Lactoferrin a multiple bioactive protein: An overview

Lactoferrin (Lf) is an 80kDa iron-binding glycoprotein of the transferrin family. It is abundant in milk and in most biological fluids and is a cell-secreted molecule that bridges innate and adaptive immune function in mammals. Its protective effects range from anticancer, anti-inflammatory and immu...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Biochimica et biophysica acta Ročník 1820; číslo 3; s. 226 - 236
Hlavní autoři:	García-Montoya, Isui Abril, Cendón, Tania Siqueiros, Arévalo-Gallegos, Sigifredo, Rascón-Cruz, Quintín
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 01.03.2012
Témata:	Adaptive Immunity Animals Anti-Bacterial Agents anti-infective properties Anti-Inflammatory Agents Antifungal Agents Antiviral Agents application Base Sequence functional foods Functional protein glycoproteins hosts humans immunomodulators infectious diseases iron Iron - metabolism Iron-binding protein Lactoferrin Lactoferrin - chemistry Lactoferrin - metabolism mechanism of action microorganisms milk Milk - chemistry pathogens Protein Structure, Tertiary Review Transferrin transferrins Lactoferrin Transferrin Functional protein Iron-binding protein
ISSN:	0304-4165, 0006-3002, 1872-8006
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Lactoferrin (Lf) is an 80kDa iron-binding glycoprotein of the transferrin family. It is abundant in milk and in most biological fluids and is a cell-secreted molecule that bridges innate and adaptive immune function in mammals. Its protective effects range from anticancer, anti-inflammatory and immune modulator activities to antimicrobial activities against a large number of microorganisms. This wide range of activities is made possible by mechanisms of action involving not only the capacity of Lf to bind iron but also interactions of Lf with molecular and cellular components of both hosts and pathogens. This review summarizes the activities of Lf, its regulation and potential applications. The extensive uses of Lf in the treatment of various infectious diseases in animals and humans has been the driving force in Lf research however, a lot of work is required to obtain a better understanding of its activity. The large potential applications of Lf have led scientists to develop this nutraceutical protein for use in feed, food and pharmaceutical applications. This article is part of a Special Issue entitled Molecular Mechanisms of Iron Transport and Disorders. ► It is well known that the mechanisms of action of antimicrobial activity are not fully understood. ► Important advances were made in heterologous Lf expression in prokaryotic systems. ► In the near future we will see the exploitation of the full capacity of lactoferrin expression in plants.
Bibliografie:	http://dx.doi.org/10.1016/j.bbagen.2011.06.018 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Review-3 Tel./fax: + 52 614 2366000.
ISSN:	0304-4165 0006-3002 1872-8006
DOI:	10.1016/j.bbagen.2011.06.018