Secretion of cytokines by villous cytotrophoblast and extravillous trophoblast in the first trimester of human pregnancy

Cytokines are proposed to play roles in regulation of trophoblast invasion, spiral artery remodeling and immunoregulation during early pregnancy. Secretion of 12 cytokines (interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, IFNγ, GM-CSF, MCP-1 and RANTES) by first trimester extravi...

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Bibliographic Details
Published in:Journal of reproductive immunology Vol. 86; no. 2; pp. 148 - 150
Main Authors: Naruse, Katsuhiko, Innes, Barbara A., Bulmer, Judith N., Robson, Stephen C., Searle, Roger F., Lash, Gendie E.
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ireland Ltd 01.11.2010
Elsevier
Subjects:
Adult
Biological and medical sciences
Cells, Cultured
Cytokines
Cytokines - secretion
Cytotrophoblast
Embryology: invertebrates and vertebrates. Teratology
Extravillous trophoblast
Female
First trimester pregnancy
Fundamental and applied biological sciences. Psychology
Humans
Obstetrics and Gynecology
Pregnancy
Pregnancy Trimester, First - metabolism
Trophoblasts - cytology
Trophoblasts - secretion
First trimester pregnancy
Extravillous trophoblast
Cytotrophoblast
Cytokines
Human
Trophoblaste
Fetal membrane
Secretion
Cytokine
First trimester
Pregnancy
Vertebrata
Mammalia
ISSN:0165-0378, 1872-7603, 1872-7603
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Summary:Cytokines are proposed to play roles in regulation of trophoblast invasion, spiral artery remodeling and immunoregulation during early pregnancy. Secretion of 12 cytokines (interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, IFNγ, GM-CSF, MCP-1 and RANTES) by first trimester extravillous trophoblast and villous cytotrophoblast cells was examined using multiplex cytokine array technology. Seven (IL-1β, IL-8, IL-12p70, IL-13, GM-CSF, MCP-1 and RANTES) of the 12 cytokines examined were detectable in the samples studied ( n = 10 each group). Villous cytotrophoblast production of IL-1β and IL-8 increased with gestational age. Extravillous trophoblast production of IL-8, IL-13 and RANTES increased with gestational age. At 12–14 weeks gestation extravillous trophoblast cells secreted higher levels of IL-8, IL-13 and RANTES than villous cytotrophoblast cells.
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ISSN:0165-0378
1872-7603
1872-7603
DOI:10.1016/j.jri.2010.04.004