossref_primary_10_1016_j_redox_2025_103735 crossref_primary_10_3390_cells12010183 crossref_primary_10_1016_j_clinsp_2025_100776 crossref_primary_10_3390_nu16183050 crossref_primary_10_3390_nu17101727 crossref_primary_10_2478_raon_2025_0035 crossref_primary_10_1016_j_maturitas_2017_12_011 crossref_primary_10_1016_j_mito_2019_10_007 crossref_primary_10_1016_j_exger_2023_112204 crossref_primary_10_3390_nu16010157 crossref_primary_10_1016_j_arr_2019_100980 crossref_primary_10_3390_cancers14225691 crossref_primary_10_1016_j_jamda_2016_11_013 crossref_primary_10_3892_ijmm_2017_2932 crossref_primary_10_3390_nu17152408 crossref_primary_10_1016_j_neubiorev_2023_105320 crossref_primary_10_1016_j_exger_2016_10_003 crossref_primary_10_3390_antiox13020249 crossref_primary_10_17987_jcsm_cr_v2i2_35 crossref_primary_10_3390_geriatrics8050092 crossref_primary_10_3390_jcm12010081 crossref_primary_10_12968_hmed_2024_0281 crossref_primary_10_1016_j_mehy_2019_04_015 crossref_primary_10_1007_s00439_013_1402_4 crossref_primary_10_1016_j_exger_2019_110637 crossref_primary_10_3390_nu16203428 crossref_primary_10_1016_j_exger_2019_110639 crossref_primary_10_1242_jcs_264018 crossref_primary_10_3389_fnut_2020_619216 crossref_primary_10_3390_ijms25020988 crossref_primary_10_1016_j_gene_2021_146178 crossref_primary_10_1016_j_exger_2015_11_010 crossref_primary_10_1002_iub_2289 crossref_primary_10_1126_scitranslmed_ade6509 crossref_primary_10_2174_0118746098315667240606052523 crossref_primary_10_3389_fendo_2024_1356312 crossref_primary_10_1002_jcsm_12508 crossref_primary_10_1007_s40520_016_0704_5 crossref_primary_10_1016_j_arr_2018_02_002 crossref_primary_10_1155_2021_4493817 crossref_primary_10_1074_jbc_M113_506733 crossref_primary_10_1089_rej_2017_1989 crossref_primary_10_1155_2019_8031705 crossref_primary_10_3390_antiox11051016 crossref_primary_10_1017_S0029665122002683 crossref_primary_10_1016_j_jshs_2020_01_001 crossref_primary_10_1186_s12263_023_00725_2 crossref_primary_10_3390_ijms22169045 crossref_primary_10_1007_s12576_017_0589_x crossref_primary_10_1007_s10522_020_09879_7 crossref_primary_10_3390_ijms21186732 crossref_primary_10_17987_jcsm_cr_v2i2_45 crossref_primary_10_3390_pharmaceutics14122588 crossref_primary_10_3390_jcm11216309 crossref_primary_10_1016_j_bone_2015_04_015 crossref_primary_10_1016_j_mad_2024_111936 crossref_primary_10_1007_s00423_024_03537_z crossref_primary_10_1016_j_mad_2020_111262 crossref_primary_10_1111_apha_14107 crossref_primary_10_1007_s40520_020_01483_6 crossref_primary_10_1016_j_arr_2016_01_007 crossref_primary_10_3390_nu14091897 crossref_primary_10_1016_j_jot_2025_06_013 crossref_primary_10_3892_mmr_2017_6238 crossref_primary_10_1002_jcsm_13710 crossref_primary_10_1039_D4FO04341C crossref_primary_10_1016_j_ejso_2016_05_040 crossref_primary_10_1097_MD_0000000000033581 crossref_primary_10_3389_fnagi_2014_00246 crossref_primary_10_3390_fermentation8090454 crossref_primary_10_1139_bcb_2015_0012 crossref_primary_10_3390_nu14102051 crossref_primary_10_3390_jcm9082669 crossref_primary_10_1016_j_isci_2023_106355 crossref_primary_10_1093_alcalc_agw107 crossref_primary_10_1016_j_metabol_2024_155972 crossref_primary_10_3389_fphys_2022_811369 crossref_primary_10_1007_s12192_023_01322_3 crossref_primary_10_1016_j_phymed_2024_155695 crossref_primary_10_1016_j_bbrc_2015_04_132 crossref_primary_10_1016_j_exger_2017_02_075 crossref_primary_10_1016_j_exger_2024_112497 crossref_primary_10_3389_fonc_2023_1144516 crossref_primary_10_1002_jcsm_12051 crossref_primary_10_1242_dmm_026591 crossref_primary_10_1007_s12257_021_0349_x crossref_primary_10_1111_apha_14119 crossref_primary_10_1152_japplphysiol_01277_2013 crossref_primary_10_1186_s12880_024_01495_y crossref_primary_10_3390_antiox7070085 crossref_primary_10_1002_jcsm_12178 crossref_primary_10_1111_jch_14944 crossref_primary_10_1371_journal_pone_0272284 crossref_primary_10_1093_bjsopen_zraa069 crossref_primary_10_3389_fmed_2017_00188 crossref_primary_10_3389_fnins_2017_00688 crossref_primary_10_1016_j_metabol_2025_156272 crossref_primary_10_1016_j_transproceed_2019_03_034 crossref_primary_10_1016_S2213_8587_14_70034_8 crossref_primary_10_3389_fnut_2023_1099143 crossref_primary_10_3389_fmed_2025_1525205 crossref_primary_10_1016_j_jfma_2023_10_010 crossref_primary_10_1038_cdd_2017_132 crossref_primary_10_3390_jcm10235552 crossref_primary_10_3390_nu12051280 crossref_primary_10_3389_fnut_2021_753643 crossref_primary_10_3390_ijms21155236 crossref_primary_10_1016_j_exger_2023_112081 crossref_primary_10_1016_j_mam_2016_06_001 crossref_primary_10_1002_jcsm_12043 crossref_primary_10_1016_j_hrtlng_2021_11_013 crossref_primary_10_1002_jcsm_12045 crossref_primary_10_1007_s13659_023_00423_x crossref_primary_10_15656_kjgg_2025_26_1_9 crossref_primary_10_3390_life11020106 crossref_primary_10_1016_j_mam_2024_101270 crossref_primary_10_1007_s11357_019_00109_8 crossref_primary_10_1016_j_mam_2024_101271 crossref_primary_10_1007_s10753_023_01929_9 crossref_primary_10_1371_journal_pgen_1004467 crossref_primary_10_1113_JP285897 crossref_primary_10_3390_nu15112526 crossref_primary_10_1016_j_metabol_2024_155998 crossref_primary_10_1139_apnm_2015_0372 crossref_primary_10_1016_j_reprotox_2024_108700 crossref_primary_10_3389_fendo_2020_00332 crossref_primary_10_1016_j_biomaterials_2024_122903 crossref_primary_10_1155_2020_9250929 crossref_primary_10_1002_jcsm_12272 crossref_primary_10_1007_s00384_018_3163_y crossref_primary_10_1016_j_bone_2019_05_021 crossref_primary_10_1016_j_exger_2019_110715 crossref_primary_10_1007_s11515_016_1383_5 crossref_primary_10_1038_ncomms9919 crossref_primary_10_1016_j_ccc_2020_08_006 crossref_primary_10_1073_pnas_2302360120 crossref_primary_10_3390_nu13010044 crossref_primary_10_3389_fphys_2021_706189 crossref_primary_10_3390_ijms26178527 crossref_primary_10_1016_j_metabol_2025_156359 crossref_primary_10_3390_ijerph18063165 crossref_primary_10_1016_j_cmet_2015_05_006 crossref_primary_10_1155_2016_8274689 crossref_primary_10_1089_ars_2015_6291 crossref_primary_10_1136_bmjnph_2024_001076 crossref_primary_10_1165_rcmb_2016_0118OC crossref_primary_10_2106_JBJS_N_00648 crossref_primary_10_1038_nrrheum_2017_60 crossref_primary_10_1080_15548627_2024_2333717 crossref_primary_10_3390_biom14040493 crossref_primary_10_1186_s13018_022_03362_4 crossref_primary_10_7759_cureus_49152 crossref_primary_10_1016_j_arr_2016_09_008 crossref_primary_10_1016_j_jcct_2018_01_007 crossref_primary_10_1002_mus_25671 crossref_primary_10_3389_fendo_2023_1160155 crossref_primary_10_1080_1061186X_2019_1648476 crossref_primary_10_1016_j_freeradbiomed_2018_08_035 crossref_primary_10_1038_s41598_024_58462_4 crossref_primary_10_3390_biology10010031 crossref_primary_10_1016_j_bbadis_2017_09_018 crossref_primary_10_1155_2018_2810840 crossref_primary_10_1007_s10068_020_00816_5 crossref_primary_10_1016_j_niox_2022_06_002 crossref_primary_10_1111_jcmm_15197 crossref_primary_10_15171_hpp_2016_21 crossref_primary_10_3390_cells9040973 crossref_primary_10_3389_fnut_2022_913155 crossref_primary_10_3390_biomedicines8050122 crossref_primary_10_3390_antiox11040725 crossref_primary_10_1007_s40520_025_03102_8 crossref_primary_10_1002_ehf2_12033 crossref_primary_10_1186_s12967_016_1060_0 crossref_primary_10_2147_CIA_S376668 crossref_primary_10_1016_j_exger_2024_112571 crossref_primary_10_3389_fphar_2025_1541373 crossref_primary_10_1016_j_exger_2021_111519 crossref_primary_10_3390_muscles2020011 crossref_primary_10_1016_j_exger_2022_111931 crossref_primary_10_1016_j_freeradbiomed_2015_06_035 crossref_primary_10_1016_j_archger_2023_104988 crossref_primary_10_3390_biomedicines9121843 crossref_primary_10_3390_metabo12070663 crossref_primary_10_1016_j_eurger_2015_12_015 crossref_primary_10_1186_s13098_023_01192_w crossref_primary_10_1038_s41598_021_98761_8 crossref_primary_10_1038_cdd_2015_171 crossref_primary_10_3390_nu12020444 crossref_primary_10_1016_j_exger_2024_112465 crossref_primary_10_14814_phy2_14526 crossref_primary_10_1016_j_exger_2024_112468 crossref_primary_10_1177_03000605251355996 crossref_primary_10_1016_j_bbamcr_2023_119649 crossref_primary_10_1002_jcsm_13455 crossref_primary_10_1016_j_lfs_2019_05_070 crossref_primary_10_1002_jcsm_13336 crossref_primary_10_3233_JAD_215448 crossref_primary_10_1155_2017_2672435 crossref_primary_10_1002_jcsm_12363 crossref_primary_10_4254_wjh_v17_i8_109444 crossref_primary_10_1016_j_lfs_2022_121213 crossref_primary_10_3390_cells11071078 crossref_primary_10_1002_jcsm_12118 crossref_primary_10_3389_fpubh_2023_990029 crossref_primary_10_3390_cells12152015 crossref_primary_10_1080_21655979_2021_1948951 crossref_primary_10_1038_s41598_021_98771_6 crossref_primary_10_14814_phy2_70265 crossref_primary_10_3928_00989134_20250811_01 crossref_primary_10_1186_s40001_017_0266_9 crossref_primary_10_3390_ijms160510674 crossref_primary_10_3390_ijms21113988 crossref_primary_10_1007_s40520_021_01942_8 crossref_primary_10_1016_j_pmrj_2015_02_013 crossref_primary_10_1002_rco2_90 crossref_primary_10_3390_ijms22073721 crossref_primary_10_1155_2017_7529104 crossref_primary_10_1016_j_jhazmat_2025_138929 crossref_primary_10_1002_jcsm_12231 crossref_primary_10_1002_jcsm_13562 crossref_primary_10_1007_s40520_016_0708_1 crossref_primary_10_2215_CJN_10320819 crossref_primary_10_3390_ijms221910735 crossref_primary_10_1002_jcsm_13558 crossref_primary_10_1007_s12011_018_1332_z crossref_primary_10_3390_biom14030260 crossref_primary_10_3390_ijerph19148866 crossref_primary_10_1055_a_2564_7551 crossref_primary_10_3389_fnut_2024_1390309 crossref_primary_10_3390_ijms242216404 crossref_primary_10_1016_j_freeradbiomed_2017_05_018 crossref_primary_10_1016_j_biopha_2022_113876 crossref_primary_10_1016_j_ecoenv_2022_113599 crossref_primary_10_1186_s12876_019_1152_4 crossref_primary_10_1016_j_arr_2024_102543 crossref_primary_10_3389_fimmu_2024_1385902 crossref_primary_10_3390_ijerph192114314 crossref_primary_10_1002_jcsm_12340 crossref_primary_10_1016_j_lfs_2015_11_005 crossref_primary_10_1002_jpen_2607 crossref_primary_10_1016_j_ijcard_2015_10_115 crossref_primary_10_3390_biomedicines11020598 crossref_primary_10_3390_healthcare10101980 crossref_primary_10_1186_2044_5040_4_20 crossref_primary_10_3390_ijms26146783 crossref_primary_10_1016_j_mad_2024_112020 crossref_primary_10_1159_000513600 crossref_primary_10_1016_j_fbio_2022_102289 crossref_primary_10_1007_s10522_018_9749_5 crossref_primary_10_3390_antiox9100951 crossref_primary_10_3390_muscles4030035 crossref_primary_10_1016_j_mam_2016_04_006 crossref_primary_10_3390_nu11091991 crossref_primary_10_1016_j_afos_2025_05_002 crossref_primary_10_1371_journal_pone_0309124 crossref_primary_10_3390_ijms21093106 crossref_primary_10_1007_s11033_022_07821_3 crossref_primary_10_1016_j_arr_2015_04_002 crossref_primary_10_1007_s00394_014_0732_x crossref_primary_10_1016_j_biopha_2024_116917 crossref_primary_10_1007_s11356_023_30379_x crossref_primary_10_1007_s10103_016_1882_2 crossref_primary_10_3389_fbioe_2020_590869 crossref_primary_10_1002_jcsm_13665 crossref_primary_10_1016_j_exger_2023_112258 crossref_primary_10_1016_j_exger_2016_04_003 crossref_primary_10_1186_s12986_025_00894_4 crossref_primary_10_3390_cells10061307 crossref_primary_10_52586_4995 crossref_primary_10_3389_fnagi_2014_00274 crossref_primary_10_1016_j_arcmed_2024_103007 crossref_primary_10_1002_rco2_57 crossref_primary_10_1080_14656566_2019_1622093 crossref_primary_10_3390_nu13051538 crossref_primary_10_1155_2022_2357616 crossref_primary_10_1002_mco2_70268 crossref_primary_10_1007_s00109_023_02326_3 crossref_primary_10_1016_j_bbadis_2025_168058 crossref_primary_10_1007_s13539_014_0157_7 crossref_primary_10_1007_s40520_015_0366_8 crossref_primary_10_3390_ijms23052808 crossref_primary_10_1007_s40520_015_0427_z crossref_primary_10_1016_j_neuint_2018_03_007 crossref_primary_10_3390_ijms21093100 crossref_primary_10_1089_ars_2022_0166 crossref_primary_10_1016_j_arr_2019_100940 crossref_primary_10_1016_j_ijcard_2014_08_086 crossref_primary_10_3389_fendo_2024_1406165 crossref_primary_10_3389_fmed_2024_1526240 crossref_primary_10_3390_biology8020040 crossref_primary_10_1016_j_cmet_2016_05_007 crossref_primary_10_1016_j_exger_2017_06_005 crossref_primary_10_3390_cells12172183 crossref_primary_10_1016_j_abb_2014_10_008 crossref_primary_10_1038_emm_2016_20 crossref_primary_10_1186_s12986_016_0158_y crossref_primary_10_1016_j_jaci_2018_02_051 crossref_primary_10_1016_j_exger_2022_111869 crossref_primary_10_3390_ijms22041937 crossref_primary_10_1002_mco2_70030 crossref_primary_10_3389_fnagi_2015_00013 crossref_primary_10_1002_jcsm_12437 crossref_primary_10_1007_s00223_015_0022_5 crossref_primary_10_1080_14728222_2019_1559827 crossref_primary_10_3390_antiox14091132 crossref_primary_10_3390_cells9061385 crossref_primary_10_1016_j_exger_2024_112519 crossref_primary_10_1007_s13539_014_0136_z crossref_primary_10_1111_nyas_14020 crossref_primary_10_1016_j_mad_2020_111230 crossref_primary_10_1016_j_injury_2016_07_057 crossref_primary_10_1111_acel_12649 crossref_primary_10_34067_KID_0000000675 crossref_primary_10_3389_fnut_2024_1358231 crossref_primary_10_1007_s13105_024_01062_7 crossref_primary_10_1016_j_hrtlng_2020_06_001 crossref_primary_10_3389_fnut_2025_1529140 crossref_primary_10_3390_biology8020030 crossref_primary_10_3389_fnut_2024_1342113 crossref_primary_10_1007_s00421_018_4023_8 crossref_primary_10_1002_jcp_25260 crossref_primary_10_1016_j_mad_2017_08_009 crossref_primary_10_1002_jcsm_12787 crossref_primary_10_1155_2022_9159101 crossref_primary_10_3390_molecules25092117 crossref_primary_10_1002_rmv_2355 crossref_primary_10_1186_s12877_021_02331_6 crossref_primary_10_3390_ijms24054546 crossref_primary_10_1016_j_jgo_2018_11_007 crossref_primary_10_3390_ijms21031010 crossref_primary_10_1002_jcsm_13194 crossref_primary_10_1186_s12877_022_03522_5 crossref_primary_10_3389_fpubh_2024_1351479 crossref_primary_10_1016_j_arr_2021_101395 crossref_primary_10_3390_biomedicines10040898 crossref_primary_10_1016_j_injury_2020_11_062 crossref_primary_10_3390_antiox13121509 crossref_primary_10_1007_s00592_025_02579_z crossref_primary_10_1016_j_arr_2024_102586 crossref_primary_10_1186_s40798_025_00825_w crossref_primary_10_3904_kjim_2015_156 crossref_primary_10_1080_15548627_2015_1009779 crossref_primary_10_3389_fnagi_2015_00153 crossref_primary_10_1152_japplphysiol_00192_2017 crossref_primary_10_1186_s12889_025_23079_3 crossref_primary_10_3390_nu15081802 crossref_primary_10_1016_j_arr_2015_05_001 crossref_primary_10_1093_ageing_afad140 crossref_primary_10_3390_cells10051054 crossref_primary_10_3390_ph15040390 crossref_primary_10_1159_000365947 crossref_primary_10_1038_s43587_025_00847_9 |
| Cites_doi | 10.1038/embor.2012.19 10.1016/j.bbamcr.2006.03.001 10.1152/ajpcell.1989.256.6.C1262 10.1016/j.arr.2010.04.004 10.1089/ars.2006.8.517 10.1089/ars.2009.2598 10.1093/gerona/gls196 10.1016/S0891-5849(98)00185-3 10.1161/CIRCULATIONAHA.108.804294 10.1002/pmic.201000173 10.1007/BF02982708 10.1007/s10522-012-9399-y 10.1161/01.ATV.0000249408.55796.da 10.1002/(SICI)1097-4598(199910)22:10<1350::AID-MUS3>3.0.CO;2-8 10.1016/j.ecl.2013.02.006 10.1172/JCI18330 10.1172/JCI34022 10.1152/japplphysiol.01298.2006 10.1016/S1474-4422(11)70155-7 10.1083/jcb.200809125 10.1093/ageing/afq034 10.1002/mus.23838 10.1001/jama.297.16.1772-b 10.1073/pnas.0501559102 10.1002/jcp.20753 10.2337/diacare.28.7.1636 10.1210/jc.2011-1798 10.1016/j.bbagen.2009.05.007 10.1007/s13105-011-0083-5 10.1002/jlb.54.2.171 10.1155/2012/316943 10.1073/pnas.0911570106 10.1152/japplphysiol.00436.2012 10.1210/jcem.87.2.8206 10.1152/japplphysiol.91353.2008 10.1007/s10495-008-0216-7 10.2337/db10-0331 10.1210/endo.143.1.8600 10.1093/ajcn/82.2.428 10.1093/gerona/51A.1.B43 10.1016/S0076-6879(08)03613-6 10.1016/j.exger.2009.11.002 10.1091/mbc.e04-04-0294 10.1371/journal.pone.0011468 10.1113/jphysiol.2009.178319 10.1152/japplphysiol.01358.2012 10.1038/embor.2012.220 10.1093/hmg/ddt251 10.4161/auto.19496 10.1016/S0092-8674(00)81590-1 10.1152/ajpheart.00666.2001 10.1159/000330064 10.1016/j.jamda.2011.01.003 10.1016/j.addr.2009.06.006 10.1073/pnas.1332551100 10.1016/j.cger.2011.03.006 10.1002/biof.1099 10.1111/j.1469-7793.2000.t01-1-00203.x 10.1042/CS20120291 10.1042/bse0470069 10.1111/j.1447-0594.2010.00668.x 10.1007/s12603-012-0004-5 10.2337/db05-1230 10.1007/s11357-012-9428-4 10.1530/JOE-12-0486 10.1152/jappl.1993.75.3.1081 10.1123/ijsnem.12.3.368 10.1073/pnas.94.2.514 10.1152/ajpheart.01346.2006 10.1084/jem.192.12.1731 10.1111/j.1474-9726.2007.00347.x 10.1016/j.jamda.2013.04.012 10.1093/gerona/gln048 10.1111/j.1474-9726.2012.00844.x 10.1113/jphysiol.2012.229690 10.1152/japplphysiol.01061.2002 10.1016/j.cmet.2010.11.004 10.1016/j.biocel.2013.04.023 10.1111/j.1474-9726.2008.00418.x 10.1016/S1534-5807(01)00055-7 10.1073/pnas.0607795103 10.1086/507132 10.1100/tsw.2010.27 10.1152/ajpcell.00031.2005 10.1093/gerona/61.3.245 10.1073/pnas.0906039107 10.1152/ajpregu.00337.2011 10.1152/ajpcell.00598.2001 10.1111/j.1474-9726.2010.00581.x 10.1016/j.biocel.2012.09.019 10.1152/ajpcell.00481.2009 10.1016/0378-3782(85)90144-6 10.1096/fj.00-0320com 10.1016/0531-5565(80)90010-8 10.1111/j.1748-1716.1978.tb06277.x 10.1016/j.resp.2004.12.009 10.1152/ajpheart.00012.2008 10.1016/j.mad.2008.05.005 10.1111/j.1532-5415.1972.tb00787.x 10.1002/(SICI)1097-0185(199707)248:3<346::AID-AR7>3.0.CO;2-N 10.1038/nature10758 10.2174/138161206777947470 10.1093/gerona/56.3.M146 10.1016/j.clnu.2009.12.004 10.1515/hsz-2012-0247 10.1038/nature08991 10.1038/emboj.2010.60 10.2337/db08-0349 10.1046/j.1432-1033.2002.02869.x 10.1242/jcs.01610 10.1371/journal.pone.0038812 10.1152/ajpregu.00567.2012 10.2337/db08-0949 10.1093/gerona/57.5.M326 10.1152/japplphysiol.01179.2003 10.1007/s11357-010-9196-y 10.1155/2012/127362 10.1007/s12603-011-0366-0 10.1126/science.1112125 10.1080/10739680701444057 10.1016/j.yjmcc.2011.09.004 10.1111/j.1532-5415.2010.03285.x 10.1111/j.1749-6632.2011.06236.x 10.1002/mus.21526 10.1002/iub.37 10.1016/j.cell.2012.10.050 10.1152/japplphysiol.90642.2008 10.1152/ajpheart.00436.2007 10.2174/138161209789058110 10.1177/0148607108324585 10.2337/diab.38.6.710 10.1046/j.1532-5415.2002.50605.x 10.1161/CIRCRESAHA.109.198911 10.1152/ajpheart.01086.2002 10.1007/s12603-011-0092-7 10.1016/S1534-5807(01)00116-2 10.1016/j.mce.2011.05.009 10.1371/journal.pone.0054716 10.1126/science.1219855 10.1016/j.exger.2013.02.009 10.1096/fasebj.13.12.1637 10.1007/s12603-011-0058-9 10.1371/journal.pone.0008670 10.1152/ajpendo.00366.2003 10.1089/ars.2011.4123 10.1111/j.1474-9726.2011.00745.x 10.1161/CIRCULATIONAHA.105.543157 10.1093/gerona/glp179 10.1093/gerona/glp091 10.1016/j.cell.2010.02.026 10.1016/j.mad.2008.08.001 10.1152/ajpregu.00620.2007 10.1016/j.jamda.2011.04.014 10.1007/s12603-009-0205-8 10.18632/aging.100444 10.1210/jc.2007-1814 10.2478/s11658-009-0030-4 10.1093/ajcn/50.5.1231 10.1530/JOE-11-0071 10.1152/ajpcell.00240.2012 10.5628/aehd.v2i2.24 10.1371/journal.pone.0051180 10.1093/gerona/60.11.1437 10.1152/jappl.2001.90.6.2157 10.1152/ajpheart.00405.2005 10.1152/ajpcell.00097.2010 10.1093/gerona/gls209 10.1371/journal.pone.0010778 10.1016/j.biocel.2012.07.006 10.1074/jbc.M110.113092 10.1152/ajpheart.00135.2003 10.1371/journal.pone.0005631 10.1038/90116 10.2174/1874827900801010014 10.1016/j.bbabio.2008.05.001 10.1126/science.1082889 10.1016/j.arr.2008.07.002 10.1111/micc.12051 10.1016/j.exger.2004.01.005 10.1089/rej.2010.1132 10.2337/diabetes.54.9.2685 10.1038/nature03260 10.1146/annurev-genet-102108-134850 10.1515/BC.2002.045 10.1152/ajpcell.00391.2004 10.1016/j.mad.2006.03.005 10.1016/j.biosystems.2013.03.014 10.1016/j.arr.2009.05.001 10.1016/j.exger.2006.08.011 10.1038/sj.emboj.7601963 10.1152/ajpcell.00248.2006 10.1371/journal.pone.0032829 10.1113/jphysiol.2009.172221 10.1152/ajpcell.00531.2009 10.1210/jc.2012-3592 10.1152/jappl.1990.69.1.58 10.1007/s00125-011-2103-y 10.1055/s-2008-1025758 10.1016/j.tem.2012.12.003 10.1152/ajpheart.00709.2009 10.1002/biof.5 |
| ContentType | Journal Article |
| Copyright | 2013 Elsevier Ltd Copyright © 2013 Elsevier Ltd. All rights reserved. 2013 Elsevier Ltd. All rights reserved. 2013 |
| Copyright_xml | – notice: 2013 Elsevier Ltd – notice: Copyright © 2013 Elsevier Ltd. All rights reserved. – notice: 2013 Elsevier Ltd. All rights reserved. 2013 |
| DBID | FBQ AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 5PM |
| DOI | 10.1016/j.biocel.2013.06.024 |
| DatabaseName | AGRIS CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE AGRICOLA |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry Biology |
| EISSN | 1878-5875 |
| EndPage | 2301 |
| ExternalDocumentID | PMC3759621 23845738 10_1016_j_biocel_2013_06_024 US201600081995 S1357272513002082 |
| Genre | Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIA NIH HHS grantid: P30 AG028740 – fundername: NIA NIH HHS grantid: 1P30AG028740 – fundername: NIA NIH HHS grantid: R01 AG021042 – fundername: NIDDK NIH HHS grantid: R01-DK090115-01A1 – fundername: NIDDK NIH HHS grantid: R01 DK090115 – fundername: NIA NIH HHS grantid: R01-AG21042 – fundername: National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK grantid: R01 DK090115 || DK – fundername: National Institute on Aging : NIA grantid: R01 AG021042 || AG – fundername: National Institute on Aging : NIA grantid: P30 AG028740 || AG |
| GroupedDBID | --- --K --M -~X .GJ .~1 0R~ 123 1B1 1RT 1~. 1~5 29J 3O- 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABFNM ABGSF ABJNI ABMAC ABUDA ABXDB ABYKQ ACDAQ ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IHE J1W K-O KOM L7B M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 PC. Q38 R2- RIG ROL RPZ SDF SDG SDP SES SEW SPCBC SSU SSZ T5K WH7 ZU3 ~G- ~KM ABPIF ABPTK FBQ 9DU AAHBH AATTM AAXKI AAYWO AAYXX ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD AGCQF AGRNS BNPGV CGR CUY CVF ECM EIF NPM SSH 7X8 7S9 L.6 5PM |
| ID | FETCH-LOGICAL-c586t-7e3c75205f64c2844a59f9605fedd81c45fa89055b64d563a9c4564c5fcb77053 |
| ISICitedReferencesCount | 470 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000324719600022&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1357-2725 1878-5875 |
| IngestDate | Tue Sep 30 16:46:37 EDT 2025 Sat Sep 27 19:56:00 EDT 2025 Sun Sep 28 00:18:45 EDT 2025 Mon Jul 21 05:34:46 EDT 2025 Sat Nov 29 07:02:24 EST 2025 Tue Nov 18 21:26:44 EST 2025 Wed Dec 27 19:09:10 EST 2023 Fri Feb 23 02:28:00 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | Bcl-2 Fusion and fission eNOS RCT mtDNA OXPHOS Vascular dysfunction Atg protein EndoG Mitophagy Drp1 CSA IFM NF-κB Mfn LAMP-2 SDH MFRTA iNOS UPS AngII LC3 AIF MQC 31P-NMR Fis1 GH VDR IGF-1 PGC-1α SSM COX TA OMM NOS TNF-α ETC VL nNOS ROS Biomarkers TFAM FoxO3 COPD Apoptosis nuclear factor κB outer mitochondrial membrane insulin-like growth factor-1 P-NMR Forkhead box O3 cytochrome c oxidase fission protein 1 mitochondrial quality control endothelial nitric oxide synthase vitamin D receptor nitric oxide synthase autophagy-related protein B-cell leukemia-2 vastus lateralis dynamin-related protein 1 ubiquitin–proteasome system oxidative phosphorylation endonuclease G angiotensin II subsarcolemmal mitochondria cross-sectional area P nuclear magnetic resonance tibialis anterior inducible nitric oxide synthase microtubule-associated protein 1 light chain 3 lysosomal-associated membrane protein 2 reactive oxygen species mitochondrial transcription factor A growth hormone electron transport chain mitochondrial free radical theory of aging mitochondrial DNA neuronal nitric oxide synthase peroxisome proliferator-activated receptor-γ coactivator-1α randomized controlled trial succinate dehydrogenase tumor-necrosis factor α apoptosis-inducing factor mitofusin chronic obstructive pulmonary disease interfibrillar mitochondria |
| Language | English |
| License | Copyright © 2013 Elsevier Ltd. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c586t-7e3c75205f64c2844a59f9605fedd81c45fa89055b64d563a9c4564c5fcb77053 |
| Notes | http://dx.doi.org/10.1016/j.biocel.2013.06.024 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 These two authors contributed equally to this work |
| OpenAccessLink | http://doi.org/10.1016/j.biocel.2013.06.024 |
| PMID | 23845738 |
| PQID | 1429642790 |
| PQPubID | 23479 |
| PageCount | 14 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3759621 proquest_miscellaneous_1803093538 proquest_miscellaneous_1429642790 pubmed_primary_23845738 crossref_primary_10_1016_j_biocel_2013_06_024 crossref_citationtrail_10_1016_j_biocel_2013_06_024 fao_agris_US201600081995 elsevier_sciencedirect_doi_10_1016_j_biocel_2013_06_024 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-10-01 |
| PublicationDateYYYYMMDD | 2013-10-01 |
| PublicationDate_xml | – month: 10 year: 2013 text: 2013-10-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | The international journal of biochemistry & cell biology |
| PublicationTitleAlternate | Int J Biochem Cell Biol |
| PublicationYear | 2013 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Chung, Cesari, Anton, Marzetti, Giovannini, Seo (bib0200) 2009; 8 Ono, Isobe, Nakada, Hayashi (bib0665) 2001; 28 Safdar, Hamadeh, Kaczor, Raha, Debeer, Tarnopolsky (bib0780) 2010; 5 Russ, Krause, Wills, Arreguin (bib0765) 2012; 13 Seo, Xu, Servais, Hofer, Marzetti, Wohlgemuth (bib0845) 2008; 7 Short, Bigelow, Kahl, Singh, Coenen-Schimke, Raghavakaimal (bib0855) 2005; 102 Conley, Jubrias, Esselman (bib0225) 2000; 526 Lee, Jeong, Karbowski, Smith, Youle (bib0520) 2004; 15 Stump, Short, Bigelow, Schimke, Nair (bib0900) 2003; 100 Myhill, Booth, McLaren-Howard (bib0640) 2009; 2 Terjung, Zarzeczny, Yang (bib0930) 2002; 12 Remels, Gosker, Schrauwen, Hommelberg, Sliwinski, Polkey (bib0730) 2010; 24 Pitteloud, Mootha, Dwyer, Hardin, Lee, Eriksson (bib0710) 2005; 28 Wagatsuma, Kotake, Mabuchi, Yamada (bib1000) 2011; 67 Reid, Khawli, Moody (bib0725) 1993; 75 Scorrano, Ashiya, Buttle, Weiler, Oakes, Mannella (bib0840) 2002; 2 Short, Vittone, Bigelow, Proctor, Nair (bib0860) 2004; 286 Koves, Noland, Bates, Henes, Muoio, Cortright (bib0460) 2005; 288 Kadowaki, Karim (bib0435) 2009; 452 Lanza, Short, Short, Raghavakaimal, Basu, Joyner (bib0490) 2008; 57 Petersen, Befroy, Dufour, Dziura, Ariyan, Rothman (bib0690) 2003; 300 Crane, Devries, Safdar, Hamadeh, Tarnopolsky (bib0230) 2010; 65 He, Bassik, Moresi, Sun, Wei, Zou (bib0380) 2012; 481 DeLorey, Kowalchuk, Paterson (bib0265) 2004; 97 Matthews, Huang, Sun, Zaidi (bib0600) 2011; 1237 Wray, Nishiyama, Monnet, Wary, Duteil, Carlier (bib1050) 2009; 297 LaRocca, Henson, Thorburn, Sindler, Pierce, Seals (bib0495) 2012; 590 Cerullo, Gambassi, Cesari (bib0150) 2012; 2012 Klionsky, Abdalla, Abeliovich, Abraham, Acevedo-Arozena, Adeli (bib0445) 2012; 8 Terman, Brunk (bib0935) 2004; 39 Abbatecola, Paolisso, Fattoretti, Evans, Fiore, Dicioccio (bib0005) 2011; 15 Allen, Roy, Edgerton (bib0015) 1999; 22 Combaret, Dardevet, Bechet, Taillandier, Mosoni, Attaix (bib0215) 2009; 12 Li, Zhu, Xu, Yuan (bib0525) 1998; 94 Figueiredo, Powers, Ferreira, Appell, Duarte (bib0310) 2009; 64 De la Fuente, Miquel (bib0255) 2009; 15 Carreras, Poderoso (bib0130) 2007; 292 Fried, Tangen, Walston, Newman, Hirsch, Gottdiener (bib0320) 2001; 56 Dai, Chen, Wanagat, Laflamme, Marcinek, Emond (bib0240) 2010; 9 O’Rourke, White, Metcalf, Olivas, Mitra, Larison (bib0660) 2011; 54 Behnke, Delp, Dougherty, Musch, Poole (bib0045) 2005; 146 Iwabu, Yamauchi, Okada-Iwabu, Sato, Nakagawa, Funata (bib0405) 2010; 464 Marzetti, Wohlgemuth, Lees, Chung, Giovannini, Leeuwenburgh (bib0595) 2008; 129 Geng, Li, Okutsu, Yin, Kwek, Zhang (bib0335) 2010; 298 Gottlieb, Carreira (bib0360) 2010; 299 Herspring, Ferreira, Copp, Snyder, Poole, Musch (bib0385) 2008; 105 Riley, Slocum, Bain, Sedlak, Sowa, Mellender (bib0745) 1990; 69 Goodpaster, Carlson, Visser, Kelley, Scherzinger, Harris (bib0355) 2001; 90 Rajawat, Hilioti, Bossis (bib0720) 2009; 8 Salvioli, Capri, Valensin, Tieri, Monti, Ottaviani (bib0810) 2006; 12 Dodd, Gagnon, Senf, Hain, Judge (bib0275) 2010; 41 Lee, Choi, Birkenfeld, Alves, Jornayvaz, Jurczak (bib0515) 2010; 12 Kortebein, Ferrando, Lombeida, Wolfe, Evans (bib0455) 2007; 297 Visser, Pahor, Taaffe, Goodpaster, Simonsick, Newman (bib0990) 2002; 57 Hoppeler (bib0395) 1986; 7 Viguie, Lu, Huang, Rengen, Carlson (bib0980) 1997; 248 Suomalainen, Elo, Pietilainen, Hakonen, Sevastianova, Korpela (bib0910) 2011; 10 Yarasheski, Zachwieja, Campbell, Bier (bib1060) 1995; 268 DeVan, Eskurza, Pierce, Walker, Jablonski, Kaplon (bib0270) 2013; 124 Muscaritoli, Anker, Argiles, Aversa, Bauer, Biolo (bib0635) 2010; 29 Terman, Kurz, Navratil, Arriaga, Brunk (bib0940) 2010; 12 Cesari, Ferrini, Zamboni, Pahor (bib0155) 2008; 1 Mitsuishi, Miyashita, Muraki, Itoh (bib0610) 2009; 58 Visser, Schaap (bib0995) 2011; 27 Marzetti, Calvani, Bernabei, Leeuwenburgh (bib0555) 2012; 58 Bach, Naon, Pich, Soriano, Vega, Rieusset (bib0035) 2005; 54 Du, Wang, Miereles, Bailey, Debigare, Zheng (bib0285) 2004; 113 Li, Pan, Li, Niemann, Aurich, Chen (bib0530) 2011; 60 Yoon, Yoon, Lim, Yoon, Chung, Rojo (bib1065) 2006; 209 Lawrenson, Poole, Kim, Brown, Patel, Richardson (bib0505) 2003; 285 Marzetti (bib0545) 2012; 1 Narendra, Tanaka, Suen, Youle (bib0645) 2008; 183 Cheek (bib0185) 1985; 12 Nussler, Billiar (bib0650) 1993; 54 Cruz-Jentoft, Baeyens, Bauer, Boirie, Cederholm, Landi (bib0235) 2010; 39 Marzetti, Lees, Manini, Buford, Aranda, Calvani (bib0575) 2012; 7 Buford, Anton, Judge, Marzetti, Wohlgemuth, Carter (bib0105) 2010; 9 Chumlea, Cesari, Evans, Ferrucci, Fielding, Pahor (bib0195) 2011; 15 Salminen, Kaarniranta, Kauppinen (bib0800) 2012; 4 Marvar, Hammer, Boegehold (bib0540) 2007; 14 Pahor, Cesari (bib0680) 2011; 15 Vina, Gomez-Cabrera, Borras, Froio, Sanchis-Gomar, Martinez-Bello (bib0985) 2009; 61 Cesari, Kritchevsky, Baumgartner, Atkinson, Penninx, Lenchik (bib0170) 2005; 82 Harman (bib0375) 1972; 20 Ruas, White, Rao, Kleiner, Brannan, Harrison (bib0760) 2012; 151 Taaffe, Pruitt, Reim, Hintz, Butterfield, Hoffman (bib0920) 1994; 79 Sato, Nakada, Hayashi (bib0835) 2006; 1763 Iqbal, Ostojic, Singh, Joseph, Hood (bib0400) 2013 Jornayvaz, Shulman (bib0425) 2010; 47 Barbat-Artigas, Rolland, Zamboni, Aubertin-Leheudre (bib0040) 2012; 16 Jensen (bib0410) 2008; 32 Aon (bib0025) 2010; 1 Boczkowski, Lisdero, Lanone, Samb, Carreras, Boveris (bib0060) 1999; 13 Saitoh, Zhang, Tune, Potter, Kiyooka, Rogers (bib0790) 2006; 26 Shaham, Slate, Goldberger, Xu, Ramanathan, Souza (bib0850) 2010; 107 Pistilli, Siu, Alway (bib0705) 2006; 61 La Colla, Vasconsuelo, Boland (bib0475) 2013; 216 Youle, van der Bliek (bib1070) 2012; 337 Lee, Lopez, Weindruch, Aiken (bib0510) 1998; 25 Bruusgaard, Egner, Larsen, Dupre-Aucouturier, Desplanches, Gundersen (bib0090) 2012; 113 Hiona, Sanz, Kujoth, Pamplona, Seo, Hofer (bib0390) 2010; 5 Song, Kwak, Lawler (bib0885) 2006; 8 Twig, Elorza, Molina, Mohamed, Wikstrom, Walzer (bib0950) 2008; 27 Lavrik, Golks, Krammer (bib0500) 2005; 118 Van der Meer, Jaspers, Degens (bib0975) 2011; 11 Carter, Onder, Kritchevsky, Pahor (bib0140) 2005; 60 Yakes, Van Houten (bib1055) 1997; 94 Fry, Drummond, Glynn, Dickinson, Gundermann, Timmerman (bib0325) 2013; 68 Dai, Wu, Yang, Wang, Satterfield, Meininger (bib0245) 2013 Russell, Kindig, Behnke, Poole, Musch (bib0770) 2003; 285 Giovannini, Marzetti, Borst, Leeuwenburgh (bib0340) 2008; 129 Alway, Degens, Krishnamurthy, Smith (bib0020) 2002; 283 Morley, Malmstrom (bib0620) 2013; 42 Sandri (bib0820) 2010; 298 Galluzzi, Kepp, Trojel-Hansen, Kroemer (bib0330) 2012; 13 Bruusgaard, Gundersen (bib0095) 2008; 118 Subramani, Malhotra (bib0905) 2013; 14 Orlander, Kiessling, Larsson, Karlsson, Aniansson (bib0670) 1978; 104 Welle, Bhatt, Shah, Needler, Delehanty, Thornton (bib1030) 2003; 94 Chen, Vermulst, Wang, Chomyn, Prolla, McCaffery (bib0190) 2010; 141 Bua, Johnson, Herbst, Delong, McKenzie, Salamat (bib0100) 2006; 79 Thorner (bib0945) 2009; 64 Teixeira, Duarte (bib0925) 2011; 2 Sampey, Freemerman, Zhang, Kuan, Galanko, O’Connell (bib0815) 2012; 7 Ungvari, Labinskyy, Gupte, Chander, Edwards, Csiszar (bib0960) 2008; 294 Silvagno, Consiglio, Foglizzo, Destefanis, Pescarmona (bib0865) 2013; 8 Sandri (bib0825) 2013 Boyd, Cadenas (bib0065) 2002; 383 Erusalimsky (bib0290) 2009; 106 Musa, Fernando, Chatterjee, Monks (bib0630) 2011; 210 Padilla, Jenkins, Vieira-Potter, Laughlin (bib0675) 2013; 304 Kujoth, Hiona, Pugh, Someya, Panzer, Wohlgemuth (bib0470) 2005; 309 Asmann, Stump, Short, Coenen-Schimke, Guo, Bigelow (bib0030) 2006; 55 Romanello, Guadagnin, Gomes, Roder, Sandri, Petersen (bib0750) 2010; 29 Picard, Ritchie, Thomas, Wright, Hepple (bib0695) 2011; 10 Sindler, Delp, Reyes, Wu, Muller-Delp (bib0875) 2009; 587 Short, Moller, Bigelow, Coenen-Schimke, Nair (bib1075) 2008; 93 Luo, Lu, Wang, Hong, Chen, Hu (bib0535) 2013; 48 Psarra, Sekeris (bib0715) 2008; 60 Saitoh, Kiyooka, Rocic, Rogers, Zhang, Swafford (bib0785) 2007; 293 Rice, Blough (bib0735) 2006; 127 Cesari, Incalzi, Zamboni, Pahor (bib0165) 2011; 11 Marzetti, Groban, Wohlgemuth, Lees, Lin, Jobe (bib0565) 2008; 294 Joseph, Adhihetty, Buford, Wohlgemuth, Lees, Nguyen (bib0430) 2012; 11 Cesari, Pahor (bib0175) 2008; 12 Ungvari, Orosz, Labinskyy, Rivera, Xiangmin, Smith (bib0965) 2007; 293 Brault, Jespersen, Goldberg (bib0080) 2010; 285 Braga, Sinha Hikim, Datta, Ferrini, Brown, Kovacheva (bib0070) 2008; 13 Lange, Andersen, Beyer, Isaksson, Larsson, Rasmussen (bib0485) 2002; 87 Wanagat, Cao, Pathare, Aiken (bib1005) 2001; 15 Cesari, Fielding, Pahor, Goodpaster, Hellerstein, Abellan van Kan (bib0160) 2012; 1 Adhihetty, Ljubicic, Menzies, Hood (bib0010) 2005; 289 Miquel, Economos, Fleming, Johnson (bib0605) 1980; 15 Wohlgemuth, Lees, Marzetti, Manini, Aranda, Daniels (bib1040) 2011; 14 Marzetti, Hwang, Lees, Wohlgemuth, Dupont-Versteegden, Carter (bib0570) 2010; 1800 Sinha, Hollingsworth, Ball, Cheetham (bib0880) 2013; 98 Kern, Svoboda, Eckel, Van Wyk (bib0440) 1989; 38 Brass, Sietsema (bib0075) 2011; 59 Weitzel, Iwen (bib1025) 2011; 342 Johnson, Robinson, Nair (bib0420) 2013; 24 Bhatia-Kissova, Camougrand (bib0055) 2013; 45 Sandri, Lin, Handschin, Yang, Arany, Lecker (bib0830) 2006; 103 Pierce, Lesniewski, Lawson, Beske, Seals (bib0700) 2009; 119 Fielding, Vellas, Evans, Bhasin, Morley, Newman (bib0305) 2011; 12 Wang, Youle (bib1010) 2009; 43 Marzetti, Buford, Bernabei (bib0550) 2012; 113 Marzetti, Leeuwenburgh (bib0585) 2006; 41 O’Leary, Vainshtein, Iqbal, Ostojic, Hood (bib0655) 2013; 304 Marzetti, Lees, Wohlgemuth, Leeuwenburgh (bib0580) 2009; 35 Calvani, Miccheli, Landi, Bossola, Cesari, Leeuwenburgh (bib0115) 2013; 2 Landi, Marzetti, Liperoti, Pahor, Russo, Martone (bib0480) 2013 Sack (bib0775) 2011; 51 Muller-Delp, Spier, Ramsey, Lesniewski, Papadopoulos, Humphrey (bib0625) 2002; 282 Suvorava, Lauer, Kumpf, Jacob, Meyer, Kojda (bib0915) 2005; 112 Davis, Stabley, Dominguez, Ramsey, McCullough, Lesniewski (bib0250) 2013; 114 van der Loo, Labugger, Skepper, Bachschmid, Kilo, Powell (bib0970) 2000; 192 Brunk, Terman (bib0085) 2002; 269 Marzetti, Calvani, Dupree, Lees, Giovannini, Seo (bib0560) 2013; 35 Carter, Giovannini, Seo, Dupree, Morgan, Chung (bib0135) 2011; 33 Sakuma, Yamaguchi (bib0795) 2012; 2012 Carlson, Faulkner (bib0120) 1989; 256 Dela (10.1016/j.biocel.2013.06.024_bib0260) 2013; 45 Aon (10.1016/j.biocel.2013.06.024_bib0025) 2010; 1 Wang (10.1016/j.biocel.2013.06.024_bib1010) 2009; 43 Carlson (10.1016/j.biocel.2013.06.024_bib0125) 1996; 51 Carter (10.1016/j.biocel.2013.06.024_bib0140) 2005; 60 Padilla (10.1016/j.biocel.2013.06.024_bib0675) 2013; 304 Fried (10.1016/j.biocel.2013.06.024_bib0320) 2001; 56 Cesari (10.1016/j.biocel.2013.06.024_bib0155) 2008; 1 Terjung (10.1016/j.biocel.2013.06.024_bib0930) 2002; 12 Li (10.1016/j.biocel.2013.06.024_bib0525) 1998; 94 Musa (10.1016/j.biocel.2013.06.024_bib0630) 2011; 210 Russell (10.1016/j.biocel.2013.06.024_bib0770) 2003; 285 Remels (10.1016/j.biocel.2013.06.024_bib0730) 2010; 24 Lawrenson (10.1016/j.biocel.2013.06.024_bib0505) 2003; 285 Short (10.1016/j.biocel.2013.06.024_bib0860) 2004; 286 Lanza (10.1016/j.biocel.2013.06.024_bib0490) 2008; 57 Beregi (10.1016/j.biocel.2013.06.024_bib0050) 1987; 35 He (10.1016/j.biocel.2013.06.024_bib0380) 2012; 481 Youle (10.1016/j.biocel.2013.06.024_bib1070) 2012; 337 Lee (10.1016/j.biocel.2013.06.024_bib0510) 1998; 25 Marzetti (10.1016/j.biocel.2013.06.024_bib0550) 2012; 113 Goodpaster (10.1016/j.biocel.2013.06.024_bib0355) 2001; 90 Wray (10.1016/j.biocel.2013.06.024_bib1050) 2009; 297 Reid (10.1016/j.biocel.2013.06.024_bib0725) 1993; 75 Matthews (10.1016/j.biocel.2013.06.024_bib0600) 2011; 1237 Luo (10.1016/j.biocel.2013.06.024_bib0535) 2013; 48 Twig (10.1016/j.biocel.2013.06.024_bib0950) 2008; 27 Iwabu (10.1016/j.biocel.2013.06.024_bib0405) 2010; 464 Thorner (10.1016/j.biocel.2013.06.024_bib0945) 2009; 64 O’Leary (10.1016/j.biocel.2013.06.024_bib0655) 2013; 304 Russ (10.1016/j.biocel.2013.06.024_bib0765) 2012; 13 Dai (10.1016/j.biocel.2013.06.024_bib0245) 2013 Chen (10.1016/j.biocel.2013.06.024_bib0190) 2010; 141 Kern (10.1016/j.biocel.2013.06.024_bib0440) 1989; 38 Adhihetty (10.1016/j.biocel.2013.06.024_bib0010) 2005; 289 Mitsuishi (10.1016/j.biocel.2013.06.024_bib0610) 2009; 58 Marzetti (10.1016/j.biocel.2013.06.024_bib0595) 2008; 129 Wanagat (10.1016/j.biocel.2013.06.024_bib1005) 2001; 15 Brault (10.1016/j.biocel.2013.06.024_bib0080) 2010; 285 Safdar (10.1016/j.biocel.2013.06.024_bib0780) 2010; 5 Vina (10.1016/j.biocel.2013.06.024_bib0985) 2009; 61 Johannsen (10.1016/j.biocel.2013.06.024_bib0415) 2012; 97 Lee (10.1016/j.biocel.2013.06.024_bib0515) 2010; 12 Davis (10.1016/j.biocel.2013.06.024_bib0250) 2013; 114 Terman (10.1016/j.biocel.2013.06.024_bib0935) 2004; 39 Allen (10.1016/j.biocel.2013.06.024_bib0015) 1999; 22 Rieu (10.1016/j.biocel.2013.06.024_bib0740) 2009; 587 Pierce (10.1016/j.biocel.2013.06.024_bib0700) 2009; 119 Coen (10.1016/j.biocel.2013.06.024_bib0210) 2013; 68 Marvar (10.1016/j.biocel.2013.06.024_bib0540) 2007; 14 Kujoth (10.1016/j.biocel.2013.06.024_bib0470) 2005; 309 Sinha (10.1016/j.biocel.2013.06.024_bib0880) 2013; 98 Ungvari (10.1016/j.biocel.2013.06.024_bib0965) 2007; 293 Hoppeler (10.1016/j.biocel.2013.06.024_bib0395) 1986; 7 Stockton (10.1016/j.biocel.2013.06.024_bib0890) 2011; 22 Suvorava (10.1016/j.biocel.2013.06.024_bib0915) 2005; 112 Visser (10.1016/j.biocel.2013.06.024_bib0990) 2002; 57 Ungvari (10.1016/j.biocel.2013.06.024_bib0960) 2008; 294 Visser (10.1016/j.biocel.2013.06.024_bib0995) 2011; 27 Boyd (10.1016/j.biocel.2013.06.024_bib0065) 2002; 383 Wohlgemuth (10.1016/j.biocel.2013.06.024_bib1045) 2010; 45 Calvani (10.1016/j.biocel.2013.06.024_bib0110) 2013; 394 Yoon (10.1016/j.biocel.2013.06.024_bib1065) 2006; 209 Viguie (10.1016/j.biocel.2013.06.024_bib0980) 1997; 248 Cheek (10.1016/j.biocel.2013.06.024_bib0185) 1985; 12 Cesari (10.1016/j.biocel.2013.06.024_bib0165) 2011; 11 Chumlea (10.1016/j.biocel.2013.06.024_bib0195) 2011; 15 Li (10.1016/j.biocel.2013.06.024_bib0530) 2011; 60 Barbat-Artigas (10.1016/j.biocel.2013.06.024_bib0040) 2012; 16 Combaret (10.1016/j.biocel.2013.06.024_bib0215) 2009; 12 Sindler (10.1016/j.biocel.2013.06.024_bib0875) 2009; 587 Nussler (10.1016/j.biocel.2013.06.024_bib0650) 1993; 54 Marzetti (10.1016/j.biocel.2013.06.024_bib0585) 2006; 41 Ono (10.1016/j.biocel.2013.06.024_bib0665) 2001; 28 LaRocca (10.1016/j.biocel.2013.06.024_bib0495) 2012; 590 Sandri (10.1016/j.biocel.2013.06.024_bib0825) 2013 Boczkowski (10.1016/j.biocel.2013.06.024_bib0060) 1999; 13 Koves (10.1016/j.biocel.2013.06.024_bib0460) 2005; 288 Behnke (10.1016/j.biocel.2013.06.024_bib0045) 2005; 146 Iqbal (10.1016/j.biocel.2013.06.024_bib0400) 2013 Calvani (10.1016/j.biocel.2013.06.024_bib0115) 2013; 2 Johnson (10.1016/j.biocel.2013.06.024_bib0420) 2013; 24 Du (10.1016/j.biocel.2013.06.024_bib0285) 2004; 113 Bach (10.1016/j.biocel.2013.06.024_bib0035) 2005; 54 Morley (10.1016/j.biocel.2013.06.024_bib0615) 2011; 12 Rice (10.1016/j.biocel.2013.06.024_bib0735) 2006; 127 Sack (10.1016/j.biocel.2013.06.024_bib0775) 2011; 51 Chung (10.1016/j.biocel.2013.06.024_bib0200) 2009; 8 Suomalainen (10.1016/j.biocel.2013.06.024_bib0910) 2011; 10 Ruas (10.1016/j.biocel.2013.06.024_bib0760) 2012; 151 Park (10.1016/j.biocel.2013.06.024_bib0685) 2010; 15 Weber (10.1016/j.biocel.2013.06.024_bib1020) 2002; 143 Donato (10.1016/j.biocel.2013.06.024_bib0280) 2006; 290 Kortebein (10.1016/j.biocel.2013.06.024_bib0455) 2007; 297 Petersen (10.1016/j.biocel.2013.06.024_bib0690) 2003; 300 Kadowaki (10.1016/j.biocel.2013.06.024_bib0435) 2009; 452 Yarasheski (10.1016/j.biocel.2013.06.024_bib1060) 1995; 268 Golub (10.1016/j.biocel.2013.06.024_bib0350) 2013 Jensen (10.1016/j.biocel.2013.06.024_bib0410) 2008; 32 Morley (10.1016/j.biocel.2013.06.024_bib0620) 2013; 42 Marzetti (10.1016/j.biocel.2013.06.024_bib0580) 2009; 35 Ferreira (10.1016/j.biocel.2013.06.024_bib0295) 2010; 10 Romanello (10.1016/j.biocel.2013.06.024_bib0750) 2010; 29 Lavrik (10.1016/j.biocel.2013.06.024_bib0500) 2005; 118 Casas (10.1016/j.biocel.2013.06.024_bib0145) 2009; 4 Marzetti (10.1016/j.biocel.2013.06.024_bib0545) 2012; 1 Stump (10.1016/j.biocel.2013.06.024_bib0900) 2003; 100 Conley (10.1016/j.biocel.2013.06.024_bib0225) 2000; 526 Bruusgaard (10.1016/j.biocel.2013.06.024_bib0090) 2012; 113 Salvioli (10.1016/j.biocel.2013.06.024_bib0810) 2006; 12 Hiona (10.1016/j.biocel.2013.06.024_bib0390) 2010; 5 Rajawat (10.1016/j.biocel.2013.06.024_bib0720) 2009; 8 Cruz-Jentoft (10.1016/j.biocel.2013.06.024_bib0235) 2010; 39 Studenski (10.1016/j.biocel.2013.06.024_bib0895) 2009; 13 Sandri (10.1016/j.biocel.2013.06.024_bib0830) 2006; 103 Welle (10.1016/j.biocel.2013.06.024_bib1030) 2003; 94 van der Loo (10.1016/j.biocel.2013.06.024_bib0970) 2000; 192 Alway (10.1016/j.biocel.2013.06.024_bib0020) 2002; 283 Galluzzi (10.1016/j.biocel.2013.06.024_bib0330) 2012; 13 Cesari (10.1016/j.biocel.2013.06.024_bib0160) 2012; 1 Fielding (10.1016/j.biocel.2013.06.024_bib0305) 2011; 12 La Colla (10.1016/j.biocel.2013.06.024_bib0475) 2013; 216 Taaffe (10.1016/j.biocel.2013.06.024_bib0920) 1994; 79 Clanton (10.1016/j.biocel.2013.06.024_bib0205) 2007; 102 Guo (10.1016/j.biocel.2013.06.024_bib0365) 2012; 7 Erusalimsky (10.1016/j.biocel.2013.06.024_bib0290) 2009; 106 Song (10.1016/j.biocel.2013.06.024_bib0885) 2006; 8 Short (10.1016/j.biocel.2013.06.024_bib1075) 2008; 93 Geng (10.1016/j.biocel.2013.06.024_bib0335) 2010; 298 Herspring (10.1016/j.biocel.2013.06.024_bib0385) 2008; 105 Wohlgemuth (10.1016/j.biocel.2013.06.024_bib1040) 2011; 14 Ferrucci (10.1016/j.biocel.2013.06.024_bib0300) 2002; 50 Muscaritoli (10.1016/j.biocel.2013.06.024_bib0635) 2010; 29 Narendra (10.1016/j.biocel.2013.06.024_bib0645) 2008; 183 Roseberg (10.1016/j.biocel.2013.06.024_bib0755) 1989; 50 Figueiredo (10.1016/j.biocel.2013.06.024_bib0310) 2009; 64 Frank (10.1016/j.biocel.2013.06.024_bib0315) 2001; 1 Pitteloud (10.1016/j.biocel.2013.06.024_bib0710) 2005; 28 Giovannini (10.1016/j.biocel.2013.06.024_bib0340) 2008; 129 Gottlieb (10.1016/j.biocel.2013.06.024_bib0360) 2010; 299 Braga (10.1016/j.biocel.2013.06.024_bib0070) 2008; 13 Orlander (10.1016/j.biocel.2013.06.024_bib0670) 1978; 104 Klionsky (10.1016/j.biocel.2013.06.024_bib0445) 2012; 8 Pahor (10.1016/j.biocel.2013.06.024_bib0680) 2011; 15 Carlson (10.1016/j.biocel.2013.06.024_bib0120) 1989; 256 Van der Meer (10.1016/j.biocel.2013.06.024_bib0975) 2011; 11 Psarra (10.1016/j.biocel.2013.06.024_bib0715) 2008; 60 Lee (10.1016/j.biocel.2013.06.024_bib0520) 2004; 15 De la Fuente (10.1016/j.biocel.2013.06.024_bib0255) 2009; 15 Cesari (10.1016/j.biocel.2013.06.024_bib0170) 2005; 82 Dai (10.1016/j.biocel.2013.06.024_bib0240) 2010; 9 Kriete (10.1016/j.biocel.2013.06.024_bib0465) 2013; 112 Gladwin (10.1016/j.biocel.2013.06.024_bib0345) 2009; 104 Salucci (10.1016/j.biocel.2013.06.024_bib0805) 2013; 28 Joseph (10.1016/j.biocel.2013.06.024_bib0430) 2012; 11 Carreras (10.1016/j.biocel.2013.06.024_bib0130) 2007; 292 Bua (10.1016/j.biocel.2013.06.024_bib0100) 2006; 79 Marzetti (10.1016/j.biocel.2013.06.024_bib0570) 2010; 1800 Muller-Delp (10.1016/j.biocel.2013.06.024_bib0625) 2002; 282 Yakes (10.1016/j.biocel.2013.06.024_bib1055) 1997; 94 Cesari (10.1016/j.biocel.2013.06.024_bib0175) 2008; 12 Teixeira (10.1016/j.biocel.2013.06.024_bib0925) 2011; 2 Buford (10.1016/j.biocel.2013.06.024_bib0105) 2010; 9 Asmann (10.1016/j.biocel.2013.06.024_bib0030) 2006; 55 Sakuma (10.1016/j.biocel.2013.06.024_bib0795) 2012; 2012 Salminen (10.1016/j.biocel.2013.06.024_bib0800) 2012; 4 Conboy (10.1016/j.biocel.2013.06.024_bib0220) 2005; 433 Bruusgaard (10.1016/j.biocel.2013.06.024_bib0095) 2008; 118 Dodd (10.1016/j.biocel.2013.06.024_bib0275) 2010; 41 Harman (10.1016/j.biocel.2013.06.024_bib0375) 1972; 20 Jornayvaz (10.1016/j.biocel.2013.06.024_bib0425) 2010; 47 Bhatia-Kissova (10.1016/j.biocel.2013.06.024_bib0055) 2013; 45 Chabi (10.1016/j.biocel.2013.06.024_bib0180) 2008; 7 Miquel (10.1016/j.biocel.2013.06.024_bib0605) 1980; 15 Picard (10.1016/j.biocel.2013.06.024_bib0695) 2011; 10 Subramani (10.1016/j.biocel.2013.06.024_bib0905) 2013; 14 Terman (10.1016/j.biocel.2013.06.024_bib0940) 2010; 12 Crane (10.1016/j.biocel.2013.06.024_bib0230) 2010; 65 Lange (10.1016/j.biocel.2013.06.024_bib0485) 2002; 87 Abbatecola (10.1016/j.biocel.2013.06.024_bib0005) 2011; 15 Weitzel (10.1016/j.biocel.2013.06.024_bib1025) 2011; 342 Fry (10.1016/j.biocel.2013.06.024_bib0325) 2013; 68 Wagatsuma (10.1016/j.biocel.2013.06.024_bib1000) 20 |
| References_xml | – volume: 8 start-page: 199 year: 2009 end-page: 213 ident: bib0720 article-title: Aging: central role for autophagy and the lysosomal degradative system publication-title: Ageing Res Rev – volume: 22 start-page: 859 year: 2011 end-page: 871 ident: bib0890 article-title: Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis publication-title: Osteoporos Int – volume: 14 start-page: 315 year: 2011 end-page: 324 ident: bib1040 article-title: An exploratory analysis of the effects of a weight loss plus exercise program on cellular quality control mechanisms in older overweight women publication-title: Rejuvenation Res – volume: 94 start-page: 491 year: 1998 end-page: 501 ident: bib0525 article-title: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis publication-title: Cell – volume: 286 start-page: E92 year: 2004 end-page: E101 ident: bib0860 article-title: Age and aerobic exercise training effects on whole body and muscle protein metabolism publication-title: Am J Physiol Endocrinol Metab – volume: 9 start-page: 369 year: 2010 end-page: 383 ident: bib0105 article-title: Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy publication-title: Ageing Res Rev – volume: 293 start-page: H3720 year: 2007 end-page: H3725 ident: bib0785 article-title: Redox-dependent coronary metabolic dilation publication-title: Am J Physiol Heart Circ Physiol – volume: 59 start-page: 530 year: 2011 end-page: 535 ident: bib0075 article-title: Considerations in the development of drugs to treat sarcopenia publication-title: J Am Geriatr Soc – volume: 113 start-page: 115 year: 2004 end-page: 123 ident: bib0285 article-title: Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions publication-title: J Clin Invest – volume: 7 start-page: e32829 year: 2012 ident: bib0575 article-title: Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study publication-title: PLoS ONE – volume: 10 start-page: 1047 year: 2011 end-page: 1055 ident: bib0695 article-title: Alterations in intrinsic mitochondrial function with aging are fiber type-specific and do not explain differential atrophy between muscles publication-title: Aging Cell – volume: 12 start-page: 3161 year: 2006 end-page: 3171 ident: bib0810 article-title: Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology publication-title: Curr Pharm Des – volume: 2 start-page: 55 year: 2002 end-page: 67 ident: bib0840 article-title: A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis publication-title: Dev Cell – volume: 1 start-page: 20 year: 2010 ident: bib0025 article-title: From isolated to networked: a paradigmatic shift in mitochondrial physiology publication-title: Front Physiol – volume: 118 start-page: 1450 year: 2008 end-page: 1457 ident: bib0095 article-title: In vivo time-lapse microscopy reveals no loss of murine myonuclei during weeks of muscle atrophy publication-title: J Clin Invest – volume: 13 start-page: 822 year: 2008 end-page: 832 ident: bib0070 article-title: Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice publication-title: Apoptosis – volume: 43 start-page: 95 year: 2009 end-page: 118 ident: bib1010 article-title: The role of mitochondria in apoptosis publication-title: Annu Rev Genet – volume: 1 start-page: 97 year: 2012 end-page: 98 ident: bib0545 article-title: Imaging, functional and biological markers for sarcopenia: the pursuit of the golden ratio publication-title: J Frailty Aging – volume: 97 start-page: 165 year: 2004 end-page: 172 ident: bib0265 article-title: Effect of age on O(2) uptake kinetics and the adaptation of muscle deoxygenation at the onset of moderate-intensity cycling exercise publication-title: J Appl Physiol – volume: 104 start-page: 249 year: 1978 end-page: 261 ident: bib0670 article-title: Skeletal muscle metabolism and ultrastructure in relation to age in sedentary men publication-title: Acta Physiol Scand – volume: 300 start-page: 1140 year: 2003 end-page: 1142 ident: bib0690 article-title: Mitochondrial dysfunction in the elderly: possible role in insulin resistance publication-title: Science – volume: 2012 start-page: 316943 year: 2012 ident: bib0150 article-title: Rationale for antioxidant supplementation in sarcopenia publication-title: J Aging Res – volume: 337 start-page: 1062 year: 2012 end-page: 1065 ident: bib1070 article-title: Mitochondrial fission, fusion, and stress publication-title: Science – volume: 7 start-page: 2 year: 2008 end-page: 12 ident: bib0180 article-title: Mitochondrial function and apoptotic susceptibility in aging skeletal muscle publication-title: Aging Cell – volume: 28 start-page: 272 year: 2001 end-page: 275 ident: bib0665 article-title: Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria publication-title: Nat Genet – volume: 68 start-page: 599 year: 2013 end-page: 607 ident: bib0325 article-title: Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults publication-title: J Gerontol A Biol Sci Med Sci – volume: 209 start-page: 468 year: 2006 end-page: 480 ident: bib1065 article-title: Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1 publication-title: J Cell Physiol – volume: 90 start-page: 2157 year: 2001 end-page: 2165 ident: bib0355 article-title: Attenuation of skeletal muscle and strength in the elderly: the Health ABC Study publication-title: J Appl Physiol – volume: 293 start-page: H37 year: 2007 end-page: H47 ident: bib0965 article-title: Increased mitochondrial H publication-title: Am J Physiol Heart Circ Physiol – volume: 290 start-page: H272 year: 2006 end-page: H278 ident: bib0280 article-title: Differential effects of aging on limb blood flow in humans publication-title: Am J Physiol Heart Circ Physiol – volume: 14 start-page: 779 year: 2007 end-page: 791 ident: bib0540 article-title: Hydrogen peroxide-dependent arteriolar dilation in contracting muscle of rats fed normal and high salt diets publication-title: Microcirculation – volume: 33 start-page: 167 year: 2011 end-page: 183 ident: bib0135 article-title: Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 x Brown Norway rats publication-title: Age (Dordr) – volume: 15 start-page: 725 year: 2011 end-page: 730 ident: bib0680 article-title: Designing Phase II B trials in sarcopenia: the best target population publication-title: J Nutr Health Aging – volume: 12 start-page: 249 year: 2011 end-page: 256 ident: bib0305 article-title: Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International Working Group on Sarcopenia publication-title: J Am Med Dir Assoc – volume: 1 start-page: 102 year: 2012 end-page: 110 ident: bib0160 article-title: Biomarkers of sarcopenia in clinical trials. Recommendations from the International Working Group on Sarcopenia publication-title: J Frailty Aging – volume: 10 start-page: 340 year: 2010 end-page: 349 ident: bib0590 article-title: Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging publication-title: ScientificWorldJournal – volume: 12 start-page: 470 year: 2008 end-page: 478 ident: bib0175 article-title: Target population for clinical trials on sarcopenia publication-title: J Nutr Health Aging – volume: 283 start-page: C66 year: 2002 end-page: C76 ident: bib0020 article-title: Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats publication-title: Am J Physiol Cell Physiol – volume: 112 start-page: 2487 year: 2005 end-page: 2495 ident: bib0915 article-title: Endogenous vascular hydrogen peroxide regulates arteriolar tension in vivo publication-title: Circulation – volume: 79 start-page: 469 year: 2006 end-page: 480 ident: bib0100 article-title: Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers publication-title: Am J Hum Genet – volume: 7 start-page: e51180 year: 2012 ident: bib0365 article-title: Testosterone plus low-intensity physical training in late life improves functional performance, skeletal muscle mitochondrial biogenesis, and mitochondrial quality control in male mice publication-title: PLoS ONE – volume: 13 start-page: 322 year: 2012 end-page: 330 ident: bib0330 article-title: Non-apoptotic functions of apoptosis-regulatory proteins publication-title: EMBO Rep – volume: 303 start-page: R127 year: 2012 end-page: R134 ident: bib0450 article-title: Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training publication-title: Am J Physiol Regul Integr Comp Physiol – volume: 526 start-page: 203 year: 2000 end-page: 210 ident: bib0225 article-title: Oxidative capacity and ageing in human muscle publication-title: J Physiol – volume: 298 start-page: C572 year: 2010 end-page: C579 ident: bib0335 article-title: PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle publication-title: Am J Physiol Cell Physiol – volume: 216 start-page: 331 year: 2013 end-page: 341 ident: bib0475 article-title: Estradiol exerts antiapoptotic effects in skeletal myoblasts via mitochondrial PTP and MnSOD publication-title: J Endocrinol – volume: 15 start-page: 890 year: 2011 end-page: 895 ident: bib0005 article-title: Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction publication-title: J Nutr Health Aging – volume: 1777 start-page: 1092 year: 2008 end-page: 1097 ident: bib0955 article-title: Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view publication-title: Biochim Biophys Acta – volume: 118 start-page: 265 year: 2005 end-page: 267 ident: bib0500 article-title: Death receptor signaling publication-title: J Cell Sci – volume: 15 start-page: 5001 year: 2004 end-page: 5011 ident: bib0520 article-title: Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis publication-title: Mol Biol Cell – volume: 28 start-page: 1073 year: 2013 end-page: 1087 ident: bib0805 article-title: The peculiar apoptotic behavior of skeletal muscle cells publication-title: Histol Histopathol – volume: 146 start-page: 259 year: 2005 end-page: 268 ident: bib0045 article-title: Effects of aging on microvascular oxygen pressures in rat skeletal muscle publication-title: Respir Physiol Neurobiol – volume: 5 start-page: e10778 year: 2010 ident: bib0780 article-title: Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults publication-title: PLoS ONE – volume: 79 start-page: 1361 year: 1994 end-page: 1366 ident: bib0920 article-title: Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men publication-title: J Clin Endocrinol Metab – volume: 12 start-page: 37 year: 2009 end-page: 41 ident: bib0215 article-title: Skeletal muscle proteolysis in aging publication-title: Curr Opin Clin Nutr Metab Care – volume: 587 start-page: 5483 year: 2009 end-page: 5492 ident: bib0740 article-title: Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats publication-title: J Physiol – volume: 41 start-page: 1234 year: 2006 end-page: 1238 ident: bib0585 article-title: Skeletal muscle apoptosis, sarcopenia and frailty at old age publication-title: Exp Gerontol – volume: 297 start-page: 1772 year: 2007 end-page: 1774 ident: bib0455 article-title: Effect of 10 days of bed rest on skeletal muscle in healthy older adults publication-title: J Am Med Assoc – volume: 60 start-page: 1437 year: 2005 end-page: 1446 ident: bib0140 article-title: Angiotensin-converting enzyme inhibition intervention in elderly persons: effects on body composition and physical performance publication-title: J Gerontol A Biol Sci Med Sci – volume: 151 start-page: 1319 year: 2012 end-page: 1331 ident: bib0760 article-title: A PGC-1alpha isoform induced by resistance training regulates skeletal muscle hypertrophy publication-title: Cell – volume: 55 start-page: 3309 year: 2006 end-page: 3319 ident: bib0030 article-title: Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia publication-title: Diabetes – volume: 12 start-page: 211 year: 1985 end-page: 239 ident: bib0185 article-title: The control of cell mass and replication. The DNA unit—a personal 20-year study publication-title: Early Hum Dev – volume: 294 start-page: H2121 year: 2008 end-page: H2128 ident: bib0960 article-title: Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats publication-title: Am J Physiol Heart Circ Physiol – volume: 10 start-page: 3142 year: 2010 end-page: 3154 ident: bib0295 article-title: Subsarcolemmal and intermyofibrillar mitochondria proteome differences disclose functional specializations in skeletal muscle publication-title: Proteomics – volume: 464 start-page: 1313 year: 2010 end-page: 1319 ident: bib0405 article-title: Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1 publication-title: Nature – volume: 15 start-page: 322 year: 2001 end-page: 332 ident: bib1005 article-title: Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia publication-title: FASEB J – volume: 13 start-page: 547 year: 2012 end-page: 555 ident: bib0765 article-title: “SR stress” in mixed hindlimb muscles of aging male rats publication-title: Biogerontology – volume: 57 start-page: 2933 year: 2008 end-page: 2942 ident: bib0490 article-title: Endurance exercise as a countermeasure for aging publication-title: Diabetes – volume: 127 start-page: 670 year: 2006 end-page: 679 ident: bib0735 article-title: Sarcopenia-related apoptosis is regulated differently in fast- and slow-twitch muscles of the aging F344/N x BN rat model publication-title: Mech Ageing Dev – volume: 27 start-page: 387 year: 2011 end-page: 399 ident: bib0995 article-title: Consequences of sarcopenia publication-title: Clin Geriatr Med – volume: 106 start-page: 20405 year: 2009 end-page: 20410 ident: bib1035 article-title: Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging publication-title: Proc Natl Acad Sci U S A – volume: 45 start-page: 11 year: 2013 end-page: 15 ident: bib0260 article-title: Insulin resistance and mitochondrial function in skeletal muscle publication-title: Int J Biochem Cell Biol – volume: 129 start-page: 593 year: 2008 end-page: 601 ident: bib0340 article-title: Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults publication-title: Mech Ageing Dev – volume: 45 start-page: 30 year: 2013 end-page: 33 ident: bib0055 article-title: Mitophagy: a process that adapts to the cell physiology publication-title: Int J Biochem Cell Biol – volume: 114 start-page: 808 year: 2013 end-page: 815 ident: bib0250 article-title: Differential effects of aging and exercise on intra-abdominal adipose arteriolar function and blood flow regulation publication-title: J Appl Physiol – volume: 68 start-page: 447 year: 2013 end-page: 455 ident: bib0210 article-title: Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults publication-title: J Gerontol A Biol Sci Med Sci – volume: 98 start-page: E509 year: 2013 end-page: E513 ident: bib0880 article-title: Improving the vitamin d status of vitamin d deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle publication-title: J Clin Endocrinol Metab – volume: 100 start-page: 7996 year: 2003 end-page: 8001 ident: bib0900 article-title: Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts publication-title: Proc Natl Acad Sci U S A – volume: 39 start-page: 412 year: 2010 end-page: 423 ident: bib0235 article-title: Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People publication-title: Age Ageing – volume: 394 start-page: 393 year: 2013 end-page: 414 ident: bib0110 article-title: Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy publication-title: Biol Chem – volume: 15 start-page: 575 year: 1980 end-page: 591 ident: bib0605 article-title: Mitochondrial role in cell aging publication-title: Exp Gerontol – volume: 2 start-page: 38 year: 2013 end-page: 53 ident: bib0115 article-title: Current nutritional recommendations and novel dietary strategies to manage sarcopenia publication-title: J Frailty Aging – volume: 2012 start-page: 127362 year: 2012 ident: bib0795 article-title: Sarcopenia and age-related endocrine function publication-title: Int J Endocrinol – volume: 1237 start-page: 95 year: 2011 end-page: 105 ident: bib0600 article-title: Translational musculoskeletal science: is sarcopenia the next clinical target after osteoporosis publication-title: Ann N Y Acad Sci – volume: 4 start-page: e5631 year: 2009 ident: bib0145 article-title: Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging publication-title: PLoS ONE – year: 2013 ident: bib0825 article-title: Protein breakdown in muscle wasting: role of autophagy–lysosome and ubiquitin–proteasome publication-title: Int J Biochem Cell Biol – volume: 56 start-page: M146 year: 2001 end-page: M156 ident: bib0320 article-title: Frailty in older adults: evidence for a phenotype publication-title: J Gerontol A Biol Sci Med Sci – volume: 29 start-page: 1774 year: 2010 end-page: 1785 ident: bib0750 article-title: Mitochondrial fission and remodelling contributes to muscle atrophy publication-title: EMBO J – volume: 1 start-page: 515 year: 2001 end-page: 525 ident: bib0315 article-title: The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis publication-title: Dev Cell – volume: 93 start-page: 597 year: 2008 end-page: 604 ident: bib1075 article-title: Enhancement of muscle mitochondrial function by growth hormone publication-title: J Clin Endocrinol Metab – year: 2013 ident: bib1015 article-title: Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell pool publication-title: Hum Mol Genet – volume: 383 start-page: 411 year: 2002 end-page: 423 ident: bib0065 article-title: Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis publication-title: Biol Chem – volume: 2 start-page: 92 year: 2011 end-page: 101 ident: bib0925 article-title: Myonuclear domain in skeletal muscle fibers. A critical review publication-title: Archives of Exercise in Health and Disease – volume: 298 start-page: C1291 year: 2010 end-page: C1297 ident: bib0820 article-title: Autophagy in health and disease. 3. Involvement of autophagy in muscle atrophy publication-title: Am J Physiol Cell Physiol – volume: 5 start-page: e11468 year: 2010 ident: bib0390 article-title: Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice publication-title: PLoS ONE – volume: 141 start-page: 280 year: 2010 end-page: 289 ident: bib0190 article-title: Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations publication-title: Cell – volume: 24 start-page: 5052 year: 2010 end-page: 5062 ident: bib0730 article-title: TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia publication-title: FASEB J – volume: 25 start-page: 964 year: 1998 end-page: 972 ident: bib0510 article-title: Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy publication-title: Free Radic Biol Med – volume: 41 start-page: 110 year: 2010 end-page: 113 ident: bib0275 article-title: Ros-mediated activation of NF-kappaB and Foxo during muscle disuse publication-title: Muscle Nerve – volume: 5 start-page: e8670 year: 2010 ident: bib0870 article-title: Mitochondrial localization of vitamin D receptor in human platelets and differentiated megakaryocytes publication-title: PLoS ONE – volume: 2 start-page: 1 year: 2009 end-page: 16 ident: bib0640 article-title: Chronic fatigue syndrome and mitochondrial dysfunction publication-title: Int J Clin Exp Med – volume: 481 start-page: 511 year: 2012 end-page: 515 ident: bib0380 article-title: Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis publication-title: Nature – volume: 58 start-page: 99 year: 2012 end-page: 106 ident: bib0555 article-title: Apoptosis in skeletal myocytes: a potential target for interventions against sarcopenia and physical frailty – a mini-review publication-title: Gerontology – volume: 7 start-page: 706 year: 2008 end-page: 716 ident: bib0845 article-title: Mitochondrial iron accumulation with age and functional consequences publication-title: Aging Cell – volume: 57 start-page: M326 year: 2002 end-page: M332 ident: bib0990 article-title: Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study publication-title: J Gerontol A Biol Sci Med Sci – volume: 210 start-page: 93 year: 2011 end-page: 104 ident: bib0630 article-title: Subcellular effects of myocyte-specific androgen receptor overexpression in mice publication-title: J Endocrinol – volume: 8 start-page: e54716 year: 2013 ident: bib0865 article-title: Mitochondrial translocation of vitamin D receptor is mediated by the permeability transition pore in human keratinocyte cell line publication-title: PLoS ONE – volume: 285 start-page: 19460 year: 2010 end-page: 19471 ident: bib0080 article-title: Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy publication-title: J Biol Chem – volume: 54 start-page: 2685 year: 2005 end-page: 2693 ident: bib0035 article-title: Expression of Mfn2, the Charcot–Marie–Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6 publication-title: Diabetes – volume: 65 start-page: 119 year: 2010 end-page: 128 ident: bib0230 article-title: The effect of aging on human skeletal muscle mitochondrial and intramyocellular lipid ultrastructure publication-title: J Gerontol A Biol Sci Med Sci – volume: 50 start-page: 1947 year: 2002 end-page: 1954 ident: bib0300 article-title: Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels publication-title: J Am Geriatr Soc – volume: 13 start-page: 729 year: 2009 end-page: 732 ident: bib0895 article-title: Target population for clinical trials publication-title: J Nutr Health Aging – volume: 104 start-page: 1136 year: 2009 end-page: 1138 ident: bib0345 article-title: The ligand binding battle at cytochrome c oxidase: how NO regulates oxygen gradients in tissue publication-title: Circ Res – volume: 15 start-page: 1 year: 2010 end-page: 12 ident: bib0685 article-title: The age-dependent induction of apoptosis-inducing factor (AIF) in the human semitendinosus skeletal muscle publication-title: Cell Mol Biol Lett – volume: 14 start-page: 143 year: 2013 end-page: 151 ident: bib0905 article-title: Non-autophagic roles of autophagy-related proteins publication-title: EMBO Rep – volume: 20 start-page: 145 year: 1972 end-page: 147 ident: bib0375 article-title: The biologic clock: the mitochondria publication-title: J Am Geriatr Soc – volume: 292 start-page: C1569 year: 2007 end-page: C1580 ident: bib0130 article-title: Mitochondrial nitric oxide in the signaling of cell integrated responses publication-title: Am J Physiol Cell Physiol – volume: 9 start-page: 536 year: 2010 end-page: 544 ident: bib0240 article-title: Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria publication-title: Aging Cell – volume: 299 start-page: C203 year: 2010 end-page: C210 ident: bib0360 article-title: Autophagy in health and disease. 5. Mitophagy as a way of life publication-title: Am J Physiol Cell Physiol – year: 2013 ident: bib0245 article-title: Nitric oxide and energy metabolism in mammals publication-title: BioFactors – volume: 32 start-page: 656 year: 2008 end-page: 659 ident: bib0410 article-title: Inflammation: roles in aging and sarcopenia publication-title: J Parenter Enteral Nutr – volume: 282 start-page: H1843 year: 2002 end-page: H1854 ident: bib0625 article-title: Effects of aging on vasoconstrictor and mechanical properties of rat skeletal muscle arterioles publication-title: Am J Physiol Heart Circ Physiol – volume: 28 start-page: 1636 year: 2005 end-page: 1642 ident: bib0710 article-title: Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men publication-title: Diabetes Care – volume: 12 start-page: 503 year: 2010 end-page: 535 ident: bib0940 article-title: Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging publication-title: Antioxid Redox Signal – volume: 1800 start-page: 235 year: 2010 end-page: 244 ident: bib0570 article-title: Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy publication-title: Biochim Biophys Acta – volume: 102 start-page: 5618 year: 2005 end-page: 5623 ident: bib0855 article-title: Decline in skeletal muscle mitochondrial function with aging in humans publication-title: Proc Natl Acad Sci U S A – volume: 304 start-page: C422 year: 2013 end-page: C430 ident: bib0655 article-title: Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle publication-title: Am J Physiol Cell Physiol – volume: 304 start-page: R543 year: 2013 end-page: R552 ident: bib0675 article-title: Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues publication-title: Am J Physiol Regul Integr Comp Physiol – volume: 11 start-page: 133 year: 2011 end-page: 142 ident: bib0165 article-title: Vitamin D hormone: a multitude of actions potentially influencing the physical function decline in older persons publication-title: Geriatr Gerontol Int – volume: 143 start-page: 177 year: 2002 end-page: 184 ident: bib1020 article-title: Glucocorticoid hormone stimulates mitochondrial biogenesis specifically in skeletal muscle publication-title: Endocrinology – volume: 8 start-page: 517 year: 2006 end-page: 528 ident: bib0885 article-title: Exercise training attenuates age-induced changes in apoptotic signaling in rat skeletal muscle publication-title: Antioxid Redox Signal – volume: 50 start-page: 1231 year: 1989 end-page: 1233 ident: bib0755 article-title: Summary comments publication-title: Am J Clin Nutr – volume: 42 start-page: 391 year: 2013 end-page: 405 ident: bib0620 article-title: Frailty, sarcopenia, and hormones publication-title: Endocrinol Metab Clin North Am – volume: 67 start-page: 359 year: 2011 end-page: 370 ident: bib1000 article-title: Expression of nuclear-encoded genes involved in mitochondrial biogenesis and dynamics in experimentally denervated muscle publication-title: J Physiol Biochem – volume: 183 start-page: 795 year: 2008 end-page: 803 ident: bib0645 article-title: Parkin is recruited selectively to impaired mitochondria and promotes their autophagy publication-title: J Cell Biol – volume: 285 start-page: H1023 year: 2003 end-page: H1031 ident: bib0505 article-title: Vascular and metabolic response to isolated small muscle mass exercise: effect of age publication-title: Am J Physiol Heart Circ Physiol – volume: 105 start-page: 1889 year: 2008 end-page: 1896 ident: bib0385 article-title: Effects of antioxidants on contracting spinotrapezius muscle microvascular oxygenation and blood flow in aged rats publication-title: J Appl Physiol – volume: 87 start-page: 513 year: 2002 end-page: 523 ident: bib0485 article-title: GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men publication-title: J Clin Endocrinol Metab – volume: 248 start-page: 346 year: 1997 end-page: 354 ident: bib0980 article-title: Quantitative study of the effects of long-term denervation on the extensor digitorum longus muscle of the rat publication-title: Anat Rec – volume: 587 start-page: 3885 year: 2009 end-page: 3897 ident: bib0875 article-title: Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles publication-title: J Physiol – volume: 12 start-page: 403 year: 2011 end-page: 409 ident: bib0615 article-title: Sarcopenia with limited mobility: an international consensus publication-title: J Am Med Dir Assoc – volume: 7 start-page: e38812 year: 2012 ident: bib0815 article-title: Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation publication-title: PLoS ONE – volume: 103 start-page: 16260 year: 2006 end-page: 16265 ident: bib0830 article-title: PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription publication-title: Proc Natl Acad Sci U S A – volume: 11 start-page: 286 year: 2011 end-page: 297 ident: bib0975 article-title: Is the myonuclear domain size fixed? publication-title: J Musculoskelet Neuronal Interact – volume: 124 start-page: 325 year: 2013 end-page: 331 ident: bib0270 article-title: Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging publication-title: Clin Sci (Lond) – volume: 61 start-page: 245 year: 2006 end-page: 255 ident: bib0705 article-title: Molecular regulation of apoptosis in fast plantaris muscles of aged rats publication-title: J Gerontol A Biol Sci Med Sci – volume: 102 start-page: 2379 year: 2007 end-page: 2388 ident: bib0205 article-title: Hypoxia-induced reactive oxygen species formation in skeletal muscle publication-title: J Appl Physiol – volume: 15 start-page: 3003 year: 2009 end-page: 3026 ident: bib0255 article-title: An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging publication-title: Curr Pharm Des – volume: 452 start-page: 199 year: 2009 end-page: 213 ident: bib0435 article-title: Cytosolic LC3 ratio as a quantitative index of macroautophagy publication-title: Methods Enzymol – volume: 106 start-page: 326 year: 2009 end-page: 332 ident: bib0290 article-title: Vascular endothelial senescence: from mechanisms to pathophysiology publication-title: J Appl Physiol – volume: 8 start-page: 18 year: 2009 end-page: 30 ident: bib0200 article-title: Molecular inflammation: underpinnings of aging and age-related diseases publication-title: Ageing Res Rev – volume: 7 start-page: 187 year: 1986 end-page: 204 ident: bib0395 article-title: Exercise-induced ultrastructural changes in skeletal muscle publication-title: Int J Sports Med – volume: 60 start-page: 157 year: 2011 end-page: 167 ident: bib0530 article-title: Mitochondrial biogenesis and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation by physical activity: intact adipocytokine signaling is required publication-title: Diabetes – volume: 15 start-page: 450 year: 2011 end-page: 455 ident: bib0195 article-title: Sarcopenia: designing phase IIB trials publication-title: J Nutr Health Aging – volume: 112 start-page: 37 year: 2013 end-page: 48 ident: bib0465 article-title: Robustness and aging—a systems-level perspective publication-title: Biosystems – volume: 47 start-page: 69 year: 2010 end-page: 84 ident: bib0425 article-title: Regulation of mitochondrial biogenesis publication-title: Essays Biochem – volume: 35 start-page: 28 year: 2009 end-page: 35 ident: bib0580 article-title: Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction publication-title: BioFactors – volume: 48 start-page: 427 year: 2013 end-page: 436 ident: bib0535 article-title: Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats publication-title: Exp Gerontol – volume: 26 start-page: 2614 year: 2006 end-page: 2621 ident: bib0790 article-title: Hydrogen peroxide: a feed-forward dilator that couples myocardial metabolism to coronary blood flow publication-title: Arterioscler Thromb Vasc Biol – volume: 97 start-page: 242 year: 2012 end-page: 250 ident: bib0415 article-title: Ectopic lipid accumulation and reduced glucose tolerance in elderly adults are accompanied by altered skeletal muscle mitochondrial activity publication-title: J Clin Endocrinol Metab – volume: 64 start-page: 21 year: 2009 end-page: 33 ident: bib0310 article-title: Aging impairs skeletal muscle mitochondrial bioenergetic function publication-title: J Gerontol A Biol Sci Med Sci – volume: 590 start-page: 3305 year: 2012 end-page: 3316 ident: bib0495 article-title: Translational evidence that impaired autophagy contributes to arterial ageing publication-title: J Physiol – volume: 82 start-page: 428 year: 2005 end-page: 434 ident: bib0170 article-title: Sarcopenia, obesity, and inflammation—results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study publication-title: Am J Clin Nutr – volume: 64 start-page: 1039 year: 2009 end-page: 1044 ident: bib0945 article-title: Statement by the Growth Hormone Research Society on the GH/IGF-I axis in extending health span publication-title: J Gerontol A Biol Sci Med Sci – volume: 60 start-page: 210 year: 2008 end-page: 223 ident: bib0715 article-title: Steroid and thyroid hormone receptors in mitochondria publication-title: IUBMB Life – year: 2013 ident: bib0400 article-title: Expression of mitochondrial fission and fusion regulatory proteins in skeletal muscle during chronic use and disuse publication-title: Muscle Nerve – volume: 4 start-page: 166 year: 2012 end-page: 175 ident: bib0800 article-title: Inflammaging: disturbed interplay between autophagy and inflammasomes publication-title: Aging (Albany NY) – volume: 38 start-page: 710 year: 1989 end-page: 717 ident: bib0440 article-title: Insulinlike growth factor action and production in adipocytes and endothelial cells from human adipose tissue publication-title: Diabetes – volume: 54 start-page: 1480 year: 2011 end-page: 1490 ident: bib0660 article-title: Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells publication-title: Diabetologia – volume: 1763 start-page: 473 year: 2006 end-page: 481 ident: bib0835 article-title: Mitochondrial dynamics and aging: mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA publication-title: Biochim Biophys Acta – volume: 107 start-page: 1571 year: 2010 end-page: 1575 ident: bib0850 article-title: A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells publication-title: Proc Natl Acad Sci U S A – volume: 289 start-page: C994 year: 2005 end-page: C1001 ident: bib0010 article-title: Differential susceptibility of subsarcolemmal and intermyofibrillar mitochondria to apoptotic stimuli publication-title: Am J Physiol Cell Physiol – volume: 12 start-page: 668 year: 2010 end-page: 674 ident: bib0515 article-title: Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance publication-title: Cell Metab – volume: 35 start-page: 219 year: 1987 end-page: 224 ident: bib0050 article-title: Comparative morphological study of age related mitochondrial changes of the lymphocytes and skeletal muscle cells publication-title: Acta Morphol Hung – volume: 39 start-page: 701 year: 2004 end-page: 705 ident: bib0935 article-title: Myocyte aging and mitochondrial turnover publication-title: Exp Gerontol – volume: 94 start-page: 514 year: 1997 end-page: 519 ident: bib1055 article-title: Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress publication-title: Proc Natl Acad Sci U S A – volume: 75 start-page: 1081 year: 1993 end-page: 1087 ident: bib0725 article-title: Reactive oxygen in skeletal muscle. III. Contractility of unfatigued muscle publication-title: J Appl Physiol – volume: 16 start-page: 1323 year: 2012 end-page: 1367 ident: bib0370 article-title: Redox regulation of mitochondrial function publication-title: Antioxid Redox Signal – volume: 309 start-page: 481 year: 2005 end-page: 484 ident: bib0470 article-title: Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging publication-title: Science – volume: 269 start-page: 1996 year: 2002 end-page: 2002 ident: bib0085 article-title: The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis publication-title: Eur J Biochem – volume: 94 start-page: 1479 year: 2003 end-page: 1484 ident: bib1030 article-title: Reduced amount of mitochondrial DNA in aged human muscle publication-title: J Appl Physiol – volume: 1 start-page: 14 year: 2008 end-page: 23 ident: bib0155 article-title: Sarcopenia: current clinical and research issues publication-title: Open Geriatr Med J – volume: 61 start-page: 1369 year: 2009 end-page: 1374 ident: bib0985 article-title: Mitochondrial biogenesis in exercise and in ageing publication-title: Adv Drug Deliv Rev – volume: 16 start-page: 67 year: 2012 end-page: 77 ident: bib0040 article-title: How to assess functional status: a new muscle quality index publication-title: J Nutr Health Aging – volume: 285 start-page: H251 year: 2003 end-page: H258 ident: bib0770 article-title: Effects of aging on capillary geometry and hemodynamics in rat spinotrapezius muscle publication-title: Am J Physiol Heart Circ Physiol – volume: 58 start-page: 710 year: 2009 end-page: 717 ident: bib0610 article-title: Angiotensin II reduces mitochondrial content in skeletal muscle and affects glycemic control publication-title: Diabetes – volume: 11 start-page: 801 year: 2012 end-page: 809 ident: bib0430 article-title: The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals publication-title: Aging Cell – volume: 51 start-page: 881 year: 2011 end-page: 882 ident: bib0775 article-title: Mitofusin function is dependent on the distinct tissue and organ specific roles of mitochondria publication-title: J Mol Cell Cardiol – volume: 256 start-page: C1262 year: 1989 end-page: C1266 ident: bib0120 article-title: Muscle transplantation between young and old rats: age of host determines recovery publication-title: Am J Physiol – volume: 69 start-page: 58 year: 1990 end-page: 66 ident: bib0745 article-title: Rat hindlimb unloading: soleus histochemistry, ultrastructure, and electromyography publication-title: J Appl Physiol – volume: 119 start-page: 1284 year: 2009 end-page: 1292 ident: bib0700 article-title: Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans publication-title: Circulation – volume: 297 start-page: H1870 year: 2009 end-page: H1875 ident: bib1050 article-title: Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics publication-title: Am J Physiol Heart Circ Physiol – volume: 29 start-page: 154 year: 2010 end-page: 159 ident: bib0635 article-title: Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics” publication-title: Clin Nutr – volume: 54 start-page: 171 year: 1993 end-page: 178 ident: bib0650 article-title: Inflammation, immunoregulation, and inducible nitric oxide synthase publication-title: J Leukoc Biol – year: 2013 ident: bib0350 article-title: Bang-bang model for regulation of local blood flow publication-title: Microcirculation – volume: 268 start-page: E268 year: 1995 end-page: E276 ident: bib1060 article-title: Effect of growth hormone and resistance exercise on muscle growth and strength in older men publication-title: Am J Physiol – volume: 10 start-page: 806 year: 2011 end-page: 818 ident: bib0910 article-title: FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study publication-title: Lancet Neurol – volume: 24 start-page: 247 year: 2013 end-page: 256 ident: bib0420 article-title: Skeletal muscle aging and the mitochondrion publication-title: Trends Endocrinol Metab – volume: 113 start-page: 680 year: 2012 ident: bib0550 article-title: Is misuse of the term sarcopenia due to a lack of biomarkers? publication-title: J Appl Physiol – volume: 12 start-page: 368 year: 2002 end-page: 378 ident: bib0930 article-title: Muscle blood flow and mitochondrial function: influence of aging publication-title: Int J Sport Nutr Exerc Metab – volume: 294 start-page: R558 year: 2008 end-page: R567 ident: bib0565 article-title: Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats publication-title: Am J Physiol Regul Integr Comp Physiol – volume: 113 start-page: 290 year: 2012 end-page: 296 ident: bib0090 article-title: No change in myonuclear number during muscle unloading and reloading publication-title: J Appl Physiol – volume: 13 start-page: 1637 year: 1999 end-page: 1646 ident: bib0060 article-title: Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia publication-title: FASEB J – volume: 51 start-page: B43 year: 1996 end-page: B49 ident: bib0125 article-title: The regeneration of noninnervated muscle grafts and marcaine-treated muscles in young and old rats publication-title: J Gerontol A Biol Sci Med Sci – volume: 8 start-page: 445 year: 2012 end-page: 544 ident: bib0445 article-title: Guidelines for the use and interpretation of assays for monitoring autophagy publication-title: Autophagy – volume: 35 start-page: 1061 year: 2013 end-page: 1075 ident: bib0560 article-title: Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle publication-title: Age (Dordr) – volume: 342 start-page: 1 year: 2011 end-page: 7 ident: bib1025 article-title: Coordination of mitochondrial biogenesis by thyroid hormone publication-title: Mol Cell Endocrinol – volume: 45 start-page: 138 year: 2010 end-page: 148 ident: bib1045 article-title: Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise publication-title: Exp Gerontol – volume: 27 start-page: 433 year: 2008 end-page: 446 ident: bib0950 article-title: Fission and selective fusion govern mitochondrial segregation and elimination by autophagy publication-title: EMBO J – volume: 129 start-page: 542 year: 2008 end-page: 549 ident: bib0595 article-title: Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle publication-title: Mech Ageing Dev – volume: 433 start-page: 760 year: 2005 end-page: 764 ident: bib0220 article-title: Rejuvenation of aged progenitor cells by exposure to a young systemic environment publication-title: Nature – volume: 22 start-page: 1350 year: 1999 end-page: 1360 ident: bib0015 article-title: Myonuclear domains in muscle adaptation and disease publication-title: Muscle Nerve – year: 2013 ident: bib0480 article-title: Nonsteroidal anti-inflammatory drug (NSAID) use and sarcopenia in older people: results from the ilSIRENTE Study publication-title: J Am Med Dir Assoc – volume: 288 start-page: C1074 year: 2005 end-page: C1082 ident: bib0460 article-title: Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism publication-title: Am J Physiol Cell Physiol – volume: 192 start-page: 1731 year: 2000 end-page: 1744 ident: bib0970 article-title: Enhanced peroxynitrite formation is associated with vascular aging publication-title: J Exp Med – volume: 13 start-page: 322 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0330 article-title: Non-apoptotic functions of apoptosis-regulatory proteins publication-title: EMBO Rep doi: 10.1038/embor.2012.19 – volume: 1763 start-page: 473 year: 2006 ident: 10.1016/j.biocel.2013.06.024_bib0835 article-title: Mitochondrial dynamics and aging: mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2006.03.001 – volume: 256 start-page: C1262 year: 1989 ident: 10.1016/j.biocel.2013.06.024_bib0120 article-title: Muscle transplantation between young and old rats: age of host determines recovery publication-title: Am J Physiol doi: 10.1152/ajpcell.1989.256.6.C1262 – volume: 9 start-page: 369 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0105 article-title: Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy publication-title: Ageing Res Rev doi: 10.1016/j.arr.2010.04.004 – volume: 8 start-page: 517 year: 2006 ident: 10.1016/j.biocel.2013.06.024_bib0885 article-title: Exercise training attenuates age-induced changes in apoptotic signaling in rat skeletal muscle publication-title: Antioxid Redox Signal doi: 10.1089/ars.2006.8.517 – volume: 24 start-page: 5052 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0730 article-title: TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia publication-title: FASEB J – volume: 12 start-page: 503 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0940 article-title: Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging publication-title: Antioxid Redox Signal doi: 10.1089/ars.2009.2598 – volume: 68 start-page: 447 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0210 article-title: Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/gls196 – volume: 25 start-page: 964 year: 1998 ident: 10.1016/j.biocel.2013.06.024_bib0510 article-title: Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(98)00185-3 – volume: 119 start-page: 1284 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0700 article-title: Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.108.804294 – volume: 10 start-page: 3142 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0295 article-title: Subsarcolemmal and intermyofibrillar mitochondria proteome differences disclose functional specializations in skeletal muscle publication-title: Proteomics doi: 10.1002/pmic.201000173 – volume: 1 start-page: 20 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0025 article-title: From isolated to networked: a paradigmatic shift in mitochondrial physiology publication-title: Front Physiol – volume: 12 start-page: 470 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0175 article-title: Target population for clinical trials on sarcopenia publication-title: J Nutr Health Aging doi: 10.1007/BF02982708 – volume: 2 start-page: 1 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0640 article-title: Chronic fatigue syndrome and mitochondrial dysfunction publication-title: Int J Clin Exp Med – volume: 13 start-page: 547 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0765 article-title: “SR stress” in mixed hindlimb muscles of aging male rats publication-title: Biogerontology doi: 10.1007/s10522-012-9399-y – volume: 11 start-page: 286 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0975 article-title: Is the myonuclear domain size fixed? publication-title: J Musculoskelet Neuronal Interact – volume: 26 start-page: 2614 year: 2006 ident: 10.1016/j.biocel.2013.06.024_bib0790 article-title: Hydrogen peroxide: a feed-forward dilator that couples myocardial metabolism to coronary blood flow publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000249408.55796.da – volume: 22 start-page: 1350 year: 1999 ident: 10.1016/j.biocel.2013.06.024_bib0015 article-title: Myonuclear domains in muscle adaptation and disease publication-title: Muscle Nerve doi: 10.1002/(SICI)1097-4598(199910)22:10<1350::AID-MUS3>3.0.CO;2-8 – volume: 42 start-page: 391 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0620 article-title: Frailty, sarcopenia, and hormones publication-title: Endocrinol Metab Clin North Am doi: 10.1016/j.ecl.2013.02.006 – volume: 113 start-page: 115 year: 2004 ident: 10.1016/j.biocel.2013.06.024_bib0285 article-title: Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions publication-title: J Clin Invest doi: 10.1172/JCI18330 – volume: 118 start-page: 1450 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0095 article-title: In vivo time-lapse microscopy reveals no loss of murine myonuclei during weeks of muscle atrophy publication-title: J Clin Invest doi: 10.1172/JCI34022 – volume: 102 start-page: 2379 year: 2007 ident: 10.1016/j.biocel.2013.06.024_bib0205 article-title: Hypoxia-induced reactive oxygen species formation in skeletal muscle publication-title: J Appl Physiol doi: 10.1152/japplphysiol.01298.2006 – volume: 10 start-page: 806 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0910 article-title: FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study publication-title: Lancet Neurol doi: 10.1016/S1474-4422(11)70155-7 – volume: 183 start-page: 795 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0645 article-title: Parkin is recruited selectively to impaired mitochondria and promotes their autophagy publication-title: J Cell Biol doi: 10.1083/jcb.200809125 – volume: 39 start-page: 412 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0235 article-title: Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People publication-title: Age Ageing doi: 10.1093/ageing/afq034 – year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0400 article-title: Expression of mitochondrial fission and fusion regulatory proteins in skeletal muscle during chronic use and disuse publication-title: Muscle Nerve doi: 10.1002/mus.23838 – volume: 297 start-page: 1772 year: 2007 ident: 10.1016/j.biocel.2013.06.024_bib0455 article-title: Effect of 10 days of bed rest on skeletal muscle in healthy older adults publication-title: J Am Med Assoc doi: 10.1001/jama.297.16.1772-b – volume: 102 start-page: 5618 year: 2005 ident: 10.1016/j.biocel.2013.06.024_bib0855 article-title: Decline in skeletal muscle mitochondrial function with aging in humans publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0501559102 – volume: 209 start-page: 468 year: 2006 ident: 10.1016/j.biocel.2013.06.024_bib1065 article-title: Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1 publication-title: J Cell Physiol doi: 10.1002/jcp.20753 – volume: 28 start-page: 1636 year: 2005 ident: 10.1016/j.biocel.2013.06.024_bib0710 article-title: Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men publication-title: Diabetes Care doi: 10.2337/diacare.28.7.1636 – volume: 97 start-page: 242 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0415 article-title: Ectopic lipid accumulation and reduced glucose tolerance in elderly adults are accompanied by altered skeletal muscle mitochondrial activity publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2011-1798 – volume: 1800 start-page: 235 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0570 article-title: Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy publication-title: Biochim Biophys Acta doi: 10.1016/j.bbagen.2009.05.007 – volume: 67 start-page: 359 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib1000 article-title: Expression of nuclear-encoded genes involved in mitochondrial biogenesis and dynamics in experimentally denervated muscle publication-title: J Physiol Biochem doi: 10.1007/s13105-011-0083-5 – volume: 54 start-page: 171 year: 1993 ident: 10.1016/j.biocel.2013.06.024_bib0650 article-title: Inflammation, immunoregulation, and inducible nitric oxide synthase publication-title: J Leukoc Biol doi: 10.1002/jlb.54.2.171 – volume: 2012 start-page: 316943 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0150 article-title: Rationale for antioxidant supplementation in sarcopenia publication-title: J Aging Res doi: 10.1155/2012/316943 – volume: 106 start-page: 20405 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib1035 article-title: Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0911570106 – volume: 113 start-page: 290 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0090 article-title: No change in myonuclear number during muscle unloading and reloading publication-title: J Appl Physiol doi: 10.1152/japplphysiol.00436.2012 – volume: 87 start-page: 513 year: 2002 ident: 10.1016/j.biocel.2013.06.024_bib0485 article-title: GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.87.2.8206 – volume: 106 start-page: 326 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0290 article-title: Vascular endothelial senescence: from mechanisms to pathophysiology publication-title: J Appl Physiol doi: 10.1152/japplphysiol.91353.2008 – volume: 13 start-page: 822 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0070 article-title: Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice publication-title: Apoptosis doi: 10.1007/s10495-008-0216-7 – volume: 60 start-page: 157 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0530 article-title: Mitochondrial biogenesis and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation by physical activity: intact adipocytokine signaling is required publication-title: Diabetes doi: 10.2337/db10-0331 – volume: 143 start-page: 177 year: 2002 ident: 10.1016/j.biocel.2013.06.024_bib1020 article-title: Glucocorticoid hormone stimulates mitochondrial biogenesis specifically in skeletal muscle publication-title: Endocrinology doi: 10.1210/endo.143.1.8600 – volume: 82 start-page: 428 year: 2005 ident: 10.1016/j.biocel.2013.06.024_bib0170 article-title: Sarcopenia, obesity, and inflammation—results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study publication-title: Am J Clin Nutr doi: 10.1093/ajcn/82.2.428 – volume: 51 start-page: B43 year: 1996 ident: 10.1016/j.biocel.2013.06.024_bib0125 article-title: The regeneration of noninnervated muscle grafts and marcaine-treated muscles in young and old rats publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/51A.1.B43 – volume: 452 start-page: 199 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0435 article-title: Cytosolic LC3 ratio as a quantitative index of macroautophagy publication-title: Methods Enzymol doi: 10.1016/S0076-6879(08)03613-6 – volume: 45 start-page: 138 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib1045 article-title: Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise publication-title: Exp Gerontol doi: 10.1016/j.exger.2009.11.002 – volume: 15 start-page: 5001 year: 2004 ident: 10.1016/j.biocel.2013.06.024_bib0520 article-title: Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis publication-title: Mol Biol Cell doi: 10.1091/mbc.e04-04-0294 – volume: 5 start-page: e11468 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0390 article-title: Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice publication-title: PLoS ONE doi: 10.1371/journal.pone.0011468 – volume: 587 start-page: 5483 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0740 article-title: Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats publication-title: J Physiol doi: 10.1113/jphysiol.2009.178319 – volume: 114 start-page: 808 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0250 article-title: Differential effects of aging and exercise on intra-abdominal adipose arteriolar function and blood flow regulation publication-title: J Appl Physiol doi: 10.1152/japplphysiol.01358.2012 – volume: 14 start-page: 143 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0905 article-title: Non-autophagic roles of autophagy-related proteins publication-title: EMBO Rep doi: 10.1038/embor.2012.220 – year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib1015 article-title: Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell pool publication-title: Hum Mol Genet doi: 10.1093/hmg/ddt251 – volume: 12 start-page: 37 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0215 article-title: Skeletal muscle proteolysis in aging publication-title: Curr Opin Clin Nutr Metab Care – volume: 8 start-page: 445 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0445 article-title: Guidelines for the use and interpretation of assays for monitoring autophagy publication-title: Autophagy doi: 10.4161/auto.19496 – volume: 94 start-page: 491 year: 1998 ident: 10.1016/j.biocel.2013.06.024_bib0525 article-title: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis publication-title: Cell doi: 10.1016/S0092-8674(00)81590-1 – volume: 282 start-page: H1843 year: 2002 ident: 10.1016/j.biocel.2013.06.024_bib0625 article-title: Effects of aging on vasoconstrictor and mechanical properties of rat skeletal muscle arterioles publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00666.2001 – volume: 58 start-page: 99 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0555 article-title: Apoptosis in skeletal myocytes: a potential target for interventions against sarcopenia and physical frailty – a mini-review publication-title: Gerontology doi: 10.1159/000330064 – volume: 12 start-page: 249 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0305 article-title: Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International Working Group on Sarcopenia publication-title: J Am Med Dir Assoc doi: 10.1016/j.jamda.2011.01.003 – volume: 61 start-page: 1369 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0985 article-title: Mitochondrial biogenesis in exercise and in ageing publication-title: Adv Drug Deliv Rev doi: 10.1016/j.addr.2009.06.006 – volume: 100 start-page: 7996 year: 2003 ident: 10.1016/j.biocel.2013.06.024_bib0900 article-title: Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1332551100 – volume: 27 start-page: 387 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0995 article-title: Consequences of sarcopenia publication-title: Clin Geriatr Med doi: 10.1016/j.cger.2011.03.006 – year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0245 article-title: Nitric oxide and energy metabolism in mammals publication-title: BioFactors doi: 10.1002/biof.1099 – volume: 526 start-page: 203 issue: Pt 1 year: 2000 ident: 10.1016/j.biocel.2013.06.024_bib0225 article-title: Oxidative capacity and ageing in human muscle publication-title: J Physiol doi: 10.1111/j.1469-7793.2000.t01-1-00203.x – volume: 124 start-page: 325 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0270 article-title: Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging publication-title: Clin Sci (Lond) doi: 10.1042/CS20120291 – volume: 47 start-page: 69 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0425 article-title: Regulation of mitochondrial biogenesis publication-title: Essays Biochem doi: 10.1042/bse0470069 – volume: 11 start-page: 133 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0165 article-title: Vitamin D hormone: a multitude of actions potentially influencing the physical function decline in older persons publication-title: Geriatr Gerontol Int doi: 10.1111/j.1447-0594.2010.00668.x – volume: 1 start-page: 97 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0545 article-title: Imaging, functional and biological markers for sarcopenia: the pursuit of the golden ratio publication-title: J Frailty Aging – volume: 16 start-page: 67 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0040 article-title: How to assess functional status: a new muscle quality index publication-title: J Nutr Health Aging doi: 10.1007/s12603-012-0004-5 – volume: 55 start-page: 3309 year: 2006 ident: 10.1016/j.biocel.2013.06.024_bib0030 article-title: Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia publication-title: Diabetes doi: 10.2337/db05-1230 – volume: 35 start-page: 1061 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0560 article-title: Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle publication-title: Age (Dordr) doi: 10.1007/s11357-012-9428-4 – volume: 216 start-page: 331 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0475 article-title: Estradiol exerts antiapoptotic effects in skeletal myoblasts via mitochondrial PTP and MnSOD publication-title: J Endocrinol doi: 10.1530/JOE-12-0486 – volume: 75 start-page: 1081 year: 1993 ident: 10.1016/j.biocel.2013.06.024_bib0725 article-title: Reactive oxygen in skeletal muscle. III. Contractility of unfatigued muscle publication-title: J Appl Physiol doi: 10.1152/jappl.1993.75.3.1081 – volume: 12 start-page: 368 year: 2002 ident: 10.1016/j.biocel.2013.06.024_bib0930 article-title: Muscle blood flow and mitochondrial function: influence of aging publication-title: Int J Sport Nutr Exerc Metab doi: 10.1123/ijsnem.12.3.368 – volume: 94 start-page: 514 year: 1997 ident: 10.1016/j.biocel.2013.06.024_bib1055 article-title: Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.94.2.514 – volume: 293 start-page: H37 year: 2007 ident: 10.1016/j.biocel.2013.06.024_bib0965 article-title: Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.01346.2006 – volume: 192 start-page: 1731 year: 2000 ident: 10.1016/j.biocel.2013.06.024_bib0970 article-title: Enhanced peroxynitrite formation is associated with vascular aging publication-title: J Exp Med doi: 10.1084/jem.192.12.1731 – volume: 7 start-page: 2 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0180 article-title: Mitochondrial function and apoptotic susceptibility in aging skeletal muscle publication-title: Aging Cell doi: 10.1111/j.1474-9726.2007.00347.x – year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0480 article-title: Nonsteroidal anti-inflammatory drug (NSAID) use and sarcopenia in older people: results from the ilSIRENTE Study publication-title: J Am Med Dir Assoc doi: 10.1016/j.jamda.2013.04.012 – volume: 64 start-page: 21 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0310 article-title: Aging impairs skeletal muscle mitochondrial bioenergetic function publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/gln048 – volume: 11 start-page: 801 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0430 article-title: The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals publication-title: Aging Cell doi: 10.1111/j.1474-9726.2012.00844.x – volume: 590 start-page: 3305 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0495 article-title: Translational evidence that impaired autophagy contributes to arterial ageing publication-title: J Physiol doi: 10.1113/jphysiol.2012.229690 – volume: 94 start-page: 1479 year: 2003 ident: 10.1016/j.biocel.2013.06.024_bib1030 article-title: Reduced amount of mitochondrial DNA in aged human muscle publication-title: J Appl Physiol doi: 10.1152/japplphysiol.01061.2002 – volume: 12 start-page: 668 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0515 article-title: Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance publication-title: Cell Metab doi: 10.1016/j.cmet.2010.11.004 – year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0825 article-title: Protein breakdown in muscle wasting: role of autophagy–lysosome and ubiquitin–proteasome publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2013.04.023 – volume: 7 start-page: 706 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0845 article-title: Mitochondrial iron accumulation with age and functional consequences publication-title: Aging Cell doi: 10.1111/j.1474-9726.2008.00418.x – volume: 1 start-page: 515 year: 2001 ident: 10.1016/j.biocel.2013.06.024_bib0315 article-title: The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis publication-title: Dev Cell doi: 10.1016/S1534-5807(01)00055-7 – volume: 103 start-page: 16260 year: 2006 ident: 10.1016/j.biocel.2013.06.024_bib0830 article-title: PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0607795103 – volume: 79 start-page: 469 year: 2006 ident: 10.1016/j.biocel.2013.06.024_bib0100 article-title: Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers publication-title: Am J Hum Genet doi: 10.1086/507132 – volume: 10 start-page: 340 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0590 article-title: Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging publication-title: ScientificWorldJournal doi: 10.1100/tsw.2010.27 – volume: 289 start-page: C994 year: 2005 ident: 10.1016/j.biocel.2013.06.024_bib0010 article-title: Differential susceptibility of subsarcolemmal and intermyofibrillar mitochondria to apoptotic stimuli publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.00031.2005 – volume: 61 start-page: 245 year: 2006 ident: 10.1016/j.biocel.2013.06.024_bib0705 article-title: Molecular regulation of apoptosis in fast plantaris muscles of aged rats publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/61.3.245 – volume: 107 start-page: 1571 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0850 article-title: A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0906039107 – volume: 303 start-page: R127 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0450 article-title: Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00337.2011 – volume: 283 start-page: C66 year: 2002 ident: 10.1016/j.biocel.2013.06.024_bib0020 article-title: Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.00598.2001 – volume: 9 start-page: 536 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0240 article-title: Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria publication-title: Aging Cell doi: 10.1111/j.1474-9726.2010.00581.x – volume: 45 start-page: 11 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0260 article-title: Insulin resistance and mitochondrial function in skeletal muscle publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2012.09.019 – volume: 298 start-page: C572 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0335 article-title: PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.00481.2009 – volume: 12 start-page: 211 year: 1985 ident: 10.1016/j.biocel.2013.06.024_bib0185 article-title: The control of cell mass and replication. The DNA unit—a personal 20-year study publication-title: Early Hum Dev doi: 10.1016/0378-3782(85)90144-6 – volume: 15 start-page: 322 year: 2001 ident: 10.1016/j.biocel.2013.06.024_bib1005 article-title: Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia publication-title: FASEB J doi: 10.1096/fj.00-0320com – volume: 15 start-page: 575 year: 1980 ident: 10.1016/j.biocel.2013.06.024_bib0605 article-title: Mitochondrial role in cell aging publication-title: Exp Gerontol doi: 10.1016/0531-5565(80)90010-8 – volume: 104 start-page: 249 year: 1978 ident: 10.1016/j.biocel.2013.06.024_bib0670 article-title: Skeletal muscle metabolism and ultrastructure in relation to age in sedentary men publication-title: Acta Physiol Scand doi: 10.1111/j.1748-1716.1978.tb06277.x – volume: 146 start-page: 259 year: 2005 ident: 10.1016/j.biocel.2013.06.024_bib0045 article-title: Effects of aging on microvascular oxygen pressures in rat skeletal muscle publication-title: Respir Physiol Neurobiol doi: 10.1016/j.resp.2004.12.009 – volume: 294 start-page: H2121 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0960 article-title: Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00012.2008 – volume: 129 start-page: 542 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0595 article-title: Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle publication-title: Mech Ageing Dev doi: 10.1016/j.mad.2008.05.005 – volume: 20 start-page: 145 year: 1972 ident: 10.1016/j.biocel.2013.06.024_bib0375 article-title: The biologic clock: the mitochondria publication-title: J Am Geriatr Soc doi: 10.1111/j.1532-5415.1972.tb00787.x – volume: 248 start-page: 346 year: 1997 ident: 10.1016/j.biocel.2013.06.024_bib0980 article-title: Quantitative study of the effects of long-term denervation on the extensor digitorum longus muscle of the rat publication-title: Anat Rec doi: 10.1002/(SICI)1097-0185(199707)248:3<346::AID-AR7>3.0.CO;2-N – volume: 481 start-page: 511 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0380 article-title: Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis publication-title: Nature doi: 10.1038/nature10758 – volume: 12 start-page: 3161 year: 2006 ident: 10.1016/j.biocel.2013.06.024_bib0810 article-title: Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology publication-title: Curr Pharm Des doi: 10.2174/138161206777947470 – volume: 56 start-page: M146 year: 2001 ident: 10.1016/j.biocel.2013.06.024_bib0320 article-title: Frailty in older adults: evidence for a phenotype publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/56.3.M146 – volume: 29 start-page: 154 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0635 article-title: Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics” publication-title: Clin Nutr doi: 10.1016/j.clnu.2009.12.004 – volume: 394 start-page: 393 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0110 article-title: Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy publication-title: Biol Chem doi: 10.1515/hsz-2012-0247 – volume: 464 start-page: 1313 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0405 article-title: Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1 publication-title: Nature doi: 10.1038/nature08991 – volume: 29 start-page: 1774 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0750 article-title: Mitochondrial fission and remodelling contributes to muscle atrophy publication-title: EMBO J doi: 10.1038/emboj.2010.60 – volume: 57 start-page: 2933 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0490 article-title: Endurance exercise as a countermeasure for aging publication-title: Diabetes doi: 10.2337/db08-0349 – volume: 269 start-page: 1996 year: 2002 ident: 10.1016/j.biocel.2013.06.024_bib0085 article-title: The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis publication-title: Eur J Biochem doi: 10.1046/j.1432-1033.2002.02869.x – volume: 118 start-page: 265 year: 2005 ident: 10.1016/j.biocel.2013.06.024_bib0500 article-title: Death receptor signaling publication-title: J Cell Sci doi: 10.1242/jcs.01610 – volume: 7 start-page: e38812 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0815 article-title: Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation publication-title: PLoS ONE doi: 10.1371/journal.pone.0038812 – volume: 304 start-page: R543 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0675 article-title: Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00567.2012 – volume: 58 start-page: 710 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0610 article-title: Angiotensin II reduces mitochondrial content in skeletal muscle and affects glycemic control publication-title: Diabetes doi: 10.2337/db08-0949 – volume: 57 start-page: M326 year: 2002 ident: 10.1016/j.biocel.2013.06.024_bib0990 article-title: Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/57.5.M326 – volume: 97 start-page: 165 year: 2004 ident: 10.1016/j.biocel.2013.06.024_bib0265 article-title: Effect of age on O(2) uptake kinetics and the adaptation of muscle deoxygenation at the onset of moderate-intensity cycling exercise publication-title: J Appl Physiol doi: 10.1152/japplphysiol.01179.2003 – volume: 33 start-page: 167 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0135 article-title: Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 x Brown Norway rats publication-title: Age (Dordr) doi: 10.1007/s11357-010-9196-y – volume: 2012 start-page: 127362 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0795 article-title: Sarcopenia and age-related endocrine function publication-title: Int J Endocrinol doi: 10.1155/2012/127362 – volume: 15 start-page: 890 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0005 article-title: Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction publication-title: J Nutr Health Aging doi: 10.1007/s12603-011-0366-0 – volume: 79 start-page: 1361 year: 1994 ident: 10.1016/j.biocel.2013.06.024_bib0920 article-title: Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men publication-title: J Clin Endocrinol Metab – volume: 309 start-page: 481 year: 2005 ident: 10.1016/j.biocel.2013.06.024_bib0470 article-title: Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging publication-title: Science doi: 10.1126/science.1112125 – volume: 14 start-page: 779 year: 2007 ident: 10.1016/j.biocel.2013.06.024_bib0540 article-title: Hydrogen peroxide-dependent arteriolar dilation in contracting muscle of rats fed normal and high salt diets publication-title: Microcirculation doi: 10.1080/10739680701444057 – volume: 51 start-page: 881 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0775 article-title: Mitofusin function is dependent on the distinct tissue and organ specific roles of mitochondria publication-title: J Mol Cell Cardiol doi: 10.1016/j.yjmcc.2011.09.004 – volume: 59 start-page: 530 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0075 article-title: Considerations in the development of drugs to treat sarcopenia publication-title: J Am Geriatr Soc doi: 10.1111/j.1532-5415.2010.03285.x – volume: 1237 start-page: 95 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0600 article-title: Translational musculoskeletal science: is sarcopenia the next clinical target after osteoporosis publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.2011.06236.x – volume: 41 start-page: 110 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0275 article-title: Ros-mediated activation of NF-kappaB and Foxo during muscle disuse publication-title: Muscle Nerve doi: 10.1002/mus.21526 – volume: 60 start-page: 210 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0715 article-title: Steroid and thyroid hormone receptors in mitochondria publication-title: IUBMB Life doi: 10.1002/iub.37 – volume: 151 start-page: 1319 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0760 article-title: A PGC-1alpha isoform induced by resistance training regulates skeletal muscle hypertrophy publication-title: Cell doi: 10.1016/j.cell.2012.10.050 – volume: 105 start-page: 1889 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0385 article-title: Effects of antioxidants on contracting spinotrapezius muscle microvascular oxygenation and blood flow in aged rats publication-title: J Appl Physiol doi: 10.1152/japplphysiol.90642.2008 – volume: 1 start-page: 102 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0160 article-title: Biomarkers of sarcopenia in clinical trials. Recommendations from the International Working Group on Sarcopenia publication-title: J Frailty Aging – volume: 293 start-page: H3720 year: 2007 ident: 10.1016/j.biocel.2013.06.024_bib0785 article-title: Redox-dependent coronary metabolic dilation publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00436.2007 – volume: 15 start-page: 3003 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0255 article-title: An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging publication-title: Curr Pharm Des doi: 10.2174/138161209789058110 – volume: 32 start-page: 656 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0410 article-title: Inflammation: roles in aging and sarcopenia publication-title: J Parenter Enteral Nutr doi: 10.1177/0148607108324585 – volume: 2 start-page: 38 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0115 article-title: Current nutritional recommendations and novel dietary strategies to manage sarcopenia publication-title: J Frailty Aging – volume: 38 start-page: 710 year: 1989 ident: 10.1016/j.biocel.2013.06.024_bib0440 article-title: Insulinlike growth factor action and production in adipocytes and endothelial cells from human adipose tissue publication-title: Diabetes doi: 10.2337/diab.38.6.710 – volume: 50 start-page: 1947 year: 2002 ident: 10.1016/j.biocel.2013.06.024_bib0300 article-title: Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels publication-title: J Am Geriatr Soc doi: 10.1046/j.1532-5415.2002.50605.x – volume: 104 start-page: 1136 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0345 article-title: The ligand binding battle at cytochrome c oxidase: how NO regulates oxygen gradients in tissue publication-title: Circ Res doi: 10.1161/CIRCRESAHA.109.198911 – volume: 285 start-page: H251 year: 2003 ident: 10.1016/j.biocel.2013.06.024_bib0770 article-title: Effects of aging on capillary geometry and hemodynamics in rat spinotrapezius muscle publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.01086.2002 – volume: 15 start-page: 450 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0195 article-title: Sarcopenia: designing phase IIB trials publication-title: J Nutr Health Aging doi: 10.1007/s12603-011-0092-7 – volume: 2 start-page: 55 year: 2002 ident: 10.1016/j.biocel.2013.06.024_bib0840 article-title: A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis publication-title: Dev Cell doi: 10.1016/S1534-5807(01)00116-2 – volume: 342 start-page: 1 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib1025 article-title: Coordination of mitochondrial biogenesis by thyroid hormone publication-title: Mol Cell Endocrinol doi: 10.1016/j.mce.2011.05.009 – volume: 8 start-page: e54716 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0865 article-title: Mitochondrial translocation of vitamin D receptor is mediated by the permeability transition pore in human keratinocyte cell line publication-title: PLoS ONE doi: 10.1371/journal.pone.0054716 – volume: 337 start-page: 1062 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib1070 article-title: Mitochondrial fission, fusion, and stress publication-title: Science doi: 10.1126/science.1219855 – volume: 268 start-page: E268 year: 1995 ident: 10.1016/j.biocel.2013.06.024_bib1060 article-title: Effect of growth hormone and resistance exercise on muscle growth and strength in older men publication-title: Am J Physiol – volume: 48 start-page: 427 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0535 article-title: Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats publication-title: Exp Gerontol doi: 10.1016/j.exger.2013.02.009 – volume: 35 start-page: 219 year: 1987 ident: 10.1016/j.biocel.2013.06.024_bib0050 article-title: Comparative morphological study of age related mitochondrial changes of the lymphocytes and skeletal muscle cells publication-title: Acta Morphol Hung – volume: 13 start-page: 1637 year: 1999 ident: 10.1016/j.biocel.2013.06.024_bib0060 article-title: Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia publication-title: FASEB J doi: 10.1096/fasebj.13.12.1637 – volume: 15 start-page: 725 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0680 article-title: Designing Phase II B trials in sarcopenia: the best target population publication-title: J Nutr Health Aging doi: 10.1007/s12603-011-0058-9 – volume: 28 start-page: 1073 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0805 article-title: The peculiar apoptotic behavior of skeletal muscle cells publication-title: Histol Histopathol – volume: 5 start-page: e8670 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0870 article-title: Mitochondrial localization of vitamin D receptor in human platelets and differentiated megakaryocytes publication-title: PLoS ONE doi: 10.1371/journal.pone.0008670 – volume: 113 start-page: 680 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0550 article-title: Is misuse of the term sarcopenia due to a lack of biomarkers? publication-title: J Appl Physiol – volume: 286 start-page: E92 year: 2004 ident: 10.1016/j.biocel.2013.06.024_bib0860 article-title: Age and aerobic exercise training effects on whole body and muscle protein metabolism publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00366.2003 – volume: 16 start-page: 1323 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0370 article-title: Redox regulation of mitochondrial function publication-title: Antioxid Redox Signal doi: 10.1089/ars.2011.4123 – volume: 10 start-page: 1047 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0695 article-title: Alterations in intrinsic mitochondrial function with aging are fiber type-specific and do not explain differential atrophy between muscles publication-title: Aging Cell doi: 10.1111/j.1474-9726.2011.00745.x – volume: 112 start-page: 2487 year: 2005 ident: 10.1016/j.biocel.2013.06.024_bib0915 article-title: Endogenous vascular hydrogen peroxide regulates arteriolar tension in vivo publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.105.543157 – volume: 65 start-page: 119 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0230 article-title: The effect of aging on human skeletal muscle mitochondrial and intramyocellular lipid ultrastructure publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/glp179 – volume: 64 start-page: 1039 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0945 article-title: Statement by the Growth Hormone Research Society on the GH/IGF-I axis in extending health span publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/glp091 – volume: 141 start-page: 280 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0190 article-title: Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations publication-title: Cell doi: 10.1016/j.cell.2010.02.026 – volume: 129 start-page: 593 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0340 article-title: Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults publication-title: Mech Ageing Dev doi: 10.1016/j.mad.2008.08.001 – volume: 294 start-page: R558 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0565 article-title: Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00620.2007 – volume: 12 start-page: 403 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0615 article-title: Sarcopenia with limited mobility: an international consensus publication-title: J Am Med Dir Assoc doi: 10.1016/j.jamda.2011.04.014 – volume: 13 start-page: 729 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0895 article-title: Target population for clinical trials publication-title: J Nutr Health Aging doi: 10.1007/s12603-009-0205-8 – volume: 4 start-page: 166 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0800 article-title: Inflammaging: disturbed interplay between autophagy and inflammasomes publication-title: Aging (Albany NY) doi: 10.18632/aging.100444 – volume: 93 start-page: 597 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib1075 article-title: Enhancement of muscle mitochondrial function by growth hormone publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2007-1814 – volume: 15 start-page: 1 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0685 article-title: The age-dependent induction of apoptosis-inducing factor (AIF) in the human semitendinosus skeletal muscle publication-title: Cell Mol Biol Lett doi: 10.2478/s11658-009-0030-4 – volume: 50 start-page: 1231 year: 1989 ident: 10.1016/j.biocel.2013.06.024_bib0755 article-title: Summary comments publication-title: Am J Clin Nutr doi: 10.1093/ajcn/50.5.1231 – volume: 210 start-page: 93 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0630 article-title: Subcellular effects of myocyte-specific androgen receptor overexpression in mice publication-title: J Endocrinol doi: 10.1530/JOE-11-0071 – volume: 304 start-page: C422 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0655 article-title: Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.00240.2012 – volume: 2 start-page: 92 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0925 article-title: Myonuclear domain in skeletal muscle fibers. A critical review publication-title: Archives of Exercise in Health and Disease doi: 10.5628/aehd.v2i2.24 – volume: 7 start-page: e51180 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0365 article-title: Testosterone plus low-intensity physical training in late life improves functional performance, skeletal muscle mitochondrial biogenesis, and mitochondrial quality control in male mice publication-title: PLoS ONE doi: 10.1371/journal.pone.0051180 – volume: 60 start-page: 1437 year: 2005 ident: 10.1016/j.biocel.2013.06.024_bib0140 article-title: Angiotensin-converting enzyme inhibition intervention in elderly persons: effects on body composition and physical performance publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/60.11.1437 – volume: 90 start-page: 2157 year: 2001 ident: 10.1016/j.biocel.2013.06.024_bib0355 article-title: Attenuation of skeletal muscle and strength in the elderly: the Health ABC Study publication-title: J Appl Physiol doi: 10.1152/jappl.2001.90.6.2157 – volume: 290 start-page: H272 year: 2006 ident: 10.1016/j.biocel.2013.06.024_bib0280 article-title: Differential effects of aging on limb blood flow in humans publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00405.2005 – volume: 299 start-page: C203 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0360 article-title: Autophagy in health and disease. 5. Mitophagy as a way of life publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.00097.2010 – volume: 68 start-page: 599 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0325 article-title: Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/gls209 – volume: 5 start-page: e10778 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0780 article-title: Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults publication-title: PLoS ONE doi: 10.1371/journal.pone.0010778 – volume: 45 start-page: 30 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0055 article-title: Mitophagy: a process that adapts to the cell physiology publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2012.07.006 – volume: 285 start-page: 19460 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0080 article-title: Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy publication-title: J Biol Chem doi: 10.1074/jbc.M110.113092 – volume: 285 start-page: H1023 year: 2003 ident: 10.1016/j.biocel.2013.06.024_bib0505 article-title: Vascular and metabolic response to isolated small muscle mass exercise: effect of age publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00135.2003 – volume: 4 start-page: e5631 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0145 article-title: Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging publication-title: PLoS ONE doi: 10.1371/journal.pone.0005631 – volume: 28 start-page: 272 year: 2001 ident: 10.1016/j.biocel.2013.06.024_bib0665 article-title: Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria publication-title: Nat Genet doi: 10.1038/90116 – volume: 1 start-page: 14 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0155 article-title: Sarcopenia: current clinical and research issues publication-title: Open Geriatr Med J doi: 10.2174/1874827900801010014 – volume: 1777 start-page: 1092 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0955 article-title: Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view publication-title: Biochim Biophys Acta doi: 10.1016/j.bbabio.2008.05.001 – volume: 300 start-page: 1140 year: 2003 ident: 10.1016/j.biocel.2013.06.024_bib0690 article-title: Mitochondrial dysfunction in the elderly: possible role in insulin resistance publication-title: Science doi: 10.1126/science.1082889 – volume: 8 start-page: 18 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0200 article-title: Molecular inflammation: underpinnings of aging and age-related diseases publication-title: Ageing Res Rev doi: 10.1016/j.arr.2008.07.002 – year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0350 article-title: Bang-bang model for regulation of local blood flow publication-title: Microcirculation doi: 10.1111/micc.12051 – volume: 39 start-page: 701 year: 2004 ident: 10.1016/j.biocel.2013.06.024_bib0935 article-title: Myocyte aging and mitochondrial turnover publication-title: Exp Gerontol doi: 10.1016/j.exger.2004.01.005 – volume: 14 start-page: 315 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib1040 article-title: An exploratory analysis of the effects of a weight loss plus exercise program on cellular quality control mechanisms in older overweight women publication-title: Rejuvenation Res doi: 10.1089/rej.2010.1132 – volume: 54 start-page: 2685 year: 2005 ident: 10.1016/j.biocel.2013.06.024_bib0035 article-title: Expression of Mfn2, the Charcot–Marie–Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6 publication-title: Diabetes doi: 10.2337/diabetes.54.9.2685 – volume: 433 start-page: 760 year: 2005 ident: 10.1016/j.biocel.2013.06.024_bib0220 article-title: Rejuvenation of aged progenitor cells by exposure to a young systemic environment publication-title: Nature doi: 10.1038/nature03260 – volume: 43 start-page: 95 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib1010 article-title: The role of mitochondria in apoptosis publication-title: Annu Rev Genet doi: 10.1146/annurev-genet-102108-134850 – volume: 383 start-page: 411 year: 2002 ident: 10.1016/j.biocel.2013.06.024_bib0065 article-title: Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis publication-title: Biol Chem doi: 10.1515/BC.2002.045 – volume: 288 start-page: C1074 year: 2005 ident: 10.1016/j.biocel.2013.06.024_bib0460 article-title: Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.00391.2004 – volume: 127 start-page: 670 year: 2006 ident: 10.1016/j.biocel.2013.06.024_bib0735 article-title: Sarcopenia-related apoptosis is regulated differently in fast- and slow-twitch muscles of the aging F344/N x BN rat model publication-title: Mech Ageing Dev doi: 10.1016/j.mad.2006.03.005 – volume: 112 start-page: 37 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0465 article-title: Robustness and aging—a systems-level perspective publication-title: Biosystems doi: 10.1016/j.biosystems.2013.03.014 – volume: 8 start-page: 199 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0720 article-title: Aging: central role for autophagy and the lysosomal degradative system publication-title: Ageing Res Rev doi: 10.1016/j.arr.2009.05.001 – volume: 41 start-page: 1234 year: 2006 ident: 10.1016/j.biocel.2013.06.024_bib0585 article-title: Skeletal muscle apoptosis, sarcopenia and frailty at old age publication-title: Exp Gerontol doi: 10.1016/j.exger.2006.08.011 – volume: 27 start-page: 433 year: 2008 ident: 10.1016/j.biocel.2013.06.024_bib0950 article-title: Fission and selective fusion govern mitochondrial segregation and elimination by autophagy publication-title: EMBO J doi: 10.1038/sj.emboj.7601963 – volume: 292 start-page: C1569 year: 2007 ident: 10.1016/j.biocel.2013.06.024_bib0130 article-title: Mitochondrial nitric oxide in the signaling of cell integrated responses publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.00248.2006 – volume: 7 start-page: e32829 year: 2012 ident: 10.1016/j.biocel.2013.06.024_bib0575 article-title: Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study publication-title: PLoS ONE doi: 10.1371/journal.pone.0032829 – volume: 587 start-page: 3885 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0875 article-title: Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles publication-title: J Physiol doi: 10.1113/jphysiol.2009.172221 – volume: 22 start-page: 859 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0890 article-title: Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis publication-title: Osteoporos Int – volume: 298 start-page: C1291 year: 2010 ident: 10.1016/j.biocel.2013.06.024_bib0820 article-title: Autophagy in health and disease. 3. Involvement of autophagy in muscle atrophy publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.00531.2009 – volume: 98 start-page: E509 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0880 article-title: Improving the vitamin d status of vitamin d deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2012-3592 – volume: 69 start-page: 58 year: 1990 ident: 10.1016/j.biocel.2013.06.024_bib0745 article-title: Rat hindlimb unloading: soleus histochemistry, ultrastructure, and electromyography publication-title: J Appl Physiol doi: 10.1152/jappl.1990.69.1.58 – volume: 54 start-page: 1480 year: 2011 ident: 10.1016/j.biocel.2013.06.024_bib0660 article-title: Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells publication-title: Diabetologia doi: 10.1007/s00125-011-2103-y – volume: 7 start-page: 187 year: 1986 ident: 10.1016/j.biocel.2013.06.024_bib0395 article-title: Exercise-induced ultrastructural changes in skeletal muscle publication-title: Int J Sports Med doi: 10.1055/s-2008-1025758 – volume: 24 start-page: 247 year: 2013 ident: 10.1016/j.biocel.2013.06.024_bib0420 article-title: Skeletal muscle aging and the mitochondrion publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2012.12.003 – volume: 297 start-page: H1870 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib1050 article-title: Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00709.2009 – volume: 35 start-page: 28 year: 2009 ident: 10.1016/j.biocel.2013.06.024_bib0580 article-title: Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction publication-title: BioFactors doi: 10.1002/biof.5 |
| SSID | ssj0001523 |
| Score | 2.598585 |
| SecondaryResourceType | review_article |
| Snippet | Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden on individuals and society. The development of preventive and... |
| SourceID | pubmedcentral proquest pubmed crossref fao elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 2288 |
| SubjectTerms | Aged Aging - metabolism Aging - pathology Animals Apoptosis Apoptosis - physiology biochemistry Biomarkers clinical trials Fusion and fission health care workers Humans inflammation lifestyle Mitochondria - metabolism Mitochondria - pathology Mitophagy Mitophagy - physiology monitoring muscles myotubes oxidative stress Oxidative Stress - physiology pathogenesis pathophysiology Randomized Controlled Trials as Topic - methods sarcopenia Sarcopenia - metabolism Sarcopenia - pathology Sarcopenia - therapy Signal Transduction society Vascular dysfunction |
| Title | Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials |
| URI | https://dx.doi.org/10.1016/j.biocel.2013.06.024 https://www.ncbi.nlm.nih.gov/pubmed/23845738 https://www.proquest.com/docview/1429642790 https://www.proquest.com/docview/1803093538 https://pubmed.ncbi.nlm.nih.gov/PMC3759621 |
| Volume | 45 |
| WOSCitedRecordID | wos000324719600022&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1878-5875 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001523 issn: 1357-2725 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLZ2AcELgg1YuUxGYrxMmdokjh3ettEK0BhIdFJfUOQ6zujUJWVNy_r3-GWcY8dpy4CNB16iKM5FzvfZPra_cw4hL8HI8IUOhceZSj2Yf0lP6CzzlK-iIAtiHSppkk3w42PR68WfVlZ-OF-Y6ZDnubi8jEf_FWq4BmCj6-w_wF2_FC7AOYAOR4AdjjcC_gO0UejT8tTk40hnYxy6Sqc6HkNtMWPWQBoFwGnl79xBLxPUckjrng524Xc5M9Efat9Jk-BjvGjNIscGS0uKC4Eo-gNMxmWzyRmC4R7BbhX0ab4QfoFiIyMpaJ_LfKKHNdMO5XBqM06h-78CKhd1kYZ6DKyvUVnq-vrBxGn1rfDJygfdqkZrro9zHXHAuOdz6xTtemobeNIxsrk72vN9RD-onqz6YN8mCqzGc1d6ZaywyxZne_g7NO5CtQITytX6dC-H5j7-mHROjo6SbrvX3Qk6o28e5i3D_f2d4I3l0CpZ9zmLxRpZ33_X7r2v7QFoDcbNw9XIOXAaleHVj__JQFrNZPG7adCvat4F86h7n9yr5jV03_LxAVnR-QbZ3AdiFOcz-ooapbGBfoPcPnBndw4dQzbJlyXi0gXiUiAunROXFhk1xH1Nkba0pi11tKVlQR1tqaXtQ3LSaXcP33pV8g9PMRGVHteB4sxvsiwKFdhQoWRxBtNtluk0FS0VskyKuMlYPwpTFgUyVhgZSbFM9TmHoeURWcuLXG8RGvotGQqpZLOfhqHWQvtxlkoRcRXBUTdI4P54oqrI-JigZZg4CeRZYnFKEKcElaB-2CBe_dTIRoa55n7uwEwq69ZarQkQ8pontwD7RJ7CsJ-cfPYxKKQx5WPWIC8cIRKACxuyzHUxGcOUHgUVPo-bf7lHWCFEIBrksSVRXRUw5UPGsYQv0au-AePSL5fkg68mPn3AMaVX68kNvvuU3J23_mdkrbyY6OfklpqWg_HFNlnlPbFdtaef7JMGDg |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mitochondrial+dysfunction+and+sarcopenia+of+aging%3A+From+signaling+pathways+to+clinical+trials&rft.jtitle=The+international+journal+of+biochemistry+%26+cell+biology&rft.au=Marzetti%2C+Emanuele&rft.au=Calvani%2C+Riccardo&rft.au=Cesari%2C+Matteo&rft.au=Buford%2C+Thomas+W&rft.date=2013-10-01&rft.issn=1357-2725&rft.volume=45&rft.issue=10+p.2288-2301&rft.spage=2288&rft.epage=2301&rft_id=info:doi/10.1016%2Fj.biocel.2013.06.024&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1357-2725&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1357-2725&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1357-2725&client=summon |