Human papillomavirus type 16 E7 oncoprotein causes a delay in repair of DNA damage

Patients with human papillomavirus related (HPV+) head and neck cancers (HNCs) demonstrate improved clinical outcomes compared to traditional HPV negative (HPV−) HNC patients. We have recently shown that HPV+ HNC cells are more sensitive to radiation than HPV− HNC cells. However, roles of HPV oncoge...

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Bibliographic Details
Published in:	Radiotherapy and oncology Vol. 113; no. 3; pp. 337 - 344
Main Authors:	Park, Jung Wook, Nickel, Kwangok P., Torres, Alexandra D., Lee, Denis, Lambert, Paul F., Kimple, Randall J.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01.12.2014
Subjects:	Animals Blotting, Western - methods Disease Models, Animal DNA Damage - genetics DNA damage repair DNA Repair - genetics Head and Neck Neoplasms - genetics Hematology, Oncology and Palliative Medicine HPV-positive head and neck cancer HPV16 E7 Humans Mice Mice, Transgenic Papillomaviridae - genetics Papillomavirus E7 Proteins - genetics Tumor Cells, Cultured HPV16 E7 DNA damage repair HPV-positive head and neck cancer
ISSN:	0167-8140, 1879-0887, 1879-0887
Online Access:	Get full text
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