Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia

Defining the mechanisms underlying the control of mitochondrial fusion and fission is critical to understanding cellular adaptation to diverse physiological conditions. Here we demonstrate that hypoxia induces fission of mitochondrial membranes, dependent on availability of the mitochondrial scaffol...

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Vydané v:	Molecular cell Ročník 44; číslo 4; s. 532
Hlavní autori:	Kim, Hyungsoo, Scimia, Maria C, Wilkinson, Deepti, Trelles, Ramon D, Wood, Malcolm R, Bowtell, David, Dillin, Andrew, Mercola, Mark, Ronai, Ze'ev A
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 18.11.2011
Predmet:	A Kinase Anchor Proteins - genetics A Kinase Anchor Proteins - metabolism Adaptation, Physiological Animals Apoptosis Caenorhabditis elegans Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Line Dynamins - genetics Dynamins - metabolism Humans Hypoxia - genetics Hypoxia - metabolism Hypoxia - pathology Immunohistochemistry Lentivirus Longevity Membrane Fusion Mice Mice, Transgenic Mitochondria - physiology Mitochondrial Membranes - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Myocardial Ischemia - genetics Myocardial Ischemia - metabolism Myocardial Ischemia - pathology Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Phosphorylation Transduction, Genetic Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
ISSN:	1097-4164, 1097-4164
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