Short-Half-Life Chemicals: Maternal Exposure and Offspring Health Consequences—The Case of Synthetic Phenols, Parabens, and Phthalates

Phenols, parabens, and phthalates (PPPs) are suspected or known endocrine disruptors. They are used in consumer products that pregnant women and their progeny are exposed to daily through the placenta, which could affect offspring health. This review aims to compile data from cohort studies and in v...

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Vydáno v:Toxics (Basel) Ročník 12; číslo 10; s. 710
Hlavní autoři: Rousseau-Ralliard, Delphine, Bozec, Jeanne, Ouidir, Marion, Jovanovic, Nicolas, Gayrard, Véronique, Mellouk, Namya, Dieudonné, Marie-Noëlle, Picard-Hagen, Nicole, Flores-Sanabria, Maria-José, Jammes, Hélène, Philippat, Claire, Couturier-Tarrade, Anne
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 01.10.2024
MDPI
Témata:
Age composition
Animal models
Bans
Bisphenol A
Blood pressure
Carbohydrate metabolism
Carbohydrates
Cardiovascular system
Chemicals
Consumer products
Cosmetics
DNA methylation
DNA structure
Endocrine disruptors
Environmental aspects
epigenetics
Exposure
Food
Gene expression
Genotype & phenotype
gestation
Health aspects
Hormones
In vivo methods and tests
Intrauterine exposure
Life Sciences
maternal exposure
Metabolic disorders
Metabolites
Offspring
offspring phenotype
Parabens
Personal grooming
Phenols
Phthalate esters
Phthalates
Placenta
Placental transfer
Pollutants
Pollution effects
Pregnancy, Complications of
Puberty
Review
Risk factors
Sex
Thyroid
Thyroid hormones
Toys
Urine
France
Europe
offspring phenotype
cardiometabolic outcomes
maternal exposure
endocrine disruptors
fertility
placenta
adulthood
gestation
epigenetics
ISSN:2305-6304, 2305-6304
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Shrnutí:Phenols, parabens, and phthalates (PPPs) are suspected or known endocrine disruptors. They are used in consumer products that pregnant women and their progeny are exposed to daily through the placenta, which could affect offspring health. This review aims to compile data from cohort studies and in vitro and in vivo models to provide a summary regarding placental transfer, fetoplacental development, and the predisposition to adult diseases resulting from maternal exposure to PPPs during the gestational period. In humans, using the concentration of pollutants in maternal urine, and taking the offspring sex into account, positive or negative associations have been observed concerning placental or newborn weight, children’s BMI, blood pressure, gonadal function, or age at puberty. In animal models, without taking sex into account, alterations of placental structure and gene expression linked to hormones or DNA methylation were related to phenol exposure. At the postnatal stage, pollutants affect the bodyweight, the carbohydrate metabolism, the cardiovascular system, gonadal development, the age of puberty, sex/thyroid hormones, and gamete quality, but these effects depend on the age and sex. Future challenges will be to explore the effects of pollutants in mixtures using models and to identify the early signatures of in utero exposure capable of predicting the health trajectory of the offspring.
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PMCID: PMC11511413
ISSN:2305-6304
2305-6304
DOI:10.3390/toxics12100710