Short-Half-Life Chemicals: Maternal Exposure and Offspring Health Consequences—The Case of Synthetic Phenols, Parabens, and Phthalates
Phenols, parabens, and phthalates (PPPs) are suspected or known endocrine disruptors. They are used in consumer products that pregnant women and their progeny are exposed to daily through the placenta, which could affect offspring health. This review aims to compile data from cohort studies and in v...
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| Vydáno v: | Toxics (Basel) Ročník 12; číslo 10; s. 710 |
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01.10.2024
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| Abstract | Phenols, parabens, and phthalates (PPPs) are suspected or known endocrine disruptors. They are used in consumer products that pregnant women and their progeny are exposed to daily through the placenta, which could affect offspring health. This review aims to compile data from cohort studies and in vitro and in vivo models to provide a summary regarding placental transfer, fetoplacental development, and the predisposition to adult diseases resulting from maternal exposure to PPPs during the gestational period. In humans, using the concentration of pollutants in maternal urine, and taking the offspring sex into account, positive or negative associations have been observed concerning placental or newborn weight, children’s BMI, blood pressure, gonadal function, or age at puberty. In animal models, without taking sex into account, alterations of placental structure and gene expression linked to hormones or DNA methylation were related to phenol exposure. At the postnatal stage, pollutants affect the bodyweight, the carbohydrate metabolism, the cardiovascular system, gonadal development, the age of puberty, sex/thyroid hormones, and gamete quality, but these effects depend on the age and sex. Future challenges will be to explore the effects of pollutants in mixtures using models and to identify the early signatures of in utero exposure capable of predicting the health trajectory of the offspring. |
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| AbstractList | Phenols, parabens, and phthalates (PPPs) are suspected or known endocrine disruptors. They are used in consumer products that pregnant women and their progeny are exposed to daily through the placenta, which could affect offspring health. This review aims to compile data from cohort studies and in vitro and in vivo models to provide a summary regarding placental transfer, fetoplacental development, and the predisposition to adult diseases resulting from maternal exposure to PPPs during the gestational period. In humans, using the concentration of pollutants in maternal urine, and taking the offspring sex into account, positive or negative associations have been observed concerning placental or newborn weight, children’s BMI, blood pressure, gonadal function, or age at puberty. In animal models, without taking sex into account, alterations of placental structure and gene expression linked to hormones or DNA methylation were related to phenol exposure. At the postnatal stage, pollutants affect the bodyweight, the carbohydrate metabolism, the cardiovascular system, gonadal development, the age of puberty, sex/thyroid hormones, and gamete quality, but these effects depend on the age and sex. Future challenges will be to explore the effects of pollutants in mixtures using models and to identify the early signatures of in utero exposure capable of predicting the health trajectory of the offspring. Phenols, parabens, and phthalates (PPPs) are suspected or known endocrine disruptors. They are used in consumer products that pregnant women and their progeny are exposed to daily through the placenta, which could affect offspring health. This review aims to compile data from cohort studies and in vitro and in vivo models to provide a summary regarding placental transfer, fetoplacental development, and the predisposition to adult diseases resulting from maternal exposure to PPPs during the gestational period. In humans, using the concentration of pollutants in maternal urine, and taking the offspring sex into account, positive or negative associations have been observed concerning placental or newborn weight, children's BMI, blood pressure, gonadal function, or age at puberty. In animal models, without taking sex into account, alterations of placental structure and gene expression linked to hormones or DNA methylation were related to phenol exposure. At the postnatal stage, pollutants affect the bodyweight, the carbohydrate metabolism, the cardiovascular system, gonadal development, the age of puberty, sex/thyroid hormones, and gamete quality, but these effects depend on the age and sex. Future challenges will be to explore the effects of pollutants in mixtures using models and to identify the early signatures of in utero exposure capable of predicting the health trajectory of the offspring.Phenols, parabens, and phthalates (PPPs) are suspected or known endocrine disruptors. They are used in consumer products that pregnant women and their progeny are exposed to daily through the placenta, which could affect offspring health. This review aims to compile data from cohort studies and in vitro and in vivo models to provide a summary regarding placental transfer, fetoplacental development, and the predisposition to adult diseases resulting from maternal exposure to PPPs during the gestational period. In humans, using the concentration of pollutants in maternal urine, and taking the offspring sex into account, positive or negative associations have been observed concerning placental or newborn weight, children's BMI, blood pressure, gonadal function, or age at puberty. In animal models, without taking sex into account, alterations of placental structure and gene expression linked to hormones or DNA methylation were related to phenol exposure. At the postnatal stage, pollutants affect the bodyweight, the carbohydrate metabolism, the cardiovascular system, gonadal development, the age of puberty, sex/thyroid hormones, and gamete quality, but these effects depend on the age and sex. Future challenges will be to explore the effects of pollutants in mixtures using models and to identify the early signatures of in utero exposure capable of predicting the health trajectory of the offspring. |
| Audience | Academic |
| Author | Couturier-Tarrade, Anne Jammes, Hélène Ouidir, Marion Jovanovic, Nicolas Bozec, Jeanne Mellouk, Namya Flores-Sanabria, Maria-José Philippat, Claire Rousseau-Ralliard, Delphine Dieudonné, Marie-Noëlle Picard-Hagen, Nicole Gayrard, Véronique |
| AuthorAffiliation | 4 ToxAlim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, 31062 Toulouse, France 1 Université Paris-Saclay, UVSQ, INRAE, BREED, 78350 Jouy-en-Josas, France 3 University Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000 Grenoble, France 2 Ecole Nationale Vétérinaire d’Alfort, BREED, 94700 Maisons-Alfort, France |
| AuthorAffiliation_xml | – name: 4 ToxAlim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, 31062 Toulouse, France – name: 3 University Grenoble Alpes, Inserm U1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000 Grenoble, France – name: 2 Ecole Nationale Vétérinaire d’Alfort, BREED, 94700 Maisons-Alfort, France – name: 1 Université Paris-Saclay, UVSQ, INRAE, BREED, 78350 Jouy-en-Josas, France |
| Author_xml | – sequence: 1 givenname: Delphine surname: Rousseau-Ralliard fullname: Rousseau-Ralliard, Delphine – sequence: 2 givenname: Jeanne surname: Bozec fullname: Bozec, Jeanne – sequence: 3 givenname: Marion orcidid: 0000-0001-6027-1484 surname: Ouidir fullname: Ouidir, Marion – sequence: 4 givenname: Nicolas orcidid: 0009-0007-3509-4202 surname: Jovanovic fullname: Jovanovic, Nicolas – sequence: 5 givenname: Véronique surname: Gayrard fullname: Gayrard, Véronique – sequence: 6 givenname: Namya surname: Mellouk fullname: Mellouk, Namya – sequence: 7 givenname: Marie-Noëlle surname: Dieudonné fullname: Dieudonné, Marie-Noëlle – sequence: 8 givenname: Nicole surname: Picard-Hagen fullname: Picard-Hagen, Nicole – sequence: 9 givenname: Maria-José orcidid: 0000-0002-2301-3854 surname: Flores-Sanabria fullname: Flores-Sanabria, Maria-José – sequence: 10 givenname: Hélène surname: Jammes fullname: Jammes, Hélène – sequence: 11 givenname: Claire surname: Philippat fullname: Philippat, Claire – sequence: 12 givenname: Anne orcidid: 0000-0003-1559-5476 surname: Couturier-Tarrade fullname: Couturier-Tarrade, Anne |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39453131$$D View this record in MEDLINE/PubMed https://hal.inrae.fr/hal-04713923$$DView record in HAL |
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| CitedBy_id | crossref_primary_10_1097_FJC_0000000000001732 crossref_primary_10_1016_j_envint_2025_109652 crossref_primary_10_1186_s12884_025_07980_8 |
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| Keywords | offspring phenotype cardiometabolic outcomes maternal exposure endocrine disruptors fertility placenta adulthood gestation epigenetics |
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