Doublecortin expression in the normal and epileptic adult human brain

Mesial temporal lobe epilepsy (MTLE) is a neurological disorder associated with spontaneous recurrent complex partial seizures and hippocampal sclerosis. Although increased hippocampal neurogenesis has been reported in animal models of MTLE, increased neurogenesis has not been reported in the hippoc...

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Vydané v:	The European journal of neuroscience Ročník 28; číslo 11; s. 2254 - 2265
Hlavní autori:	Liu, Y. W. J., Curtis, M. A., Gibbons, H. M., Mee, E. W., Bergin, P. S., Teoh, H. H., Connor, B., Dragunow, M., Faull, R. L. M.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Oxford, UK Blackwell Publishing Ltd 01.12.2008
Predmet:	Adolescent Adult Biomarkers - analysis Biomarkers - metabolism Cell Movement - physiology Cell Proliferation Epilepsy, Temporal Lobe - metabolism Epilepsy, Temporal Lobe - pathology Epilepsy, Temporal Lobe - physiopathology Female hippocampus Hippocampus - metabolism Hippocampus - pathology Hippocampus - physiopathology Humans Immunohistochemistry Male Microtubule-Associated Proteins - metabolism Middle Aged neurogenesis Neurogenesis - physiology Neuronal Plasticity - physiology Neurons - metabolism Neuropeptides - metabolism Proliferating Cell Nuclear Antigen - analysis Proliferating Cell Nuclear Antigen - metabolism Recovery of Function - physiology Regeneration - physiology Stem Cells - metabolism temporal cortex temporal lobe epilepsy Tubulin - analysis Tubulin - metabolism Up-Regulation - physiology Young Adult
ISSN:	0953-816X, 1460-9568, 1460-9568
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Shrnutí:	Mesial temporal lobe epilepsy (MTLE) is a neurological disorder associated with spontaneous recurrent complex partial seizures and hippocampal sclerosis. Although increased hippocampal neurogenesis has been reported in animal models of MTLE, increased neurogenesis has not been reported in the hippocampus of adult human MTLE cases. Here we showed that cells expressing doublecortin (Dcx), a microtubule‐associated protein expressed in migrating neuroblasts, were present in the hippocampus and temporal cortex of the normal and MTLE adult human brain. In particular, increased numbers of Dcx‐positive cells were observed in the epileptic compared with the normal temporal cortex. Importantly, 56% of Dcx‐expressing cells in the epileptic temporal cortex coexpressed both the proliferative cell marker, proliferating cell nuclear antigen and early neuronal marker, TuJ1, suggesting that they may be newly generated neurons. A subpopulation of Dcx‐positive cells in the epileptic temporal cortex also coexpressed the mature neuronal marker, NeuN, suggesting that epilepsy may promote the generation of new neurons in the temporal cortex. This study has identified, for the first time, a novel population of Dcx‐positive cells in the adult human temporal cortex that can be upregulated by epilepsy and thus, raises the possibility that these cells may have functional significance in the pathophysiology of epilepsy.
Bibliografia:	ark:/67375/WNG-BF0S7R8R-H istex:E7796C72F257A10B4054A9D666B4B9CCBCC2B736 ArticleID:EJN6518 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0953-816X 1460-9568 1460-9568
DOI:	10.1111/j.1460-9568.2008.06518.x