Retinoid signaling determines germ cell fate in mice

Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified. We found that retinoic acid, produced by mesonephroi of both sexes, causes germ cells in the ovary to enter meiosis and initiate oogenesis. Meiosis is retarded in the fe...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 312; H. 5773; S. 596
Hauptverfasser:	Bowles, Josephine, Knight, Deon, Smith, Christopher, Wilhelm, Dagmar, Richman, Joy, Mamiya, Satoru, Yashiro, Kenta, Chawengsaksophak, Kallayanee, Wilson, Megan J, Rossant, Janet, Hamada, Hiroshi, Koopman, Peter
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 28.04.2006
Schlagworte:	Animals Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Female Gene Expression Regulation, Developmental Genes, Reporter Germ Cells - physiology In Situ Hybridization Lac Operon Male Meiosis Mesonephros - metabolism Mice Mice, Knockout Naphthalenes - pharmacology Oogenesis Ovary - embryology Ovary - metabolism Receptors, Retinoic Acid - antagonists & inhibitors Retinoic Acid 4-Hydroxylase Sertoli Cells - enzymology Sex Characteristics Signal Transduction Spermatogenesis Testis - embryology Testis - metabolism Tissue Culture Techniques Tretinoin - metabolism Tretinoin - pharmacology
ISSN:	1095-9203, 1095-9203
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