Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein, but also removes ubiquitin‐like ISG15 protein modifications as well as, with lower activity, Lys48‐linked polyubiquitin....

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Bibliographic Details
Published in:	The EMBO journal Vol. 39; no. 18; pp. e106275 - n/a
Main Authors:	Klemm, Theresa, Ebert, Gregor, Calleja, Dale J, Allison, Cody C, Richardson, Lachlan W, Bernardini, Jonathan P, Lu, Bernadine GC, Kuchel, Nathan W, Grohmann, Christoph, Shibata, Yuri, Gan, Zhong Yan, Cooney, James P, Doerflinger, Marcel, Au, Amanda E, Blackmore, Timothy R, van der Heden van Noort, Gerbrand J, Geurink, Paul P, Ovaa, Huib, Newman, Janet, Riboldi‐Tunnicliffe, Alan, Czabotar, Peter E, Mitchell, Jeffrey P, Feltham, Rebecca, Lechtenberg, Bernhard C, Lowes, Kym N, Dewson, Grant, Pellegrini, Marc, Lessene, Guillaume, Komander, David
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15.09.2020 Springer Nature B.V John Wiley and Sons Inc
Subjects:	Animals Antiviral activity Antiviral agents Antiviral Agents - pharmacology Antiviral drugs Binding Sites Chains Chlorocebus aethiops Coronavirus 3C Proteases - antagonists & inhibitors Coronavirus 3C Proteases - chemistry Coronavirus 3C Proteases - genetics Coronavirus 3C Proteases - metabolism Coronaviruses COVID-19 Crystal structure Crystallography, X-Ray Cytokines - genetics Drug Evaluation, Preclinical - methods Drug Repositioning Drugs EMBO23 EMBO31 EMBO40 Fluorescence Polarization HEK293 Cells Humans Inhibitors ISG15 Kinases Kinetics Models, Molecular Papain papain‐like protease Protease Protease Inhibitors - pharmacology Protein Conformation Proteinase Proteins SARS-CoV-2 - chemistry SARS-CoV-2 - genetics SARS-CoV-2 - metabolism Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 small molecule inhibitor Ubiquitin Ubiquitin - metabolism Ubiquitins - genetics Vero Cells Viral diseases ISG15 COVID‐19 papain‐like protease ubiquitin small molecule inhibitor COVID-19 papain-like protease
ISSN:	0261-4189, 1460-2075, 1460-2075
Online Access:	Get full text
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