Short-Half-Life Chemicals: Maternal Exposure and Offspring Health Consequences—The Case of Synthetic Phenols, Parabens, and Phthalates

Phenols, parabens, and phthalates (PPPs) are suspected or known endocrine disruptors. They are used in consumer products that pregnant women and their progeny are exposed to daily through the placenta, which could affect offspring health. This review aims to compile data from cohort studies and in v...

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Vydáno v:Toxics (Basel) Ročník 12; číslo 10; s. 710
Hlavní autoři: Rousseau-Ralliard, Delphine, Bozec, Jeanne, Ouidir, Marion, Jovanovic, Nicolas, Gayrard, Véronique, Mellouk, Namya, Dieudonné, Marie-Noëlle, Picard-Hagen, Nicole, Flores-Sanabria, Maria-José, Jammes, Hélène, Philippat, Claire, Couturier-Tarrade, Anne
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 01.10.2024
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ISSN:2305-6304, 2305-6304
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Abstract Phenols, parabens, and phthalates (PPPs) are suspected or known endocrine disruptors. They are used in consumer products that pregnant women and their progeny are exposed to daily through the placenta, which could affect offspring health. This review aims to compile data from cohort studies and in vitro and in vivo models to provide a summary regarding placental transfer, fetoplacental development, and the predisposition to adult diseases resulting from maternal exposure to PPPs during the gestational period. In humans, using the concentration of pollutants in maternal urine, and taking the offspring sex into account, positive or negative associations have been observed concerning placental or newborn weight, children’s BMI, blood pressure, gonadal function, or age at puberty. In animal models, without taking sex into account, alterations of placental structure and gene expression linked to hormones or DNA methylation were related to phenol exposure. At the postnatal stage, pollutants affect the bodyweight, the carbohydrate metabolism, the cardiovascular system, gonadal development, the age of puberty, sex/thyroid hormones, and gamete quality, but these effects depend on the age and sex. Future challenges will be to explore the effects of pollutants in mixtures using models and to identify the early signatures of in utero exposure capable of predicting the health trajectory of the offspring.
AbstractList Phenols, parabens, and phthalates (PPPs) are suspected or known endocrine disruptors. They are used in consumer products that pregnant women and their progeny are exposed to daily through the placenta, which could affect offspring health. This review aims to compile data from cohort studies and in vitro and in vivo models to provide a summary regarding placental transfer, fetoplacental development, and the predisposition to adult diseases resulting from maternal exposure to PPPs during the gestational period. In humans, using the concentration of pollutants in maternal urine, and taking the offspring sex into account, positive or negative associations have been observed concerning placental or newborn weight, children’s BMI, blood pressure, gonadal function, or age at puberty. In animal models, without taking sex into account, alterations of placental structure and gene expression linked to hormones or DNA methylation were related to phenol exposure. At the postnatal stage, pollutants affect the bodyweight, the carbohydrate metabolism, the cardiovascular system, gonadal development, the age of puberty, sex/thyroid hormones, and gamete quality, but these effects depend on the age and sex. Future challenges will be to explore the effects of pollutants in mixtures using models and to identify the early signatures of in utero exposure capable of predicting the health trajectory of the offspring.
Phenols, parabens, and phthalates (PPPs) are suspected or known endocrine disruptors. They are used in consumer products that pregnant women and their progeny are exposed to daily through the placenta, which could affect offspring health. This review aims to compile data from cohort studies and in vitro and in vivo models to provide a summary regarding placental transfer, fetoplacental development, and the predisposition to adult diseases resulting from maternal exposure to PPPs during the gestational period. In humans, using the concentration of pollutants in maternal urine, and taking the offspring sex into account, positive or negative associations have been observed concerning placental or newborn weight, children's BMI, blood pressure, gonadal function, or age at puberty. In animal models, without taking sex into account, alterations of placental structure and gene expression linked to hormones or DNA methylation were related to phenol exposure. At the postnatal stage, pollutants affect the bodyweight, the carbohydrate metabolism, the cardiovascular system, gonadal development, the age of puberty, sex/thyroid hormones, and gamete quality, but these effects depend on the age and sex. Future challenges will be to explore the effects of pollutants in mixtures using models and to identify the early signatures of in utero exposure capable of predicting the health trajectory of the offspring.Phenols, parabens, and phthalates (PPPs) are suspected or known endocrine disruptors. They are used in consumer products that pregnant women and their progeny are exposed to daily through the placenta, which could affect offspring health. This review aims to compile data from cohort studies and in vitro and in vivo models to provide a summary regarding placental transfer, fetoplacental development, and the predisposition to adult diseases resulting from maternal exposure to PPPs during the gestational period. In humans, using the concentration of pollutants in maternal urine, and taking the offspring sex into account, positive or negative associations have been observed concerning placental or newborn weight, children's BMI, blood pressure, gonadal function, or age at puberty. In animal models, without taking sex into account, alterations of placental structure and gene expression linked to hormones or DNA methylation were related to phenol exposure. At the postnatal stage, pollutants affect the bodyweight, the carbohydrate metabolism, the cardiovascular system, gonadal development, the age of puberty, sex/thyroid hormones, and gamete quality, but these effects depend on the age and sex. Future challenges will be to explore the effects of pollutants in mixtures using models and to identify the early signatures of in utero exposure capable of predicting the health trajectory of the offspring.
Audience Academic
Author Couturier-Tarrade, Anne
Jammes, Hélène
Ouidir, Marion
Jovanovic, Nicolas
Bozec, Jeanne
Mellouk, Namya
Flores-Sanabria, Maria-José
Philippat, Claire
Rousseau-Ralliard, Delphine
Dieudonné, Marie-Noëlle
Picard-Hagen, Nicole
Gayrard, Véronique
AuthorAffiliation 4 ToxAlim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, 31062 Toulouse, France
1 Université Paris-Saclay, UVSQ, INRAE, BREED, 78350 Jouy-en-Josas, France
3 University Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000 Grenoble, France
2 Ecole Nationale Vétérinaire d’Alfort, BREED, 94700 Maisons-Alfort, France
AuthorAffiliation_xml – name: 4 ToxAlim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, 31062 Toulouse, France
– name: 3 University Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000 Grenoble, France
– name: 2 Ecole Nationale Vétérinaire d’Alfort, BREED, 94700 Maisons-Alfort, France
– name: 1 Université Paris-Saclay, UVSQ, INRAE, BREED, 78350 Jouy-en-Josas, France
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  surname: Flores-Sanabria
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/39453131$$D View this record in MEDLINE/PubMed
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crossref_primary_10_1186_s12884_025_07980_8
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Issue 10
Keywords offspring phenotype
cardiometabolic outcomes
maternal exposure
endocrine disruptors
fertility
placenta
adulthood
gestation
epigenetics
Language English
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Snippet Phenols, parabens, and phthalates (PPPs) are suspected or known endocrine disruptors. They are used in consumer products that pregnant women and their progeny...
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SubjectTerms Age composition
Animal models
Bans
Bisphenol A
Blood pressure
Carbohydrate metabolism
Carbohydrates
Cardiovascular system
Chemicals
Consumer products
Cosmetics
DNA methylation
DNA structure
Endocrine disruptors
Environmental aspects
epigenetics
Exposure
Food
Gene expression
Genotype & phenotype
gestation
Health aspects
Hormones
In vivo methods and tests
Intrauterine exposure
Life Sciences
maternal exposure
Metabolic disorders
Metabolites
Offspring
offspring phenotype
Parabens
Personal grooming
Phenols
Phthalate esters
Phthalates
Placenta
Placental transfer
Pollutants
Pollution effects
Pregnancy, Complications of
Puberty
Review
Risk factors
Sex
Thyroid
Thyroid hormones
Toys
Urine
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Title Short-Half-Life Chemicals: Maternal Exposure and Offspring Health Consequences—The Case of Synthetic Phenols, Parabens, and Phthalates
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