A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast

To examine global changes in breast heterogeneity across different states, we determined the single‐cell transcriptomes of > 340,000 cells encompassing normal breast, preneoplastic BRCA1 +/– tissue, the major breast cancer subtypes, and pairs of tumors and involved lymph nodes. Elucidation of the...

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Veröffentlicht in:	The EMBO journal Jg. 40; H. 11; S. e107333 - n/a
Hauptverfasser:	Pal, Bhupinder, Chen, Yunshun, Vaillant, François, Capaldo, Bianca D, Joyce, Rachel, Song, Xiaoyu, Bryant, Vanessa L, Penington, Jocelyn S, Di Stefano, Leon, Tubau Ribera, Nina, Wilcox, Stephen, Mann, Gregory B, Papenfuss, Anthony T, Lindeman, Geoffrey J, Smyth, Gordon K, Visvader, Jane E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.06.2021 Springer Nature B.V John Wiley and Sons Inc
Schlagworte:	BRCA1 carriers BRCA1 protein Breast cancer Breast Neoplasms - classification Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology CD8 antigen CD8-Positive T-Lymphocytes - metabolism Clonal selection Copy number Cycles EMBO03 EMBO19 EMBO22 ErbB-2 protein Estrogen receptors Estrogens Female Fibroblasts Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic Heterogeneity Heterogeneity Humans Immunoregulation Immunotherapy Leukocyte migration LN metastasis Lymph nodes Lymphatic system Lymphocytes Lymphocytes T Macrophages Mammary gland Mammary glands Mammary Glands, Human - cytology Mammary Glands, Human - metabolism Mammary Glands, Human - pathology Menopause Metastases microenvironment Microenvironments Mutation Preneoplasia Receptors Resource RNA-Seq Single-Cell Analysis single‐cell RNA‐seq Stroma Transcriptomes Tumor cells Tumor Microenvironment Tumors microenvironment single‐cell RNA‐seq breast cancer carriers LN metastasis single-cell RNA-seq BRCA1 carriers
ISSN:	0261-4189, 1460-2075, 1460-2075
Online-Zugang:	Volltext
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