Reduced telomerase activity in human T lymphocytes exposed to cortisol

Accelerated telomere shortening in lymphocytes has been associated with a variety of human pathologies, including HIV disease, Down syndrome, and cardiovascular disease. Recent findings indicate that reduced telomere length is also associated with chronic psychological stress and mood disorders. Tel...

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Vydáno v:Brain, behavior, and immunity Ročník 22; číslo 4; s. 600 - 605
Hlavní autoři: Choi, Jenny, Fauce, Steven R., Effros, Rita B.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier Inc 01.05.2008
Témata:
Adult
Allergy and Immunology
Anti-Inflammatory Agents - pharmacology
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - enzymology
CD8-Positive T-Lymphocytes - drug effects
CD8-Positive T-Lymphocytes - enzymology
Cells, Cultured
Cortisol
Enzyme Activation - drug effects
Enzyme Activation - immunology
Female
Human
Human immunodeficiency virus
Humans
Hydrocortisone - pharmacology
Male
Middle Aged
Protein Subunits - genetics
Protein Subunits - metabolism
Psychiatry
RNA, Messenger - metabolism
Stress
T lymphocytes
Telomerase
Telomerase - genetics
Telomerase - metabolism
Telomeres
T lymphocytes
Human
Telomeres
Cortisol
Telomerase
Stress
ISSN:0889-1591, 1090-2139, 1090-2139
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Shrnutí:Accelerated telomere shortening in lymphocytes has been associated with a variety of human pathologies, including HIV disease, Down syndrome, and cardiovascular disease. Recent findings indicate that reduced telomere length is also associated with chronic psychological stress and mood disorders. Telomerase, which prevents telomere shortening, can be upregulated in T lymphocytes in concert with activation, thereby retarding telomere shortening. Here, we demonstrate that exposure of human T lymphocytes to cortisol is associated with a significant reduction in telomerase activity both during primary stimulation of resting cells and secondary stimulation of previously activated cells. The effect is observed in both CD4 and CD8 T lymphocytes, and is associated with reduced transcription of hTERT, the telomerase catalytic component. These findings provide a potential mechanism for stress-associated telomere length attrition, and suggest that strategies to enhance T lymphocyte telomerase activity may provide beneficial effects on immune function in situations of chronic emotional stress.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0889-1591
1090-2139
1090-2139
DOI:10.1016/j.bbi.2007.12.004