The bone marrow microenvironment is similarly impaired in allogeneic hematopoietic stem cell transplantation patients with early and late poor graft function

Poor graft function (PGF), including early and late PGF, is a serious complication following allotransplant. We recently reported that bone marrow microenvironment abnormalities may occur in cases of late PGF. Whether these abnormalities occur in early PGF remains unknown. To answer this question, w...

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Bibliographic Details
Published in:Bone marrow transplantation (Basingstoke) Vol. 51; no. 2; pp. 249 - 255
Main Authors: Kong, Y, Wang, Y-T, Hu, Y, Han, W, Chang, Y-J, Zhang, X-H, Jiang, Z-F, Huang, X-J
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.02.2016
Nature Publishing Group
Subjects:
13/1
13/31
13/51
692/308/575
692/700/139
Abnormalities
Adolescent
Adult
Allografts
Analysis
Bone marrow
Bone Marrow - metabolism
Bone Marrow - pathology
Bone marrow transplantation
Care and treatment
Cell Biology
Cellular Microenvironment
Endothelial cells
Erythrocytes
Female
Flow cytometry
Health aspects
Hematologic Neoplasms - metabolism
Hematologic Neoplasms - pathology
Hematologic Neoplasms - physiopathology
Hematologic Neoplasms - therapy
Hematology
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Hemorrhagic disorders
Humans
Immunohistochemistry
Internal Medicine
Male
Medicine
Medicine & Public Health
Mesenchyme
Microenvironments
Middle Aged
original-article
Prospective Studies
Public Health
Risk factors
Stem cell transplantation
Stem Cells
Transplantation
Transplants & implants
Transplants - metabolism
Transplants - pathology
Transplants - physiopathology
China
ISSN:0268-3369, 1476-5365, 1476-5365
Online Access:Get full text
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Summary:Poor graft function (PGF), including early and late PGF, is a serious complication following allotransplant. We recently reported that bone marrow microenvironment abnormalities may occur in cases of late PGF. Whether these abnormalities occur in early PGF remains unknown. To answer this question, we performed a nested case–control study comparing cellular elements of the bone marrow microenvironment in 10 subjects with early PGF, 30 subjects with late PGF and 40 subjects without PGF. Bone marrow endosteal cells, perivascular cells and endothelial cells were analyzed by flow cytometry and by hematoxylin–eosin and immunohistochemical staining in situ . Subjects with early and late PGF had similar abnormalities in these cell types compared with transplant recipients without PGF. However, none of the aforementioned elements of the bone marrow microenvironment were significantly different between early and late PGF patients. Our data suggest that similar abnormalities in the bone marrow microenvironment may occur in early and late PGF post allotransplant. Cellular approaches, such as the administration of mesenchymal stem cells, promise to be beneficial therapeutic strategies in patients with early or late PGF.
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ISSN:0268-3369
1476-5365
1476-5365
DOI:10.1038/bmt.2015.229