BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

BNT162b2, a nucleoside-modified mRNA formulated in lipid nanoparticles that encodes the SARS-CoV-2 spike glycoprotein (S) stabilized in its prefusion conformation, has demonstrated 95% efficacy in preventing COVID-19 1 . Here we extend a previous phase-I/II trial report 2 by presenting data on the i...

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Bibliographic Details
Published in:	Nature (London) Vol. 595; no. 7868; pp. 572 - 577
Main Authors:	Sahin, Ugur, Muik, Alexander, Vogler, Isabel, Derhovanessian, Evelyna, Kranz, Lena M., Vormehr, Mathias, Quandt, Jasmin, Bidmon, Nicole, Ulges, Alexander, Baum, Alina, Pascal, Kristen E., Maurus, Daniel, Brachtendorf, Sebastian, Lörks, Verena, Sikorski, Julian, Koch, Peter, Hilker, Rolf, Becker, Dirk, Eller, Ann-Kathrin, Grützner, Jan, Tonigold, Manuel, Boesler, Carsten, Rosenbaum, Corinna, Heesen, Ludwig, Kühnle, Marie-Cristine, Poran, Asaf, Dong, Jesse Z., Luxemburger, Ulrich, Kemmer-Brück, Alexandra, Langer, David, Bexon, Martin, Bolte, Stefanie, Palanche, Tania, Schultz, Armin, Baumann, Sybille, Mahiny, Azita J., Boros, Gábor, Reinholz, Jonas, Szabó, Gábor T., Karikó, Katalin, Shi, Pei-Yong, Fontes-Garfias, Camila, Perez, John L., Cutler, Mark, Cooper, David, Kyratsous, Christos A., Dormitzer, Philip R., Jansen, Kathrin U., Türeci, Özlem
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 22.07.2021 Nature Publishing Group
Subjects:	13 13/21 13/31 14/1 14/34 631/154/1438 631/250/255/2514 631/326/596/4130 631/61/391 692/308/153 692/700/459/1748 Adolescent Adult Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antigens BNT162 Vaccine CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell differentiation Conformation Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - virology COVID-19 vaccines COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - adverse effects COVID-19 Vaccines - immunology Effector cells Epitopes Epitopes, T-Lymphocyte - immunology Female Glycoproteins Health aspects Humanities and Social Sciences Humans Immune response Immune response (cell-mediated) Immune response (humoral) Immune system Immunoglobulin G - immunology Immunologic Memory Interferon-gamma - immunology Interleukin 2 Interleukin-2 - immunology Laboratories Lipids Lymphocytes Lymphocytes T Major histocompatibility complex Male Memory cells Middle Aged mRNA multidisciplinary Mutation Nanoparticles Neutralizing Pain Pandemics Phenotypes SARS-CoV-2 - chemistry SARS-CoV-2 - immunology Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - immunology T cells T-Lymphocytes - immunology Th1 Cells - immunology Vaccination Viral antibodies Young Adult Germany United States > US
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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