The bone marrow microenvironment is similarly impaired in allogeneic hematopoietic stem cell transplantation patients with early and late poor graft function

Poor graft function (PGF), including early and late PGF, is a serious complication following allotransplant. We recently reported that bone marrow microenvironment abnormalities may occur in cases of late PGF. Whether these abnormalities occur in early PGF remains unknown. To answer this question, w...

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Vydané v:	Bone marrow transplantation (Basingstoke) Ročník 51; číslo 2; s. 249 - 255
Hlavní autori:	Kong, Y, Wang, Y-T, Hu, Y, Han, W, Chang, Y-J, Zhang, X-H, Jiang, Z-F, Huang, X-J
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.02.2016 Nature Publishing Group
Predmet:	13/1 13/31 13/51 692/308/575 692/700/139 Abnormalities Adolescent Adult Allografts Analysis Bone marrow Bone Marrow - metabolism Bone Marrow - pathology Bone marrow transplantation Care and treatment Cell Biology Cellular Microenvironment Endothelial cells Erythrocytes Female Flow cytometry Health aspects Hematologic Neoplasms - metabolism Hematologic Neoplasms - pathology Hematologic Neoplasms - physiopathology Hematologic Neoplasms - therapy Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Hemorrhagic disorders Humans Immunohistochemistry Internal Medicine Male Medicine Medicine & Public Health Mesenchyme Microenvironments Middle Aged original-article Prospective Studies Public Health Risk factors Stem cell transplantation Stem Cells Transplantation Transplants & implants Transplants - metabolism Transplants - pathology Transplants - physiopathology China
ISSN:	0268-3369, 1476-5365, 1476-5365
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Shrnutí:	Poor graft function (PGF), including early and late PGF, is a serious complication following allotransplant. We recently reported that bone marrow microenvironment abnormalities may occur in cases of late PGF. Whether these abnormalities occur in early PGF remains unknown. To answer this question, we performed a nested case–control study comparing cellular elements of the bone marrow microenvironment in 10 subjects with early PGF, 30 subjects with late PGF and 40 subjects without PGF. Bone marrow endosteal cells, perivascular cells and endothelial cells were analyzed by flow cytometry and by hematoxylin–eosin and immunohistochemical staining in situ . Subjects with early and late PGF had similar abnormalities in these cell types compared with transplant recipients without PGF. However, none of the aforementioned elements of the bone marrow microenvironment were significantly different between early and late PGF patients. Our data suggest that similar abnormalities in the bone marrow microenvironment may occur in early and late PGF post allotransplant. Cellular approaches, such as the administration of mesenchymal stem cells, promise to be beneficial therapeutic strategies in patients with early or late PGF.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-2 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	0268-3369 1476-5365 1476-5365
DOI:	10.1038/bmt.2015.229