Comprehensive analysis on subchondral bone marrow lesions of human osteoarthritis by integrating bulk and single-cell transcriptomes

Objective This study aims to demonstrate the cellular composition and underlying mechanisms in subchondral bone marrow lesions (BMLs) of knee osteoarthritis (OA). Methods BMLs were assessed by MRI Osteoarthritis Knee Score (MOAKS)≥2. Bulk RNA-sequencing (bulk-seq) and BML-specific differentially exp...

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Vydáno v:	BMC musculoskeletal disorders Ročník 24; číslo 1; s. 1 - 14
Hlavní autoři:	Zeng, Muhui, Wang, Xiaoshuai, Chen, Tianyu, Ruan, Guangfeng, Li, Jia, Xue, Song, Zhao, Yang, Hu, Zhiyang, Xie, Ye, Fan, Tianxiang, Chen, Shibo, Li, Yang, Wang, Qianyi, Zhang, Yue, Zhang, Rongkai, Lin, Lijun, Ding, Changhai, Zhu, Zhaohua
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 25.08.2023 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Algorithms Analysis Arthritis Bone composition Bone marrow Bone marrow lesions Care and treatment Cartilage Chondrocytes Chromosome 5 Deconvolution algorithm Development and progression Encyclopedias Epidemiology Gene expression Genetic aspects Genomes Health aspects Interleukin 11 Internal Medicine Knee Lesions Magnetic resonance imaging Medicine Medicine & Public Health Microenvironments MicroRNAs Molecular modelling Musculoskeletal diseases Ontology Orthopedics Osteoarthritis Rehabilitation Rheumatology RNA sequencing Single-cell RNA sequencing Sports Medicine Subchondral bone Transcriptomes Transcriptomics China United States > US Deconvolution algorithm Subchondral bone Single-cell RNA sequencing Osteoarthritis Bone marrow lesions
ISSN:	1471-2474, 1471-2474
On-line přístup:	Získat plný text
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