Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

Women carrying germ-line mutations in BRCA1 are strongly predisposed to developing breast cancers with characteristic features also observed in sporadic basal-like breast cancers. They appear as high-grade tumors with high proliferation rates and pushing borders. On the molecular level, they are neg...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 104; H. 29; S. 12111
Hauptverfasser:	Liu, Xiaoling, Holstege, Henne, van der Gulden, Hanneke, Treur-Mulder, Marcelle, Zevenhoven, John, Velds, Arno, Kerkhoven, Ron M, van Vliet, Martin H, Wessels, Lodewyk F A, Peterse, Johannes L, Berns, Anton, Jonkers, Jos
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.07.2007
Schlagworte:	Alleles Animals Biomarkers, Tumor - metabolism BRCA1 Protein - deficiency Breast Neoplasms - pathology Cluster Analysis Epithelial Cells - pathology Female Genomic Instability - genetics Humans Loss of Heterozygosity Mammary Neoplasms, Animal - classification Mammary Neoplasms, Animal - pathology Mice Mutation - genetics Species Specificity Tumor Suppressor Protein p53 - deficiency
ISSN:	0027-8424
Online-Zugang:	Weitere Angaben
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