Delivery and Safety of a Two-Dose Preventive Ebola Virus Disease Vaccine in Pregnant and Non-Pregnant Participants during an Outbreak in the Democratic Republic of the Congo
During the 2018–2020 Ebola virus disease (EVD) outbreak, residents in Goma, Democratic Republic of the Congo, were offered a two-dose prophylactic EVD vaccine. This was the first study to evaluate the safety of this vaccine in pregnant women. Adults, including pregnant women, and children aged ≥1 ye...
Gespeichert in:
| Veröffentlicht in: | Vaccines Jg. 12; H. 8; S. 825 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Switzerland
MDPI AG
23.07.2024
MDPI |
| Schlagworte: | |
| ISSN: | 2076-393X, 2076-393X |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | During the 2018–2020 Ebola virus disease (EVD) outbreak, residents in Goma, Democratic Republic of the Congo, were offered a two-dose prophylactic EVD vaccine. This was the first study to evaluate the safety of this vaccine in pregnant women. Adults, including pregnant women, and children aged ≥1 year old were offered the Ad26.ZEBOV (day 0; dose 1), MVA-BN-Filo (day 56; dose 2) EVD vaccine through an open-label clinical trial. In total, 20,408 participants, including 6635 (32.5%) children, received dose 1. Fewer than 1% of non-pregnant participants experienced a serious adverse event (SAE) following dose 1; one SAE was possibly related to the Ad26.ZEBOV vaccine. Of the 1221 pregnant women, 371 (30.4%) experienced an SAE, with caesarean section being the most common event. No SAEs in pregnant women were considered related to vaccination. Of 1169 pregnancies with a known outcome, 55 (4.7%) ended in a miscarriage, and 30 (2.6%) in a stillbirth. Eleven (1.0%) live births ended in early neonatal death, and five (0.4%) had a congenital abnormality. Overall, 188/891 (21.1%) were preterm births and 79/1032 (7.6%) had low birth weight. The uptake of the two-dose regimen was high: 15,328/20,408 (75.1%). The vaccine regimen was well-tolerated among the study participants, including pregnant women, although further data, ideally from controlled trials, are needed in this crucial group. |
|---|---|
| AbstractList | During the 2018–2020 Ebola virus disease (EVD) outbreak, residents in Goma, Democratic Republic of the Congo, were offered a two-dose prophylactic EVD vaccine. This was the first study to evaluate the safety of this vaccine in pregnant women. Adults, including pregnant women, and children aged ≥1 year old were offered the Ad26.ZEBOV (day 0; dose 1), MVA-BN-Filo (day 56; dose 2) EVD vaccine through an open-label clinical trial. In total, 20,408 participants, including 6635 (32.5%) children, received dose 1. Fewer than 1% of non-pregnant participants experienced a serious adverse event (SAE) following dose 1; one SAE was possibly related to the Ad26.ZEBOV vaccine. Of the 1221 pregnant women, 371 (30.4%) experienced an SAE, with caesarean section being the most common event. No SAEs in pregnant women were considered related to vaccination. Of 1169 pregnancies with a known outcome, 55 (4.7%) ended in a miscarriage, and 30 (2.6%) in a stillbirth. Eleven (1.0%) live births ended in early neonatal death, and five (0.4%) had a congenital abnormality. Overall, 188/891 (21.1%) were preterm births and 79/1032 (7.6%) had low birth weight. The uptake of the two-dose regimen was high: 15,328/20,408 (75.1%). The vaccine regimen was well-tolerated among the study participants, including pregnant women, although further data, ideally from controlled trials, are needed in this crucial group. During the 2018-2020 Ebola virus disease (EVD) outbreak, residents in Goma, Democratic Republic of the Congo, were offered a two-dose prophylactic EVD vaccine. This was the first study to evaluate the safety of this vaccine in pregnant women. Adults, including pregnant women, and children aged ≥1 year old were offered the Ad26.ZEBOV (day 0; dose 1), MVA-BN-Filo (day 56; dose 2) EVD vaccine through an open-label clinical trial. In total, 20,408 participants, including 6635 (32.5%) children, received dose 1. Fewer than 1% of non-pregnant participants experienced a serious adverse event (SAE) following dose 1; one SAE was possibly related to the Ad26.ZEBOV vaccine. Of the 1221 pregnant women, 371 (30.4%) experienced an SAE, with caesarean section being the most common event. No SAEs in pregnant women were considered related to vaccination. Of 1169 pregnancies with a known outcome, 55 (4.7%) ended in a miscarriage, and 30 (2.6%) in a stillbirth. Eleven (1.0%) live births ended in early neonatal death, and five (0.4%) had a congenital abnormality. Overall, 188/891 (21.1%) were preterm births and 79/1032 (7.6%) had low birth weight. The uptake of the two-dose regimen was high: 15,328/20,408 (75.1%). The vaccine regimen was well-tolerated among the study participants, including pregnant women, although further data, ideally from controlled trials, are needed in this crucial group.During the 2018-2020 Ebola virus disease (EVD) outbreak, residents in Goma, Democratic Republic of the Congo, were offered a two-dose prophylactic EVD vaccine. This was the first study to evaluate the safety of this vaccine in pregnant women. Adults, including pregnant women, and children aged ≥1 year old were offered the Ad26.ZEBOV (day 0; dose 1), MVA-BN-Filo (day 56; dose 2) EVD vaccine through an open-label clinical trial. In total, 20,408 participants, including 6635 (32.5%) children, received dose 1. Fewer than 1% of non-pregnant participants experienced a serious adverse event (SAE) following dose 1; one SAE was possibly related to the Ad26.ZEBOV vaccine. Of the 1221 pregnant women, 371 (30.4%) experienced an SAE, with caesarean section being the most common event. No SAEs in pregnant women were considered related to vaccination. Of 1169 pregnancies with a known outcome, 55 (4.7%) ended in a miscarriage, and 30 (2.6%) in a stillbirth. Eleven (1.0%) live births ended in early neonatal death, and five (0.4%) had a congenital abnormality. Overall, 188/891 (21.1%) were preterm births and 79/1032 (7.6%) had low birth weight. The uptake of the two-dose regimen was high: 15,328/20,408 (75.1%). The vaccine regimen was well-tolerated among the study participants, including pregnant women, although further data, ideally from controlled trials, are needed in this crucial group. |
| Author | Edward Man-Lik Choi Hugo Kavunga-Membo Mateus Kambale Sahani Paul Campbell Benjamin Faguer Anton Camacho Hannah Brindle Rockyath Makarimi Nathalie Imbault Deborah Watson-Jones Soumah Aboubacar Mathilde Mousset Benith Balingene Cynthia Robinson John Johnson Zephyrin Mossoko Daniela Manno Jean Jacques Muyembe-Tamfum Grace Mambula Kambale Kasonia Tansy Edwards Michel Kakule Darius Tetsa-Tata Daniel G. Bausch Oumar Toure Ibrahim Seyni Ama Shelley Lees Nicholas Connor Rebecca F. Grais Pierre Mukadi Babajide Keshinro Robert Nsaibirni Chrissy Roberts Kikongo Kambale Janvier Esther Kaningu Mapendo Badara Cissé |
| AuthorAffiliation | 5 Faculty of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK; benjamin.faguer@icloud.com 2 Faculty of Infectious and Tropical Diseases, London School of Hygiene &Tropical Medicine, London WC1E 7HT, UK; kambale.kasonia@lshtm.ac.uk (K.K.); darius.tetsatata@lshtm.ac.uk (D.T.-T.); edward.choi@lshtm.ac.uk (E.M.-L.C.); hannah.brindle@lshtm.ac.uk (H.B.); chrissy.roberts@lshtm.ac.uk (C.R.); daniela.manno@lshtm.ac.uk (D.M.); badara.cisse@iressef.org (B.C.); mateus-kambale.sahani@lshtm.ac.uk (M.K.S.); nicholas.connor@lshtm.ac.uk (N.C.); daniel.bausch@finddx.org (D.G.B.) 3 Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza P.O. Box 1462, Tanzania 1 Institut National de Recherche Biomédicale, Kinshasa P.O. Box 1192, Democratic Republic of the Congo; hugokavunga@gmail.com (H.K.-M.); zmossoko@yahoo.fr (Z.M.); kepha4@hotmail.com (P.M.); jjmuyembet@gmail.com (J.J.M.-T.) 4 School of Tropical Medicine and Global Health, Nagasa |
| AuthorAffiliation_xml | – name: 8 Médecins Sans Frontières, 75019 Paris, France; john.johnson@paris.msf.org – name: 6 Epicentre, 75019 Paris, France; anton.camacho@epicentre.msf.org (A.C.); grace.mambula@epicentre.msf.org (G.M.); soumahaboubacar82@yahoo.fr (S.A.); michelkahumba@yahoo.fr (M.K.); benqbali@gmail.com (B.B.); kaninguesthermap@gmail.com (E.K.M.); costoreau@gmail.com (R.M.); oumar.toure@epicentre.msf.org (O.T.); paul.campbell@epicentre.msf.org (P.C.); mathilde.mousset@epicentre.msf.org (M.M.); robert.nsaibirni@epicentre.msf.org (R.N.); wandeybaisa@gmail.com (I.S.A.); kikongokambale@gmail.com (K.K.J.); rebecca.grais@pasteur.fr (R.F.G.) – name: 2 Faculty of Infectious and Tropical Diseases, London School of Hygiene &Tropical Medicine, London WC1E 7HT, UK; kambale.kasonia@lshtm.ac.uk (K.K.); darius.tetsatata@lshtm.ac.uk (D.T.-T.); edward.choi@lshtm.ac.uk (E.M.-L.C.); hannah.brindle@lshtm.ac.uk (H.B.); chrissy.roberts@lshtm.ac.uk (C.R.); daniela.manno@lshtm.ac.uk (D.M.); badara.cisse@iressef.org (B.C.); mateus-kambale.sahani@lshtm.ac.uk (M.K.S.); nicholas.connor@lshtm.ac.uk (N.C.); daniel.bausch@finddx.org (D.G.B.) – name: 7 Janssen Vaccines and Prevention, 2333 CN Leiden, The Netherlands; bkeshinr@its.jnj.com (B.K.); crobin29@its.jnj.com (C.R.) – name: 1 Institut National de Recherche Biomédicale, Kinshasa P.O. Box 1192, Democratic Republic of the Congo; hugokavunga@gmail.com (H.K.-M.); zmossoko@yahoo.fr (Z.M.); kepha4@hotmail.com (P.M.); jjmuyembet@gmail.com (J.J.M.-T.) – name: 5 Faculty of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK; benjamin.faguer@icloud.com – name: 4 School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki 852-8131, Japan; tansy.edwards@lshtm.ac.uk – name: 9 Faculty of Public Health & Policy, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK; shelley.lees@lshtm.ac.uk – name: 11 Foundation for Innovative New Diagnostics (FIND), Campus Biotech Chemin des Mines 9, 1202 Geneva, Switzerland – name: 10 Coalition for Epidemic Preparedness Innovations, 0277 Oslo, Norway; nathalie.imbault@cepi.net – name: 3 Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza P.O. Box 1462, Tanzania |
| Author_xml | – sequence: 1 givenname: Hugo surname: Kavunga-Membo fullname: Kavunga-Membo, Hugo – sequence: 2 givenname: Deborah orcidid: 0000-0001-6247-1746 surname: Watson-Jones fullname: Watson-Jones, Deborah – sequence: 3 givenname: Kambale orcidid: 0000-0001-5340-7048 surname: Kasonia fullname: Kasonia, Kambale – sequence: 4 givenname: Tansy orcidid: 0000-0002-6110-014X surname: Edwards fullname: Edwards, Tansy – sequence: 5 givenname: Anton orcidid: 0000-0002-0023-3985 surname: Camacho fullname: Camacho, Anton – sequence: 6 givenname: Grace surname: Mambula fullname: Mambula, Grace – sequence: 7 givenname: Darius orcidid: 0000-0001-5261-6251 surname: Tetsa-Tata fullname: Tetsa-Tata, Darius – sequence: 8 givenname: Edward Man-Lik orcidid: 0000-0002-8148-120X surname: Choi fullname: Choi, Edward Man-Lik – sequence: 9 givenname: Soumah surname: Aboubacar fullname: Aboubacar, Soumah – sequence: 10 givenname: Hannah surname: Brindle fullname: Brindle, Hannah – sequence: 11 givenname: Chrissy orcidid: 0000-0003-1064-5980 surname: Roberts fullname: Roberts, Chrissy – sequence: 12 givenname: Daniela orcidid: 0000-0001-7633-1357 surname: Manno fullname: Manno, Daniela – sequence: 13 givenname: Benjamin surname: Faguer fullname: Faguer, Benjamin – sequence: 14 givenname: Zephyrin surname: Mossoko fullname: Mossoko, Zephyrin – sequence: 15 givenname: Pierre orcidid: 0000-0003-2673-7740 surname: Mukadi fullname: Mukadi, Pierre – sequence: 16 givenname: Michel surname: Kakule fullname: Kakule, Michel – sequence: 17 givenname: Benith surname: Balingene fullname: Balingene, Benith – sequence: 18 givenname: Esther Kaningu surname: Mapendo fullname: Mapendo, Esther Kaningu – sequence: 19 givenname: Rockyath surname: Makarimi fullname: Makarimi, Rockyath – sequence: 20 givenname: Oumar surname: Toure fullname: Toure, Oumar – sequence: 21 givenname: Paul surname: Campbell fullname: Campbell, Paul – sequence: 22 givenname: Mathilde surname: Mousset fullname: Mousset, Mathilde – sequence: 23 givenname: Robert orcidid: 0000-0002-8550-9185 surname: Nsaibirni fullname: Nsaibirni, Robert – sequence: 24 givenname: Ibrahim Seyni surname: Ama fullname: Ama, Ibrahim Seyni – sequence: 25 givenname: Kikongo Kambale surname: Janvier fullname: Janvier, Kikongo Kambale – sequence: 26 givenname: Babajide orcidid: 0000-0003-4673-2955 surname: Keshinro fullname: Keshinro, Babajide – sequence: 27 givenname: Badara surname: Cissé fullname: Cissé, Badara – sequence: 28 givenname: Mateus Kambale orcidid: 0000-0001-8838-6793 surname: Sahani fullname: Sahani, Mateus Kambale – sequence: 29 givenname: John surname: Johnson fullname: Johnson, John – sequence: 30 givenname: Nicholas orcidid: 0000-0002-5013-407X surname: Connor fullname: Connor, Nicholas – sequence: 31 givenname: Shelley surname: Lees fullname: Lees, Shelley – sequence: 32 givenname: Nathalie surname: Imbault fullname: Imbault, Nathalie – sequence: 33 givenname: Cynthia surname: Robinson fullname: Robinson, Cynthia – sequence: 34 givenname: Rebecca F. orcidid: 0000-0002-5037-8218 surname: Grais fullname: Grais, Rebecca F. – sequence: 35 givenname: Daniel G. surname: Bausch fullname: Bausch, Daniel G. – sequence: 36 givenname: Jean Jacques surname: Muyembe-Tamfum fullname: Muyembe-Tamfum, Jean Jacques |
| BackLink | https://cir.nii.ac.jp/crid/1872836541410851200$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/39203952$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9ksFv0zAUxiM0xMbYnROyBAcuBTu2Y_uEUDtg0sQmGBM3y3FeOpfULnZS1D-K_xGn3aatB3JInvx-35fP9nteHPjgoSheEvyOUoXfr421zkMiJZZYlvxJcVRiUU2ooj8PHtSHxUlKC5wfRaisxLPikKoSU8XLo-LvDDq3hrhBxjfou2mh36DQIoOu_oTJLCRAlxHW4PtModM6dAZduzgkNHMJTG5f72Ig50dy7o3vt15fg5_cL1ya2DvrVrlOqBmi8_MMoYuhryOYX6O4vwE0g2Ww0WQUfYPVUHe5yGHG1jT4eXhRPG1Nl-Dk9ntc_Ph0ejX9Mjm_-Hw2_Xg-sVxW_aQ0yrSmUkxUVmDF20rQVpYNISURpYGaY4FBcmBtzWWDMbC6bpQoraHY1oweF2c73yaYhV5FtzRxo4NxersQ4lxvN9SBZqxqmMVGMQBmFZMAVDJOwFpRg7TZ68POK-9nCY3NRxlN98j0cce7Gz0Pa00I5Ypxmh3e3jrE8HuA1OulSxa6zngIQ9IUKyUUy7eb0dd76CIM0eezGilJVEWUyNSrh5Hus9yNRQaqHWBjSClCq63r87WEMaHrNMF6HEG9P4JZiPeEd97_kbzZSbxz-Tfjm0hRSlpxRhjBkmcU039sr-yf |
| CitedBy_id | crossref_primary_10_3390_vaccines12080828 crossref_primary_10_1080_21645515_2025_2538340 crossref_primary_10_1111_maq_70015 |
| Cites_doi | 10.1186/s12884-021-03980-6 10.4269/ajtmh.19-0143 10.1016/j.vaccine.2022.04.094 10.1016/j.ijid.2016.11.080 10.1016/S1473-3099(20)30476-X 10.1371/journal.pone.0237450 10.1186/s13063-022-06360-3 10.1056/NEJMp1814020 10.1001/jama.2016.4218 10.3390/vaccines8010038 10.1371/journal.pone.0264251 10.1371/journal.pone.0272712 10.1111/j.0001-6349.2004.00193.x 10.1093/infdis/jiz070 10.1371/journal.pmed.1003813 10.1111/j.1471-0528.2004.00311.x 10.1136/bmjgh-2020-003121 10.4314/eamj.v83i2.9395 10.1038/s41541-020-00261-9 10.1186/s12978-017-0430-2 10.1007/978-3-319-97637-2_10 10.1371/journal.pmed.1003865 10.1371/journal.pone.0223104 10.7189/jogh.12.04006 10.1136/bmjopen-2021-055596 10.1056/NEJMsr1904253 10.1016/S1473-3099(21)00128-6 10.1007/s40475-019-00195-w 10.1186/s13031-021-00395-0 10.15585/mmwr.mm7316a1 10.1016/j.vaccine.2007.02.064 10.1016/S1473-3099(21)00125-0 |
| ContentType | Journal Article |
| Copyright | 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2024 by the authors. 2024 |
| Copyright_xml | – notice: 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2024 by the authors. 2024 |
| DBID | RYH AAYXX CITATION NPM 3V. 7T7 7XB 8FD 8FE 8FH 8FK 8G5 ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU COVID DWQXO FR3 GNUQQ GUQSH HCIFZ LK8 M2O M7P MBDVC P64 PHGZM PHGZT PIMPY PKEHL PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA |
| DOI | 10.3390/vaccines12080825 |
| DatabaseName | CiNii Complete CrossRef PubMed ProQuest Central (Corporate) Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (purchase pre-March 2016) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College Coronavirus Research Database ProQuest Central Engineering Research Database ProQuest Central Student Research Library Prep SciTech Premium Collection Biological Sciences Research Library Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database Research Library Prep ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Research Library Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Biological Science Collection ProQuest Central Basic ProQuest One Academic Eastern Edition Coronavirus Research Database Biological Science Database ProQuest SciTech Collection Biotechnology and BioEngineering Abstracts ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef Publicly Available Content Database PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology Public Health |
| EISSN | 2076-393X |
| ExternalDocumentID | oai_doaj_org_article_446d4c0a94ee4c948ee38451ecc7be8c PMC11359453 39203952 10_3390_vaccines12080825 |
| Genre | Journal Article |
| GeographicLocations | Congo-Democratic Republic of Congo United States--US |
| GeographicLocations_xml | – name: United States--US – name: Congo-Democratic Republic of Congo |
| GrantInformation_xml | – fundername: UK Foreign, Commonwealth & Development Office (FCDO), Wellcome grantid: 220506/Z/20/Z – fundername: Wellcome Trust – fundername: Coalition for Epidemic Preparedness Innovations (CEPI) grantid: FELS1903 – fundername: Department of Health and Social Care using UK Aid Funding as part of the UK Vaccine Network grantid: PR-OD-1017-20001 – fundername: European Union's Horizon 2020 research and innovation programme grantid: 857935 – fundername: European Union’s Horizon 2020 research and innovation programme grantid: 857935 – fundername: Paul G. Allen Family Foundation grantid: 12885 |
| GroupedDBID | 53G 5VS 8FE 8FH 8G5 AADQD AAHBH ABUWG ADBBV AEUYN AFFHD AFKRA AFZYC ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BBNVY BCNDV BENPR BHPHI BPHCQ CCPQU DIK DWQXO GNUQQ GROUPED_DOAJ GUQSH HCIFZ HYE IAO IHR ITC KQ8 LK8 M2O M48 M7P MODMG M~E OK1 PGMZT PHGZM PHGZT PIMPY PQGLB PQQKQ PROAC RNS RPM RYH AAYXX CITATION 3V. NPM 7T7 7XB 8FD 8FK C1K COVID FR3 MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c586t-2a9afa69476c7095f673f82d112172aeb5070e85e4fb58d00e4bbd972ca30cb43 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 5 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001305070200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2076-393X |
| IngestDate | Fri Oct 03 12:51:33 EDT 2025 Tue Nov 04 02:05:29 EST 2025 Wed Oct 01 17:21:44 EDT 2025 Fri Jul 25 10:42:06 EDT 2025 Thu Jan 02 22:33:16 EST 2025 Tue Nov 18 21:48:12 EST 2025 Sat Nov 29 07:19:48 EST 2025 Mon Nov 10 09:05:31 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Keywords | vaccine pregnant women DRC safety outbreak Ad26.ZEBOV/MVA-BN-Filo general population Ebola |
| Language | English |
| License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c586t-2a9afa69476c7095f673f82d112172aeb5070e85e4fb58d00e4bbd972ca30cb43 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally to this work. |
| ORCID | 0000-0001-6247-1746 0000-0002-8148-120x 0000-0001-6284-7838 0000-0001-8838-6793 0000-0003-4673-2955 0000-0002-8550-9185 0000-0001-5340-7048 0000-0002-0023-3985 0000-0003-1684-5801 0000-0002-6110-014x 0000-0002-7026-3581 0000-0002-5037-8218 0000-0002-5013-407x 0000-0003-1064-5980 0000-0003-2673-7740 0000-0002-8148-120X 0000-0001-7633-1357 0000-0002-6110-014X 0000-0002-5013-407X 0000-0001-5261-6251 |
| OpenAccessLink | https://doaj.org/article/446d4c0a94ee4c948ee38451ecc7be8c |
| PMID | 39203952 |
| PQID | 3098196197 |
| PQPubID | 2032320 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_446d4c0a94ee4c948ee38451ecc7be8c pubmedcentral_primary_oai_pubmedcentral_nih_gov_11359453 proquest_miscellaneous_3099794913 proquest_journals_3098196197 pubmed_primary_39203952 crossref_citationtrail_10_3390_vaccines12080825 crossref_primary_10_3390_vaccines12080825 nii_cinii_1872836541410851200 |
| PublicationCentury | 2000 |
| PublicationDate | 20240723 |
| PublicationDateYYYYMMDD | 2024-07-23 |
| PublicationDate_xml | – month: 7 year: 2024 text: 20240723 day: 23 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Basel |
| PublicationTitle | Vaccines |
| PublicationTitleAlternate | Vaccines (Basel) |
| PublicationYear | 2024 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| References | ref_35 ref_34 ref_33 ref_10 Olesen (ref_22) 2004; 83 ref_30 ref_19 ref_18 Usman (ref_29) 2019; 101 Pollard (ref_16) 2021; 21 ref_17 Mizerero (ref_24) 2021; 15 Grais (ref_3) 2022; 12 Afolabi (ref_6) 2022; 22 Roozendaal (ref_32) 2020; 5 Ishola (ref_5) 2022; 22 Lemey (ref_28) 2022; 40 Gold (ref_13) 2007; 25 Schwartz (ref_11) 2019; 6 Gomes (ref_9) 2017; 14 Anywaine (ref_15) 2019; 220 Ahuka (ref_20) 2006; 83 ref_25 ref_23 Haddad (ref_7) 2018; 379 ref_1 Karita (ref_36) 2022; 23 Anoko (ref_26) 2019; 4 Moeti (ref_2) 2019; 381 ref_8 Kallay (ref_31) 2024; 73 Milligan (ref_12) 2016; 315 Morin (ref_21) 2005; 112 Jalloh (ref_27) 2022; 12 ref_4 Anzala (ref_14) 2016; 53 |
| References_xml | – ident: ref_23 doi: 10.1186/s12884-021-03980-6 – volume: 101 start-page: 68 year: 2019 ident: ref_29 article-title: The CORE Group Partners Project in North East Nigeria: Community Engagement Strategies to Combat Skepticism and Build Trust for Vaccine Acceptance publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.19-0143 – volume: 40 start-page: 3470 year: 2022 ident: ref_28 article-title: Setting-up an Ebola vaccine trial in a remote area of the Democratic Republic of the Congo: Challenges, mitigations, and lessons learned publication-title: Vaccine doi: 10.1016/j.vaccine.2022.04.094 – ident: ref_34 – volume: 53 start-page: 29 year: 2016 ident: ref_14 article-title: First data in African subjects for the monovalent Janssen Ebola Zaire heterologous prime-boost vaccines, combining Ad26. ZEBOV and MVA-BN-Filo publication-title: Int. J. Infect. Dis. doi: 10.1016/j.ijid.2016.11.080 – volume: 21 start-page: 493 year: 2021 ident: ref_16 article-title: Safety and immunogenicity of a two-dose heterologous Ad26. ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Europe (EBOVAC2): A randomised, observer-blind, participant-blind, placebo-controlled, phase 2 trial publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(20)30476-X – ident: ref_19 doi: 10.1371/journal.pone.0237450 – volume: 23 start-page: 513 year: 2022 ident: ref_36 article-title: Safety, reactogenicity, and immunogenicity of a 2-dose Ebola vaccine regimen of Ad26.ZEBOV followed by MVA-BN-Filo in healthy adult pregnant women: Study protocol for a phase 3 open-label randomized controlled trial publication-title: Trials doi: 10.1186/s13063-022-06360-3 – volume: 379 start-page: 2492 year: 2018 ident: ref_7 article-title: Pregnant Women and the Ebola Crisis publication-title: N. Engl. J. Med. doi: 10.1056/NEJMp1814020 – volume: 315 start-page: 1610 year: 2016 ident: ref_12 article-title: Safety and immunogenicity of novel adenovirus type 26–and modified vaccinia ankara–vectored ebola vaccines: A randomized clinical trial publication-title: JAMA doi: 10.1001/jama.2016.4218 – ident: ref_8 doi: 10.3390/vaccines8010038 – ident: ref_1 – ident: ref_25 doi: 10.1371/journal.pone.0264251 – ident: ref_18 doi: 10.1371/journal.pone.0272712 – volume: 83 start-page: 1039 year: 2004 ident: ref_22 article-title: Correlation between self-reported gestational age and ultrasound measurements publication-title: Acta Obstet. Gynecol. Scand. doi: 10.1111/j.0001-6349.2004.00193.x – volume: 220 start-page: 46 year: 2019 ident: ref_15 article-title: Safety and immunogenicity of a 2-dose heterologous vaccination regimen with Ad26. ZEBOV and MVA-BN-Filo Ebola vaccines: 12-month data from a phase 1 randomized clinical trial in Uganda and Tanzania publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiz070 – ident: ref_4 doi: 10.1371/journal.pmed.1003813 – volume: 112 start-page: 145 year: 2005 ident: ref_21 article-title: Determinants and consequences of discrepancies in menstrual and ultrasonographic gestational age estimates publication-title: BJOG Int. J. Obstet. Gynaecol. doi: 10.1111/j.1471-0528.2004.00311.x – volume: 4 start-page: e003121 year: 2019 ident: ref_26 article-title: Community engagement for successful COVID-19 pandemic response: 10 lessons from Ebola outbreak responses in Africa publication-title: BMJ Glob. Health doi: 10.1136/bmjgh-2020-003121 – ident: ref_33 – volume: 83 start-page: 95 year: 2006 ident: ref_20 article-title: Congenital malformations in the North-Eastern Democratic Republic of Congo during Civil War publication-title: East Afr. Med. J. doi: 10.4314/eamj.v83i2.9395 – volume: 5 start-page: 112 year: 2020 ident: ref_32 article-title: Nonhuman primate to human immunobridging to infer the protective effect of an Ebola virus vaccine candidate publication-title: npj Vaccines doi: 10.1038/s41541-020-00261-9 – volume: 14 start-page: 172 year: 2017 ident: ref_9 article-title: Protected to death: Systematic exclusion of pregnant women from Ebola virus disease trials publication-title: Reprod. Health doi: 10.1186/s12978-017-0430-2 – ident: ref_10 doi: 10.1007/978-3-319-97637-2_10 – ident: ref_35 doi: 10.1371/journal.pmed.1003865 – ident: ref_30 doi: 10.1371/journal.pone.0223104 – volume: 12 start-page: 04006 year: 2022 ident: ref_27 article-title: Association of community engagement with vaccination confidence and uptake: A cross-sectional survey in Sierra Leone, 2019 publication-title: J. Glob. Health doi: 10.7189/jogh.12.04006 – volume: 12 start-page: e055596 year: 2022 ident: ref_3 article-title: Protocol for a phase 3 trial to evaluate the effectiveness and safety of a heterologous, two-dose vaccine for Ebola virus disease in the Democratic Republic of the Congo publication-title: BMJ Open doi: 10.1136/bmjopen-2021-055596 – volume: 381 start-page: 373 year: 2019 ident: ref_2 article-title: The ongoing Ebola epidemic in the Democratic Republic of Congo, 2018–2019 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMsr1904253 – volume: 22 start-page: 110 year: 2022 ident: ref_6 article-title: Safety and immunogenicity of the two-dose heterologous Ad26. ZEBOV and MVA-BN-Filo Ebola vaccine regimen in children in Sierra Leone: A randomised, double-blind, controlled trial publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(21)00128-6 – volume: 6 start-page: 213 year: 2019 ident: ref_11 article-title: Maternal and infant death and the rVSV-ZEBOV vaccine through three recent Ebola virus epidemics-West Africa, DRC Équateur and DRC Kivu: 4 years of excluding pregnant and lactating women and their infants from immunization publication-title: Curr. Trop. Med. Rep. doi: 10.1007/s40475-019-00195-w – ident: ref_17 – volume: 15 start-page: 61 year: 2021 ident: ref_24 article-title: The status of emergency obstetric and newborn care in post-conflict eastern DRC: A facility-level cross-sectional study publication-title: Confl. Health doi: 10.1186/s13031-021-00395-0 – volume: 73 start-page: 360 year: 2024 ident: ref_31 article-title: Use of Ebola Vaccines—Worldwide, 2021–2023 publication-title: MMWR Morb. Mortal. Wkly. Rep. doi: 10.15585/mmwr.mm7316a1 – volume: 25 start-page: 5675 year: 2007 ident: ref_13 article-title: Anaphylaxis: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data publication-title: Vaccine doi: 10.1016/j.vaccine.2007.02.064 – volume: 22 start-page: 97 year: 2022 ident: ref_5 article-title: Safety and long-term immunogenicity of the two-dose heterologous Ad26. ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Sierra Leone: A combined open-label, non-randomised stage 1, and a randomised, double-blind, controlled stage 2 trial publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(21)00125-0 |
| SSID | ssj0000913867 |
| Score | 2.3085923 |
| Snippet | During the 2018–2020 Ebola virus disease (EVD) outbreak, residents in Goma, Democratic Republic of the Congo, were offered a two-dose prophylactic EVD vaccine.... During the 2018-2020 Ebola virus disease (EVD) outbreak, residents in Goma, Democratic Republic of the Congo, were offered a two-dose prophylactic EVD vaccine.... |
| SourceID | doaj pubmedcentral proquest pubmed crossref nii |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 825 |
| SubjectTerms | Ad26.ZEBOV/MVA-BN-Filo Babies Birth weight Births Breastfeeding & lactation Case reports Cesarean section Children Clinical trials Consent DRC Ebola Ebola virus Ebolavirus Fatalities Hypothesis testing Immunization Low birth weight Medicine Menstruation Neonates outbreak Outbreaks Pregnancy Premature birth Public health R safety vaccine Vaccines Viral diseases Womens health |
| SummonAdditionalLinks | – databaseName: ProQuest Central dbid: BENPR link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFLag4wEJcRm3wIaMhCYhLWriS2w_IbZ24gGVaoxpb5HjOCViJKNJi_qj-I8cJ2m6TmgvvPQhdlIn-nz8HR-f7yD0TguaUiW1r7OM-SwT1FeWh34KS0eUaWlF2CQKfxaTiby4UNNuw63qjlWubWJjqNPSuD3yIQ0ULF5A98WHq1--qxrloqtdCY27aMcplbEB2jkaT6an_S6LU72UkWjjkxT8--FSGxexrkICXEm6CtnX1qNGth9WmSLP_8U4bx6cvLYSnTz633d4jB52HBR_bEHzBN2xxS46mLYi1qtDfLbJyaoO8QGebuStV7voQbvTh9sEpqfoz8heusMdK6yLFH_Vma1XuMywxme_S39UVhavdaKWFo8T8KXxeT5fVHjUBofwefuxcF64njN3NKd51qQs_P7CVHcHwIu6wm1yJXTCXxY1OPX6h7sZuCwe2Z-lcag2-NS2Gt5uMK7puCxm5TP07WR8dvzJ74pA-IbLqPaJVjrTkWIiMgL4YBYJmkmSAk8E7qVtAoQ2sJJbliVcpkFgWZKkShCjaWASRp-jQVEW9iXCXHMdJiGJSEJYRJS0TdSWmghIVJJwDw3XUIhNp5DuCnVcxuApOfDEN8Hjoff9HVetOsgtfY8cuvp-Tte7uVDOZ3FnJmJwzlNmAq2YtcwoJq2lkvEQJppIrDQe2gdswujcbygFkMOmkLvLIYE_Cjy0t0Ze3BmjKt7AzkNv-2YwIy42pAtbLpo-CkwzTBcPvWhB3o8UKHRAFSceklvw33qV7ZYi_95IlYch5Ypx-ur2cb1G9wmQRbdnTugeGtTzhd1H98yyzqv5m25S_wWJYlhr priority: 102 providerName: ProQuest |
| Title | Delivery and Safety of a Two-Dose Preventive Ebola Virus Disease Vaccine in Pregnant and Non-Pregnant Participants during an Outbreak in the Democratic Republic of the Congo |
| URI | https://cir.nii.ac.jp/crid/1872836541410851200 https://www.ncbi.nlm.nih.gov/pubmed/39203952 https://www.proquest.com/docview/3098196197 https://www.proquest.com/docview/3099794913 https://pubmed.ncbi.nlm.nih.gov/PMC11359453 https://doaj.org/article/446d4c0a94ee4c948ee38451ecc7be8c |
| Volume | 12 |
| WOSCitedRecordID | wos001305070200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2076-393X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000913867 issn: 2076-393X databaseCode: DOA dateStart: 20130101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2076-393X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000913867 issn: 2076-393X databaseCode: M~E dateStart: 20130101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2076-393X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000913867 issn: 2076-393X databaseCode: M7P dateStart: 20130301 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2076-393X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000913867 issn: 2076-393X databaseCode: BENPR dateStart: 20130301 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2076-393X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000913867 issn: 2076-393X databaseCode: PIMPY dateStart: 20130301 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 2076-393X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000913867 issn: 2076-393X databaseCode: M2O dateStart: 20130301 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Pb9MwFLZgcOCC-E1gq4yEJiEtWmI7sX1kayeQWBeNMpVT5DjOiBgOatKiXviP-B95TtKunRBcuPgQvzR2_cX-Xvz8PYReK05zKoXyVVEwnxWc-tJEoZ_D0hEXShgetgeFP_DxWEynMtlI9eViwjp54O6POwR3JWc6UJIZw7RkwhgqWBTCo3lmhHazL7CeDWeqnYNlSEXMu31JCn794UJpt1Ndh85auMzYG-tQK9cPq4styz8xzZsBkxsr0MkDdL-njvht1-SH6Jaxj9B-0mlPLw_w5PooVX2A93FyrUq9fIx-Dc2Vi8FYYmVz_FEVplniqsAKT35U_rCqDV7JOS0MHmXg8uKLcjav8bDbw8EXXd9waZ3lpYugaX9rXFl_fSFRfZy2bWrcnYEEI3w2b8D3Vl_dzUA58dB8q7QDn8bnppPado1xVceVvayeoE8no8nxO7_P1eDrSMSNT5RUhYol47HmQNuKmNNCkBzoHFAkZTLgnYERkWFFFok8CAzLslxyohUNdMboU7RjK2ueIxypSIVZSGKSERYTKUy7uUp1DFwnyyIPHa5GLtW9kLnLp3GVgkPjxjq9OdYeerO-43sn4vEX2yMHhrWdk99uLwAo0x6U6b9A6aE9gBK0zpWh4MDh2nzr7qgHPCjw0O4KZGk_Z9QpDSTQM3BouYderavhbXdbOMqaat7aSJhBAd0eetZhct1SYLoBlRHxkNhC61ZXtmts-aVVFA9DGkkW0Rf_o_Mv0T0CzM99ACd0F-00s7nZQ3f1oinr2QDd5lMxQHeORuPkfNC-tVCekjNX8sSVP0dQn7w_TT7_BilRTCo |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLbGQAIJcRm3wAZGgklIi5rYTmI_IATrpk0rpYIy7S04jlMiSjKatlN_FPxGjnPrOqG97YGXPMQniZOcy2efG0KvZEBjKri0ZZIwmyUBtYX2XDsG0-EnkuvALROFe0G_z09OxGAN_WlyYUxYZaMTS0Ud58rskXeoI8B4AdwP3p3-sk3XKONdbVpoVGxxpBdnsGQr3h524f--JmR_b7h7YNddBWzlcX9qEylkIn3BAl8FADASP6AJJzEADzDmUkeAkBzNPc2SyOOx42gWRbEIiJLUURGjcN9r6DrACMLLUMFBu6djamxyP6i8oZQKpzOXyvjHC5cAMuOmH_c561c2CQCblqXpv_DtxTDNc3Zv_-7_9sXuoTs1wsbvK5G4j9Z0toG2B1WJ7sUOHi4zzoodvI0Hy-Ldiw10u9rHxFV61gP0u6vHJnRlgWUW4y8y0dMFzhMs8fAst7t5oXFTBWuu8V6UjyU-TiezAncr1xc-rn4OTjNDOTKBR-W9-nlmtycGsg5vz6YFrlJHgQh_mk0jQPU_zMWA1HFX_8yVkVmFP-uqQrmZjBnazbNR_hB9vZJP-witZ3mmnyDsSU-6kUt8EhHmE8F16ZOmygeIGEWehToN64Wqrv9u2pCMQ1gHGmYNLzKrhd60V5xWtU8uof1guLmlM1XLyxP5ZBTWSjBkzI-ZcqRgWjMlGNeacua5oEaCSHNloS2QBZidObo8AOhbtqk3GTLwIMdCmw2nh7WqLcIlm1voZTsMStJ4vmSm81lJI8DwgHha6HElVO1MYYHgUOERC_EVcVt5ldWRLP1eFmJ3XeoJ5tGnl8_rBbp5MPzYC3uH_aNn6BYBWGy8A4RuovXpZKa30A01n6bF5HmpTjD6dtXS-Be2UbO_ |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLbGhhAS4jJugQ2MBJOQFjWxndh-QIitrZg2lWp0096C4ziloiSjaTv1R_EH-HUcJ2m7Tmhve-ClD7GTOsn5zvnic0PoreI0oVIoV6Upc1nKqStN4LsJmI4wVcJwv0wUPuKdjjg7k9019GeeC2PDKuc6sVTUSa7tHnmDehKMF9B93kjrsIhus_3x_JdrO0hZT-u8nUYlIodmdgGfb8WHgya863eEtFu9_c9u3WHA1YEIxy5RUqUqlIyHmgPZSENOU0ESICFg2JWJgS15RgSGpXEgEs8zLI4TyYlW1NMxo3DdW2iDA8kAdG3stTrd48UOj624KUJe-UYplV5jqrT1lhc-AZ4mbHfuS7awbBkAFi4bDP7Fdq8GbV6ygu0H__Pze4ju19wbf6rA8gitmWwT7XSr4t2zXdxb5qIVu3gHd5dlvWeb6F61w4mrxK3H6HfTDG1QywyrLMFfVWrGM5ynWOHeRe4288LgeX2sqcGtOB8qfDoYTQrcrJxi-LR6UXiQ2Zl9G5JUXquTZ-7iQFfVge_ZuMBVUilMwl8m4xj4_g97MnB43DQ_c23RrPGxqWqX28XYof086-dP0MmNPNqnaD3LM_Mc4UAFyo99EpKYsJBIYUpvNdUhkMc4DhzUmIthpOvK8LZByTCCL0QruNFVwXXQ-8UZ51VVlGvm7lnJXsyz9czLA_moH9XqMWIsTJj2lGTGMC2ZMIYKFvigYHhshHbQNuACVmd_fcGBFJcN7G3uDPyR56CtudRHtRIuoqXIO-jNYhjUp_WJqczkk3KOBJMEUHXQswpgi5UCqj0qA-IgsQK9lVtZHckG38sS7b5PA8kC-uL6db1GdwCE0dFB5_AlukuAL1u3AaFbaH08mphtdFtPx4Ni9KrWLRh9u2k4_gXL273P |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Delivery+and+Safety+of+a+Two-Dose+Preventive+Ebola+Virus+Disease+Vaccine+in+Pregnant+and+Non-Pregnant+Participants+during+an+Outbreak+in+the+Democratic+Republic+of+the+Congo&rft.jtitle=Vaccines&rft.au=Hugo+Kavunga-Membo&rft.au=Deborah+Watson-Jones&rft.au=Kambale+Kasonia&rft.au=Tansy+Edwards&rft.date=2024-07-23&rft.pub=MDPI+AG&rft.eissn=2076-393X&rft.volume=12&rft.spage=825&rft_id=info:doi/10.3390%2Fvaccines12080825 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2076-393X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2076-393X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2076-393X&client=summon |