Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage

Mitochondria play a central role in the host response to viral infection and immunity, being key to antiviral signaling and exacerbating inflammatory processes. Mitochondria and Toll-like receptor (TLR) have been suggested as potential targets in SARS-CoV-2 infection. However, the involvement of TLR...

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Bibliographic Details
Published in:	Vascular pharmacology Vol. 142; p. 106946
Main Authors:	Costa, Tiago J., Potje, Simone R., Fraga-Silva, Thais F.C., da Silva-Neto, Júlio A., Barros, Paula R., Rodrigues, Daniel, Machado, Mirele R., Martins, Ronaldo B., Santos-Eichler, Rosangela A., Benatti, Maira N., de Sá, Keyla S.G., Almado, Carlos Eduardo L., Castro, Ítalo A., Pontelli, Marjorie C., Serra, Leonardo La, Carneiro, Fernando S., Becari, Christiane, Louzada-Junior, Paulo, Oliveira, Rene D.R., Zamboni, Dario S., Arruda, Eurico, Auxiliadora-Martins, Maria, Giachini, Fernanda R.C., Bonato, Vânia L.D., Zachara, Natasha E., Bomfim, Gisele F., Tostes, Rita C.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.02.2022 Elsevier Science Ltd Published by Elsevier Inc
Subjects:	ACE2 Angiotensin-converting enzyme 2 Animals Arteries Calcium (intracellular) Calcium ions Cardiovascular Complications Coronaviruses COVID-19 Cytokines DNA probes DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Endothelial cells Endothelial Cells - metabolism Endothelial dysfunction Endothelin 1 Enzyme-linked immunosorbent assay Humans Immunofluorescence Infections Inflammation Interleukin 6 Membrane potential Metabolic pathways Mice Mitochondria Mitochondria - metabolism Mitochondrial DNA NF-κB protein Nitric oxide Nitric-oxide synthase Polymerase chain reaction Proteins SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Signaling Superoxide anions TLR9 protein Toll like receptor 9 Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism Toll-like receptors Umbilical vein Viral diseases Endothelial dysfunction SARS-CoV-2 Mitochondria Toll like receptor 9
ISSN:	1537-1891, 1879-3649, 1879-3649
Online Access:	Get full text
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